Cebpb (CCAAT/enhancer binding protein beta) - Rat Genome Database

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Gene: Cebpb (CCAAT/enhancer binding protein beta) Rattus norvegicus
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Symbol: Cebpb
Name: CCAAT/enhancer binding protein beta
RGD ID: 2327
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear glucocorticoid receptor binding activity; and protein dimerization activity. Involved in several processes, including cellular response to interleukin-1; hepatocyte proliferation; and regulation of transcription by RNA polymerase II. Located in nuclear matrix. Part of CHOP-C/EBP complex. Orthologous to human CEBPB (CCAAT enhancer binding protein beta); PARTICIPATES IN forkhead class A signaling pathway; interleukin-3 signaling pathway; interleukin-4 signaling pathway; INTERACTS WITH (-)-cotinine; (S)-nicotine; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C/EBP beta; c/EBP-related protein 2; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; IL-6DBP; Il6dbp; interleukin-6-dependent-binding protein; LAP; LIP; Liver activating protein (LAP also NF-IL6 nuclear factor-IL6 previously designated TCF5); liver activating protein (LAP); Liver activating protein (LAP, also NF-IL6, nuclear factor-IL6, previously designated TCF5); liver-enriched inhibitory protein; liver-enriched transcriptional activator; NF-IL6; nuclear factor-IL6; SF-B; silencer factor B; TCF5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23156,398,035 - 156,399,466 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,397,052 - 156,399,473 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3160,193,187 - 160,194,618 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03168,692,267 - 168,693,698 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03166,433,973 - 166,435,404 (+)NCBIRnor_WKY
Rnor_6.03164,424,502 - 164,425,933 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,424,515 - 164,425,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,577,328 - 170,579,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,826,021 - 158,827,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,732,056 - 158,733,825 (+)NCBI
Celera3154,977,150 - 154,977,588 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-cotinine  (EXP)
(R)-adrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
8-(4-chlorophenylthio)-cGMP  (ISO)
9-cis-retinoic acid  (EXP)
acetaldehyde  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-linolenic acid  (EXP)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
apigenin  (ISO)
aripiprazole  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atrazine  (EXP,ISO)
Azaspiracid  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
betulinic acid  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bortezomib  (EXP,ISO)
bucladesine  (ISO)
butylated hydroxyanisole  (ISO)
C60 fullerene  (EXP)
caffeine  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
carmustine  (ISO)
ceruletide  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
chloroquine  (ISO)
choline  (ISO)
Chorionic gonadotropin  (ISO)
ciglitazone  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinous acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
fenpyroximate  (ISO)
flavone  (EXP)
flavonoids  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
gallic acid  (ISO)
gallocatechin  (EXP)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (EXP)
gemcitabine  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
geraniol  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (EXP)
glycyrrhizinic acid  (ISO)
GW 4064  (ISO)
herbimycin  (EXP)
hexadecanoic acid  (EXP)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin  (ISO)
indometacin  (ISO)
Iodine aqueous  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoniazide  (ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
L-serine  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP,ISO)
levofloxacin  (EXP)
linalool  (EXP)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
MeIQx  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
naphthalenes  (EXP)
nickel dichloride  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitroprusside  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oltipraz  (EXP)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentane  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
picene  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
prostaglandin J2  (EXP)
pyrazinecarboxamide  (EXP)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
riboflavin  (EXP)
rifampicin  (ISO)
rolipram  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
sevoflurane  (EXP)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sincalide  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
stavudine  (EXP)
streptozocin  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
tebufenpyrad  (ISO)
telmisartan  (EXP)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
Tetramethylthiourea  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torin 1  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brown fat cell differentiation  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to interleukin-1  (IDA)
cellular response to lipopolysaccharide  (IDA)
cellular response to organic cyclic compound  (IEP)
defense response to bacterium  (ISO,ISS)
DNA-templated transcription  (ISO)
DNA-templated transcription elongation  (ISO)
embryonic placenta development  (ISO)
fat cell differentiation  (ISO)
granuloma formation  (ISO,ISS)
hepatocyte proliferation  (IDA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
liver development  (IEP)
liver regeneration  (ISO,ISS)
mammary gland epithelial cell differentiation  (ISO)
mammary gland epithelial cell proliferation  (ISO)
memory  (IEP)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of T cell proliferation  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IC,IDA)
neuron differentiation  (ISO)
ovarian follicle development  (ISO,ISS)
positive regulation of biomineral tissue development  (ISO)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fat cell differentiation  (ISO,ISS)
positive regulation of gene expression  (IMP)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-4 production  (ISO,ISS)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of sodium-dependent phosphate transport  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (ISO)
regulation of cell differentiation  (IBA)
regulation of dendritic cell differentiation  (ISO)
regulation of DNA-templated transcription  (IC,IEA,ISO,ISS)
regulation of interleukin-6 production  (ISO)
regulation of odontoblast differentiation  (IDA)
regulation of osteoclast differentiation  (ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA,IC,ISO,ISS)
response to endoplasmic reticulum stress  (ISO,ISS)
response to lipopolysaccharide  (ISO)
T-helper 1 cell activation  (ISO,ISS)
transcription by RNA polymerase II  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Association of the glucocorticoid receptor with STAT3, C/EBPbeta, and the hormone-responsive element within the rat haptoglobin gene promoter during the acute phase response. Arambasic J, etal., IUBMB Life. 2010 Mar;62(3):227-36.
2. Acute-phase-dependent binding affinity of C/EBPbeta from the nuclear extract and nuclear matrix towards the hormone response element of the alpha2-macroglobulin gene in rat hepatocytes. Bogojevic D, etal., Gen Physiol Biophys. 2003 Jun;22(2):279-85.
3. Transthyretin: A key gene involved in the maintenance of memory capacities during aging. Brouillette J and Quirion R, Neurobiol Aging. 2007 May 16.
4. Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. Buck M, etal., Mol Cell. 1999 Dec;4(6):1087-92.
5. Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages. Cain DW, etal., J Immunol. 2013 Nov 1;191(9):4665-75. doi: 10.4049/jimmunol.1300581. Epub 2013 Sep 27.
6. Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta. Carmona MC, etal., Biochem J. 2005 Jul 1;389(Pt 1):47-56. doi: 10.1042/BJ20050009.
7. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. Colangelo V, etal., J Neurosci Res. 2002 Nov 1;70(3):462-73.
8. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Descombes P, etal., Genes Dev 1990 Sep;4(9):1541-51.
9. Mammalian target of rapamycin regulates IL-10 and resistance to Pseudomonas aeruginosa corneal infection. Foldenauer ME, etal., J Immunol. 2013 Jun 1;190(11):5649-58. doi: 10.4049/jimmunol.1203094. Epub 2013 Apr 26.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Identification of a molecular signature of sarcopenia. Giresi PG, etal., Physiol Genomics. 2005 Apr 14;21(2):253-63. Epub 2005 Feb 1.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon. Gombart AF, etal., Blood 2001 May 1;97(9):2561-7.
14. IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway. Gong B, etal., Mol Immunol. 2013 Dec;56(4):619-29. doi: 10.1016/j.molimm.2013.06.016. Epub 2013 Aug 1.
15. CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. Greenbaum LE, etal., J Clin Invest 1998 Sep 1;102(5):996-1007.
16. CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis. Hayashida M, etal., Arthritis Rheum. 2009 Mar;60(3):708-16. doi: 10.1002/art.24332.
17. C/EBPbeta and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2alpha as the inducer in chondrocytes. Hirata M, etal., Hum Mol Genet. 2012 Mar 1;21(5):1111-23. doi: 10.1093/hmg/ddr540. Epub 2011 Nov 17.
18. Transcriptional Co-activators CREB-binding protein/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein. Imamura T, etal., J Biol Chem. 2005 Apr 29;280(17):16625-34. Epub 2005 Feb 18.
19. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Jeschke MG, etal., Endocrinology. 2004 Sep;145(9):4084-93. Epub 2004 Jun 10.
20. Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Ki SH, etal., Mol Cell Biol. 2005 May;25(10):4150-65.
21. Pro-bone and antifat effects of green tea and its polyphenol, epigallocatechin, in rat mesenchymal stem cells in vitro. Ko CH, etal., J Agric Food Chem. 2011 Sep 28;59(18):9870-6. doi: 10.1021/jf202015t. Epub 2011 Sep 6.
22. Role of C/EBP proteins in hepatic and vascular smooth muscle transcription of human NHE1 gene. Kolyada AY, etal., Am J Physiol. 1995 Dec;269(6 Pt 1):C1408-16.
23. The helix-loop-helix protein rE12 and the C/EBP-related factor rNFIL-6 bind to neighboring sites within the c-fos serum response element. Metz R and Ziff E, Oncogene 1991 Dec;6(12):2165-78.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation. Miau LH, etal., J Biol Chem. 1998 Apr 24;273(17):10784-91.
26. Peroxisome proliferator-activated receptor alpha physically interacts with CCAAT/enhancer binding protein (C/EBPbeta) to inhibit C/EBPbeta-responsive alpha1-acid glycoprotein gene expression. Mouthiers A, etal., Mol Endocrinol. 2005 May;19(5):1135-46. doi: 10.1210/me.2004-0188. Epub 2005 Jan 20.
27. The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation. Narayanan K, etal., J Biol Chem. 2004 Oct 29;279(44):45423-32. Epub 2004 Aug 12.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. CRE-mediated transcription is increased in Huntington's disease transgenic mice. Obrietan K and Hoyt KR, J Neurosci. 2004 Jan 28;24(4):791-6.
30. CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials. Ossipow V, etal., Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8219-23.
31. Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene. Palii SS, etal., Biochem J. 2006 May 1;395(3):517-27. doi: 10.1042/BJ20051867.
32. C/EBP DNA-binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle. Penner G, etal., Am J Physiol Regul Integr Comp Physiol 2002 Feb;282(2):R439-44.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
35. IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Poli V, etal., Cell 1990 Nov 2;63(3):643-53.
36. C/EBP beta in rheumatoid arthritis: correlation with inflammation, not disease specificity. Pope RM, etal., Clin Immunol. 1999 Jun;91(3):271-82.
37. GOA pipeline RGD automated data pipeline
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Ron D and Habener JF, Genes Dev. 1992 Mar;6(3):439-53.
40. Members of the C/EBP transcription factor family stimulate expression of the human and rat surfactant protein A (SP-A) genes. Rosenberg E, etal., Biochim Biophys Acta 2002 May 3;1575(1-3):82-90.
41. MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection. Sahu SK, etal., PLoS Pathog. 2017 May 30;13(5):e1006410. doi: 10.1371/journal.ppat.1006410. eCollection 2017 May.
42. Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis. Saito H, etal., Mech Ageing Dev. 2003 Dec;124(10-12):1047-58. doi: 10.1016/j.mad.2003.08.002.
43. Alzheimer amyloid-beta peptides block the activation of C/EBPbeta and C/EBPdelta in glial cells. Samuelsson M, etal., Biochem Biophys Res Commun. 2008 Jun 13;370(4):619-22. doi: 10.1016/j.bbrc.2008.03.150. Epub 2008 Apr 9.
44. Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury in mice. Sandhir R and Berman NE, Neurochem Int. 2010 Jan;56(1):188-93. doi: 10.1016/j.neuint.2009.10.002. Epub 2009 Oct 13.
45. Insulin activates CCAAT/enhancer binding proteins and proinflammatory gene expression through the phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Sekine O, etal., J Biol Chem 2002 Sep 27;277(39):36631-9.
46. Impairment of Hematopoietic Precursor Cell Activation during the Granulopoietic Response to Bacteremia in Mice with Chronic-Plus-Binge Alcohol Administration. Shi X, etal., Infect Immun. 2017 Oct 18;85(11). pii: IAI.00369-17. doi: 10.1128/IAI.00369-17. Print 2017 Nov.
47. C/EBPbeta Promotes Immunity to Oral Candidiasis through Regulation of beta-Defensins. Simpson-Abelson MR, etal., PLoS One. 2015 Aug 28;10(8):e0136538. doi: 10.1371/journal.pone.0136538. eCollection 2015.
48. Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBPβ-regulated atrogin1 expression in cancer cachexia. Sun R, etal., Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C101-15. doi: 10.1152/ajpcell.00344.2015. Epub 2016 Apr 27.
49. Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma. Thomassin H, etal., Nucleic Acids Res 1992 Jun 25;20(12):3091-8.
50. Downregulation of cytochromes P450 in growth-stimulated rat hepatocytes: role of c-Myc induction and impaired C/EBP binding to DNA. Tinel M, etal., J Hepatol. 2003 Aug;39(2):171-8.
51. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
52. Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Ubeda M, etal., Mol Cell Biol. 1996 Apr;16(4):1479-89.
53. The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing. Uematsu S, etal., J Immunol. 2007 Oct 15;179(8):5378-86. doi: 10.4049/jimmunol.179.8.5378.
54. Solubility partitioning of C/EBPbeta on the rat hepatocyte nuclear matrix by hydrophobic interactions. Uskokovic A, etal., Cell Biol Int. 2002;26(5):451-61.
55. Increased insulin receptor substrate-1 and enhanced skeletal muscle insulin sensitivity in mice lacking CCAAT/enhancer-binding protein beta. Wang L, etal., J Biol Chem 2000 May 12;275(19):14173-81.
56. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Williams SC, etal., Genes Dev 1991 Sep;5(9):1553-67.
57. Melatonin set out to ER stress signaling thwarts epithelial mesenchymal transition and peritoneal dissemination via calpain-mediated C/EBPbeta and NFkappaB cleavage. Wu SM, etal., J Pineal Res. 2016 Mar;60(2):142-54. doi: 10.1111/jpi.12295. Epub 2015 Dec 16.
58. Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming. Xiong L, etal., Nat Commun. 2019 Jan 18;10(1):335. doi: 10.1038/s41467-018-08245-z.
59. Inhibited activities in CCAAT/enhancer-binding protein, activating protein-1 and cyclins after hepatectomy in rats with thioacetamide-induced liver cirrhosis. Zhao G, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):474-81.
Additional References at PubMed
PMID:1655570   PMID:1934061   PMID:7959007   PMID:8200992   PMID:8972203   PMID:9303532   PMID:9531536   PMID:9545285   PMID:10510303   PMID:10588870   PMID:10683373   PMID:10707954  
PMID:10859308   PMID:10921906   PMID:11684016   PMID:11733516   PMID:11940593   PMID:11976687   PMID:12177065   PMID:12213809   PMID:12477932   PMID:12821655   PMID:12871593   PMID:15175325  
PMID:15187136   PMID:15299028   PMID:15383601   PMID:15509779   PMID:15509789   PMID:15519652   PMID:15601867   PMID:15659391   PMID:15669015   PMID:15669083   PMID:15721291   PMID:15775988  
PMID:15785238   PMID:16055922   PMID:16106045   PMID:16172914   PMID:16223488   PMID:16585579   PMID:16682116   PMID:16772287   PMID:16980548   PMID:17180354   PMID:17301242   PMID:17644752  
PMID:17724128   PMID:17727681   PMID:17884934   PMID:17888405   PMID:18052938   PMID:18486321   PMID:18559338   PMID:18650268   PMID:18824566   PMID:19103603   PMID:19324970   PMID:19407981  
PMID:19440205   PMID:19641492   PMID:19875812   PMID:20351173   PMID:20452968   PMID:20548288   PMID:20797423   PMID:20829347   PMID:20930553   PMID:21122806   PMID:21183071   PMID:21249617  
PMID:21539866   PMID:21586575   PMID:21678417   PMID:21935930   PMID:22078933   PMID:22242598   PMID:23257266   PMID:23508841   PMID:23643813   PMID:23881867   PMID:24061474   PMID:24191285  
PMID:24216764   PMID:24279606   PMID:24344329   PMID:24438488   PMID:24704266   PMID:25109894   PMID:25110868   PMID:25173154   PMID:25209292   PMID:25403356   PMID:25450863   PMID:25472717  
PMID:26024764   PMID:26459835   PMID:26505752   PMID:26526992   PMID:27382175   PMID:27746211   PMID:27812542   PMID:29852820   PMID:30305575   PMID:31732897   PMID:31958467   PMID:32215270  
PMID:35298717  


Genomics

Candidate Gene Status
Cebpb is a candidate Gene for QTL Eau4
Comparative Map Data
Cebpb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23156,398,035 - 156,399,466 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,397,052 - 156,399,473 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3160,193,187 - 160,194,618 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03168,692,267 - 168,693,698 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03166,433,973 - 166,435,404 (+)NCBIRnor_WKY
Rnor_6.03164,424,502 - 164,425,933 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,424,515 - 164,425,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,577,328 - 170,579,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,826,021 - 158,827,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,732,056 - 158,733,825 (+)NCBI
Celera3154,977,150 - 154,977,588 (+)NCBICelera
Cytogenetic Map3q42NCBI
CEBPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382050,190,583 - 50,192,690 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2050,190,830 - 50,192,668 (+)EnsemblGRCh38hg38GRCh38
GRCh372048,807,120 - 48,809,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,240,783 - 48,242,619 (+)NCBINCBI36Build 36hg18NCBI36
Build 342048,240,782 - 48,242,619NCBI
Celera2045,511,633 - 45,513,469 (+)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2045,555,433 - 45,557,595 (+)NCBIHuRef
CHM1_12048,711,778 - 48,713,885 (+)NCBICHM1_1
T2T-CHM13v2.02051,960,086 - 51,962,193 (+)NCBIT2T-CHM13v2.0
Cebpb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,530,835 - 167,532,352 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,530,835 - 167,532,338 (+)EnsemblGRCm39 Ensembl
GRCm382167,688,915 - 167,690,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,688,915 - 167,690,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv372167,514,415 - 167,515,918 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362167,380,120 - 167,381,623 (+)NCBIMGSCv36mm8
MGSCv362168,673,393 - 168,674,898 (+)NCBIMGSCv36mm8
Celera2173,629,112 - 173,630,498 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.58NCBI
Cebpb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554458,060,432 - 8,061,289 (-)NCBIChiLan1.0ChiLan1.0
CEBPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v02046,533,163 - 46,535,282 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CEBPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,661,294 - 36,663,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,661,616 - 36,662,656 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,905,196 - 35,907,045 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02437,368,136 - 37,369,976 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2437,368,234 - 37,369,274 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12436,608,936 - 36,610,792 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,742,145 - 36,743,331 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02437,285,911 - 37,287,750 (+)NCBIUU_Cfam_GSD_1.0
CEBPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,722,426 - 51,724,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,722,633 - 51,723,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,041,640 - 58,042,680 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CEBPB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,780,538 - 13,782,639 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,781,160 - 13,782,194 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605062,211,871 - 62,213,968 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cebpb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247905,368,349 - 5,369,377 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,367,808 - 5,369,686 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
PMC55812P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,398,064 - 156,398,178 (+)MAPPERmRatBN7.2
Rnor_6.03164,424,532 - 164,424,645NCBIRnor6.0
Rnor_5.03170,577,754 - 170,577,867UniSTSRnor5.0
RGSC_v3.43158,826,447 - 158,826,560UniSTSRGSC3.4
Cytogenetic Map3q42UniSTS
PMC114562P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,398,377 - 156,398,852 (+)MAPPERmRatBN7.2
Rnor_6.03164,424,845 - 164,425,319NCBIRnor6.0
Rnor_5.03170,578,065 - 170,578,751UniSTSRnor5.0
RGSC_v3.43158,826,760 - 158,827,234UniSTSRGSC3.4
Cytogenetic Map3q42UniSTS
PMC21741P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,398,744 - 156,399,172 (+)MAPPERmRatBN7.2
Rnor_6.03164,425,212 - 164,425,639NCBIRnor6.0
Rnor_5.03170,578,644 - 170,579,071UniSTSRnor5.0
RGSC_v3.43158,827,127 - 158,827,554UniSTSRGSC3.4
Cytogenetic Map3q42UniSTS
PMC316377P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,398,328 - 156,398,475 (+)MAPPERmRatBN7.2
Rnor_6.03164,424,796 - 164,424,942NCBIRnor6.0
Rnor_5.03170,578,016 - 170,578,162UniSTSRnor5.0
RGSC_v3.43158,826,711 - 158,826,857UniSTSRGSC3.4
Cytogenetic Map3q42UniSTS
PMC55812P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,398,061 - 156,398,178 (+)MAPPERmRatBN7.2
Rnor_6.03164,424,529 - 164,424,645NCBIRnor6.0
Rnor_5.03170,577,751 - 170,577,867UniSTSRnor5.0
RGSC_v3.43158,826,444 - 158,826,560UniSTSRGSC3.4
Cytogenetic Map3q42UniSTS
Cebpb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,399,163 - 156,399,260 (+)MAPPERmRatBN7.2
Rnor_6.03164,425,631 - 164,425,727NCBIRnor6.0
Rnor_5.03170,579,063 - 170,579,159UniSTSRnor5.0
Celera3154,977,286 - 154,977,382UniSTS
Cytogenetic Map3q42UniSTS
Cebpb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23156,399,013 - 156,399,274 (+)MAPPERmRatBN7.2
Rnor_6.03164,425,481 - 164,425,741NCBIRnor6.0
Rnor_5.03170,578,913 - 170,579,173UniSTSRnor5.0
Cytogenetic Map3q42UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:63
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000072673
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 3 51 39 15 39 8 11 7 18 11 8
Low 2 40 6 2 4 2 74 28 23
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083876   ⟹   ENSRNOP00000071427
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3156,397,052 - 156,399,473 (+)Ensembl
Rnor_6.0 Ensembl3164,424,515 - 164,425,910 (+)Ensembl
RefSeq Acc Id: NM_001301715   ⟹   NP_001288644
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23156,398,035 - 156,399,466 (+)NCBI
Rnor_6.03164,424,502 - 164,425,933 (+)NCBI
Celera3154,977,150 - 154,977,588 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001301720   ⟹   NP_001288649
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23156,398,035 - 156,399,466 (+)NCBI
Rnor_6.03164,424,502 - 164,425,933 (+)NCBI
Celera3154,977,150 - 154,977,588 (+)NCBI
Sequence:
RefSeq Acc Id: NM_024125   ⟹   NP_077039
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23156,398,035 - 156,399,466 (+)NCBI
Rnor_6.03164,424,502 - 164,425,933 (+)NCBI
Rnor_5.03170,577,328 - 170,579,365 (+)NCBI
RGSC_v3.43158,826,021 - 158,827,848 (+)RGD
Celera3154,977,150 - 154,977,588 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_077039   ⟸   NM_024125
- Peptide Label: isoform LAP1
- UniProtKB: A2VD03 (UniProtKB/Swiss-Prot),   P21272 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288644   ⟸   NM_001301715
- Peptide Label: isoform LAP2
- UniProtKB: P21272 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288649   ⟸   NM_001301720
- Peptide Label: isoform LIP
- UniProtKB: P21272 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071427   ⟸   ENSRNOT00000083876
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21272-F1-model_v2 AlphaFold P21272 1-297 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692694
Promoter ID:EPDNEW_R3219
Type:single initiation site
Name:Cebpb_1
Description:CCAAT/enhancer binding protein beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03164,424,500 - 164,424,560EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2327 AgrOrtholog
BioCyc Gene G2FUF-46718 BioCyc
Ensembl Genes ENSRNOG00000057347 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000071427.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083876.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7458221 IMAGE-MGC_LOAD
InterPro bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
  C/EBP_chordates UniProtKB/Swiss-Prot
KEGG Report rno:24253 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156483 IMAGE-MGC_LOAD
NCBI Gene 24253 ENTREZGENE
Pfam bZIP_2 UniProtKB/Swiss-Prot
PhenoGen Cebpb PhenoGen
PIRSF CCAAT/enhancer-binding UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
UniProt A0A8L2R490_RAT UniProtKB/TrEMBL
  A2VD03 ENTREZGENE
  CEBPB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2VD03 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Cebpb  CCAAT/enhancer binding protein beta  Cebpb  CCAAT/enhancer binding protein (C/EBP), beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-17 Cebpb  CCAAT/enhancer binding protein (C/EBP), beta      Name updated 68913 APPROVED
2001-07-23 Cebpb  Liver activating protein (LAP, also NF-IL6, nuclear factor-IL6, previously designated TCF5)      Name withdrawn 67952 WITHDRAWN
2001-07-23 Cebpb  CCAAT/enhancer binding protein (C/EBP), gamma      Name updated to reflect Human and Mouse nomenclature 67952 RESERVED

RGD Curation Notes
Note Type Note Reference
gene_disease binding activity is lower in thioacetamie-induced liver cirrhosis after partial hepatectomy 70813
gene_drugs treatment with glucocorticoid receptor antagonist RU-38486 inhibits the sepsis-induced activation in the skeletal muscles 625506
gene_expression expressed in the skeletal muscle 625506
gene_expression may be induced in hepatocyte regeneration after certain types of liver damage 70249
gene_expression sepsis upregulates the DNA-binding activity of the CEBP resulting in activation  
gene_expression expressed in liver, lung, spleen, kidney, brain, and testis 1298750
gene_physical_interaction binds as a homodimer or as a heterodimer with C/EBP to bind DNA 1298751
gene_physical_interaction binds to CCAATT motif that overlaps the c-fos dyad symmetry element where serum regulatory factor (SRF) binds 1298753
gene_process may mediate IL-6 induced transcriptional activation of acute phase response genes in liver 1298751
gene_product member of the C/EBP family of transcription factors 625506
gene_regulation sepsis upregulates the DNA-binding activity of the CEBP resulting in activation 625506
gene_regulation expression upregulated by sepsis that is induced by cecal ligation and puncture 625506
gene_regulation trans-activating activity induced by IL-6 1298751