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Gene: Nr1h4 (nuclear receptor subfamily 1, group H, member 4) Rattus norvegicus
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Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; bile acid receptor activity; and chenodeoxycholic acid binding activity. Contributes to double-stranded DNA binding activity. Involved in several processes, including cellular response to bile acid; intracellular bile acid receptor signaling pathway; and negative regulation of biosynthetic process. Localizes to nucleus and receptor complex. Used to study extrahepatic cholestasis; intrahepatic cholestasis; and portal hypertension. Biomarker of bile duct disease (multiple); liver disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; and premature menopause. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4); PARTICIPATES IN bile acid signaling pathway; bile acid signaling pathway; bile acid signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: bile acid receptor; farnesoid X activated receptor; farnesoid X-activated receptor; farnesol receptor HRR-1; Fxr; MGC94878; nuclear receptor subfamily 1 group H member 4; retinoid X receptor-interacting protein 14; RXR-interacting protein 14
Orthologs:
Homo sapiens (human) : NR1H4 (nuclear receptor subfamily 1 group H member 4)  HGNC  Alliance
Mus musculus (house mouse) : Nr1h4 (nuclear receptor subfamily 1, group H, member 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr1h4 (nuclear receptor subfamily 1 group H member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NR1H4 (nuclear receptor subfamily 1 group H member 4)
Canis lupus familiaris (dog) : NR1H4 (nuclear receptor subfamily 1 group H member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr1h4 (nuclear receptor subfamily 1 group H member 4)
Sus scrofa (pig) : NR1H4 (nuclear receptor subfamily 1 group H member 4)
Chlorocebus sabaeus (African green monkey) : NR1H4 (nuclear receptor subfamily 1 group H member 4)
Heterocephalus glaber (naked mole-rat) : Nr1h4 (nuclear receptor subfamily 1 group H member 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0730,003,429 - 30,162,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl730,003,429 - 30,162,056 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0730,104,960 - 30,107,142 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0730,170,397 - 30,214,796 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4726,189,759 - 26,307,061 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1726,210,029 - 26,327,332 (-)NCBI
Celera720,992,814 - 21,085,820 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nr1h4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628831
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.