Thrb (thyroid hormone receptor beta) - Rat Genome Database

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Gene: Thrb (thyroid hormone receptor beta) Mus musculus
Analyze
Symbol: Thrb
Name: thyroid hormone receptor beta
RGD ID: 737557
MGI Page MGI
Description: Enables chromatin DNA binding activity and nuclear receptor activity. Acts upstream of or within several processes, including female mating behavior; regulation of transcription by RNA polymerase II; and retinal cone cell apoptotic process. Located in nucleus. Is expressed in several structures, including brown fat; endocrine gland; liver; sensory organ; and vestibulo-cochlear ganglion. Used to study attention deficit hyperactivity disorder; follicular thyroid carcinoma; and thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-erbA-2; c-erbA-beta; c-erbAb; c-erbAbeta; MGC141269; MGC141270; Nr; Nr1a2; nuclear receptor subfamily 1 group A member 2; T3R[b; T3R[b]; T3Rbe; T3Rbeta; Thrb1; Thrb2; TR beta
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,429,599 - 4,810,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl144,431,611 - 4,809,435 (-)EnsemblGRCm39 Ensembl
GRCm381417,659,225 - 18,040,097 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1417,660,261 - 18,038,090 (+)EnsemblGRCm38mm10GRCm38
MGSCv371418,493,474 - 18,870,602 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361416,774,842 - 16,827,040 (+)NCBIMGSCv36mm8
Celera1413,338,110 - 13,729,284 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map147.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-citrinin  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthol  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trichlorophenol  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-diisopropylnaphthalene  (ISO)
2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol  (ISO)
2-acetamidofluorene  (ISO)
2-benzyl-4-chlorophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-naphthol  (ISO)
2-phenylpropan-2-ol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-Dimethylbenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3-acetyldeoxynivalenol  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-chloro-3,5-dimethylphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
9-phenanthrol  (ISO)
acetamide  (ISO)
acetochlor  (ISO)
acetylcholine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP,ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
androst-4-ene-3,17-dione  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
biochanin A  (ISO)
biphenyl-2-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Bisphenol Z  (ISO)
bithionol  (ISO)
bleomycin A2  (ISO)
butachlor  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbaryl  (ISO)
carbon nanotube  (EXP)
chlordecone  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chrysin  (ISO)
cisplatin  (ISO)
clomiphene  (ISO)
closantel  (ISO)
clozapine  (ISO)
coumaphos  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
daidzein  (ISO)
DDD  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (EXP)
diethyl hydrogen phosphate  (ISO)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
diiodine  (EXP)
diisobutyl phthalate  (ISO)
Diosbulbin B  (EXP)
dodecylamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
elemental selenium  (EXP)
emetine  (ISO)
entinostat  (ISO)
estrone  (ISO)
ethanol  (EXP,ISO)
ethyl myristate  (ISO)
Ethylenethiourea  (EXP)
fenarimol  (ISO)
fenitrothion  (ISO)
fenobucarb  (ISO)
fentin chloride  (ISO)
fentin hydroxide  (ISO)
fenvalerate  (EXP,ISO)
finasteride  (ISO)
Flumetralin  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
genistein  (EXP,ISO)
glyphosate  (ISO)
hexestrol  (ISO)
hydroxyflutamide  (ISO)
imidacloprid  (ISO)
iprodione  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
kojic acid  (ISO)
kresoxim-methyl  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP)
maneb  (EXP)
Melengestrol acetate  (ISO)
mestranol  (ISO)
methoxyacetic acid  (ISO)
methyl laurate  (ISO)
metolcarb  (ISO)
mifepristone  (ISO)
MK-2206  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-benzoyl-L-alanine  (ISO)
N-desethylamiodarone  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nilutamide  (ISO)
nitrofen  (ISO)
Nonylphenol  (ISO)
norethisterone  (ISO)
ochratoxin A  (ISO)
oryzalin  (ISO)
Oxadiazon  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
pazopanib  (ISO)
pendimethalin  (ISO)
pentachlorophenol  (ISO)
perchlorate  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
procymidone  (ISO)
propanil  (ISO)
propylparaben  (ISO)
Ptaquiloside  (EXP)
pymetrozine  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
staurosporine  (ISO)
sulfasalazine  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
taurine  (EXP)
teniposide  (ISO)
testosterone  (ISO)
Testosterone propionate  (ISO)
Tetrachlorobisphenol A  (ISO)
thiazolidinediones  (ISO)
thioacetamide  (ISO)
thyroxine  (EXP,ISO)
tiratricol  (ISO)
titanium dioxide  (EXP)
trenbolone  (ISO)
tributylstannane  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IAGP)
abnormal cerebellar Purkinje cell layer  (IAGP)
abnormal chondrocyte physiology  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear inner hair cell physiology  (IAGP)
abnormal cochlear nerve compound action potential  (IAGP)
abnormal cochlear outer hair cell physiology  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal fetal growth/weight/body size  (IAGP)
abnormal habituation  (IAGP)
abnormal limb morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal pillar cell morphology  (IAGP)
abnormal pituitary gland physiology  (IAGP)
abnormal pituitary hormone level  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal retina cone cell morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal sperm motility  (IAGP)
abnormal tectorial membrane morphology  (IAGP)
abnormal tectorial membrane striated-sheet matrix morphology  (IAGP)
abnormal thyroid follicle morphology  (IAGP)
abnormal thyroid gland physiology  (IAGP)
abnormal thyroid hormone level  (IAGP)
abnormal trabecular bone morphology  (IAGP)
absent distortion product otoacoustic emissions  (IAGP)
audiogenic seizures  (IAGP)
cochlear hair cell degeneration  (IAGP)
cochlear outer hair cell degeneration  (IAGP)
deafness  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating glycerol level  (IEA)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating thyroid-stimulating hormone level  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased circulating triiodothyronine level  (IAGP)
decreased cochlear microphonics  (IAGP)
decreased cochlear outer hair cell electromotility  (IAGP)
decreased cochlear outer hair cell number  (IAGP)
decreased compact bone thickness  (IAGP)
decreased endocochlear potential  (IAGP)
decreased excitatory postsynaptic current amplitude  (IAGP)
decreased follicle stimulating hormone level  (IAGP)
decreased growth hormone level  (IAGP)
decreased hemoglobin content  (IEA)
decreased long bone epiphyseal plate size  (IAGP)
decreased luteinizing hormone level  (IAGP)
decreased prolactin level  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased small intestinal villus size  (IAGP)
decreased testis weight  (IAGP)
decreased thyroid gland weight  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased vertical activity  (IAGP)
degeneration of organ of Corti supporting cells  (IAGP)
delayed inner ear development  (IAGP)
delayed intestine development  (IAGP)
delayed skeletal maturation  (IAGP)
detached tectorial membrane  (IAGP)
enlarged pituitary gland  (IAGP)
enlarged tectorial membrane  (IAGP)
enlarged thyroid gland  (IAGP)
female infertility  (IAGP)
hyperactivity  (IAGP)
impaired hearing  (IAGP)
impaired learning  (IAGP)
impaired synaptic plasticity  (IAGP)
increased activity of thyroid gland  (IAGP)
increased cardiac muscle cell glucose uptake  (IAGP)
increased circulating levels of thyroid hormone  (IAGP)
increased circulating thyroid-stimulating hormone level  (IAGP)
increased circulating thyroxine level  (IAGP)
increased circulating triiodothyronine level  (IAGP)
increased compact bone thickness  (IAGP)
increased heart rate  (IAGP)
increased or absent distortion product otoacoustic emission threshold  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased osteoclast cell number  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased thyroid carcinoma incidence  (IAGP)
increased thyroid gland weight  (IAGP)
increased thyroid-stimulating hormone level  (IAGP)
increased thyrotroph cell number  (IAGP)
increased thyroxine level  (IAGP)
increased triiodothyronine level  (IAGP)
organ of Corti degeneration  (IAGP)
osteoporosis  (IAGP)
postnatal growth retardation  (IAGP)
premature cranial suture closure  (IAGP)
premature death  (IAGP)
premature endochondral bone ossification  (IAGP)
premature intramembranous bone ossification  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
reduced long-term potentiation  (IAGP)
respiratory distress  (IAGP)
sensorineural hearing loss  (IAGP)
short cochlear outer hair cells  (IAGP)
short femur  (IAGP)
short limbs  (IAGP)
short tail  (IAGP)
short tibia  (IAGP)
small cerebellum  (IAGP)
small fontanelles  (IAGP)
small pituitary gland  (IAGP)
spiral ligament degeneration  (IAGP)
thin cerebellar molecular layer  (IAGP)
thyroid gland hyperplasia  (IAGP)
tremors  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Presence of two members of c-erbA receptor gene family (c-erbA beta and c-erbA2) in smallest region of somatic homozygosity on chromosome 3p21-p25 in human breast carcinoma. Ali IU, etal., J Natl Cancer Inst. 1989 Dec 6;81(23):1815-20.
2. Microsatellite alterations in exfoliated cervical epithelia deoxyribonucleic acid as a marker for high-grade dysplasia. Chang CL, etal., Am J Obstet Gynecol. 2001 Jul;185(1):108-15.
3. HPV-associated cervical cancers show frequent allelic loss at 3p14 but no apparent aberration of FHIT mRNA. Chu TY, etal., Int J Cancer. 1998 Jan 19;75(2):199-204.
4. Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma. Kamiya Y, etal., Carcinogenesis. 2002 Jan;23(1):25-33.
5. DNA-based diagnosis of thyroid hormone resistance syndrome: a novel THRB mutation associated with mild resistance to thyroid hormone. Lam CW, etal., Clin Chim Acta. 2005 Aug;358(1-2):55-9.
6. Aberrant methylation of the THRB gene in tissue and plasma of breast cancer patients. Ling Y, etal., Cancer Genet Cytogenet. 2010 Jan 15;196(2):140-145.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling. Pantos C, etal., Eur J Endocrinol. 2007 Apr;156(4):415-24.
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Microsatellite analysis of allelic imbalance in tumour and blood from patients with prostate cancer. Schwarzenbach H, etal., BJU Int. 2008 Jul;102(2):253-8. Epub 2008 Jul 1.
16. Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer. Silva JM, etal., Oncogene. 2002 Jun 20;21(27):4307-16.
Additional References at PubMed
PMID:1944303   PMID:1958530   PMID:7491112   PMID:7566114   PMID:7708051   PMID:8559662   PMID:8670802   PMID:8673137   PMID:8792212   PMID:8838149   PMID:8910392   PMID:9048636  
PMID:9220031   PMID:9250685   PMID:9275045   PMID:9372952   PMID:9390004   PMID:9405624   PMID:9605512   PMID:9804293   PMID:9832432   PMID:9859898   PMID:9861043   PMID:9927321  
PMID:9927422   PMID:10346821   PMID:10348820   PMID:10349636   PMID:10362681   PMID:10393183   PMID:10430610   PMID:10595466   PMID:10681503   PMID:10691312   PMID:10712278   PMID:10747007  
PMID:10769387   PMID:10848522   PMID:10860982   PMID:11042159   PMID:11069286   PMID:11075809   PMID:11076861   PMID:11113349   PMID:11120878   PMID:11138006   PMID:11159823   PMID:11217851  
PMID:11222741   PMID:11222747   PMID:11274423   PMID:11306605   PMID:11481455   PMID:11496110   PMID:11572786   PMID:11725045   PMID:11726557   PMID:11731612   PMID:11739587   PMID:11786385  
PMID:11867729   PMID:11929806   PMID:11940593   PMID:12040013   PMID:12145333   PMID:12169435   PMID:12198244   PMID:12356724   PMID:12382103   PMID:12388168   PMID:12407160   PMID:12466851  
PMID:12477932   PMID:12490073   PMID:12511610   PMID:12562961   PMID:12576486   PMID:12576488   PMID:12591179   PMID:12591240   PMID:12677005   PMID:12750454   PMID:12776178   PMID:12782404  
PMID:12837629   PMID:12869418   PMID:12925699   PMID:12933686   PMID:12933689   PMID:12959993   PMID:14500358   PMID:14630998   PMID:14684607   PMID:14726446   PMID:15062571   PMID:15062575  
PMID:15128445   PMID:15180993   PMID:15231697   PMID:15240882   PMID:15304375   PMID:15467737   PMID:15601836   PMID:15618518   PMID:15673575   PMID:15713690   PMID:15780976   PMID:15858214  
PMID:15983791   PMID:16002527   PMID:16043864   PMID:16051666   PMID:16100573   PMID:16107715   PMID:16110338   PMID:16141072   PMID:16141073   PMID:16260719   PMID:16260782   PMID:16314832  
PMID:16339138   PMID:16446424   PMID:16574740   PMID:16579977   PMID:16594981   PMID:16602821   PMID:16606843   PMID:16648291   PMID:16803873   PMID:16902998   PMID:16936638   PMID:16971476  
PMID:16985257   PMID:17039256   PMID:17065405   PMID:17127711   PMID:17170101   PMID:17197619   PMID:17210747   PMID:17256722   PMID:17317766   PMID:17327419   PMID:17329208   PMID:17341594  
PMID:17436273   PMID:17461985   PMID:17488972   PMID:17606624   PMID:17653082   PMID:17660507   PMID:17690164   PMID:17761769   PMID:17932484   PMID:17952069   PMID:18037966   PMID:18199774  
PMID:18203951   PMID:18287507   PMID:18367606   PMID:18372241   PMID:18436838   PMID:18474620   PMID:18523124   PMID:18974269   PMID:18987029   PMID:18997818   PMID:19001373   PMID:19004853  
PMID:19014374   PMID:19052228   PMID:19074585   PMID:19094093   PMID:19095741   PMID:19114539   PMID:19131509   PMID:19244534   PMID:19282388   PMID:19282790   PMID:19302190   PMID:19324998  
PMID:19406944   PMID:19439650   PMID:19549593   PMID:19645616   PMID:19805139   PMID:19828801   PMID:19850024   PMID:19906816   PMID:20006618   PMID:20017954   PMID:20018842   PMID:20059953  
PMID:20062085   PMID:20080985   PMID:20090848   PMID:20110327   PMID:20133453   PMID:20160073   PMID:20193766   PMID:20194731   PMID:20203194   PMID:20211142   PMID:20237281   PMID:20299527  
PMID:20463215   PMID:20726222   PMID:20729845   PMID:20959135   PMID:21149577   PMID:21151910   PMID:21267068   PMID:21389087   PMID:21399657   PMID:21532616   PMID:21566120   PMID:21594896  
PMID:21677750   PMID:21746794   PMID:21813673   PMID:21858227   PMID:21873635   PMID:21878515   PMID:21909131   PMID:21987803   PMID:22001906   PMID:22079090   PMID:22178950   PMID:22253431  
PMID:22322976   PMID:22323600   PMID:22442145   PMID:22468949   PMID:22570333   PMID:22684107   PMID:22797060   PMID:22829580   PMID:22919057   PMID:22930759   PMID:23223288   PMID:23257356  
PMID:23493375   PMID:23558175   PMID:23567476   PMID:23681253   PMID:23698635   PMID:23748362   PMID:23840792   PMID:23867227   PMID:23896434   PMID:23995837   PMID:24012852   PMID:24058409  
PMID:24265449   PMID:24288132   PMID:24324671   PMID:24395638   PMID:24523460   PMID:24713658   PMID:24731098   PMID:24797634   PMID:24847117   PMID:24932806   PMID:24952961   PMID:25228773  
PMID:25246276   PMID:25254665   PMID:25296752   PMID:25313862   PMID:25331958   PMID:25501997   PMID:25576159   PMID:25612897   PMID:25657324   PMID:25737207   PMID:25774556   PMID:25867707  
PMID:26123589   PMID:26241124   PMID:26451739   PMID:26453307   PMID:26484580   PMID:26672044   PMID:27026086   PMID:27247403   PMID:27720451   PMID:28288836   PMID:28428265   PMID:28457184  
PMID:28591635   PMID:28614708   PMID:28743746   PMID:28864529   PMID:28893949   PMID:28911178   PMID:28923959   PMID:28972075   PMID:29229863   PMID:29377458   PMID:29669286   PMID:29753845  
PMID:29895698   PMID:29945885   PMID:30822304   PMID:31189119   PMID:31260032   PMID:31488567   PMID:31789450   PMID:31949107   PMID:31968244   PMID:32071204   PMID:32122258   PMID:32817515  
PMID:33110146   PMID:33602873   PMID:33757992   PMID:34215813   PMID:34237030   PMID:34248495   PMID:34474245   PMID:34544870   PMID:35196498   PMID:35451126   PMID:35697700   PMID:36109497  
PMID:36374165   PMID:36454759   PMID:36631163   PMID:36753417   PMID:37033230   PMID:37424431   PMID:37751417   PMID:37822510   PMID:37992217   PMID:38081939   PMID:38355793   PMID:38531895  
PMID:38609183   PMID:38757582   PMID:38889231   PMID:39018199  


Genomics

Comparative Map Data
Thrb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,429,599 - 4,810,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl144,431,611 - 4,809,435 (-)EnsemblGRCm39 Ensembl
GRCm381417,659,225 - 18,040,097 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1417,660,261 - 18,038,090 (+)EnsemblGRCm38mm10GRCm38
MGSCv371418,493,474 - 18,870,602 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361416,774,842 - 16,827,040 (+)NCBIMGSCv36mm8
Celera1413,338,110 - 13,729,284 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map147.08NCBI
THRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38324,117,153 - 24,495,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl324,117,153 - 24,495,756 (-)EnsemblGRCh38hg38GRCh38
GRCh37324,158,644 - 24,537,199 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36324,134,709 - 24,511,317 (-)NCBINCBI36Build 36hg18NCBI36
Build 34324,139,235 - 24,511,317NCBI
Celera324,094,249 - 24,472,076 (-)NCBICelera
Cytogenetic Map3p24.2NCBI
HuRef324,104,526 - 24,481,917 (-)NCBIHuRef
CHM1_1324,110,176 - 24,487,912 (-)NCBICHM1_1
T2T-CHM13v2.0324,121,636 - 24,500,130 (-)NCBIT2T-CHM13v2.0
Thrb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81510,115,954 - 10,465,231 (-)NCBIGRCr8
mRatBN7.2157,685,180 - 8,031,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl157,685,180 - 7,882,916 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx159,830,939 - 10,169,014 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01510,743,731 - 11,081,799 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0159,044,158 - 9,382,240 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0158,890,578 - 9,239,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl158,890,578 - 9,086,282 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01512,951,550 - 13,299,586 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4159,282,845 - 9,345,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1159,279,949 - 9,685,583 (-)NCBI
Celera157,735,185 - 8,077,355 (-)NCBICelera
Cytogenetic Map15p16NCBI
Thrb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543015,992,146 - 16,323,238 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543015,992,146 - 16,322,696 (-)NCBIChiLan1.0ChiLan1.0
THRB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2224,072,698 - 24,449,852 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1324,077,464 - 24,454,587 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0324,024,025 - 24,401,024 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1324,345,760 - 24,722,803 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl324,346,824 - 24,564,960 (-)Ensemblpanpan1.1panPan2
THRB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12319,278,650 - 19,648,547 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2319,277,493 - 19,660,283 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2319,274,402 - 19,646,202 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02319,582,486 - 19,954,456 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2319,582,797 - 19,954,439 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12319,398,045 - 19,769,727 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02319,507,580 - 19,879,481 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02319,616,877 - 19,988,327 (+)NCBIUU_Cfam_GSD_1.0
Thrb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118182,627,645 - 182,847,821 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647315,770,146 - 15,986,561 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647315,766,214 - 15,986,389 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THRB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1310,900,724 - 11,359,544 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11310,900,716 - 11,360,587 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21312,399,964 - 12,857,951 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THRB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11568,797,410 - 69,161,256 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1568,802,078 - 68,902,292 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604141,924,134 - 42,291,602 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thrb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247881,950,890 - 2,349,343 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247881,950,888 - 2,348,895 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Thrb
2505 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4523
Count of miRNA genes:709
Interacting mature miRNAs:914
Transcripts:ENSMUST00000022303, ENSMUST00000022304, ENSMUST00000091471
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301991Wta3_mweight adult 3 (mouse)Not determined14388747337887650Mouse
11532711Sluc40_msusceptibility to lung cancer 40 (mouse)14127379943Mouse
10412071Ssen3_msuseptibility to Sendai virus 3 (mouse)Not determined14126987934Mouse
11532739Prdt6_mprion disease incubation time 6 (mouse)1444316066038924Mouse
13824988Phsq1_mpercent hyperactivated sperm QTL 1 (mouse)14305000119469772Mouse

Markers in Region
D14Mit220  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381417,698,811 - 17,699,105UniSTSGRCm38
MGSCv371418,531,325 - 18,531,619UniSTSGRCm37
Celera1413,376,033 - 13,376,327UniSTS
Cytogenetic Map14A3UniSTS
cM Map142.5UniSTS
Whitehead Genetic141.1UniSTS
Whitehead_YAC14 UniSTS
Thrb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14A3UniSTS
cM Map14 UniSTS
PMC27204P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381418,037,049 - 18,037,232UniSTSGRCm38
MGSCv371418,869,563 - 18,869,746UniSTSGRCm37
Celera1413,728,242 - 13,728,425UniSTS
Cytogenetic Map14A3UniSTS
Thrb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14A3UniSTS
Thrb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14A3UniSTS
Thrb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14A3UniSTS
cM Map14 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001113417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030247720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB221613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC138400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC163039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S62756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S62758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000022303   ⟹   ENSMUSP00000022303
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl144,433,137 - 4,808,800 (-)Ensembl
GRCm38.p6 Ensembl1417,660,896 - 18,036,559 (+)Ensembl
Ensembl Acc Id: ENSMUST00000022304   ⟹   ENSMUSP00000022304
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl144,431,611 - 4,488,167 (-)Ensembl
GRCm38.p6 Ensembl1417,981,529 - 18,038,090 (+)Ensembl
Ensembl Acc Id: ENSMUST00000091471   ⟹   ENSMUSP00000089053
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl144,435,904 - 4,808,800 (-)Ensembl
GRCm38.p6 Ensembl1417,660,896 - 18,033,792 (+)Ensembl
Ensembl Acc Id: ENSMUST00000224438
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl144,642,415 - 4,808,804 (-)Ensembl
GRCm38.p6 Ensembl1417,660,892 - 17,827,281 (+)Ensembl
Ensembl Acc Id: ENSMUST00000224470   ⟹   ENSMUSP00000153230
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl144,506,571 - 4,809,435 (-)Ensembl
GRCm38.p6 Ensembl1417,660,261 - 17,963,125 (+)Ensembl
Ensembl Acc Id: ENSMUST00000224597   ⟹   ENSMUSP00000153055
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl144,506,452 - 4,809,164 (-)Ensembl
GRCm38.p6 Ensembl1417,660,532 - 17,963,244 (+)Ensembl
Ensembl Acc Id: ENSMUST00000224934   ⟹   ENSMUSP00000153355
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl144,458,435 - 4,506,875 (-)Ensembl
GRCm38.p6 Ensembl1417,962,821 - 18,011,261 (+)Ensembl
RefSeq Acc Id: NM_001113417   ⟹   NP_001106888
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,608 - 4,808,763 (-)NCBI
GRCm381417,660,960 - 18,038,088 (+)NCBI
MGSCv371418,493,474 - 18,870,602 (+)RGD
Celera1413,338,110 - 13,729,284 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001424663   ⟹   NP_001411592
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,608 - 4,808,763 (-)NCBI
RefSeq Acc Id: NM_001424664   ⟹   NP_001411593
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,608 - 4,810,427 (-)NCBI
RefSeq Acc Id: NM_001424665   ⟹   NP_001411594
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,608 - 4,809,192 (-)NCBI
RefSeq Acc Id: NM_001424666   ⟹   NP_001411595
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,608 - 4,809,192 (-)NCBI
RefSeq Acc Id: NM_001424667   ⟹   NP_001411596
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,608 - 4,809,192 (-)NCBI
RefSeq Acc Id: NM_001424668   ⟹   NP_001411597
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,608 - 4,808,763 (-)NCBI
RefSeq Acc Id: NM_009380   ⟹   NP_033406
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,608 - 4,488,052 (-)NCBI
GRCm381417,981,644 - 18,038,088 (+)NCBI
MGSCv371418,493,474 - 18,870,602 (+)RGD
Celera1413,338,110 - 13,729,284 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006517967   ⟹   XP_006518030
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,606 - 4,809,324 (-)NCBI
GRCm381417,660,377 - 18,038,090 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006517970   ⟹   XP_006518033
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,606 - 4,809,924 (-)NCBI
GRCm381417,659,228 - 18,040,097 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006517971   ⟹   XP_006518034
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,429,599 - 4,551,410 (-)NCBI
GRCm381417,918,360 - 18,040,097 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006517972   ⟹   XP_006518035
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,429,599 - 4,553,988 (-)NCBI
GRCm381417,915,689 - 18,040,097 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011244737   ⟹   XP_011243039
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,606 - 4,808,844 (-)NCBI
GRCm381417,660,761 - 18,038,090 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011244740   ⟹   XP_011243042
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,429,599 - 4,685,227 (-)NCBI
GRCm381417,784,320 - 18,040,097 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011244741   ⟹   XP_011243043
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,429,599 - 4,810,475 (-)NCBI
GRCm381417,659,228 - 18,040,097 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011244742   ⟹   XP_011243044
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,606 - 4,808,744 (-)NCBI
GRCm381417,660,761 - 18,038,090 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011244743   ⟹   XP_011243045
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,429,599 - 4,685,227 (-)NCBI
GRCm381417,784,320 - 18,040,097 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247720   ⟹   XP_030103580
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,606 - 4,808,743 (-)NCBI
GRCm381417,660,761 - 18,038,090 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158536   ⟹   XP_036014429
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,431,606 - 4,808,740 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036158537   ⟹   XP_036014430
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,429,599 - 4,810,538 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036158539   ⟹   XP_036014432
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39144,429,599 - 4,810,538 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001106888 (Get FASTA)   NCBI Sequence Viewer  
  NP_001411592 (Get FASTA)   NCBI Sequence Viewer  
  NP_001411593 (Get FASTA)   NCBI Sequence Viewer  
  NP_001411594 (Get FASTA)   NCBI Sequence Viewer  
  NP_001411595 (Get FASTA)   NCBI Sequence Viewer  
  NP_001411596 (Get FASTA)   NCBI Sequence Viewer  
  NP_001411597 (Get FASTA)   NCBI Sequence Viewer  
  NP_033406 (Get FASTA)   NCBI Sequence Viewer  
  XP_006518030 (Get FASTA)   NCBI Sequence Viewer  
  XP_006518033 (Get FASTA)   NCBI Sequence Viewer  
  XP_006518034 (Get FASTA)   NCBI Sequence Viewer  
  XP_006518035 (Get FASTA)   NCBI Sequence Viewer  
  XP_011243039 (Get FASTA)   NCBI Sequence Viewer  
  XP_011243042 (Get FASTA)   NCBI Sequence Viewer  
  XP_011243043 (Get FASTA)   NCBI Sequence Viewer  
  XP_011243044 (Get FASTA)   NCBI Sequence Viewer  
  XP_011243045 (Get FASTA)   NCBI Sequence Viewer  
  XP_030103580 (Get FASTA)   NCBI Sequence Viewer  
  XP_036014429 (Get FASTA)   NCBI Sequence Viewer  
  XP_036014430 (Get FASTA)   NCBI Sequence Viewer  
  XP_036014432 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA86957 (Get FASTA)   NCBI Sequence Viewer  
  AAB20226 (Get FASTA)   NCBI Sequence Viewer  
  AAB20227 (Get FASTA)   NCBI Sequence Viewer  
  AAH89035 (Get FASTA)   NCBI Sequence Viewer  
  AAI19553 (Get FASTA)   NCBI Sequence Viewer  
  AAI19554 (Get FASTA)   NCBI Sequence Viewer  
  BAE21770 (Get FASTA)   NCBI Sequence Viewer  
  BAE23323 (Get FASTA)   NCBI Sequence Viewer  
  BAE34683 (Get FASTA)   NCBI Sequence Viewer  
  EDL20646 (Get FASTA)   NCBI Sequence Viewer  
  EDL20647 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000022303
  ENSMUSP00000022303.10
  ENSMUSP00000022304
  ENSMUSP00000022304.11
  ENSMUSP00000089053
  ENSMUSP00000089053.5
  ENSMUSP00000153055.2
  ENSMUSP00000153230.2
  ENSMUSP00000153355.2
GenBank Protein P37242 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033406   ⟸   NM_009380
- Peptide Label: isoform 2
- UniProtKB: Q3UZT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106888   ⟸   NM_001113417
- Peptide Label: isoform 1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006518033   ⟸   XM_006517970
- Peptide Label: isoform X1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006518030   ⟸   XM_006517967
- Peptide Label: isoform X1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006518035   ⟸   XM_006517972
- Peptide Label: isoform X1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006518034   ⟸   XM_006517971
- Peptide Label: isoform X1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011243043   ⟸   XM_011244741
- Peptide Label: isoform X1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011243039   ⟸   XM_011244737
- Peptide Label: isoform X1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011243044   ⟸   XM_011244742
- Peptide Label: isoform X1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011243042   ⟸   XM_011244740
- Peptide Label: isoform X1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011243045   ⟸   XM_011244743
- Peptide Label: isoform X1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030103580   ⟸   XM_030247720
- Peptide Label: isoform X1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000089053   ⟸   ENSMUST00000091471
Ensembl Acc Id: ENSMUSP00000153355   ⟸   ENSMUST00000224934
Ensembl Acc Id: ENSMUSP00000153055   ⟸   ENSMUST00000224597
Ensembl Acc Id: ENSMUSP00000153230   ⟸   ENSMUST00000224470
Ensembl Acc Id: ENSMUSP00000022304   ⟸   ENSMUST00000022304
Ensembl Acc Id: ENSMUSP00000022303   ⟸   ENSMUST00000022303
RefSeq Acc Id: XP_036014432   ⟸   XM_036158539
- Peptide Label: isoform X2
- UniProtKB: Q3UZT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036014430   ⟸   XM_036158537
- Peptide Label: isoform X1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_036014429   ⟸   XM_036158536
- Peptide Label: isoform X1
- UniProtKB: Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot),   Q3TY80 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001411593   ⟸   NM_001424664
- Peptide Label: isoform 1
- UniProtKB: Q3TY80 (UniProtKB/Swiss-Prot),   Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001411595   ⟸   NM_001424666
- Peptide Label: isoform 1
- UniProtKB: Q3TY80 (UniProtKB/Swiss-Prot),   Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001411596   ⟸   NM_001424667
- Peptide Label: isoform 1
- UniProtKB: Q3TY80 (UniProtKB/Swiss-Prot),   Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001411594   ⟸   NM_001424665
- Peptide Label: isoform 1
- UniProtKB: Q3TY80 (UniProtKB/Swiss-Prot),   Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001411592   ⟸   NM_001424663
- Peptide Label: isoform 3
- UniProtKB: Q3UZT5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001411597   ⟸   NM_001424668
- Peptide Label: isoform 1
- UniProtKB: Q3TY80 (UniProtKB/Swiss-Prot),   Q0VDR8 (UniProtKB/Swiss-Prot),   P37244 (UniProtKB/Swiss-Prot),   P37242 (UniProtKB/Swiss-Prot)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P37242-F1-model_v2 AlphaFold P37242 1-461 view protein structure

Promoters
RGD ID:8681554
Promoter ID:EPDNEW_M18808
Type:initiation region
Name:Thrb_1
Description:Mus musculus thyroid hormone receptor beta , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18809  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381417,660,945 - 17,661,005EPDNEW
RGD ID:8681582
Promoter ID:EPDNEW_M18809
Type:single initiation site
Name:Thrb_2
Description:Mus musculus thyroid hormone receptor beta , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18808  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381417,749,096 - 17,749,156EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98743 AgrOrtholog
Ensembl Genes ENSMUSG00000021779 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022303 ENTREZGENE
  ENSMUST00000022303.17 UniProtKB/Swiss-Prot
  ENSMUST00000022304 ENTREZGENE
  ENSMUST00000022304.12 UniProtKB/Swiss-Prot
  ENSMUST00000091471 ENTREZGENE
  ENSMUST00000091471.12 UniProtKB/Swiss-Prot
  ENSMUST00000224470.2 UniProtKB/TrEMBL
  ENSMUST00000224597.2 UniProtKB/TrEMBL
  ENSMUST00000224934.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, Uni