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Gene: TFF1 (trefoil factor 1) Homo sapiens
Symbol: TFF1
Name: trefoil factor 1
Description: Predicted to have growth factor activity. Predicted to be involved in maintenance of gastrointestinal epithelium. Predicted to localize to the extracellular space. Biomarker of several diseases, including ductal carcinoma in situ; endometrial hyperplasia; reproductive organ cancer (multiple); signet ring cell adenocarcinoma; and transitional cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BCEI; breast cancer estrogen-inducible protein; breast cancer estrogen-inducible sequence; D21S21; gastrointestinal trefoil protein pS2; HP1.A; HPS2; pNR-2; polypeptide P1.A; pS2; trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in)
Mus musculus (house mouse) : Tff1 (trefoil factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tff1 (trefoil factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tff1 (trefoil factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TFF1 (trefoil factor 1)
Canis lupus familiaris (dog) : TFF1 (trefoil factor 1)
Sus scrofa (pig) : TFF1 (trefoil factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382142,362,282 - 42,366,535 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372143,782,391 - 43,786,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,655,460 - 42,659,713 (-)NCBINCBI36hg18NCBI36
Build 342142,655,459 - 42,659,713NCBI
Celera2128,931,367 - 28,935,619 (-)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2129,199,645 - 29,203,896 (-)NCBIHuRef
CHM1_12143,342,564 - 43,346,817 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TFF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344671
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.