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Gene: Map3k7 (mitogen activated protein kinase kinase kinase 7) Rattus norvegicus
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Symbol: Map3k7
Name: mitogen activated protein kinase kinase kinase 7
Description: Exhibits ATP binding activity and MAP kinase kinase kinase activity. Involved in MAPK cascade; activation of MAPKK activity; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to colocalize with the IkappaB kinase complex. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7); PARTICIPATES IN p38 MAPK signaling pathway; Bone morphogenetic proteins signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; INTERACTS WITH (R)-rosmarinic acid; 17beta-estradiol; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: mitogen-activated protein kinase kinase kinase 7; Tak1; TGF-beta activated kinase 1
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0547,183,142 - 47,244,424 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0551,793,737 - 51,852,677 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4548,252,637 - 48,308,820 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1548,252,815 - 48,309,011 (+)NCBI
Celera545,121,067 - 45,178,378 (+)NCBICelera
Cytogenetic Map5q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Map3k7
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309438
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.