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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3369
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:60312
Term: 2-amino-2-deoxy-D-galactopyranose
Definition: The pyranose form of D-galactosamine.
Chemical ID: MESH:D005688
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparadecreases expressionISOPPARA (Homo sapiens)6480464CTDGalactosamine results in decreased expression of PPARA mRNAPMID:17936189
Pparaincreases activityISOPpara (Mus musculus)6480464CTDGalactosamine results in increased activity of PPARA proteinPMID:30203046
Pparaincreases expressionISOPpara (Mus musculus)6480464CTDGalactosamine results in increased expression of PPARA mRNAPMID:25689681
Pparamultiple interactionsISOPpara (Mus musculus)6480464CTD[Plant Extracts co-treated with Lipopolysaccharides co-treated with Galactosamine] results in increased expression of PPARA mRNA; [Plant Extracts co-treated with Lipopolysaccharides co-treated with Galactosamine] results in increased expression of PPARA protein; [Silymarin co-treated with Lipopolysaccharides co-treated with Galactosamine] results in increased expression of PPARA mRNA; [Silymarin co-treated with Lipopolysaccharides co-treated with Galactosamine] results in increased expression of PPARA proteinPMID:30236599
Pparamultiple interactionsISOPPARA (Homo sapiens)6480464CTDalpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of PPARA mRNA]PMID:17936189
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