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Gene: TFF1 (trefoil factor 1) Homo sapiens
Symbol: TFF1
Name: trefoil factor 1
RGD ID: 1344671
Description: Predicted to have growth factor activity. Predicted to be involved in maintenance of gastrointestinal epithelium. Predicted to localize to extracellular space. Biomarker of several diseases, including ductal carcinoma in situ; endometrial hyperplasia; reproductive organ cancer (multiple); signet ring cell adenocarcinoma; and transitional cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BCEI; breast cancer estrogen-inducible protein; breast cancer estrogen-inducible sequence; D21S21; gastrointestinal trefoil protein pS2; HP1.A; HPS2; pNR-2; polypeptide P1.A; pS2; trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in)
Mus musculus (house mouse) : Tff1 (trefoil factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tff1 (trefoil factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tff1 (trefoil factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TFF1 (trefoil factor 1)
Canis lupus familiaris (dog) : TFF1 (trefoil factor 1)
Sus scrofa (pig) : TFF1 (trefoil factor 1)
Chlorocebus sabaeus (African green monkey) : TFF1 (trefoil factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2142,362,282 - 42,366,535 (-)EnsemblGRCh38hg38GRCh38
GRCh382142,362,282 - 42,366,535 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372143,782,391 - 43,786,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,655,460 - 42,659,713 (-)NCBINCBI36hg18NCBI36
Build 342142,655,459 - 42,659,713NCBI
Celera2128,931,367 - 28,935,619 (-)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2129,199,645 - 29,203,896 (-)NCBIHuRef
CHM1_12143,342,564 - 43,346,817 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TFF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344671
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.