Thrb (thyroid hormone receptor beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Thrb (thyroid hormone receptor beta) Ictidomys tridecemlineatus
Analyze
Symbol: Thrb
Name: thyroid hormone receptor beta
RGD ID: 12556334
Description: ENCODES a protein that exhibits double-stranded DNA binding (ortholog); identical protein binding (ortholog); nuclear receptor activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); embryonic organ development (ortholog); female courtship behavior (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); attention deficit hyperactivity disorder (ortholog); breast cancer (ortholog); FOUND IN RNA polymerase II transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: thyroid hormone receptor beta, transcript variant X1; thyroid hormone receptor beta, transcript variant X2; thyroid hormone receptor beta, transcript variant X3; thyroid hormone receptor beta, transcript variant X4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118182,627,645 - 182,847,821 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647315,770,146 - 15,986,561 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647315,766,214 - 15,986,389 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Thrb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118182,627,645 - 182,847,821 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647315,770,146 - 15,986,561 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647315,766,214 - 15,986,389 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38324,117,153 - 24,495,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl324,117,153 - 24,495,756 (-)EnsemblGRCh38hg38GRCh38
GRCh37324,158,644 - 24,537,199 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36324,134,709 - 24,511,317 (-)NCBINCBI36Build 36hg18NCBI36
Build 34324,139,235 - 24,511,317NCBI
Celera324,094,249 - 24,472,076 (-)NCBICelera
Cytogenetic Map3p24.2NCBI
HuRef324,104,526 - 24,481,917 (-)NCBIHuRef
CHM1_1324,110,176 - 24,487,912 (-)NCBICHM1_1
T2T-CHM13v2.0324,121,636 - 24,500,130 (-)NCBIT2T-CHM13v2.0
Thrb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,429,599 - 4,810,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl144,431,611 - 4,809,435 (-)EnsemblGRCm39 Ensembl
GRCm381417,659,225 - 18,040,097 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1417,660,261 - 18,038,090 (+)EnsemblGRCm38mm10GRCm38
MGSCv371418,493,474 - 18,870,602 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361416,774,842 - 16,827,040 (+)NCBIMGSCv36mm8
Celera1413,338,110 - 13,729,284 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map147.08NCBI
Thrb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81510,115,954 - 10,465,231 (-)NCBIGRCr8
mRatBN7.2157,685,180 - 8,031,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl157,685,180 - 7,882,916 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx159,830,939 - 10,169,014 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01510,743,731 - 11,081,799 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0159,044,158 - 9,382,240 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0158,890,578 - 9,239,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl158,890,578 - 9,086,282 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01512,951,550 - 13,299,586 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4159,282,845 - 9,345,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1159,279,949 - 9,685,583 (-)NCBI
Celera157,735,185 - 8,077,355 (-)NCBICelera
Cytogenetic Map15p16NCBI
Thrb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543015,992,146 - 16,323,238 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543015,992,146 - 16,322,696 (-)NCBIChiLan1.0ChiLan1.0
THRB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2224,072,698 - 24,449,852 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1324,077,464 - 24,454,587 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0324,024,025 - 24,401,024 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1324,345,760 - 24,722,803 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl324,346,824 - 24,564,960 (-)Ensemblpanpan1.1panPan2
THRB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12319,278,650 - 19,648,547 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2319,277,493 - 19,660,283 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2319,274,402 - 19,646,202 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02319,582,486 - 19,954,456 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2319,582,797 - 19,954,439 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12319,398,045 - 19,769,727 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02319,507,580 - 19,879,481 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02319,616,877 - 19,988,327 (+)NCBIUU_Cfam_GSD_1.0
THRB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1310,900,724 - 11,359,544 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11310,900,716 - 11,360,587 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21312,399,964 - 12,857,951 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THRB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11568,797,410 - 69,161,256 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1568,802,078 - 68,902,292 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604141,924,134 - 42,291,602 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thrb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247881,950,890 - 2,349,343 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247881,950,888 - 2,348,895 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000005194   ⟹   ENSSTOP00000004661
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647315,770,146 - 15,815,192 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000036201   ⟹   ENSSTOP00000031473
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647315,770,146 - 15,871,536 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000036354   ⟹   ENSSTOP00000030992
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647315,770,878 - 15,840,360 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000040224   ⟹   ENSSTOP00000024230
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647315,770,878 - 15,986,561 (-)Ensembl
RefSeq Acc Id: XM_005317268   ⟹   XP_005317325
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118182,627,645 - 182,676,481 (-)NCBI
SpeTri2.0NW_00493647315,766,214 - 15,815,998 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005317269   ⟹   XP_005317326
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118182,627,645 - 182,847,821 (-)NCBI
SpeTri2.0NW_00493647315,766,214 - 15,986,389 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040289863   ⟹   XP_040145797
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118182,627,645 - 182,676,491 (-)NCBI
RefSeq Acc Id: XM_040289864   ⟹   XP_040145798
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118182,627,645 - 182,847,821 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005317326   ⟸   XM_005317269
- Peptide Label: isoform X2
- UniProtKB: A0A287CSC2 (UniProtKB/TrEMBL),   A0A287DBP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005317325   ⟸   XM_005317268
- Peptide Label: isoform X1
- UniProtKB: I3M5M5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040145798   ⟸   XM_040289864
- Peptide Label: isoform X4
- UniProtKB: A0A287DBP3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040145797   ⟸   XM_040289863
- Peptide Label: isoform X3
RefSeq Acc Id: ENSSTOP00000031473   ⟸   ENSSTOT00000036201
RefSeq Acc Id: ENSSTOP00000030992   ⟸   ENSSTOT00000036354
RefSeq Acc Id: ENSSTOP00000004661   ⟸   ENSSTOT00000005194
RefSeq Acc Id: ENSSTOP00000024230   ⟸   ENSSTOT00000040224
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000005197 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000005194.3 UniProtKB/TrEMBL
  ENSSTOT00000036201.1 UniProtKB/TrEMBL
  ENSSTOT00000036354.1 UniProtKB/TrEMBL
  ENSSTOT00000040224.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  ThyrH_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene Thrb ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
  THYROID HORMONE RECEPTOR BETA UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
  THYROIDHORMR UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A287CSC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A287DBP3 ENTREZGENE, UniProtKB/TrEMBL
  I3M5M5 ENTREZGENE, UniProtKB/TrEMBL