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Gene: Nr1h2 (nuclear receptor subfamily 1, group H, member 2) Rattus norvegicus
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Symbol: Nr1h2
Name: nuclear receptor subfamily 1, group H, member 2
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and retinoid X receptor binding activity. Contributes to sequence-specific DNA binding activity. Involved in regulation of gene expression; response to nutrient levels; and retinoic acid receptor signaling pathway. Predicted to localize to RNA polymerase II transcription factor complex and cytoplasm. Biomarker of obesity. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR1H2 (nuclear receptor subfamily 1 group H member 2); INTERACTS WITH (S)-nicotine; 2,4-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: liver X receptor beta; LXR beta; LXRB; LXRbeta; nuclear orphan receptor LXR-beta; nuclear receptor subfamily 1 group H member 2; OR-1; orphan nuclear receptor OR-1; oxysterols receptor LXR-beta; ubiquitous receptor; ubiquitously-expressed nuclear receptor; UR
Orthologs:
Homo sapiens (human) : NR1H2 (nuclear receptor subfamily 1 group H member 2)  HGNC  Alliance
Mus musculus (house mouse) : Nr1h2 (nuclear receptor subfamily 1, group H, member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr1h2 (nuclear receptor subfamily 1 group H member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NR1H2 (nuclear receptor subfamily 1 group H member 2)
Canis lupus familiaris (dog) : NR1H2 (nuclear receptor subfamily 1 group H member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr1h2 (nuclear receptor subfamily 1 group H member 2)
Sus scrofa (pig) : NR1H2 (nuclear receptor subfamily 1 group H member 2)
Chlorocebus sabaeus (African green monkey) : NR1H2 (nuclear receptor subfamily 1 group H member 2)
Heterocephalus glaber (naked mole-rat) : Nr1h2 (nuclear receptor subfamily 1 group H member 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01100,554,577 - 100,559,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,554,544 - 100,559,942 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,619,964 - 101,625,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,027,197 - 95,032,516 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1195,105,321 - 95,110,627 (-)NCBI
Celera189,304,444 - 89,309,763 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nr1h2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61906
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.