Thrb (thyroid hormone receptor beta) - Rat Genome Database

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Gene: Thrb (thyroid hormone receptor beta) Rattus norvegicus
Analyze
Symbol: Thrb
Name: thyroid hormone receptor beta
RGD ID: 3858
Description: Enables double-stranded DNA binding activity; identical protein binding activity; and nuclear receptor activity. Involved in several processes, including positive regulation of chondrocyte differentiation; positive regulation of ossification; and regulation of lipid metabolic process. Predicted to be located in nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Used to study breast cancer. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; prostate cancer; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta); INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-erbA-2; C-erba-beta; ERBA2; Nr1a2; nuclear receptor subfamily 1 group A member 2; RATT3REC; T3rec; Thyroid hormone receptor beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor beta 3; thyroid hormone receptor beta2delta; thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); TRbeta; TRbeta2Delta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2157,685,180 - 8,031,920 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl157,685,180 - 7,882,916 (-)Ensembl
Rnor_6.0158,890,578 - 9,239,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl158,890,578 - 9,086,282 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01512,951,550 - 13,299,586 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4159,282,845 - 9,345,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1159,279,949 - 9,685,583 (-)NCBI
Celera157,735,185 - 8,077,355 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-citrinin  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthol  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4,6-trichlorophenol  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-diisopropylnaphthalene  (ISO)
2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol  (EXP)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-naphthol  (ISO)
2-phenylpropan-2-ol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-Dimethylbenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3-acetyldeoxynivalenol  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-chloro-3,5-dimethylphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
9-phenanthrol  (ISO)
[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID  (ISO)
acetamide  (EXP)
acetochlor  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP,ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
androst-4-ene-3,17-dione  (ISO)
apigenin  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (EXP)
bicalutamide  (ISO)
biochanin A  (ISO)
biphenyl-2-ol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bithionol  (EXP)
bleomycin A2  (EXP)
butachlor  (ISO)
butyric acid  (EXP)
cadmium dichloride  (EXP)
calciol  (EXP)
calcitriol  (ISO)
camptothecin  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clomiphene  (ISO)
closantel  (EXP)
clozapine  (EXP)
coumaphos  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
daidzein  (ISO)
DDD  (ISO)
DDE  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diethyl hydrogen phosphate  (EXP)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
dronedarone  (EXP)
elemental selenium  (ISO)
emetine  (ISO)
entinostat  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethyl myristate  (ISO)
fenarimol  (ISO)
fenitrothion  (ISO)
fenobucarb  (ISO)
fentin chloride  (ISO)
fentin hydroxide  (ISO)
fenvalerate  (EXP,ISO)
finasteride  (ISO)
Flumetralin  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glyphosate  (EXP)
hexestrol  (ISO)
hydroxyflutamide  (ISO)
imidacloprid  (ISO)
iprodione  (ISO)
isoprenaline  (EXP)
isotretinoin  (EXP)
kojic acid  (ISO)
kresoxim-methyl  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
Melengestrol acetate  (ISO)
mestranol  (ISO)
methoxyacetic acid  (ISO)
methyl laurate  (ISO)
metolcarb  (ISO)
mifepristone  (ISO)
MK-2206  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzoyl-L-alanine  (ISO)
N-desethylamiodarone  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nilutamide  (ISO)
nitrofen  (EXP)
Nonylphenol  (EXP)
norethisterone  (ISO)
ochratoxin A  (ISO)
oryzalin  (ISO)
Oxadiazon  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
pazopanib  (ISO)
pendimethalin  (ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
permethrin  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
procymidone  (ISO)
propanil  (ISO)
propylparaben  (ISO)
Ptaquiloside  (ISO)
pymetrozine  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
staurosporine  (ISO)
sulfasalazine  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
taurine  (ISO)
teniposide  (ISO)
testosterone  (ISO)
Testosterone propionate  (ISO)
Tetrachlorobisphenol A  (ISO)
thiazolidinediones  (EXP)
thioacetamide  (EXP)
thyroxine  (EXP,ISO)
Trenbolone  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Ali IU, etal., J Natl Cancer Inst. 1989 Dec 6;81(23):1815-20.
2. Chang CL, etal., Am J Obstet Gynecol. 2001 Jul;185(1):108-15.
3. Chu TY, etal., Int J Cancer. 1998 Jan 19;75(2):199-204.
4. Columbano A, etal., Endocrinology. 2006 Jul;147(7):3211-8. Epub 2006 Mar 30.
5. Diallo EM, etal., Protein Expr Purif. 2005 Apr;40(2):292-8.
6. Erion MD, etal., Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15490-5. Epub 2007 Sep 18.
7. Freitas FR, etal., J Bone Miner Res. 2005 Feb;20(2):294-304. Epub 2004 Nov 22.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. GOA data from the GO Consortium
10. Kamiya Y, etal., Carcinogenesis. 2002 Jan;23(1):25-33.
11. Keijzer R, etal., J Mol Endocrinol. 2007 May;38(5):523-35.
12. Koenig RJ, etal., Proc Natl Acad Sci U S A 1988 Jul;85(14):5031-5.
13. Lam CW, etal., Clin Chim Acta. 2005 Aug;358(1-2):55-9.
14. Ling Y, etal., Cancer Genet Cytogenet. 2010 Jan 15;196(2):140-145.
15. MGD data from the GO Consortium
16. Murray MB, etal., J Biol Chem 1988 Sep 5;263(25):12770-7.
17. NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline
19. Pantos C, etal., Eur J Endocrinol. 2007 Apr;156(4):415-24.
20. Prieur X, etal., J Biol Chem. 2005 Jul 29;280(30):27533-43. Epub 2005 Jun 7.
21. RGD automated data pipeline
22. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. RGD automated import pipeline for gene-chemical interactions
24. Schwarzenbach H, etal., BJU Int. 2008 Jul;102(2):253-8. Epub 2008 Jul 1.
25. Silva JM, etal., Oncogene. 2002 Jun 20;21(27):4307-16.
Additional References at PubMed
PMID:2539642   PMID:7566114   PMID:7776974   PMID:8673137   PMID:9795230   PMID:9832432   PMID:9927422   PMID:10769387   PMID:11046130   PMID:11739747   PMID:12039952   PMID:12407160  
PMID:14657007   PMID:14767065   PMID:15062575   PMID:15180993   PMID:15466465   PMID:16549781   PMID:16645037   PMID:16803873   PMID:17218414   PMID:17952069   PMID:18000305   PMID:18299881  
PMID:19052228   PMID:19082768   PMID:19171649   PMID:19629520   PMID:20203194   PMID:20610536   PMID:20615868   PMID:20719854   PMID:20949361   PMID:21149577   PMID:22001906   PMID:22079090  
PMID:22930759   PMID:22985455   PMID:23148211   PMID:23376485   PMID:23384771   PMID:23629656   PMID:25156012   PMID:25666034   PMID:33255695   PMID:33834296  


Genomics

Comparative Map Data
Thrb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2157,685,180 - 8,031,920 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl157,685,180 - 7,882,916 (-)Ensembl
Rnor_6.0158,890,578 - 9,239,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl158,890,578 - 9,086,282 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01512,951,550 - 13,299,586 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4159,282,845 - 9,345,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1159,279,949 - 9,685,583 (-)NCBI
Celera157,735,185 - 8,077,355 (-)NCBICelera
Cytogenetic Map15p16NCBI
THRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38324,117,153 - 24,495,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl324,117,153 - 24,495,756 (-)EnsemblGRCh38hg38GRCh38
GRCh37324,158,644 - 24,537,199 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36324,134,709 - 24,511,317 (-)NCBINCBI36hg18NCBI36
Build 34324,139,235 - 24,511,317NCBI
Celera324,094,249 - 24,472,076 (-)NCBI
Cytogenetic Map3p24.2NCBI
HuRef324,104,526 - 24,481,917 (-)NCBIHuRef
CHM1_1324,110,176 - 24,487,912 (-)NCBICHM1_1
Thrb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,429,599 - 4,810,538 (-)NCBIGRCm39mm39
GRCm39 Ensembl144,431,611 - 4,809,435 (-)Ensembl
GRCm381417,659,225 - 18,040,097 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1417,660,261 - 18,038,090 (+)EnsemblGRCm38mm10GRCm38
MGSCv371418,493,474 - 18,870,602 (+)NCBIGRCm37mm9NCBIm37
MGSCv361416,774,842 - 16,827,040 (+)NCBImm8
Celera1413,338,110 - 13,729,284 (+)NCBICelera
Cytogenetic Map14A1NCBI
Thrb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543015,992,146 - 16,323,238 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543015,992,146 - 16,322,696 (-)NCBIChiLan1.0ChiLan1.0
THRB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1324,345,760 - 24,722,803 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl324,346,824 - 24,564,960 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0324,024,025 - 24,401,024 (-)NCBIMhudiblu_PPA_v0panPan3
THRB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12319,278,650 - 19,648,547 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2319,277,493 - 19,660,283 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2319,274,402 - 19,646,202 (+)NCBI
ROS_Cfam_1.02319,582,486 - 19,954,456 (+)NCBI
ROS_Cfam_1.0 Ensembl2319,582,797 - 19,954,439 (+)Ensembl
UMICH_Zoey_3.12319,398,045 - 19,769,727 (+)NCBI
UNSW_CanFamBas_1.02319,507,580 - 19,879,481 (+)NCBI
UU_Cfam_GSD_1.02319,616,877 - 19,988,327 (+)NCBI
Thrb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118182,627,645 - 182,847,821 (-)NCBI
SpeTri2.0NW_00493647315,766,214 - 15,986,389 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THRB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1310,900,718 - 11,359,544 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11310,900,716 - 11,360,587 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21312,399,964 - 12,857,951 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THRB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11568,797,410 - 69,161,256 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1568,802,078 - 68,902,292 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604141,924,134 - 42,291,602 (-)NCBIVero_WHO_p1.0
Thrb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247881,950,888 - 2,348,895 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D15Wox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,688,354 - 7,688,569 (+)MAPPERmRatBN7.2
Rnor_6.0158,893,753 - 8,893,967NCBIRnor6.0
Rnor_5.01512,954,725 - 12,954,939UniSTSRnor5.0
RGSC_v3.4159,281,524 - 9,281,738UniSTSRGSC3.4
Celera157,738,360 - 7,738,574UniSTS
Cytogenetic Map15p16UniSTS
D15Rat76  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,772,649 - 7,772,785 (+)MAPPERmRatBN7.2
Rnor_6.0158,977,237 - 8,977,372NCBIRnor6.0
Rnor_5.01513,038,226 - 13,038,361UniSTSRnor5.0
RGSC_v3.4159,367,158 - 9,367,293UniSTSRGSC3.4
RGSC_v3.4159,366,823 - 9,367,294RGDRGSC3.4
RGSC_v3.1159,367,158 - 9,367,293RGD
Celera157,822,410 - 7,822,545UniSTS
RH 3.4 Map21650.92UniSTS
RH 3.4 Map21650.92RGD
RH 2.0 Map21223.4RGD
SHRSP x BN Map153.9298RGD
Cytogenetic Map15p16UniSTS
PMC27204P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,686,060 - 7,686,242 (+)MAPPERmRatBN7.2
Rnor_6.0158,891,459 - 8,891,640NCBIRnor6.0
Rnor_5.01512,952,431 - 12,952,612UniSTSRnor5.0
RGSC_v3.4159,279,230 - 9,279,411UniSTSRGSC3.4
Celera157,736,066 - 7,736,247UniSTS
Cytogenetic Map15p16UniSTS
RH132907  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,686,287 - 7,686,472 (+)MAPPERmRatBN7.2
Rnor_6.0158,891,686 - 8,891,870NCBIRnor6.0
Rnor_5.01512,952,658 - 12,952,842UniSTSRnor5.0
RGSC_v3.4159,279,457 - 9,279,641UniSTSRGSC3.4
Celera157,736,293 - 7,736,477UniSTS
RH 3.4 Map1592.23UniSTS
Cytogenetic Map15p16UniSTS
BF399305  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,860,336 - 7,860,487 (+)MAPPERmRatBN7.2
Rnor_6.0159,063,703 - 9,063,853NCBIRnor6.0
Rnor_5.01513,124,710 - 13,124,860UniSTSRnor5.0
Celera157,907,834 - 7,907,984UniSTS
RH 3.4 Map1595.4UniSTS
Cytogenetic Map15p16UniSTS
BE119389  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2157,827,635 - 7,827,818 (+)MAPPERmRatBN7.2
Rnor_6.0159,031,434 - 9,031,616NCBIRnor6.0
Rnor_5.01513,092,423 - 13,092,605UniSTSRnor5.0
RGSC_v3.4159,422,139 - 9,422,321UniSTSRGSC3.4
Celera157,877,061 - 7,877,243UniSTS
RH 3.4 Map1593.21UniSTS
Cytogenetic Map15p16UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15226636822711984Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir27arno-miR-27a-3pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//Western Functional MTI21149577

Predicted Target Of
Summary Value
Count of predictions:1311
Count of miRNA genes:282
Interacting mature miRNAs:361
Transcripts:ENSRNOT00000008752, ENSRNOT00000008989, ENSRNOT00000061402
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 11 23 23 23 21 23 11
Low 2 28 34 18 19 18 8 11 51 12 39 8
Below cutoff 4 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF239914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF239915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF239916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ191165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM043807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000008752   ⟹   ENSRNOP00000008752
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl157,685,180 - 7,751,120 (-)Ensembl
Rnor_6.0 Ensembl158,890,578 - 8,914,501 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000008989   ⟹   ENSRNOP00000008989
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl157,685,180 - 7,882,916 (-)Ensembl
Rnor_6.0 Ensembl158,890,578 - 9,086,282 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000061402   ⟹   ENSRNOP00000058119
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl157,685,180 - 7,751,154 (-)Ensembl
Rnor_6.0 Ensembl158,894,875 - 8,989,580 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085322   ⟹   ENSRNOP00000073083
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl157,685,180 - 7,727,455 (-)Ensembl
Rnor_6.0 Ensembl158,895,074 - 8,931,983 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114169   ⟹   ENSRNOP00000082752
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl157,685,180 - 7,727,455 (-)Ensembl
RefSeq Acc Id: NM_001270854   ⟹   NP_001257783
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2157,685,180 - 8,030,688 (-)NCBI
Rnor_6.0158,890,578 - 9,239,815 (-)NCBI
Rnor_5.01512,951,550 - 13,299,586 (-)NCBI
Celera157,735,185 - 8,077,355 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012672   ⟹   NP_036804
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2157,685,180 - 8,030,688 (-)NCBI
Rnor_6.0158,890,578 - 9,239,815 (-)NCBI
Rnor_5.01512,951,550 - 13,299,586 (-)NCBI
RGSC_v3.4159,282,845 - 9,345,506 (-)RGD
Celera157,735,185 - 8,077,355 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251709   ⟹   XP_006251771
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2157,685,180 - 7,727,446 (-)NCBI
Rnor_6.0158,890,578 - 8,932,209 (-)NCBI
Rnor_5.01512,951,550 - 13,299,586 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092995   ⟹   XP_038948923
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2157,685,180 - 8,031,920 (-)NCBI
RefSeq Acc Id: XM_039092997   ⟹   XP_038948925
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2157,685,180 - 8,030,794 (-)NCBI
RefSeq Acc Id: XM_039092998   ⟹   XP_038948926
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2157,685,180 - 8,030,794 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036804   ⟸   NM_012672
- Peptide Label: isoform 1
- UniProtKB: Q3HW36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257783   ⟸   NM_001270854
- Peptide Label: isoform 2
- UniProtKB: F1LQ07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251771   ⟸   XM_006251709
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000008989   ⟸   ENSRNOT00000008989
RefSeq Acc Id: ENSRNOP00000008752   ⟸   ENSRNOT00000008752
RefSeq Acc Id: ENSRNOP00000073083   ⟸   ENSRNOT00000085322
RefSeq Acc Id: ENSRNOP00000058119   ⟸   ENSRNOT00000061402
RefSeq Acc Id: XP_038948923   ⟸   XM_039092995
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948926   ⟸   XM_039092998
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948925   ⟸   XM_039092997
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000082752   ⟸   ENSRNOT00000114169
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18113-F1-model_v2 AlphaFold P18113 1-461 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3858 AgrOrtholog
BioCyc Gene G2FUF-14456 BioCyc
Ensembl Genes ENSRNOG00000006649 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008752 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000008989 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000058119 UniProtKB/TrEMBL
  ENSRNOP00000073083 UniProtKB/TrEMBL
  ENSRNOP00000082752 ENTREZGENE
Ensembl Transcript ENSRNOT00000008752 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000008989 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000061402 UniProtKB/TrEMBL
  ENSRNOT00000085322 UniProtKB/TrEMBL
  ENSRNOT00000114169 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThyrH_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24831 UniProtKB/TrEMBL
NCBI Gene 24831 ENTREZGENE
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Thrb PhenoGen
PRINTS STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROIDHORMR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2QC48_RAT UniProtKB/TrEMBL
  D3ZGG0_RAT UniProtKB/TrEMBL
  F1LQ07 ENTREZGENE, UniProtKB/TrEMBL
  P18113 ENTREZGENE
  Q3HW36 ENTREZGENE, UniProtKB/TrEMBL
  THB_RAT UniProtKB/Swiss-Prot
UniProt Secondary D7R7X1 UniProtKB/TrEMBL
  F1LP32 UniProtKB/TrEMBL
  P37826 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Thrb  Thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in liver, heart, kidney and brain 730099
gene_product member of the thyroid hormone nuclear receptor family 729962
gene_protein predicted protein is 52 kDa 729962