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Gene: THRB (thyroid hormone receptor beta) Homo sapiens
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Symbol: THRB
Name: thyroid hormone receptor beta
Description: Exhibits enzyme binding activity; nuclear receptor activity; and thyroid hormone binding activity. Predicted to be involved in several processes, including animal organ development; regulation of transcription by RNA polymerase II; and thyroid hormone mediated signaling pathway. Localizes to nuclear body. Implicated in several diseases, including cervix uteri carcinoma in situ; prostate cancer; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2; C-ERBA-2; C-ERBA-BETA; ERBA-BETA; ERBA2; GRTH; MGC126109; MGC126110; NR1A2; nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; pituitary resistance to thyroid hormone; PRTH; THR1; THRB1; THRB2; thyroid hormone nuclear receptor beta variant 1; thyroid hormone receptor beta 1; thyroid hormone receptor beta isoform; thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
Orthologs:
Mus musculus (house mouse) : Thrb (thyroid hormone receptor beta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Thrb (thyroid hormone receptor beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thrb (thyroid hormone receptor beta)
Pan paniscus (bonobo/pygmy chimpanzee) : THRB (thyroid hormone receptor beta)
Canis lupus familiaris (dog) : THRB (thyroid hormone receptor beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thrb (thyroid hormone receptor beta)
Sus scrofa (pig) : THRB (thyroid hormone receptor beta)
Chlorocebus sabaeus (African green monkey) : THRB (thyroid hormone receptor beta)
Heterocephalus glaber (naked mole-rat) : Thrb (thyroid hormone receptor beta)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl324,117,153 - 24,495,756 (-)EnsemblGRCh38hg38GRCh38
GRCh38324,117,153 - 24,495,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37324,158,644 - 24,536,772 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36324,134,709 - 24,511,317 (-)NCBINCBI36hg18NCBI36
Build 34324,139,235 - 24,511,317NCBI
Celera324,094,249 - 24,472,076 (-)NCBI
Cytogenetic Map3p24.2NCBI
HuRef324,104,526 - 24,481,917 (-)NCBIHuRef
CHM1_1324,110,176 - 24,487,912 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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