Map3k7 (mitogen activated protein kinase kinase kinase 7) - Rat Genome Database

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Gene: Map3k7 (mitogen activated protein kinase kinase kinase 7) Rattus norvegicus
Analyze
Symbol: Map3k7
Name: mitogen activated protein kinase kinase kinase 7
RGD ID: 1309438
Description: Enables ATP binding activity and MAP kinase kinase kinase activity. Involved in MAPK cascade; positive regulation of intracellular signal transduction; and protein phosphorylation. Predicted to be located in cytosol; plasma membrane; and postsynaptic density. Predicted to be part of ATAC complex. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7); PARTICIPATES IN p38 MAPK signaling pathway; Bone morphogenetic proteins signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100910771; mitogen-activated protein kinase kinase kinase 7; mitogen-activated protein kinase kinase kinase 7-like; Tak1; TGF-beta activated kinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2546,356,973 - 46,415,597 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl546,357,931 - 46,415,597 (+)Ensembl
Rnor_6.0547,183,142 - 47,244,424 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9114,022,137 - 114,079,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl547,186,558 - 47,244,416 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0551,793,737 - 51,852,677 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4548,252,637 - 48,308,820 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1548,252,815 - 48,309,011 (+)NCBI
Celera545,121,067 - 45,178,378 (+)NCBICelera
Cytogenetic Map5q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alpha-Chaconine  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
cisplatin  (EXP)
corticosterone  (EXP)
cortisol  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fasudil  (ISO)
filipin III  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
hypochlorous acid  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
kaempferol  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylparaben  (ISO)
N-phosphocreatine  (EXP)
nickel dichloride  (EXP)
nonanoic acid  (ISO)
o-anisidine  (ISO)
oxazepam  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
Pentoxifylline  (EXP,ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rosmarinic acid  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sulfates  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
toluene 2,4-diisocyanate  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:8663074   PMID:9079627   PMID:10094049   PMID:10702308   PMID:11460167   PMID:12464436   PMID:12477932   PMID:12556533   PMID:12969270   PMID:14982987   PMID:15125833   PMID:15831522  
PMID:16145668   PMID:16157589   PMID:16260493   PMID:16556914   PMID:17085580   PMID:17114649   PMID:17209006   PMID:18293403   PMID:18762249   PMID:18838386   PMID:20538596   PMID:20615388  
PMID:20730577   PMID:21052097   PMID:21630459   PMID:22829592   PMID:23378049   PMID:23751595   PMID:23776175   PMID:23778976   PMID:26002466   PMID:26100626   PMID:27012613   PMID:27426733  
PMID:28842570   PMID:29273596   PMID:29291351   PMID:29348267   PMID:30361391   PMID:30367484   PMID:31028803   PMID:31953451   PMID:32798288  


Genomics

Comparative Map Data
Map3k7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2546,356,973 - 46,415,597 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl546,357,931 - 46,415,597 (+)Ensembl
Rnor_6.0547,183,142 - 47,244,424 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9114,022,137 - 114,079,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl547,186,558 - 47,244,416 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0551,793,737 - 51,852,677 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4548,252,637 - 48,308,820 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1548,252,815 - 48,309,011 (+)NCBI
Celera545,121,067 - 45,178,378 (+)NCBICelera
Cytogenetic Map5q21NCBI
MAP3K7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38690,513,579 - 90,587,072 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl690,513,573 - 90,587,072 (-)EnsemblGRCh38hg38GRCh38
GRCh37691,223,298 - 91,296,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36691,282,074 - 91,353,628 (-)NCBINCBI36hg18NCBI36
Celera691,646,249 - 91,717,462 (-)NCBI
Cytogenetic Map6q15NCBI
HuRef688,442,517 - 88,515,844 (-)NCBIHuRef
CHM1_1691,320,725 - 91,394,113 (-)NCBICHM1_1
Map3k7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39431,963,659 - 32,023,470 (+)NCBIGRCm39mm39
GRCm39 Ensembl431,964,097 - 32,023,467 (+)Ensembl
GRCm38431,963,492 - 32,023,470 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl431,964,097 - 32,023,467 (+)EnsemblGRCm38mm10GRCm38
MGSCv37432,051,082 - 32,110,442 (+)NCBIGRCm37mm9NCBIm37
MGSCv36432,292,735 - 32,349,405 (+)NCBImm8
Celera431,710,402 - 31,768,496 (+)NCBICelera
Cytogenetic Map4A5NCBI
Map3k7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541117,177,335 - 17,229,957 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541117,177,335 - 17,229,957 (-)NCBIChiLan1.0ChiLan1.0
MAP3K7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1691,664,263 - 91,737,468 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl691,664,263 - 91,737,468 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0688,398,329 - 88,470,926 (-)NCBIMhudiblu_PPA_v0panPan3
MAP3K7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11249,669,849 - 49,740,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1249,672,389 - 49,739,850 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1249,477,606 - 49,546,370 (-)NCBI
ROS_Cfam_1.01250,481,094 - 50,549,843 (-)NCBI
ROS_Cfam_1.0 Ensembl1250,481,149 - 50,549,837 (-)Ensembl
UMICH_Zoey_3.11249,798,234 - 49,867,173 (-)NCBI
UNSW_CanFamBas_1.01249,697,121 - 49,766,116 (-)NCBI
UU_Cfam_GSD_1.01249,887,662 - 49,956,849 (-)NCBI
Map3k7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494684,634,746 - 84,697,875 (-)NCBI
SpeTri2.0NW_0049365101,772,971 - 1,836,075 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl158,481,956 - 58,548,057 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1158,482,046 - 58,548,087 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2165,479,754 - 65,542,430 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11315,284,927 - 15,360,539 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1315,284,923 - 15,360,832 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040191,671,798 - 191,744,917 (-)NCBIVero_WHO_p1.0
Map3k7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247993,554,644 - 3,623,317 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS
BE120532  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2546,391,359 - 46,391,525 (+)MAPPERmRatBN7.2
Rnor_6.0547,220,180 - 47,220,345NCBIRnor6.0
Rnor_6.09114,055,103 - 114,055,268NCBIRnor6.0
Rnor_5.09113,573,073 - 113,573,238UniSTSRnor5.0
Rnor_5.0551,828,433 - 51,828,598UniSTSRnor5.0
RGSC_v3.4548,286,051 - 48,286,216UniSTSRGSC3.4
Celera545,154,141 - 45,154,306UniSTS
RH 3.4 Map5263.39UniSTS
Cytogenetic Map5q21UniSTS
RH134828  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2546,415,264 - 46,415,453 (+)MAPPERmRatBN7.2
Rnor_6.0547,244,084 - 47,244,272NCBIRnor6.0
Rnor_6.09114,079,007 - 114,079,204NCBIRnor6.0
Rnor_5.09113,596,977 - 113,597,174UniSTSRnor5.0
Rnor_5.0551,852,337 - 51,852,525UniSTSRnor5.0
RGSC_v3.4548,309,955 - 48,310,143UniSTSRGSC3.4
Celera545,178,034 - 45,178,234UniSTS
RH 3.4 Map5260.4UniSTS
Cytogenetic Map5q21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:904
Count of miRNA genes:298
Interacting mature miRNAs:384
Transcripts:ENSRNOT00000007654, ENSRNOT00000007657
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 36 52 36 19 36 2 4 74 35 39 11 2
Below cutoff 7 5 5 5 6 7 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007654   ⟹   ENSRNOP00000007654
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl546,357,931 - 46,415,597 (+)Ensembl
Rnor_6.0 Ensembl547,186,558 - 47,244,416 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000007657   ⟹   ENSRNOP00000007657
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl546,357,931 - 46,415,597 (+)Ensembl
Rnor_6.0 Ensembl9114,022,137 - 114,079,089 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098749   ⟹   ENSRNOP00000083011
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl546,357,931 - 46,415,597 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109648   ⟹   ENSRNOP00000090653
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl546,357,931 - 46,412,886 (+)Ensembl
RefSeq Acc Id: NM_001107920   ⟹   NP_001101390
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2546,357,931 - 46,415,597 (+)NCBI
Rnor_6.0547,186,558 - 47,244,416 (+)NCBI
Rnor_5.0551,793,737 - 51,852,677 (+)NCBI
RGSC_v3.4548,252,637 - 48,308,820 (+)RGD
Celera545,121,067 - 45,178,378 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237966   ⟹   XP_006238028
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2546,356,973 - 46,413,034 (+)NCBI
Rnor_6.0547,183,142 - 47,244,424 (+)NCBI
Rnor_5.0551,793,737 - 51,852,677 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109819   ⟹   XP_038965747
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2546,356,973 - 46,389,490 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101390 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238028 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965747 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98558 (Get FASTA)   NCBI Sequence Viewer  
  EDL98559 (Get FASTA)   NCBI Sequence Viewer  
  P0C8E4 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101390   ⟸   NM_001107920
- UniProtKB: P0C8E4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238028   ⟸   XM_006237966
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000007654   ⟸   ENSRNOT00000007654
RefSeq Acc Id: XP_038965747   ⟸   XM_039109819
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000007657   ⟸   ENSRNOT00000007657
RefSeq Acc Id: ENSRNOP00000090653   ⟸   ENSRNOT00000109648
RefSeq Acc Id: ENSRNOP00000083011   ⟸   ENSRNOT00000098749
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C8E4-F1-model_v2 AlphaFold P0C8E4 1-606 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309438 AgrOrtholog
BioCyc Gene G2FUF-41739 BioCyc
Ensembl Genes ENSRNOG00000005724 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000047516 Ensembl, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000007654 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000007657 UniProtKB/Swiss-Prot
  ENSRNOP00000083011 ENTREZGENE
Ensembl Transcript ENSRNOT00000007654 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000007657 UniProtKB/Swiss-Prot
  ENSRNOT00000098749 ENTREZGENE
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAPKKK7 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:313121 UniProtKB/Swiss-Prot
NCBI Gene 313121 ENTREZGENE
PANTHER PTHR46716 UniProtKB/Swiss-Prot
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot
PhenoGen Map3k7 PhenoGen
PIRSF MAPKKK7 UniProtKB/Swiss-Prot
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt M3K7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Map3k7  mitogen activated protein kinase kinase kinase 7  LOC100910771  mitogen-activated protein kinase kinase kinase 7-like  Data Merged 737654 PROVISIONAL
2012-07-05 LOC100910771  mitogen-activated protein kinase kinase kinase 7-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Map3k7  mitogen activated protein kinase kinase kinase 7   Map3k7_predicted  mitogen activated protein kinase kinase kinase 7 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Map3k7_predicted  mitogen activated protein kinase kinase kinase 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED