Gene: Map3k7 (mitogen activated protein kinase kinase kinase 7) Rattus norvegicus
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Symbol: Map3k7
Name: mitogen activated protein kinase kinase kinase 7
Description: ENCODES a protein that exhibits ATP binding; MAP kinase kinase kinase activity; identical protein binding (ortholog); INVOLVED IN activation of MAPKK activity; MAPK cascade; positive regulation of I-kappaB kinase/NF-kappaB signaling; PARTICIPATES IN p38 MAPK signaling pathway; Bone morphogenetic proteins signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH extrahepatic cholestasis (ortholog); Forney Robinson Pascoe Syndrome (ortholog); Frontometaphyseal Dysplasia (ortholog); FOUND IN Ada2/Gcn5/Ada3 transcription activator complex (ortholog); IkappaB kinase complex (ortholog); postsynaptic density (ortholog); INTERACTS WITH (R)-rosmarinic acid; 17beta-estradiol; 2,6-dinitrotoluene
AGR Description: Exhibits ATP binding activity and MAP kinase kinase kinase activity; involved in MAPK cascade, activation of MAPKK activity, and positive regulation of I-kappaB kinase/NF-kappaB signaling; predicted to colocalize with the IkappaB kinase complex; orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7).
Merged Description: Exhibits ATP binding activity and MAP kinase kinase kinase activity; involved in MAPK cascade, activation of MAPKK activity, and positive regulation of I-kappaB kinase/NF-kappaB signaling; predicted to colocalize with the IkappaB kinase complex; orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7); PARTICIPATES IN p38 MAPK signaling pathway; Bone morphogenetic proteins signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; INTERACTS WITH (R)-rosmarinic acid; 17beta-estradiol; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: mitogen-activated protein kinase kinase kinase 7; Tak1; TGF-beta activated kinase 1
Orthologs:
Homo sapiens (human) : MAP3K7 (mitogen-activated protein kinase kinase kinase 7)  HGNC  Alliance
Mus musculus (house mouse) : Map3k7 (mitogen-activated protein kinase kinase kinase 7)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map3k7 (mitogen-activated protein kinase kinase kinase 7)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP3K7 (mitogen-activated protein kinase kinase kinase 7)
Canis lupus familiaris (dog) : MAP3K7 (mitogen-activated protein kinase kinase kinase 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map3k7 (mitogen-activated protein kinase kinase kinase 7)
Sus scrofa (pig) : MAP3K7 (mitogen-activated protein kinase kinase kinase 7)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0547,183,142 - 47,244,424 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0551,793,737 - 51,852,677 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4548,252,637 - 48,308,820 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1548,252,815 - 48,309,011 (+)NCBI
Celera545,121,067 - 45,178,378 (+)NCBICelera
Cytogenetic Map5q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Strain Sequence Variants (Rnor 5.0)

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Nomenclature History
  
More on Map3k7
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309438
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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