Tff3 (trefoil factor 3) - Rat Genome Database

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Gene: Tff3 (trefoil factor 3) Rattus norvegicus
Analyze
Symbol: Tff3
Name: trefoil factor 3
RGD ID: 3847
Description: Predicted to enable identical protein binding activity. Involved in response to peptide hormone. Predicted to be located in extracellular region and secretory granule. Predicted to be active in extracellular space. Biomarker of colon cancer and pre-malignant neoplasm. Orthologous to human TFF3 (trefoil factor 3); PARTICIPATES IN hypoxia inducible factor pathway; interleukin-4 signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: intestinal trefoil factor; ITF; polypeptide P1.B; rITF; rP1.B; TREFOIL; Trefoil factor (intestinal); trefoil factor 3, intestinal
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,194,623 - 9,199,333 (-)NCBIGRCr8
mRatBN7.2209,193,259 - 9,197,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,193,262 - 9,198,054 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx209,888,414 - 9,893,424 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,249,594 - 9,254,604 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,724,117 - 9,728,984 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,850,800 - 9,855,481 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,850,803 - 9,855,481 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02012,030,957 - 12,035,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,469,888 - 9,474,604 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1209,470,114 - 9,474,831 (-)NCBI
Celera2010,718,676 - 10,723,298 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-acetamidofluorene  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
adenine  (ISO)
aflatoxin B1  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
ciguatoxin CTX1B  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
coumestrol  (ISO)
cytarabine  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
doxorubicin  (EXP,ISO)
enilconazole  (ISO)
Enterolactone  (ISO)
etoposide  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
gamma-linolenic acid  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (EXP)
lidocaine  (EXP)
melamine  (EXP)
menadione  (ISO)
methapyrilene  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
prochloraz  (EXP)
progesterone  (ISO)
propanal  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 203580  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfasalazine  (EXP)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Localization of intestinal trefoil-factor mRNA in rat stomach and intestine by hybridization in situ. Chinery R, etal., Biochem J 1992 Jul 1;285 ( Pt 1):5-8.
2. Gastric TFF1 Expression from Acute to Chronic Helicobacter Infection. Esposito R, etal., Front Cell Infect Microbiol. 2017 Oct 9;7:434. doi: 10.3389/fcimb.2017.00434. eCollection 2017.
3. Intrauterine growth restriction alters postnatal colonic barrier maturation in rats. Fanca-Berthon P, etal., Pediatr Res. 2009 Jul;66(1):47-52. doi: 10.1203/PDR.0b013e3181a2047e.
4. K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine. Femia AP, etal., Int J Cancer. 2008 Jan 1;122(1):117-23.
5. Trefoil peptide expression and goblet cell number in rat intestine: effects of KGF and fasting-refeeding. Fernandez-Estivariz C, etal., Am J Physiol Regul Integr Comp Physiol 2003 Feb;284(2):R564-73.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Trefoil factors are expressed in human and rat endocrine pancreas: differential regulation by growth hormone. Jackerott M, etal., Endocrinology. 2006 Dec;147(12):5752-9. Epub 2006 Sep 14.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Trefoil peptide expression in intestinal adaptation and renewal. Poulsom R, etal., Scand J Gastroenterol Suppl 1992;192:17-28.
13. Molecular and cellular analysis of rP1.B in the rat hypothalamus: in situ hybridization and immunohistochemistry of a new P-domain neuropeptide. Probst JC, etal., Brain Res Mol Brain Res 1995 Nov;33(2):269-76.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Characterization of a putative receptor for intestinal trefoil factor in rat small intestine: identification by in situ binding and ligand blotting. Tan XD, etal., Biochem Biophys Res Commun 1997 Aug 28;237(3):673-7.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Metaplasia of the duodenum shows a Helicobacter pylori-correlated differentiation into gastric-type protein expression. Van De Bovenkamp JH, etal., Hum Pathol. 2003 Feb;34(2):156-65.
20. Plasma levels of trefoil factors are increased in patients with advanced prostate cancer. Vestergaard EM, etal., Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):807-12.
21. Mouse trefoil factor 3 ameliorated high-fat-diet-induced hepatic steatosis via increasing peroxisome proliferator-activated receptor-α-mediated fatty acid oxidation. Wu X, etal., Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E436-E445. doi: 10.1152/ajpendo.00454.2018. Epub 2019 Jun 18.
22. The rat IgGFcgammaBP and Muc2 C-terminal domains and TFF3 in two intestinal mucus layers bind together by covalent interaction. Yu H, etal., PLoS One. 2011;6(5):e20334. doi: 10.1371/journal.pone.0020334. Epub 2011 May 23.
Additional References at PubMed
PMID:1763017   PMID:7721858   PMID:8454642   PMID:12477932   PMID:15645444   PMID:15680474   PMID:15818741   PMID:16086236   PMID:16865413   PMID:17436098   PMID:17624936   PMID:18258687  
PMID:18813976   PMID:18979216   PMID:23376485   PMID:24086476   PMID:24588600   PMID:25504043   PMID:29453360   PMID:29723130  


Genomics

Comparative Map Data
Tff3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,194,623 - 9,199,333 (-)NCBIGRCr8
mRatBN7.2209,193,259 - 9,197,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,193,262 - 9,198,054 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx209,888,414 - 9,893,424 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,249,594 - 9,254,604 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,724,117 - 9,728,984 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,850,800 - 9,855,481 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,850,803 - 9,855,481 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02012,030,957 - 12,035,638 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,469,888 - 9,474,604 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1209,470,114 - 9,474,831 (-)NCBI
Celera2010,718,676 - 10,723,298 (-)NCBICelera
Cytogenetic Map20p12NCBI
TFF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382142,311,667 - 42,315,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2142,311,667 - 42,315,409 (-)EnsemblGRCh38hg38GRCh38
GRCh372143,731,777 - 43,735,519 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,605,232 - 42,608,775 (-)NCBINCBI36Build 36hg18NCBI36
Build 342142,605,232 - 42,608,775NCBI
Celera2128,880,742 - 28,884,671 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2129,149,059 - 29,152,988 (-)NCBIHuRef
CHM1_12143,291,988 - 43,295,917 (-)NCBICHM1_1
T2T-CHM13v2.02140,701,121 - 40,704,863 (-)NCBIT2T-CHM13v2.0
Tff3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,344,280 - 31,348,585 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,344,280 - 31,348,620 (-)EnsemblGRCm39 Ensembl
GRCm381731,125,306 - 31,129,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1731,125,306 - 31,129,646 (-)EnsemblGRCm38mm10GRCm38
MGSCv371731,262,251 - 31,266,556 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361730,852,327 - 30,856,623 (-)NCBIMGSCv36mm8
Celera1732,042,584 - 32,046,915 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.8NCBI
Tff3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540739,398,074 - 39,401,248 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540739,398,534 - 39,401,085 (+)NCBIChiLan1.0ChiLan1.0
TFF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22238,375,036 - 38,379,891 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12133,229,675 - 33,234,530 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,627,191 - 28,631,341 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12141,948,674 - 41,952,207 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2141,948,696 - 41,952,268 (-)Ensemblpanpan1.1panPan2
TFF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,638,762 - 36,641,696 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3135,789,681 - 35,792,613 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03136,155,220 - 36,158,156 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3136,155,093 - 36,158,196 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13136,048,305 - 36,051,229 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03136,028,347 - 36,031,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,523,422 - 36,526,353 (-)NCBIUU_Cfam_GSD_1.0
TFF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13205,641,038 - 205,644,333 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113205,641,038 - 205,644,333 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213216,043,521 - 216,046,817 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Tff3
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:99
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000066266
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat

Markers in Region
AI411511  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,193,278 - 9,193,378 (+)MAPPERmRatBN7.2
Rnor_6.0209,850,820 - 9,850,919NCBIRnor6.0
Rnor_5.02012,030,977 - 12,031,076UniSTSRnor5.0
RGSC_v3.4209,469,905 - 9,470,004UniSTSRGSC3.4
Celera2010,718,696 - 10,718,795UniSTS
RH 3.4 Map20117.7UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 7
Medium 1 16 16 16 6 22 7
Low 2 20 18 2 18 1 1 53 6 29 3 1
Below cutoff 26 19 7 12 7 3 4 13 5 8 3

Sequence


RefSeq Acc Id: ENSRNOT00000066266   ⟹   ENSRNOP00000060620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,193,262 - 9,198,054 (-)Ensembl
Rnor_6.0 Ensembl209,850,803 - 9,855,481 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090275   ⟹   ENSRNOP00000071550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl209,851,448 - 9,855,443 (-)Ensembl
RefSeq Acc Id: NM_013042   ⟹   NP_037174
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,194,623 - 9,199,333 (-)NCBI
mRatBN7.2209,193,259 - 9,197,969 (-)NCBI
Rnor_6.0209,850,800 - 9,855,481 (-)NCBI
Rnor_5.02012,030,957 - 12,035,638 (-)NCBI
RGSC_v3.4209,469,888 - 9,474,604 (-)RGD
Celera2010,718,676 - 10,723,298 (-)NCBI
Sequence:
RefSeq Acc Id: NP_037174   ⟸   NM_013042
- Peptide Label: precursor
- UniProtKB: Q68FZ2 (UniProtKB/Swiss-Prot),   Q03191 (UniProtKB/Swiss-Prot),   A6JJY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071550   ⟸   ENSRNOT00000090275
RefSeq Acc Id: ENSRNOP00000060620   ⟸   ENSRNOT00000066266
Protein Domains
P-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03191-F1-model_v2 AlphaFold Q03191 1-81 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701482
Promoter ID:EPDNEW_R11994
Type:multiple initiation site
Name:Tff3_1
Description:trefoil factor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0209,855,474 - 9,855,534EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3847 AgrOrtholog
BioCyc Gene G2FUF-4328 BioCyc
Ensembl Genes ENSRNOG00000001159 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066266.4 UniProtKB/TrEMBL
Gene3D-CATH 4.10.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127312 IMAGE-MGC_LOAD
InterPro P_trefoil_chordata UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_trefoil_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_trefoil_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_trefoil_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25563 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93548 IMAGE-MGC_LOAD
NCBI Gene 25563 ENTREZGENE
PANTHER PTHR13826 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TREFOIL FACTOR 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trefoil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tff3 PhenoGen
PRINTS PTREFOIL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P_TREFOIL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_TREFOIL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001159 RatGTEx
SMART SM00018 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57492 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208131
UniProt A0A0G2JSY6_RAT UniProtKB/TrEMBL
  A6JJY2 ENTREZGENE, UniProtKB/TrEMBL
  Q03191 ENTREZGENE
  Q68FZ2 ENTREZGENE
  TFF3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q68FZ2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-29 Tff3  trefoil factor 3  Tff3  trefoil factor 3, intestinal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Tff3  trefoil factor 3, intestinal  Tff3  trefoil factor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Tff3  trefoil factor 3  Tff3  Trefoil factor (intestinal)  Name updated 629478 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization secreted by intestinal goblet cells 730274