Gene: Map3k7 (mitogen activated protein kinase kinase kinase 7) Rattus norvegicus
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Symbol:
Map3k7
Name:
mitogen activated protein kinase kinase kinase 7
Description:
Exhibits ATP binding activity and MAP kinase kinase kinase activity. Involved in MAPK cascade; activation of MAPKK activity; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to colocalize with IkappaB kinase complex. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7); PARTICIPATES IN p38 MAPK signaling pathway; Bone morphogenetic proteins signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; INTERACTS WITH 17beta-estradiol; 2,6-dinitrotoluene; bisphenol A.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
mitogen-activated protein kinase kinase kinase 7; Tak1; TGF-beta activated kinase 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
MAP3K7 (mitogen-activated protein kinase kinase kinase 7) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Map3k7 (mitogen-activated protein kinase kinase kinase 7) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Map3k7 (mitogen-activated protein kinase kinase kinase 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
MAP3K7 (mitogen-activated protein kinase kinase kinase 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
MAP3K7 (mitogen-activated protein kinase kinase kinase 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Map3k7 (mitogen-activated protein kinase kinase kinase 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
MAP3K7 (mitogen-activated protein kinase kinase kinase 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
MAP3K7 (mitogen-activated protein kinase kinase kinase 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Map3k7 (mitogen-activated protein kinase kinase kinase 7) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
MAP3K7 (mitogen-activated protein kinase kinase kinase 7)
Alliance
DIOPT (OMA|HGNC|TreeFam|Ensembl Compara)
Mus musculus (house mouse):
Map3k7 (mitogen-activated protein kinase kinase kinase 7)
Alliance
DIOPT (OMA|TreeFam|Ensembl Compara)
Danio rerio (zebrafish):
map3k7 (mitogen-activated protein kinase kinase kinase 7)
Alliance
DIOPT (OMA|TreeFam|Ensembl Compara)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 5 47,183,142 - 47,244,424 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 47,186,558 - 47,244,416 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 5 51,793,737 - 51,852,677 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 5 48,252,637 - 48,308,820 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 5 48,252,815 - 48,309,011 (+) NCBI Celera 5 45,121,067 - 45,178,378 (+) NCBI Celera Cytogenetic Map 5 q21 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
frontometaphyseal dysplasia 2 ISO RGD:1319782 8554872 ClinVar Annotator: match by term: FRONTOMETAPHYSEAL DYSPLASIA 2 ClinVar PMID:27426733 frontometaphyseal dysplasia 2 ISO RGD:1319782 8554872 ClinVar Annotator: match by term: Frontometaphyseal dysplasia 2 ClinVar frontometaphyseal dysplasia 2 ISO RGD:1319782 8554872 ClinVar Annotator: match by term: FRONTOMETAPHYSEAL DYSPLASIA 2 ClinVar PMID:12503106 , PMID:27426733 frontometaphyseal dysplasia 2 ISO RGD:1319782 8554872 ClinVar Annotator: match by term: FRONTOMETAPHYSEAL DYSPLASIA 2 ClinVar PMID:25899317 , PMID:27426733 Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal Bones ISO RGD:1319782 8554872 ClinVar Annotator: match by term: Cardiospondylocarpofacial syndrome ClinVar PMID:25741868 Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal Bones ISO RGD:1319782 8554872 ClinVar Annotator: match by term: Cardiospondylocarpofacial syndrome ClinVar PMID:20186786 , PMID:27426734 Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal Bones ISO RGD:1319782 8554872 ClinVar Annotator: match by term: Cardiospondylocarpofacial syndrome ClinVar PMID:27426734
Imported Annotations - CTD
extrahepatic cholestasis ISO RGD:1319782 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28789951 Forney Robinson Pascoe Syndrome ISO RGD:1319782 11554173 CTD Direct Evidence: marker/mechanism CTD frontometaphyseal dysplasia ISO RGD:1319782 11554173 CTD Direct Evidence: marker/mechanism CTD Prostatic Neoplasms ISO RGD:1319782 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17199135 Imported Annotations - MGI
Wolff-Parkinson-White syndrome ISS RGD:1319783 13592920 OMIM:194200 MouseDO Imported Annotations - OMIM
frontometaphyseal dysplasia 2 ISO RGD:1319782 7240710 OMIM Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal Bones ISO RGD:1319782 7240710 OMIM
(-)-demecolcine decreases expression ISO RGD:1319782 6480464 Demecolcine results in decreased expression of MAP3K7 mRNA CTD PMID:23649840 17beta-estradiol multiple interactions EXP 6480464 1 more ... CTD PMID:29625166 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1319783 6480464 Tetrachlorodibenzodioxin results in decreased expression of MAP3K7 mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1319783 6480464 Tetrachlorodibenzodioxin affects the expression of MAP3K7 mRNA CTD PMID:21570461 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of MAP3K7 mRNA CTD PMID:21346803 2-hydroxypropanoic acid decreases expression ISO RGD:1319782 6480464 Lactic Acid results in decreased expression of MAP3K7 mRNA CTD PMID:30851411 5-(1,4-diazepane-1-sulfonyl)isoquinoline decreases expression ISO RGD:1319783 6480464 fasudil results in decreased expression of MAP3K7 protein CTD PMID:22465603 actinomycin D decreases expression ISO RGD:1319782 6480464 Dactinomycin results in decreased expression of MAP3K7 mRNA CTD PMID:16001973 aflatoxin B1 decreases methylation ISO RGD:1319782 6480464 Aflatoxin B1 results in decreased methylation of MAP3K7 gene CTD PMID:27153756 alpha-Chaconine multiple interactions ISO RGD:1319783 6480464 alpha-chaconine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAP3K7 protein] CTD PMID:25913072 Anacardic acid decreases activity ISO RGD:1319782 6480464 anacardic acid results in decreased activity of MAP3K7 protein CTD PMID:18349320 antirheumatic drug increases expression ISO RGD:1319782 6480464 Antirheumatic Agents results in increased expression of MAP3K7 mRNA CTD PMID:24449571 antirheumatic drug decreases expression ISO RGD:1319782 6480464 Antirheumatic Agents results in decreased expression of MAP3K7 mRNA CTD PMID:25339124 benzo[a]pyrene increases expression ISO RGD:1319783 6480464 Benzo(a)pyrene results in increased expression of MAP3K7 mRNA CTD PMID:20127859 benzo[a]pyrene decreases expression ISO RGD:1319783 6480464 Benzo(a)pyrene results in decreased expression of MAP3K7 mRNA CTD PMID:19770486 bis(2-chloroethyl) sulfide increases expression ISO RGD:1319783 6480464 Mustard Gas results in increased expression of MAP3K7 mRNA CTD PMID:18955075 bisphenol A decreases expression ISO RGD:1319782 6480464 bisphenol A results in decreased expression of MAP3K7 mRNA CTD PMID:16029874 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with tributyltin] results in increased expression of MAP3K7 mRNA CTD PMID:31129395 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of MAP3K7 mRNA CTD PMID:25181051 more ... bisphenol A decreases expression ISO RGD:1319783 6480464 bisphenol A results in decreased expression of MAP3K7 mRNA CTD PMID:26063408 cadmium dichloride increases expression ISO RGD:1319783 6480464 Cadmium Chloride results in increased expression of MAP3K7 mRNA CTD PMID:18974090 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of MAP3K7 promoter CTD PMID:22457795 camptothecin decreases response to substance ISO RGD:1319782 6480464 MAP3K7 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 capsaicin multiple interactions ISO RGD:1319782 6480464 5-7-oxo-zeaenol inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAP3K7 protein] more ... CTD PMID:22171160 capsazepine multiple interactions ISO RGD:1319782 6480464 capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAP3K7 protein] CTD PMID:22171160 carbamazepine affects expression ISO RGD:1319782 6480464 Carbamazepine affects the expression of MAP3K7 mRNA CTD PMID:24752500 carbon nanotube increases expression ISO RGD:1319783 6480464 Nanotubes, Carbon results in increased expression of MAP3K7 mRNA CTD PMID:25620056 casticin increases expression ISO RGD:1319782 6480464 casticin results in increased expression of MAP3K7 mRNA CTD PMID:27862857 corticosterone multiple interactions EXP 6480464 1 more ... CTD PMID:29625166 corticosterone increases phosphorylation EXP 6480464 Corticosterone results in increased phosphorylation of MAP3K7 protein CTD PMID:29625166 cortisol decreases expression ISO RGD:1319782 6480464 Hydrocortisone results in decreased expression of MAP3K7 mRNA CTD PMID:21267416 cyclosporin A increases phosphorylation ISO RGD:1319783 6480464 Cyclosporine results in increased phosphorylation of MAP3K7 protein CTD PMID:23958496 dibutyl phthalate increases expression ISO RGD:1319783 6480464 Dibutyl Phthalate results in increased expression of MAP3K7 mRNA CTD PMID:21266533 diclofenac affects expression ISO RGD:1319782 6480464 Diclofenac affects the expression of MAP3K7 mRNA CTD PMID:24752500 disodium selenite increases expression ISO RGD:1319782 6480464 Sodium Selenite results in increased expression of MAP3K7 mRNA CTD PMID:18175754 dorsomorphin multiple interactions ISO RGD:1319782 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAP3K7 mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1319782 6480464 Doxorubicin results in decreased expression of MAP3K7 mRNA CTD PMID:29803840 elemental selenium decreases expression ISO RGD:1319782 6480464 Selenium results in decreased expression of MAP3K7 mRNA CTD PMID:19244175 ethanol affects splicing ISO RGD:1319783 6480464 Ethanol affects the splicing of MAP3K7 mRNA CTD PMID:30319688 fasudil hydrochloride decreases expression ISO RGD:1319783 6480464 fasudil results in decreased expression of MAP3K7 protein CTD PMID:22465603 filipin III multiple interactions EXP 6480464 Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]] more ... CTD PMID:17172471 flutamide multiple interactions EXP 6480464 Flutamide inhibits the reaction [Estradiol inhibits the reaction [Corticosterone results in increased phosphorylation of MAP3K7 protein]] CTD PMID:29625166 formaldehyde decreases expression ISO RGD:1319782 6480464 Formaldehyde results in decreased expression of MAP3K7 mRNA CTD PMID:23649840 hypochlorous acid increases expression ISO RGD:1319783 6480464 Hypochlorous Acid results in increased expression of MAP3K7 mRNA CTD PMID:19376150 iron atom multiple interactions EXP 6480464 Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]] more ... CTD PMID:17172471 iron atom increases activity EXP 6480464 Iron results in increased activity of MAP3K7 protein CTD PMID:17172471 iron atom affects localization EXP 6480464 Iron affects the localization of MAP3K7 protein CTD PMID:17172471 iron(0) multiple interactions EXP 6480464 Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]] more ... CTD PMID:17172471 iron(0) affects localization EXP 6480464 Iron affects the localization of MAP3K7 protein CTD PMID:17172471 iron(0) increases activity EXP 6480464 Iron results in increased activity of MAP3K7 protein CTD PMID:17172471 iron(2+) sulfate (anhydrous) increases activity EXP 6480464 ferrous sulfate results in increased activity of MAP3K7 protein CTD PMID:17172471 iron(2+) sulfate (anhydrous) multiple interactions EXP 6480464 ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein] more ... CTD PMID:17172471 iron(2+) sulfate (anhydrous) affects localization EXP 6480464 ferrous sulfate affects the localization of MAP3K7 protein CTD PMID:17172471 kaempferol multiple interactions ISO RGD:1319782 6480464 kaempferol inhibits the reaction [IL1B protein results in increased phosphorylation of MAP3K7 protein] CTD PMID:30769083 lipopolysaccharide increases expression ISO RGD:1319783 6480464 Lipopolysaccharides results in increased expression of MAP3K7 mRNA CTD PMID:12057914 manganese(II) chloride increases methylation ISO RGD:1319782 6480464 manganese chloride results in increased methylation of MAP3K7 gene CTD PMID:27913844 metformin multiple interactions ISO RGD:1319782 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K7 mRNA CTD PMID:29309887 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of MAP3K7 mRNA CTD PMID:19564919 methotrexate increases phosphorylation ISO RGD:1319782 6480464 Methotrexate results in increased phosphorylation of MAP3K7 protein CTD PMID:19100307 methotrexate decreases expression ISO RGD:1319782 6480464 Methotrexate results in decreased expression of MAP3K7 mRNA CTD PMID:25339124 methylparaben increases expression ISO RGD:1319782 6480464 methylparaben results in increased expression of MAP3K7 mRNA CTD PMID:31745603 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of MAP3K7 mRNA CTD PMID:22546817 nonanoic acid decreases expression ISO RGD:1319783 6480464 pelargonic acid results in decreased expression of MAP3K7 mRNA CTD PMID:11379042 o-anisidine decreases expression ISO RGD:1319782 6480464 2-anisidine results in decreased expression of MAP3K7 mRNA CTD PMID:28089782 oxazepam increases expression ISO RGD:1319783 6480464 Oxazepam results in increased expression of MAP3K7 mRNA CTD PMID:12727805 paclitaxel multiple interactions ISO RGD:1319782 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K7 mRNA CTD PMID:29309887 paracetamol affects expression ISO RGD:1319783 6480464 Acetaminophen affects the expression of MAP3K7 mRNA CTD PMID:17562736 paraquat increases expression ISO RGD:1319783 6480464 Paraquat results in increased expression of MAP3K7 mRNA CTD PMID:21371552 phenylmercury acetate decreases expression ISO RGD:1319782 6480464 Phenylmercuric Acetate results in decreased expression of MAP3K7 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1319782 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAP3K7 mRNA CTD PMID:27188386 phlorizin decreases expression ISO RGD:1319783 6480464 Phlorhizin results in decreased expression of MAP3K7 mRNA CTD PMID:22538082 pirinixic acid increases expression ISO RGD:1319783 6480464 pirinixic acid results in increased expression of MAP3K7 mRNA CTD PMID:12727805 pirinixic acid decreases expression ISO RGD:1319783 6480464 pirinixic acid results in decreased expression of MAP3K7 mRNA CTD PMID:12727805 quercetin multiple interactions ISO RGD:1319783 6480464 5-7-oxo-zeaenol inhibits the reaction [Quercetin results in increased phosphorylation of MAP3K7 protein] CTD PMID:22711909 quercetin increases phosphorylation ISO RGD:1319783 6480464 Quercetin results in increased phosphorylation of MAP3K7 protein CTD PMID:22711909 rac-lactic acid decreases expression ISO RGD:1319782 6480464 Lactic Acid results in decreased expression of MAP3K7 mRNA CTD PMID:30851411 reactive oxygen species multiple interactions ISO RGD:1319783 6480464 [MAP3K7 protein results in increased expression of NFE2L2 protein] which results in decreased abundance of Reactive Oxygen Species CTD PMID:20855879 reactive oxygen species affects abundance ISO RGD:1319783 6480464 MAP3K7 protein affects the abundance of Reactive Oxygen Species CTD PMID:20855879 reactive oxygen species decreases abundance ISO RGD:1319783 6480464 MAP3K7 protein results in decreased abundance of Reactive Oxygen Species CTD PMID:20959492 rosmarinic acid decreases phosphorylation EXP 6480464 rosmarinic acid results in decreased phosphorylation of MAP3K7 protein CTD PMID:28789951 SB 431542 multiple interactions ISO RGD:1319782 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAP3K7 mRNA CTD PMID:27188386 selenium atom decreases expression ISO RGD:1319782 6480464 Selenium results in decreased expression of MAP3K7 mRNA CTD PMID:19244175 simvastatin multiple interactions ISO RGD:1319782 6480464 Simvastatin results in decreased activity of [MAP3K7 protein co-treated with TAB1 protein] CTD PMID:17277159 sodium arsenite increases expression ISO RGD:1319782 6480464 sodium arsenite results in increased expression of MAP3K7 protein CTD PMID:21925251 sodium arsenite decreases expression ISO RGD:1319783 6480464 sodium arsenite results in decreased expression of MAP3K7 mRNA CTD PMID:31233874 sodium dichromate increases expression ISO RGD:1319783 6480464 sodium bichromate results in increased expression of MAP3K7 mRNA CTD PMID:22155349 sodium fluoride increases expression ISO RGD:1319783 6480464 Sodium Fluoride results in increased expression of MAP3K7 mRNA CTD PMID:27862939 sulfates affects methylation ISO RGD:1319782 6480464 Sulfates affects the methylation of MAP3K7 promoter CTD PMID:25395096 sunitinib increases expression ISO RGD:1319782 6480464 Sunitinib results in increased expression of MAP3K7 mRNA CTD PMID:31533062 tacrolimus hydrate increases phosphorylation ISO RGD:1319783 6480464 Tacrolimus results in increased phosphorylation of MAP3K7 protein CTD PMID:23958496 tert-butyl hydroperoxide decreases expression ISO RGD:1319782 6480464 tert-Butylhydroperoxide results in decreased expression of MAP3K7 mRNA CTD PMID:15336504 testosterone multiple interactions EXP 6480464 Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in increased phosphorylation of MAP3K7 protein]] CTD PMID:29625166 toluene 2,4-diisocyanate decreases expression ISO RGD:1319783 6480464 Toluene 2, 4-Diisocyanate results in decreased expression of MAP3K7 mRNA CTD PMID:11379042 tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of MAP3K7 mRNA CTD PMID:31129395 tributylstannane multiple interactions EXP 6480464 [bisphenol A co-treated with tributyltin] results in increased expression of MAP3K7 mRNA CTD PMID:31129395 trichostatin A affects expression ISO RGD:1319782 6480464 trichostatin A affects the expression of MAP3K7 mRNA CTD PMID:28542535 tunicamycin increases expression ISO RGD:1319783 6480464 Tunicamycin results in increased expression of MAP3K7 mRNA CTD PMID:17127020 valproic acid decreases expression ISO RGD:1319783 6480464 Valproic Acid results in decreased expression of MAP3K7 mRNA CTD PMID:21427059 valproic acid decreases methylation ISO RGD:1319782 6480464 Valproic Acid results in decreased methylation of MAP3K7 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:1319782 6480464 Valproic Acid affects the expression of MAP3K7 mRNA CTD PMID:25979313 vincristine decreases expression ISO RGD:1319782 6480464 Vincristine results in decreased expression of MAP3K7 mRNA CTD PMID:23649840
Biological Process activation of MAPK activity ISO RGD:1319782 1624291 (PMID:9079627) RGD PMID:9079627 activation of MAPKK activity IDA 2298758 RGD activation of MAPKK activity ISO RGD:1319782 1624291 (PMID:8663074), (PMID:9079627) RGD PMID:8663074 , PMID:9079627 activation of NF-kappaB-inducing kinase activity ISO RGD:1319782 1624291 (PMID:10094049), (PMID:15125833) RGD PMID:10094049 , PMID:15125833 angiogenesis ISO RGD:1319783 1624291 MGI:MGI:3608889 (MGI:MGI:3621089 , PMID:16556914) RGD MGI:MGI:3621089 , PMID:16556914 anoikis ISO RGD:1319783 1624291 (MGI:MGI:5819337, PMID:23778976) RGD MGI:MGI:5819337 , PMID:23778976 histone H3 acetylation ISO RGD:1319782 1624291 (PMID:18838386) RGD PMID:18838386 I-kappaB phosphorylation ISO RGD:1319782 1624291 (PMID:11460167) RGD PMID:11460167 I-kappaB phosphorylation ISS UniProtKB:O43318 1600115 GO_REF:0000024 UniProt GO_REF:0000024 I-kappaB phosphorylation ISO RGD:1319783 1624291 MGI:MGI:104798 more ... RGD MGI:MGI:3607973 , PMID:16260493 JNK cascade ISO RGD:1319782 1624291 (PMID:9079627) RGD PMID:9079627 JNK cascade IBA MGI:MGI:1346877 more ... 13792537 PMID:21873635 GO_Central JNK cascade ISO RGD:1319783 1624291 (MGI:MGI:6162308, PMID:29291351) RGD MGI:MGI:6162308 , PMID:29291351 JNK cascade ISS UniProtKB:Q62073 1600115 GO_REF:0000024 UniProt GO_REF:0000024 MAPK cascade IDA 2298758 RGD MAPK cascade ISO RGD:1319783 1624291 (MGI:MGI:2668070, PMID:12556533) RGD MGI:MGI:2668070 , PMID:12556533 negative regulation of apoptotic signaling pathway ISO RGD:1319783 1624291 MGI:MGI:104798 (MGI:MGI:3607973 , PMID:16260493) RGD MGI:MGI:3607973 , PMID:16260493 negative regulation of necroptotic process ISO RGD:1319783 1624291 (MGI:MGI:5315337, PMID:21052097) RGD MGI:MGI:5315337 , PMID:21052097 negative regulation of reactive oxygen species metabolic process ISO RGD:1319783 1624291 (MGI:MGI:5315337, PMID:21052097) RGD MGI:MGI:5315337 , PMID:21052097 negative regulation of ripoptosome assembly involved in necroptotic process ISO RGD:1319783 1624291 MGI:MGI:104798 more ... RGD MGI:MGI:5315337 , PMID:21052097 neural tube formation ISO RGD:1319783 1624291 (MGI:MGI:3607973, PMID:16260493) RGD MGI:MGI:3607973 , PMID:16260493 peptidyl-threonine phosphorylation ISO RGD:1319783 1624291 (MGI:MGI:6148351, PMID:18762249) RGD MGI:MGI:6148351 , PMID:18762249 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:1319782 1624291 (PMID:14982987) RGD PMID:14982987 positive regulation of I-kappaB kinase/NF-kappaB signaling IBA MGI:MGI:1346877 more ... 13792537 PMID:21873635 GO_Central positive regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:1319783 1624291 MGI:MGI:104798 more ... RGD MGI:MGI:3607973 , PMID:16260493 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 5508194 RGD positive regulation of interleukin-2 production ISO RGD:1319782 1624291 (PMID:15125833) RGD PMID:15125833 positive regulation of JNK cascade ISO RGD:1319783 1624291 MGI:MGI:104798 more ... RGD MGI:MGI:3607973 , PMID:16260493 positive regulation of JUN kinase activity ISO RGD:1319782 1624291 (PMID:10094049), (PMID:11460167) RGD PMID:10094049 , PMID:11460167 positive regulation of JUN kinase activity ISS UniProtKB:O43318 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of macroautophagy ISO RGD:1319783 1624291 (MGI:MGI:5819337, PMID:23778976) RGD MGI:MGI:5819337 , PMID:23778976 positive regulation of T cell cytokine production ISO RGD:1319782 1624291 (PMID:15125833) RGD PMID:15125833 protein phosphorylation IDA 2298758 RGD protein phosphorylation ISO RGD:1319783 1624291 (MGI:MGI:2447107 more ... RGD MGI:MGI:2447107 more ... regulation of reactive oxygen species metabolic process ISO RGD:1319783 1624291 (MGI:MGI:5315337, PMID:21052097) RGD MGI:MGI:5315337 , PMID:21052097 stress-activated MAPK cascade ISO RGD:1319782 1624291 (PMID:9079627) RGD PMID:9079627 transforming growth factor beta receptor signaling pathway ISO RGD:1319783 1624291 (MGI:MGI:3607216, PMID:16145668) RGD MGI:MGI:3607216 , PMID:16145668 Cellular Component Ada2/Gcn5/Ada3 transcription activator complex ISO RGD:1319782 1624291 (PMID:18838386) RGD PMID:18838386 cytosol ISO RGD:1319782 1624291 RGD GO_REF:0000052 IkappaB kinase complex colocalizes_with ISO RGD:1319782 1624291 UniProtKB:O15111 (PMID:10094049) RGD PMID:10094049 plasma membrane ISO RGD:1319782 1624291 RGD GO_REF:0000052 plasma membrane IEA UniProtKB-SubCell:SL-0039 1600115 GO_REF:0000044 UniProt GO_REF:0000044 postsynaptic density ISO RGD:1319783 1624291 (MGI:MGI:5436301, PMID:17114649) RGD MGI:MGI:5436301 , PMID:17114649 Molecular Function ATP binding IDA 2298758 RGD identical protein binding ISO RGD:1319782 1624291 UniProtKB:O43318 (PMID:27426733) RGD PMID:27426733 magnesium ion binding IEA InterPro:IPR017421 1600115 GO_REF:0000002 InterPro GO_REF:0000002 MAP kinase kinase activity ISO RGD:1319783 1624291 (MGI:MGI:2447107, PMID:12464436) RGD MGI:MGI:2447107 , PMID:12464436 MAP kinase kinase kinase activity IDA 2298758 RGD MAP kinase kinase kinase activity IBA PANTHER:PTN000723805 more ... 13792537 PMID:21873635 GO_Central MAP kinase kinase kinase activity ISS UniProtKB:O43318 1600115 GO_REF:0000024 UniProt GO_REF:0000024 MAP kinase kinase kinase activity ISO RGD:1319782 1624291 (PMID:11460167) RGD PMID:11460167 protein binding IPI RGD:69651 1579925 RGD protein binding ISO RGD:1319783 1624291 PR:P70236 more ... RGD MGI:MGI:2668070 more ... protein binding ISO RGD:1319782 1624291 UniProtKB:B5Z6S0 more ... RGD PMID:10094049 more ... protein kinase activity ISO RGD:1319782 1624291 (PMID:10094049) RGD PMID:10094049 protein serine/threonine kinase activity ISO RGD:1319782 1624291 (PMID:10702308), (PMID:11460167), (PMID:20538596) RGD PMID:10702308 more ... protein serine/threonine kinase activity ISO RGD:1319783 1624291 (MGI:MGI:6148351, PMID:18762249) RGD MGI:MGI:6148351 , PMID:18762249 receptor tyrosine kinase binding ISO RGD:1319782 1624291 UniProtKB:Q01974 (PMID:18762249) RGD PMID:18762249 receptor tyrosine kinase binding ISO RGD:1319783 1624291 UniProtKB:Q9Z138 (MGI:MGI:6148351 , PMID:18762249) RGD MGI:MGI:6148351 , PMID:18762249 scaffold protein binding ISO RGD:1319782 1624291 (PMID:23776175) RGD PMID:23776175
Gene-Chemical Interaction Annotations
