Nr1h2 (nuclear receptor subfamily 1, group H, member 2) - Rat Genome Database

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Gene: Nr1h2 (nuclear receptor subfamily 1, group H, member 2) Rattus norvegicus
Symbol: Nr1h2
Name: nuclear receptor subfamily 1, group H, member 2
RGD ID: 61906
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear retinoid X receptor binding activity. Contributes to sequence-specific DNA binding activity. Involved in regulation of gene expression; response to nutrient levels; and retinoic acid receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Biomarker of obesity. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR1H2 (nuclear receptor subfamily 1 group H member 2); INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: liver X receptor beta; LXR beta; LXRB; LXRbeta; nuclear orphan receptor LXR-beta; nuclear receptor subfamily 1 group H member 2; OR-1; orphan nuclear receptor OR-1; oxysterols receptor LXR-beta; ubiquitous receptor; ubiquitously-expressed nuclear receptor; UR
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81104,178,483 - 104,183,863 (-)NCBIGRCr8
mRatBN7.2195,041,967 - 95,047,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,041,967 - 95,047,377 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,427,372 - 100,432,752 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,900,016 - 108,905,396 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,190,437 - 102,195,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,554,577 - 100,559,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,554,544 - 100,559,942 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,619,964 - 101,625,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,027,197 - 95,032,516 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,105,321 - 95,110,627 (-)NCBI
Celera189,304,444 - 89,309,763 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pinoresinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
22-Hydroxycholesterol  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-linolenic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
bucladesine  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
clofibrate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
diethylstilbestrol  (EXP)
etoposide  (ISO)
ezetimibe  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
gemfibrozil  (ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
guggulsterone  (ISO)
GW 3965  (ISO)
GW 501516  (ISO)
hexadecanoic acid  (ISO)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
lansoprazole  (ISO)
lipopolysaccharide  (EXP,ISO)
loliolide  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Morroniside  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP,ISO)
nicotine  (EXP,ISO)
octanoic acid  (ISO)
Octicizer  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
rac-lactic acid  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
temozolomide  (ISO)
teniposide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)
vecuronium bromide  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IBA,IEA)
cellular lipid metabolic process  (ISO)
cholesterol homeostasis  (IEA,ISO,ISS)
intracellular receptor signaling pathway  (IEA)
lipid homeostasis  (ISO)
negative regulation of cholesterol storage  (IEA,ISO)
negative regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (IDA)
negative regulation of lipid transport  (IEA,ISO)
negative regulation of pinocytosis  (IEA,ISO)
negative regulation of proteolysis  (IEA,ISO)
negative regulation of response to endoplasmic reticulum stress  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
phosphatidylcholine acyl-chain remodeling  (IEA,ISO,ISS)
positive regulation of cholesterol efflux  (IEA,ISO)
positive regulation of cholesterol transport  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fatty acid biosynthetic process  (IEA,ISO)
positive regulation of gene expression  (IDA)
positive regulation of high-density lipoprotein particle assembly  (IEA,ISO)
positive regulation of lipid storage  (IEA,ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of pancreatic juice secretion  (IEA,ISO)
positive regulation of protein metabolic process  (IEA,ISO)
positive regulation of secretion of lysosomal enzymes  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,ISO)
positive regulation of triglyceride biosynthetic process  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to nutrient levels  (IEP)
retinoic acid receptor signaling pathway  (IDA)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Simultaneous activation of the liver X receptors (LXRalpha and LXRbeta) drives murine collagen-induced arthritis disease pathology. Asquith DL, etal., Ann Rheum Dis. 2011 Dec;70(12):2225-8. Epub 2011 Aug 22.
2. Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/- mice, a model of adult neuron disease. Bigini P, etal., J Neuropathol Exp Neurol. 2010 Jun;69(6):593-605.
3. Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation. Cui G, etal., J Clin Invest. 2011 Feb;121(2):658-70. doi: 10.1172/JCI42974. Epub 2011 Jan 25.
4. Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity. Dahlman I, etal., Pharmacogenet Genomics. 2006 Dec;16(12):881-9.
5. Identification of a novel DNA binding site for nuclear orphan receptor OR1. Feltkamp D, etal., J Biol Chem. 1999 Apr 9;274(15):10421-9.
6. Estrogen-dependent gallbladder carcinogenesis in LXRbeta-/- female mice. Gabbi C, etal., Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14763-8. Epub 2010 Aug 2.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition. Ghoneim RH, etal., Br J Nutr. 2015 Feb 14;113(3):507-16. doi: 10.1017/S0007114514003717. Epub 2015 Jan 23.
9. Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. Korach-André M, etal., Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):403-8. doi: 10.1073/pnas.1017884108. Epub 2010 Dec 20.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Suggestive evidence of associations between liver X receptor ß polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe). Solaas K, etal., BMC Med Genet. 2010 Oct 12;11:144. doi: 10.1186/1471-2350-11-144.
15. Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors. Song C, etal., Proc Natl Acad Sci U S A 1994 Nov 8;91(23):10809-13.
16. OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. Teboul M, etal., Proc Natl Acad Sci U S A 1995 Mar 14;92(6):2096-100.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B. Wang W, etal., Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018.
19. Liver X receptor protects against liver injury in sepsis caused by rodent cecal ligation and puncture. Wang YY, etal., Surg Infect (Larchmt). 2011 Aug;12(4):283-9. Epub 2011 Aug 4.
20. Heterodimeric interaction between retinoid X receptor alpha and orphan nuclear receptor OR1 reveals dimerization-induced activation as a novel mechanism of nuclear receptor activation. Wiebel FF and Gustafsson JA, Mol Cell Biol. 1997 Jul;17(7):3977-86.
21. Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD. Zhang Y, etal., J Ethnopharmacol. 2021 Feb 10;266:113436. doi: 10.1016/j.jep.2020.113436. Epub 2020 Oct 1.
Additional References at PubMed
PMID:7760852   PMID:9013544   PMID:12393874   PMID:12477932   PMID:14739254   PMID:16141411   PMID:16354191   PMID:16524875   PMID:16825483   PMID:17186944   PMID:17657314   PMID:17693624  
PMID:17766241   PMID:18055760   PMID:18806227   PMID:19228891   PMID:19351492   PMID:19782030   PMID:20219900   PMID:20388921   PMID:22729460   PMID:22836489   PMID:22984598   PMID:23931754  
PMID:24398515   PMID:25661920   PMID:27352290   PMID:27485016   PMID:29654801   PMID:30471864   PMID:31161476  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81104,178,483 - 104,183,863 (-)NCBIGRCr8
mRatBN7.2195,041,967 - 95,047,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,041,967 - 95,047,377 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,427,372 - 100,432,752 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,900,016 - 108,905,396 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,190,437 - 102,195,817 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,554,577 - 100,559,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,554,544 - 100,559,942 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,619,964 - 101,625,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,027,197 - 95,032,516 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,105,321 - 95,110,627 (-)NCBI
Celera189,304,444 - 89,309,763 (-)NCBICelera
Cytogenetic Map1q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381950,376,457 - 50,383,388 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,329,653 - 50,383,388 (+)EnsemblGRCh38hg38GRCh38
GRCh371950,879,714 - 50,886,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,571,497 - 55,578,079 (+)NCBINCBI36Build 36hg18NCBI36
Build 341955,571,514 - 55,578,048NCBI
Celera1947,929,924 - 47,936,510 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1947,217,814 - 47,224,423 (+)NCBIHuRef
CHM1_11950,881,453 - 50,888,062 (+)NCBICHM1_1
T2T-CHM13v2.01953,464,005 - 53,470,940 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39744,199,040 - 44,204,928 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,199,040 - 44,203,375 (-)EnsemblGRCm39 Ensembl
GRCm38744,549,616 - 44,553,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,549,616 - 44,553,951 (-)EnsemblGRCm38mm10GRCm38
MGSCv37751,805,002 - 51,809,293 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,417,674 - 44,421,965 (-)NCBIMGSCv36mm8
Celera739,999,761 - 40,004,052 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.83NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955559730,670 - 737,505 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955559731,630 - 736,973 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v22056,442,021 - 56,448,701 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11958,363,472 - 58,370,113 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,340,077 - 47,346,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,243,124 - 56,250,024 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,243,124 - 56,250,024 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11106,332,691 - 106,339,168 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,332,798 - 106,339,135 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,905,786 - 105,912,261 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,843,783 - 106,850,258 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,843,781 - 106,850,221 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,515,887 - 106,522,355 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,157,420 - 106,163,895 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,998,070 - 107,004,546 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934922,347,505 - 22,353,794 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889223,101 - 229,990 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889223,137 - 229,968 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl655,239,500 - 55,245,456 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,238,536 - 55,245,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,087,383 - 51,094,318 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1643,438,428 - 43,445,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl643,437,950 - 43,446,063 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607323,425,677 - 23,432,503 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248324,132,904 - 4,140,896 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,136,052 - 4,141,648 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Nr1h2
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:197
Count of miRNA genes:136
Interacting mature miRNAs:151
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,042,004 - 95,042,112 (+)MAPPERmRatBN7.2
Rnor_6.01100,554,604 - 100,554,711NCBIRnor6.0
Rnor_5.01101,619,991 - 101,620,098UniSTSRnor5.0
RGSC_v3.4195,027,224 - 95,027,331UniSTSRGSC3.4
Celera189,304,471 - 89,304,578UniSTS
Cytogenetic Map1q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,042,056 - 95,042,210 (+)MAPPERmRatBN7.2
Rnor_6.01100,554,656 - 100,554,809NCBIRnor6.0
Rnor_5.01101,620,043 - 101,620,196UniSTSRnor5.0
RGSC_v3.4195,027,276 - 95,027,429UniSTSRGSC3.4
Celera189,304,523 - 89,304,676UniSTS
RH 3.4 Map1886.8UniSTS
Cytogenetic Map1q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,042,803 - 95,044,216 (+)MAPPERmRatBN7.2
Rnor_6.01100,555,403 - 100,556,815NCBIRnor6.0
Rnor_5.01101,620,790 - 101,622,202UniSTSRnor5.0
RGSC_v3.4195,028,023 - 95,029,435UniSTSRGSC3.4
Celera189,305,270 - 89,306,682UniSTS
RH 3.4 Map1906.5UniSTS
Cytogenetic Map1q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000026862   ⟹   ENSRNOP00000026862
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,041,967 - 95,047,377 (-)Ensembl
Rnor_6.0 Ensembl1100,554,544 - 100,559,942 (-)Ensembl
RefSeq Acc Id: NM_001398609   ⟹   NP_001385538
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81104,178,483 - 104,183,863 (-)NCBI
mRatBN7.2195,041,967 - 95,047,347 (-)NCBI
RefSeq Acc Id: NM_001398610   ⟹   NP_001385539
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81104,178,483 - 104,183,863 (-)NCBI
mRatBN7.2195,041,967 - 95,047,347 (-)NCBI
RefSeq Acc Id: NM_001398611   ⟹   NP_001385540
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81104,178,483 - 104,183,863 (-)NCBI
mRatBN7.2195,041,967 - 95,047,347 (-)NCBI
RefSeq Acc Id: NM_031626   ⟹   NP_113814
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81104,178,483 - 104,183,863 (-)NCBI
mRatBN7.2195,041,967 - 95,047,347 (-)NCBI
Rnor_6.01100,554,577 - 100,559,896 (-)NCBI
Rnor_5.01101,619,964 - 101,625,283 (-)NCBI
RGSC_v3.4195,027,197 - 95,032,516 (-)RGD
Celera189,304,444 - 89,309,763 (-)RGD
RefSeq Acc Id: XM_039088764   ⟹   XP_038944692
Rat AssemblyChrPosition (strand)Source
GRCr81104,178,499 - 104,182,502 (-)NCBI
mRatBN7.2195,041,983 - 95,047,358 (-)NCBI
RefSeq Acc Id: NP_113814   ⟸   NM_031626
- Peptide Label: isoform b
- UniProtKB: A0A8L2QE94 (UniProtKB/TrEMBL),   A9UMV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026862   ⟸   ENSRNOT00000026862
RefSeq Acc Id: XP_038944692   ⟸   XM_039088764
- Peptide Label: isoform X1
- UniProtKB: A9UMV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385539   ⟸   NM_001398610
- Peptide Label: isoform a
- UniProtKB: Q62755 (UniProtKB/Swiss-Prot),   Q62694 (UniProtKB/Swiss-Prot),   A6JAR1 (UniProtKB/TrEMBL),   A9UMV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385540   ⟸   NM_001398611
- Peptide Label: isoform b
- UniProtKB: A0A8L2QE94 (UniProtKB/TrEMBL),   A9UMV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385538   ⟸   NM_001398609
- Peptide Label: isoform a
- UniProtKB: Q62755 (UniProtKB/Swiss-Prot),   Q62694 (UniProtKB/Swiss-Prot),   A6JAR1 (UniProtKB/TrEMBL),   A9UMV6 (UniProtKB/TrEMBL)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62755-F1-model_v2 AlphaFold Q62755 1-446 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690001
Promoter ID:EPDNEW_R526
Type:initiation region
Description:nuclear receptor subfamily 1, group H, member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01100,559,912 - 100,559,972EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61906 AgrOrtholog
BioCyc Gene G2FUF-59760 BioCyc
Ensembl Genes ENSRNOG00000019812 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055005528 UniProtKB/Swiss-Prot
  ENSRNOG00060007205 UniProtKB/Swiss-Prot
  ENSRNOG00065027607 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026862 ENTREZGENE
  ENSRNOT00000026862.6 UniProtKB/TrEMBL
  ENSRNOT00055008873 UniProtKB/Swiss-Prot
  ENSRNOT00060011864 UniProtKB/Swiss-Prot
  ENSRNOT00065047610 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Liver_X_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58851 UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nr1h2 PhenoGen
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019812 RatGTEx
  ENSRNOG00055005528 RatGTEx
  ENSRNOG00060007205 RatGTEx
  ENSRNOG00065027607 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204017
  NR1H2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q62694 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr1h2  nuclear receptor subfamily 1, group H, member 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function OR-1/RXR complex to bind to a DNA direct repeat (DR4) 729016
gene_physical_interaction interacts with the 9-cis-retinoic acid receptor 729016