Cebpb (CCAAT/enhancer binding protein beta) - Rat Genome Database

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Gene: Cebpb (CCAAT/enhancer binding protein beta) Rattus norvegicus
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Symbol: Cebpb
Name: CCAAT/enhancer binding protein beta
RGD ID: 2327
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; glucocorticoid receptor binding activity; and protein dimerization activity. Involved in several processes, including cellular response to interleukin-1; hepatocyte proliferation; and regulation of transcription by RNA polymerase II. Localizes to CHOP-C/EBP complex and nuclear matrix. Orthologous to human CEBPB (CCAAT enhancer binding protein beta); PARTICIPATES IN forkhead class A signaling pathway; interleukin-3 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (-)-cotinine; (S)-nicotine; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C/EBP beta; c/EBP-related protein 2; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; IL-6DBP; Il6dbp; interleukin-6-dependent-binding protein; LAP; LIP; Liver activating protein (LAP also NF-IL6 nuclear factor-IL6 previously designated TCF5); liver activating protein (LAP); Liver activating protein (LAP, also NF-IL6, nuclear factor-IL6, previously designated TCF5); liver-enriched inhibitory protein; liver-enriched transcriptional activator; NF-IL6; nuclear factor-IL6; SF-B; silencer factor B; TCF5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23156,398,035 - 156,399,466 (+)NCBI
Rnor_6.0 Ensembl3164,424,515 - 164,425,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03164,424,502 - 164,425,933 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03170,577,328 - 170,579,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,826,021 - 158,827,848 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13158,732,056 - 158,733,825 (+)NCBI
Celera3154,977,150 - 154,977,588 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-cotinine  (EXP)
(R)-adrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
8-(4-chlorophenylthio)-cGMP  (ISO)
9-cis-retinoic acid  (EXP)
acetaldehyde  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-linolenic acid  (EXP)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atrazine  (EXP,ISO)
Azaspiracid  (ISO)
baicalein  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
betulinic acid  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bortezomib  (EXP,ISO)
bucladesine  (ISO)
butylated hydroxyanisole  (ISO)
C60 fullerene  (EXP)
caffeine  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
carmustine  (ISO)
ceruletide  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
chloroquine  (ISO)
choline  (ISO)
Chorionic gonadotropin  (ISO)
ciglitazone  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinous acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
flavone  (EXP)
flavonoids  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
gallic acid  (ISO)
gallocatechin  (EXP)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (EXP)
gemcitabine  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
geraniol  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (EXP)
GW 4064  (ISO)
herbimycin  (EXP)
hexadecanoic acid  (EXP)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
Iodine aqueous  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoniazide  (ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP,ISO)
levofloxacin  (EXP)
linalool  (EXP)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
MeIQx  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalenes  (EXP)
nickel dichloride  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitroprusside  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oltipraz  (EXP)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentane  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
picene  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
prostaglandin J2  (EXP)
pyrazinecarboxamide  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
riboflavin  (EXP)
rolipram  (EXP)
rotenone  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
sevoflurane  (EXP)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sincalide  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
stavudine  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
telmisartan  (EXP)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torin 1  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brown fat cell differentiation  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to interleukin-1  (IDA)
cellular response to lipopolysaccharide  (IDA)
cellular response to organic cyclic compound  (IEP)
defense response to bacterium  (ISO,ISS)
embryonic placenta development  (ISO)
fat cell differentiation  (ISO)
granuloma formation  (ISO,ISS)
hepatocyte proliferation  (IDA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
liver development  (IEP)
liver regeneration  (ISO,ISS)
mammary gland epithelial cell differentiation  (ISO)
mammary gland epithelial cell proliferation  (ISO)
memory  (IEP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of T cell proliferation  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IDA)
negative regulation of transcription, DNA-templated  (ISO)
neuron differentiation  (ISO)
ovarian follicle development  (ISO,ISS)
positive regulation of biomineral tissue development  (ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of fat cell differentiation  (ISO,ISS)
positive regulation of gene expression  (IMP)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-4 production  (ISO,ISS)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of sodium-dependent phosphate transport  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of cell differentiation  (IBA)
regulation of dendritic cell differentiation  (ISO)
regulation of interleukin-6 production  (ISO)
regulation of odontoblast differentiation  (IDA)
regulation of osteoclast differentiation  (ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA,ISO,ISS)
regulation of transcription, DNA-templated  (IC,ISO,ISS)
response to endoplasmic reticulum stress  (ISO,ISS)
response to lipopolysaccharide  (ISO)
T-helper 1 cell activation  (ISO,ISS)

Cellular Component

References

References - curated
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Additional References at PubMed
PMID:1655570   PMID:1934061   PMID:7959007   PMID:8200992   PMID:8972203   PMID:9303532   PMID:9531536   PMID:9545285   PMID:10510303   PMID:10588870   PMID:10683373   PMID:10707954  
PMID:10859308   PMID:10921906   PMID:11684016   PMID:11733516   PMID:11940593   PMID:11976687   PMID:12177065   PMID:12213809   PMID:12477932   PMID:12821655   PMID:12871593   PMID:15175325  
PMID:15187136   PMID:15299028   PMID:15383601   PMID:15509779   PMID:15509789   PMID:15519652   PMID:15601867   PMID:15659391   PMID:15669015   PMID:15669083   PMID:15721291   PMID:15775988  
PMID:15785238   PMID:16055922   PMID:16106045   PMID:16172914   PMID:16223488   PMID:16585579   PMID:16682116   PMID:16772287   PMID:16980548   PMID:17180354   PMID:17301242   PMID:17644752  
PMID:17724128   PMID:17727681   PMID:17884934   PMID:17888405   PMID:18052938   PMID:18486321   PMID:18559338   PMID:18650268   PMID:18824566   PMID:19103603   PMID:19324970   PMID:19407981  
PMID:19440205   PMID:19641492   PMID:19875812   PMID:20351173   PMID:20452968   PMID:20548288   PMID:20797423   PMID:20829347   PMID:20930553   PMID:21122806   PMID:21183071   PMID:21249617  
PMID:21539866   PMID:21586575   PMID:21678417   PMID:21935930   PMID:22078933   PMID:22242598   PMID:23257266   PMID:23508841   PMID:23643813   PMID:23881867   PMID:24061474   PMID:24191285  
PMID:24216764   PMID:24279606   PMID:24344329   PMID:24438488   PMID:24704266   PMID:25109894   PMID:25110868   PMID:25173154   PMID:25209292   PMID:25403356   PMID:25450863   PMID:25472717  
PMID:26024764   PMID:26459835   PMID:26505752   PMID:26526992   PMID:27382175   PMID:27746211   PMID:27812542   PMID:29852820   PMID:30305575   PMID:31732897   PMID:31958467   PMID:32215270  


Genomics

Candidate Gene Status
Cebpb is a candidate Gene for QTL Eau4
Comparative Map Data
Cebpb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23156,398,035 - 156,399,466 (+)NCBI
Rnor_6.0 Ensembl3164,424,515 - 164,425,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03164,424,502 - 164,425,933 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03170,577,328 - 170,579,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,826,021 - 158,827,848 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13158,732,056 - 158,733,825 (+)NCBI
Celera3154,977,150 - 154,977,588 (+)NCBICelera
Cytogenetic Map3q42NCBI
CEBPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2050,190,830 - 50,192,668 (+)EnsemblGRCh38hg38GRCh38
GRCh382050,190,583 - 50,192,690 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372048,807,120 - 48,809,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,240,783 - 48,242,619 (+)NCBINCBI36hg18NCBI36
Build 342048,240,782 - 48,242,619NCBI
Celera2045,511,633 - 45,513,469 (+)NCBI
Cytogenetic Map20q13.13NCBI
HuRef2045,555,433 - 45,557,595 (+)NCBIHuRef
CHM1_12048,711,778 - 48,713,885 (+)NCBICHM1_1
Cebpb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,530,835 - 167,532,352 (+)NCBIGRCm39mm39
GRCm39 Ensembl2167,530,835 - 167,532,338 (+)Ensembl
GRCm382167,688,915 - 167,690,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,688,915 - 167,690,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv372167,514,415 - 167,515,918 (+)NCBIGRCm37mm9NCBIm37
MGSCv362167,380,120 - 167,381,623 (+)NCBImm8
MGSCv362168,673,393 - 168,674,898 (+)NCBImm8
Celera2173,629,112 - 173,630,498 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.58NCBI
Cebpb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554458,060,432 - 8,061,289 (-)NCBIChiLan1.0ChiLan1.0
CEBPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v02046,533,163 - 46,535,282 (+)NCBIMhudiblu_PPA_v0panPan3
CEBPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,661,294 - 36,663,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,661,616 - 36,662,656 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,905,196 - 35,907,045 (+)NCBI
ROS_Cfam_1.02437,368,136 - 37,369,976 (+)NCBI
UMICH_Zoey_3.12436,608,936 - 36,610,792 (+)NCBI
UNSW_CanFamBas_1.02436,742,145 - 36,743,331 (+)NCBI
UU_Cfam_GSD_1.02437,285,911 - 37,287,750 (+)NCBI
CEBPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,722,426 - 51,724,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,722,633 - 51,723,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,041,640 - 58,042,680 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CEBPB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,780,538 - 13,782,639 (-)NCBI
ChlSab1.1 Ensembl213,781,160 - 13,782,194 (-)Ensembl
Cebpb
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247905,367,808 - 5,369,686 (-)NCBI

Position Markers
PMC55812P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,398,064 - 156,398,178 (+)MAPPER
Rnor_6.03164,424,532 - 164,424,645NCBIRnor6.0
Rnor_5.03170,577,754 - 170,577,867UniSTSRnor5.0
RGSC_v3.43158,826,447 - 158,826,560UniSTSRGSC3.4
Cytogenetic Map3q42UniSTS
PMC114562P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,398,377 - 156,398,852 (+)MAPPER
Rnor_6.03164,424,845 - 164,425,319NCBIRnor6.0
Rnor_5.03170,578,065 - 170,578,751UniSTSRnor5.0
RGSC_v3.43158,826,760 - 158,827,234UniSTSRGSC3.4
Cytogenetic Map3q42UniSTS
PMC21741P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,398,744 - 156,399,172 (+)MAPPER
Rnor_6.03164,425,212 - 164,425,639NCBIRnor6.0
Rnor_5.03170,578,644 - 170,579,071UniSTSRnor5.0
RGSC_v3.43158,827,127 - 158,827,554UniSTSRGSC3.4
Cytogenetic Map3q42UniSTS
PMC316377P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,398,328 - 156,398,475 (+)MAPPER
Rnor_6.03164,424,796 - 164,424,942NCBIRnor6.0
Rnor_5.03170,578,016 - 170,578,162UniSTSRnor5.0
RGSC_v3.43158,826,711 - 158,826,857UniSTSRGSC3.4
Cytogenetic Map3q42UniSTS
PMC55812P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,398,061 - 156,398,178 (+)MAPPER
Rnor_6.03164,424,529 - 164,424,645NCBIRnor6.0
Rnor_5.03170,577,751 - 170,577,867UniSTSRnor5.0
RGSC_v3.43158,826,444 - 158,826,560UniSTSRGSC3.4
Cytogenetic Map3q42UniSTS
Cebpb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,399,163 - 156,399,260 (+)MAPPER
Rnor_6.03164,425,631 - 164,425,727NCBIRnor6.0
Rnor_5.03170,579,063 - 170,579,159UniSTSRnor5.0
Celera3154,977,286 - 154,977,382UniSTS
Cytogenetic Map3q42UniSTS
Cebpb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,399,013 - 156,399,274 (+)MAPPER
Rnor_6.03164,425,481 - 164,425,741NCBIRnor6.0
Rnor_5.03170,578,913 - 170,579,173UniSTSRnor5.0
Cytogenetic Map3q42UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3119471263164471263Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3125848628170848628Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3126575595165355668Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128986468173986468Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3129787213177699992Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3130006659175006659Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3132875075176418101Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3136876155170935007Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3138374177177699992Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3138374177177699992Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3139578365177699992Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3146232777177699992Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3148034701177699992Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3148348517171467264Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3150368003177699992Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3153381237174632112Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3153381237174632112Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3153381237174632112Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3153381237174632112Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3153381237174632112Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3153381237174632112Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3153381237174632112Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3153412455165355668Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)3153412455170534769Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3153412455177699992Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3153918022177699992Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3156381661176418101Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:63
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000072673
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 3 51 39 15 39 8 11 7 18 11 8
Low 2 40 6 2 4 2 74 28 23
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083876   ⟹   ENSRNOP00000071427
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3164,424,515 - 164,425,910 (+)Ensembl
RefSeq Acc Id: NM_001301715   ⟹   NP_001288644
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23156,398,035 - 156,399,466 (+)NCBI
Rnor_6.03164,424,502 - 164,425,933 (+)NCBI
Celera3154,977,150 - 154,977,588 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001301720   ⟹   NP_001288649
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23156,398,035 - 156,399,466 (+)NCBI
Rnor_6.03164,424,502 - 164,425,933 (+)NCBI
Celera3154,977,150 - 154,977,588 (+)NCBI
Sequence:
RefSeq Acc Id: NM_024125   ⟹   NP_077039
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23156,398,035 - 156,399,466 (+)NCBI
Rnor_6.03164,424,502 - 164,425,933 (+)NCBI
Rnor_5.03170,577,328 - 170,579,365 (+)NCBI
RGSC_v3.43158,826,021 - 158,827,848 (+)RGD
Celera3154,977,150 - 154,977,588 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_077039   ⟸   NM_024125
- Peptide Label: isoform LAP1
- UniProtKB: P21272 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288644   ⟸   NM_001301715
- Peptide Label: isoform LAP2
- UniProtKB: P21272 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288649   ⟸   NM_001301720
- Peptide Label: isoform LIP
- UniProtKB: P21272 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071427   ⟸   ENSRNOT00000083876
Protein Domains
bZIP

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692694
Promoter ID:EPDNEW_R3219
Type:single initiation site
Name:Cebpb_1
Description:CCAAT/enhancer binding protein beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03164,424,500 - 164,424,560EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2327 AgrOrtholog
Ensembl Genes ENSRNOG00000057347 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000071427 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083876 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7458221 IMAGE-MGC_LOAD
InterPro bZIP UniProtKB/Swiss-Prot
  C/EBP_chordates UniProtKB/Swiss-Prot
KEGG Report rno:24253 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156483 IMAGE-MGC_LOAD
NCBI Gene 24253 ENTREZGENE
Pfam bZIP_2 UniProtKB/Swiss-Prot
PhenoGen Cebpb PhenoGen
PIRSF CCAAT/enhancer-binding UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
SMART BRLZ UniProtKB/Swiss-Prot
UniProt CEBPB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2VD03 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Cebpb  CCAAT/enhancer binding protein beta  Cebpb  CCAAT/enhancer binding protein (C/EBP), beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-17 Cebpb  CCAAT/enhancer binding protein (C/EBP), beta      Name updated 68913 APPROVED
2001-07-23 Cebpb  Liver activating protein (LAP, also NF-IL6, nuclear factor-IL6, previously designated TCF5)      Name withdrawn 67952 WITHDRAWN
2001-07-23 Cebpb  CCAAT/enhancer binding protein (C/EBP), gamma      Name updated to reflect Human and Mouse nomenclature 67952 RESERVED

RGD Curation Notes
Note Type Note Reference
gene_disease binding activity is lower in thioacetamie-induced liver cirrhosis after partial hepatectomy 70813
gene_drugs treatment with glucocorticoid receptor antagonist RU-38486 inhibits the sepsis-induced activation in the skeletal muscles 625506
gene_expression expressed in the skeletal muscle 625506
gene_expression may be induced in hepatocyte regeneration after certain types of liver damage 70249
gene_expression sepsis upregulates the DNA-binding activity of the CEBP resulting in activation  
gene_expression expressed in liver, lung, spleen, kidney, brain, and testis 1298750
gene_physical_interaction binds as a homodimer or as a heterodimer with C/EBP to bind DNA 1298751
gene_physical_interaction binds to CCAATT motif that overlaps the c-fos dyad symmetry element where serum regulatory factor (SRF) binds 1298753
gene_process may mediate IL-6 induced transcriptional activation of acute phase response genes in liver 1298751
gene_product member of the C/EBP family of transcription factors 625506
gene_regulation sepsis upregulates the DNA-binding activity of the CEBP resulting in activation 625506
gene_regulation expression upregulated by sepsis that is induced by cecal ligation and puncture 625506
gene_regulation trans-activating activity induced by IL-6 1298751