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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3369
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:50867
Term: ciprofibrate
Definition: A cyclopropane that has formula C13H14Cl2O3.
Chemical ID: MESH:C019304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparaincreases activityEXP 6480464CTDciprofibrate results in increased activity of PPARA proteinPMID:9688458
Pparamultiple interactionsEXP 6480464CTDciprofibrate binds to and results in increased activity of PPARA proteinPMID:15853379 PMID:16731579
Pparaaffects response to substanceISOPpara (Mus musculus)6480464CTDPPARA protein affects the susceptibility to ciprofibratePMID:18375545
Pparaincreases activityISOPpara (Mus musculus)6480464CTDciprofibrate results in increased activity of PPARA proteinPMID:30203046
Pparaincreases expressionISOPpara (Mus musculus)6480464CTDciprofibrate results in increased expression of PPARA mRNAPMID:17627975 PMID:25689681
Pparaincreases expressionISOPPARA (Homo sapiens)6480464CTDciprofibrate results in increased expression of PPARA mRNAPMID:16680075
Pparamultiple interactionsISOPpara (Mus musculus)6480464CTD[ciprofibrate binds to PPARA protein] which results in increased expression of ABCC3 mRNA; ciprofibrate binds to and results in increased activity of PPARA proteinPMID:15833929 PMID:15919853 PMID:15968640 PMID:16731579
Pparamultiple interactionsISOPPARA (Homo sapiens)6480464CTDciprofibrate binds to and results in increased activity of PPARA proteinPMID:16731579
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