Ppara (peroxisome proliferator activated receptor alpha) - Rat Genome Database
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Gene: Ppara (peroxisome proliferator activated receptor alpha) Mus musculus
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
RGD ID: 732638
Description: Exhibits several functions, including DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription factor binding activity. Involved in several processes, including circadian regulation of gene expression; enamel mineralization; and positive regulation of cellular metabolic process. Predicted to localize to nucleoplasm. Is expressed in several structures, including adipose tissue; early conceptus; heart; liver; and oocyte. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha); PARTICIPATES IN hepatitis C pathway; INTERACTS WITH (+)-alpha-tocopherol; (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4933429D07Rik; AI118064; AW742785; expressed sequence AI118064; Nr1; Nr1c1; nuclear receptor subfamily 1 group C member 1; P; peroxisome proliferator-activated receptor alpha; PP; Ppar; PPAR-alpha; PPARalpha; RIKEN cDNA 4933429D07 gene
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391585,619,112 - 85,691,052 (+)NCBIGRCm39mm39
GRCm381585,734,910 - 85,806,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,734,983 - 85,802,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv371585,565,994 - 85,637,281 (+)NCBIGRCm37mm9NCBIm37
MGSCv361585,563,542 - 85,630,585 (+)NCBImm8
Celera1587,868,281 - 87,938,913 (+)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic hepatitis  (ISO)
Alcoholic Liver Diseases  (IAGP)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anti-basement membrane glomerulonephritis  (IDA)
atopic dermatitis  (IDA,ISO)
Brain Injuries  (ISO)
Cachexia  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (IDA,ISO)
Chronic Hepatitis C  (IEP,ISO)
colitis  (IDA)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (IEA)
Diabetic Cardiomyopathies  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (IDA,IEP,ISO)
hepatocellular carcinoma  (IAGP)
Hepatomegaly  (ISO)
hydrocephalus  (ISO)
Hyperapobetalipoproteinemia  (ISO)
Hyperlipoproteinemias  (ISO)
hypertension  (ISO)
hypertensive encephalopathy  (ISO)
Hypertensive Nephropathy  (ISO)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Inflammation  (ISO)
Insulin Resistance  (IDA,ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
lipid metabolism disorder  (ISO)
Liver Neoplasms  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Multiple Organ Failure  (IAGP)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
non-alcoholic fatty liver disease  (IEP,ISO)
obesity  (ISO)
periodontitis  (ISO)
Phelan-McDermid syndrome  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Reperfusion Injury  (ISO)
Sepsis  (IAGP)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP,ISO)
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(3-phenoxyphenyl)methanol  (ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dichloropropan-2-ol  (EXP)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,4-dichlorobenzene  (EXP)
1-benzofuran  (EXP)
1-chloro-2,4,6-trinitrobenzene  (EXP)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
2-deoxy-D-glucose  (EXP)
2-Ethylhexanoic acid  (EXP,ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP,ISO)
25-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-hydroxybutyric acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-phenoxybenzoic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
7-ketocholesterol  (EXP)
8-Br-cAMP  (ISO)
9-cis,11-trans-octadecadienoic acid  (ISO)
9-cis-retinoic acid  (ISO)
9E,11E-octadecadienoic acid  (ISO)
acadesine  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
alcohol  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allopurinol  (ISO)
alpha-linolenic acid  (EXP,ISO)
alpha-naphthoflavone  (EXP)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
apigenin  (EXP)
arachidonic acid  (ISO)
arachidonoyl-CoA  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (EXP)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP)
atropine  (EXP)
avobenzone  (ISO)
benzalkonium chloride  (EXP)
benzamides  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
Benzyl parahydroxybenzoate  (ISO)
berberine  (EXP)
beta-carotene  (EXP)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (EXP)
bisphenol F diglycidyl ether  (EXP)
bleomycin A2  (EXP)
budesonide  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (EXP,ISO)
carbaryl  (ISO)
carbon dioxide  (EXP)
carbon nanotube  (EXP)
carvedilol  (ISO)
cefuroxime  (EXP)
celecoxib  (ISO)
cerivastatin  (ISO)
chenodeoxycholic acid  (EXP,ISO)
CHIR 99021  (EXP)
chitosan  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP)
choline  (EXP,ISO)
chromium atom  (EXP,ISO)
chrysin  (ISO)
ciglitazone  (EXP,ISO)
ciguatoxin CTX1B  (EXP)
ciprofibrate  (EXP,ISO)
cisplatin  (ISO)
citronellol  (ISO)
Clinofibrate  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP,ISO)
Clofop  (ISO)
cobalt dichloride  (ISO)
conjugated linoleic acid  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cyanamide  (ISO)
cyanocob(III)alamin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (EXP)
cyproconazole  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP)
daunorubicin  (ISO)
dehydroepiandrosterone  (ISO)
dehydroepiandrosterone sulfate  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
Di-n-decyl phthalate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (EXP)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (EXP,ISO)
diclofop-methyl  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (EXP,ISO)
diheptyl phthalate  (ISO)
dihydroartemisinin  (ISO)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
Dimethyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioscin  (EXP,ISO)
dioxygen  (EXP)
dipentyl phthalate  (ISO)
dipropyl phthalate  (ISO)
disodium selenite  (EXP)
dodecanoic acid  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
enalapril  (EXP)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
fenoprofen  (ISO)
flufenamic acid  (ISO)
fluoxetine  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
fomepizole  (ISO)
fructose  (EXP,ISO)
fucoxanthin  (EXP)
fumonisin B1  (EXP)
furan  (ISO)
gadolinium trichloride  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-linolenic acid  (ISO)
gedunin  (EXP)
gemcitabine  (EXP)
gemfibrozil  (EXP,ISO)
gentamycin  (ISO)
geraniol  (ISO)
geranylgeraniol  (ISO)
ginsenoside Rf  (EXP)
glucagon  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP)
glycine betaine  (EXP)
glyphosate  (EXP)
gossypetin  (EXP)
griseofulvin  (EXP)
guggulsterone  (EXP,ISO)
GW 4064  (EXP,ISO)
GW 501516  (EXP,ISO)
GW 6471  (EXP,ISO)
GW 7647  (EXP,ISO)
hexadecanoic acid  (EXP,ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
hydroxytyrosol  (EXP)
ibuprofen  (EXP,ISO)
icariin  (EXP)
idebenone  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
isoniazide  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-methionine  (EXP,ISO)
lead diacetate  (EXP)
leukotriene B4  (EXP,ISO)
levofloxacin  (EXP)
linalool  (EXP,ISO)
linoleic acid  (EXP,ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP,ISO)
losartan  (ISO)
LY294002  (ISO)
malathion  (EXP)
malonyl-CoA  (EXP)
mangiferin  (EXP,ISO)
mechlorethamine  (EXP)
meldonium  (EXP)
mercury dichloride  (EXP,ISO)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methiocarb  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methylparaben  (ISO)
metoprolol  (ISO)
miquelianin  (ISO)
monascin  (EXP)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP,ISO)
Monobutylphthalate  (ISO)
monocrotophos  (ISO)
monoethyl phthalate  (EXP,ISO)
monohexyl phthalate  (ISO)
Monomethyl phthalate  (ISO)
monooctyl phthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
myricetin  (ISO)
myristoyl-CoA  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-beta-D-glucosamine  (EXP)
N-acetyl-D-glucosamine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-phenylthiourea  (ISO)
nafenopin  (EXP,ISO)
naphthalene  (EXP)
naproxen  (ISO)
naringin  (EXP)
nicotine  (ISO)
nicotinic acid  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrites  (EXP)
NMN zwitterion  (EXP)
nonanoic acid  (ISO)
norathyriol  (ISO)
NS-398  (ISO)
obeticholic acid  (EXP,ISO)
octadecanoic acid  (ISO)
octanoic acid  (EXP,ISO)
okadaic acid  (ISO)
olaparib  (EXP)
oleanolic acid  (EXP)
oleic acid  (EXP,ISO)
oleoyl ethanolamide  (EXP,ISO)
oleoyl-CoA  (ISO)
orotic acid  (ISO)
oroxylin A  (EXP,ISO)
osthole  (EXP,ISO)
oxazepam  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
palmitoyl ethanolamide  (ISO)
palmitoyl-CoA  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
penconazole  (EXP)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
perfluorobutanesulfonic acid  (EXP,ISO)
perfluorobutyric acid  (EXP,ISO)
perfluorodecanoic acid  (EXP,ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorohexanoic acid  (EXP,ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (EXP,ISO)
permethrin  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalic acid  (ISO)
phytanic acid  (EXP,ISO)
phytol  (EXP)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (ISO)
propiconazole  (EXP)
propylparaben  (ISO)
propyzamide  (EXP)
Ptaquiloside  (EXP)
pterostilbene  (ISO)
puerarin  (EXP)
pyrazinecarboxamide  (EXP,ISO)
pyrethrins  (EXP)
Pyridostigmine bromide  (EXP)
pyridoxal 5'-phosphate  (ISO)
quercetin  (EXP,ISO)
quinoline  (ISO)
quizalofop-ethyl  (ISO)
raffinose  (EXP,ISO)
reactive oxygen species  (ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
rutin  (ISO)
saccharin  (EXP)
salicylamide  (EXP)
SB 431542  (ISO)
scopoletin  (ISO)
selenium atom  (EXP)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium cholate  (EXP)
sodium dichromate  (EXP,ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (EXP)
stearoyl-CoA  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
Sudan III  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
taurine  (ISO)
tauro-beta-muricholic acid  (EXP)
taurocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
tectoridin  (EXP)
tert-butyl ethyl ether  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP,ISO)
testosterone  (EXP,ISO)
testosterone cypionate  (EXP)
tetrachloroethene  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
tetradecanoic acid  (ISO)
tetramethylpyrazine  (EXP)
tetraphene  (EXP)
tetrathiomolybdate(2-)  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tolazoline  (EXP)
tolmetin  (EXP)
tomelukast  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP)
trichloroacetic acid  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (EXP,ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
Tris(2,3-dibromopropyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (EXP)
tunicamycin  (EXP)
ubiquinones  (EXP)
urea  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin E  (EXP,ISO)
WIN 55212-2  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to nicotine  (ISO)
cell differentiation  (IBA)
cellular response to starvation  (IMP)
circadian regulation of gene expression  (IDA)
enamel mineralization  (IMP)
epidermis development  (IMP)
fatty acid metabolic process  (IBA,IMP,ISO,TAS)
glucose metabolic process  (TAS)
heart development  (ISO)
hormone-mediated signaling pathway  (IBA)
lipid localization  (ISO)
lipid metabolic process  (TAS)
lipoprotein metabolic process  (ISO)
negative regulation of appetite  (IMP)
negative regulation of blood pressure  (ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of cholesterol storage  (IBA,ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of inflammatory response  (IBA,ISO)
negative regulation of leukocyte cell-cell adhesion  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of sequestering of triglyceride  (ISO)
negative regulation of signaling receptor activity  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of fatty acid metabolic process  (IBA)
positive regulation of fatty acid oxidation  (IMP)
positive regulation of gluconeogenesis  (IMP)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IGI,IMP,ISO)
positive regulation of transcription, DNA-templated  (IMP,ISO)
positive regulation of viral genome replication  (ISO)
regulation of cellular ketone metabolic process  (ISO)
regulation of circadian rhythm  (IDA)
regulation of fatty acid metabolic process  (ISO)
regulation of gene expression  (IMP)
regulation of lipid metabolic process  (IBA)
regulation of lipid storage  (ISO)
regulation of transcription, DNA-templated  (ISO,TAS)
response to ethanol  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipid  (IBA)
response to organic cyclic compound  (ISO)
rhythmic process  (IEA)
wound healing  (IMP)

Cellular Component
nucleoplasm  (ISO,TAS)
nucleus  (ISO,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardiovascular system physiology  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal circulating HDL cholesterol level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal circulating ketone body level  (IAGP)
abnormal coat appearance  (IEA)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal glucose tolerance  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal skin coloration  (IEA)
abnormal vascular endothelial cell morphology  (IAGP)
cardiac fibrosis  (IAGP)
cardiomyopathy  (IAGP)
decreased circulating glucose level  (IAGP)
decreased fatty acid oxidation  (IAGP)
decreased keratohyalin granule number  (IAGP)
decreased lean body mass  (IAGP)
decreased liver glycogen level  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
delayed wound healing  (IAGP)
enlarged kidney  (IAGP)
enlarged liver  (IAGP)
heart inflammation  (IAGP)
hepatic steatosis  (IAGP)
hypoglycemia  (IAGP)
hypotension  (IAGP)
impaired adaptive thermogenesis  (IAGP)
improved glucose tolerance  (IAGP)
increased body weight  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased insulin sensitivity  (IAGP)
increased kidney cell proliferation  (IAGP)
increased muscle cell glucose uptake  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased total body fat amount  (IAGP)
increased triglyceride level  (IAGP)
insulin resistance  (IAGP)
myocardial fiber degeneration  (IAGP)
myocardium necrosis  (IAGP)
polycystic kidney  (IAGP)
thin epidermis stratum granulosum  (IAGP)

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