Ppara (peroxisome proliferator activated receptor alpha) - Rat Genome Database

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Gene: Ppara (peroxisome proliferator activated receptor alpha) Heterocephalus glaber
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Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
RGD ID: 18905207
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); Alcoholic Fatty Liver (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: peroxisome proliferator-activated receptor alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247523,650,922 - 3,701,672 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247523,646,499 - 3,702,553 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic hepatitis  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
atopic dermatitis  (ISO)
Brain Injuries  (ISO)
Cachexia  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
colitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
hydrocephalus  (ISO)
Hyperapobetalipoproteinemia  (ISO)
Hyperlipoproteinemias  (ISO)
hypertension  (ISO)
hypertensive encephalopathy  (ISO)
Hypertensive Nephropathy  (ISO)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
lipid metabolism disorder  (ISO)
Liver Neoplasms  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
Multiple Organ Failure  (ISO)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
periodontitis  (ISO)
Phelan-McDermid syndrome  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
steatotic liver disease  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to nicotine  (ISO)
cell differentiation  (IEA)
cellular response to fructose stimulus  (ISO)
cellular response to starvation  (IEA)
circadian regulation of gene expression  (IEA)
enamel mineralization  (IEA,ISO)
epidermis development  (IEA,ISO)
fatty acid metabolic process  (IEA,ISO)
gluconeogenesis  (IEA,ISO)
heart development  (ISO)
hormone-mediated signaling pathway  (IEA)
intracellular receptor signaling pathway  (IEA)
lipoprotein metabolic process  (ISO)
negative regulation of appetite  (IEA)
negative regulation of blood pressure  (ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of cholesterol storage  (IEA)
negative regulation of cytokine production involved in inflammatory response  (IEA,ISO)
negative regulation of glycolytic process  (IEA)
negative regulation of hepatocyte apoptotic process  (IEA,ISO)
negative regulation of inflammatory response  (IEA)
negative regulation of leukocyte cell-cell adhesion  (IEA)
negative regulation of macrophage derived foam cell differentiation  (IEA)
negative regulation of miRNA transcription  (IEA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of protein binding  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
negative regulation of sequestering of triglyceride  (IEA)
negative regulation of signaling receptor activity  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
nitric oxide metabolic process  (ISO)
positive regulation of ATP biosynthetic process  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of fatty acid metabolic process  (IEA)
positive regulation of fatty acid oxidation  (IEA)
positive regulation of gluconeogenesis  (IEA,ISO)
positive regulation of lipid biosynthetic process  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of circadian rhythm  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of fatty acid metabolic process  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of ketone metabolic process  (IEA)
regulation of lipid storage  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to ethanol  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
steroid hormone receptor signaling pathway  (IEA)
wound healing  (IEA,ISO)

Cellular Component
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ppara
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247523,650,922 - 3,701,672 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247523,646,499 - 3,702,553 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PPARA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382246,150,526 - 46,243,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2246,150,521 - 46,243,755 (+)EnsemblGRCh38hg38GRCh38
GRCh372246,546,429 - 46,639,653 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,925,163 - 45,018,317 (+)NCBINCBI36Build 36hg18NCBI36
Build 342244,893,181 - 44,937,060NCBI
Celera2230,453,877 - 30,547,038 (+)NCBICelera
Cytogenetic Map22q13.31ENTREZGENE
HuRef2229,490,745 - 29,583,687 (+)NCBIHuRef
CHM1_12246,506,503 - 46,598,389 (+)NCBICHM1_1
T2T-CHM13v2.02246,635,225 - 46,728,457 (+)NCBIT2T-CHM13v2.0
Ppara
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,619,112 - 85,691,052 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1585,619,184 - 85,687,020 (+)EnsemblGRCm39 Ensembl
GRCm381585,734,910 - 85,806,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,734,983 - 85,802,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv371585,565,994 - 85,637,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361585,563,542 - 85,630,585 (+)NCBIMGSCv36mm8
Celera1587,868,281 - 87,938,913 (+)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.42NCBI
Ppara
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87118,712,261 - 118,780,723 (+)NCBIGRCr8
mRatBN7.27116,832,405 - 116,900,878 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,832,756 - 116,895,346 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7118,583,352 - 118,646,124 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,808,966 - 120,871,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,778,539 - 120,841,315 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07126,618,872 - 126,687,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,330,559 - 126,397,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47123,729,774 - 123,807,090 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17123,764,003 - 123,841,320 (+)NCBI
Celera7113,125,201 - 113,187,404 (+)NCBICelera
RH 3.4 Map7922.4RGD
Cytogenetic Map7q34NCBI
Ppara
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,307,219 - 30,359,500 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541330,306,563 - 30,366,245 (+)NCBIChiLan1.0ChiLan1.0
PPARA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22355,981,175 - 56,072,797 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12258,679,171 - 58,770,754 (+)NCBINHGRI_mPanPan1
PanPan1.12245,218,364 - 45,302,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2245,218,364 - 45,302,970 (+)Ensemblpanpan1.1panPan2
PPARA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11019,934,020 - 20,006,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1019,934,165 - 20,006,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1019,862,969 - 19,928,467 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01020,667,818 - 20,740,885 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1020,668,580 - 20,740,947 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11020,394,544 - 20,460,174 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01020,707,323 - 20,772,988 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01020,889,156 - 20,954,630 (-)NCBIUU_Cfam_GSD_1.0
Ppara
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049453,665,412 - 3,725,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366293,672,460 - 3,725,626 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366293,672,445 - 3,725,645 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl53,300,741 - 3,364,239 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.153,302,755 - 3,321,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25470,097 - 488,440 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103223491
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11928,614,892 - 28,709,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1928,615,413 - 28,708,763 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236661593,466 - 79,995 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Sequence


Ensembl Acc Id: ENSHGLT00000016528   ⟹   ENSHGLP00000016359
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247523,650,922 - 3,701,672 (-)Ensembl
RefSeq Acc Id: XM_013072444   ⟹   XP_012927898
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247523,646,499 - 3,702,060 (-)NCBI
RefSeq Acc Id: XM_013072445   ⟹   XP_012927899
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247523,652,657 - 3,702,060 (-)NCBI
RefSeq Acc Id: XM_021258801   ⟹   XP_021114460
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247523,646,499 - 3,702,140 (-)NCBI
RefSeq Acc Id: XM_021258802   ⟹   XP_021114461
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247523,646,499 - 3,702,553 (-)NCBI
RefSeq Acc Id: XM_021258803   ⟹   XP_021114462
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247523,651,755 - 3,702,060 (-)NCBI
RefSeq Acc Id: XR_002395211
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247523,646,499 - 3,702,060 (-)NCBI
RefSeq Acc Id: XP_021114461   ⟸   XM_021258802
- Peptide Label: isoform X1
- UniProtKB: G5BVA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114460   ⟸   XM_021258801
- Peptide Label: isoform X1
- UniProtKB: G5BVA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927898   ⟸   XM_013072444
- Peptide Label: isoform X1
- UniProtKB: G5BVA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114462   ⟸   XM_021258803
- Peptide Label: isoform X3
RefSeq Acc Id: XP_012927899   ⟸   XM_013072445
- Peptide Label: isoform X2
Ensembl Acc Id: ENSHGLP00000016359   ⟸   ENSHGLT00000016528


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011724 Ensembl, ENTREZGENE
  ENSHGLG00100017387 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000016528 ENTREZGENE
  ENSHGLT00100061056 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro 1Cnucl_rcpt UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hormone_rcpt_NR1 UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  PPAR-alpha UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
KEGG Report hgl:101725514 UniProtKB/TrEMBL
NCBI Gene Ppara ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
  PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS PROXISOMEPAR UniProtKB/TrEMBL
  PROXISOMPAAR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt G5BVA9 ENTREZGENE, UniProtKB/TrEMBL