RGD Reference Report - Mouse trefoil factor 3 ameliorated high-fat-diet-induced hepatic steatosis via increasing peroxisome proliferator-activated receptor-α-mediated fatty acid oxidation. - Rat Genome Database

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Mouse trefoil factor 3 ameliorated high-fat-diet-induced hepatic steatosis via increasing peroxisome proliferator-activated receptor-α-mediated fatty acid oxidation.

Authors: Wu, Xiaojie  Zheng, Hongze  Yang, Rui  Luan, Xiying  Zhang, Lingyun  Jin, Qingsong  Jin, Yongjun  Xue, Jiangnan 
Citation: Wu X, etal., Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E436-E445. doi: 10.1152/ajpendo.00454.2018. Epub 2019 Jun 18.
RGD ID: 14747028
Pubmed: PMID:31211621   (View Abstract at PubMed)
DOI: DOI:10.1152/ajpendo.00454.2018   (Journal Full-text)

Hepatic trefoil factor 3 (Tff3) was identified as a potential protein for the treatment of diabetes, yet the effect of Tff3 on nonalcoholic fatty liver disease (NAFLD) has never been explored. Here, we found that the expression of hepatic Tff3 was significantly decreased in NAFLD mice models, suggesting that Tff3 was a potential marker gene for NAFLD. Restoring the expression of Tff3 in the liver of NAFLD mice, including diabetic (db), obese (ob/ob), and diet-induced obese mice, with adenovirus-mediated Tff3 (Ad-Tff3) apparently attenuates the fatty liver phenotype. In contrast, adenovirus-mediated knockdown of Tff3 (Ad-shTff3) in C57BL/6J mice results in an obvious fatty liver phenotype. Furthermore, our molecular experiments indicated that hepatic Tff3 could alleviate hepatic steatosis via upregulating the expression of peroxisome proliferator-activated receptor-α (PPARα) directly, thereby enhancing the fatty acid oxidation process in the liver. Notably, we found that Tff3 attenuates the fatty liver phenotype independent of modulation of lipogenesis and improves the capacity of anti-inflammation. Overall, our results suggested that hepatic Tff3 could be effectively used as a potential therapy target for the treatment of NAFLD.



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Genes (Rattus norvegicus)
Cpt1a  (carnitine palmitoyltransferase 1A) Ppara  (peroxisome proliferator activated receptor alpha) Tff3  (trefoil factor 3)

Genes (Mus musculus)
Cpt1a  (carnitine palmitoyltransferase 1a, liver) Ppara  (peroxisome proliferator activated receptor alpha) Tff3  (trefoil factor 3, intestinal)

Genes (Homo sapiens)
CPT1A  (carnitine palmitoyltransferase 1A) PPARA  (peroxisome proliferator activated receptor alpha) TFF3  (trefoil factor 3)