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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3369
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparadecreases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PPARA mRNAPMID:26396156 PMID:29474705
Pparaincreases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PPARA mRNAPMID:34848246
Pparamultiple interactionsEXP 6480464CTDAHR protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PPARA mRNA]PMID:34848246
Pparaaffects expressionISOPpara (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl affects the expression of PPARA mRNAPMID:37080397
Pparamultiple interactionsISOPpara (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of PPARA mRNA]; [Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of PPARA mRNAPMID:28163111 PMID:28973532
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