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Gene: Thrb (thyroid hormone receptor beta) Rattus norvegicus
Symbol: Thrb
Name: thyroid hormone receptor beta
Description: Exhibits double-stranded DNA binding activity; identical protein binding activity; and nuclear receptor activity. Involved in several processes, including positive regulation of chondrocyte differentiation; positive regulation of ossification; and regulation of lipid metabolic process. Predicted to colocalize with nuclear chromatin. Used to study breast cancer. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; prostate cancer; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta); INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: c-erbA-2; C-erba-beta; ERBA2; Nr1a2; nuclear receptor subfamily 1 group A member 2; RATT3REC; T3rec; Thyroid hormone receptor beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor beta 3; thyroid hormone receptor beta2delta; thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); TRbeta; TRbeta2Delta
Homo sapiens (human) : THRB (thyroid hormone receptor beta)  HGNC  Alliance
Mus musculus (house mouse) : Thrb (thyroid hormone receptor beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thrb (thyroid hormone receptor beta)
Pan paniscus (bonobo/pygmy chimpanzee) : THRB (thyroid hormone receptor beta)
Canis lupus familiaris (dog) : THRB (thyroid hormone receptor beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thrb (thyroid hormone receptor beta)
Sus scrofa (pig) : THRB (thyroid hormone receptor beta)
Chlorocebus sabaeus (African green monkey) : THRB (thyroid hormone receptor beta)
Heterocephalus glaber (naked mole-rat) : Thrb (thyroid hormone receptor beta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0158,890,578 - 9,239,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl158,890,578 - 9,086,282 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01512,951,550 - 13,299,586 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4159,282,845 - 9,345,506 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1159,279,949 - 9,685,583 (-)NCBI
Celera157,735,185 - 8,077,355 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Thrb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3858
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.