Ppara (peroxisome proliferator activated receptor alpha) - Rat Genome Database

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Gene: Ppara (peroxisome proliferator activated receptor alpha) Chinchilla lanigera
Analyze
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
RGD ID: 8768302
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholog); cellular response to starvation (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); acute myeloid leukemia (ortholog); FOUND IN fibrillar center (ortholog); nuclear body (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: peroxisome proliferator-activated receptor alpha
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,307,219 - 30,359,500 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495541330,306,563 - 30,366,245 (+)NCBIChiLan1.0ChiLan1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney tubular necrosis  (ISO)
acute myeloid leukemia  (ISO)
alcohol use disorder  (ISO)
alcohol-associated liver disease  (ISO)
alcoholic hepatitis  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
atopic dermatitis  (ISO)
Brain Injuries  (ISO)
Cachexia  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cervical cancer  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
clear cell renal cell carcinoma  (ISO)
colitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
hydrocephalus  (ISO)
Hyperapobetalipoproteinemia  (ISO)
Hyperlipoproteinemias  (ISO)
hypertension  (ISO)
hypertensive encephalopathy  (ISO)
Hypertensive Nephropathy  (ISO)
Hypertriglyceridemia  (ISO)
hypoglycemia  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
lipid metabolism disorder  (ISO)
Liver Neoplasms  (ISO)
melanoma  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
morbid obesity  (ISO)
Multiple Organ Failure  (ISO)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
periodontitis  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Reperfusion Injury  (ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
steatotic liver disease  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uterine corpus endometrial carcinoma  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to nicotine  (ISO)
cellular response to fructose stimulus  (ISO)
cellular response to starvation  (ISO)
circadian regulation of gene expression  (ISO)
enamel mineralization  (ISO)
epidermis development  (ISO)
fatty acid beta-oxidation  (ISO)
fatty acid metabolic process  (ISO)
gene expression  (ISO)
heart development  (ISO)
lactation  (ISO)
lipid metabolic process  (ISO)
lipoprotein metabolic process  (ISO)
negative regulation of appetite  (ISO)
negative regulation of blood pressure  (ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of cholesterol storage  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of leukocyte cell-cell adhesion  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
nitric oxide metabolic process  (ISO)
peroxisome proliferator activated receptor signaling pathway  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fatty acid oxidation  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein ubiquitination  (ISO)
regulation of circadian rhythm  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of fatty acid metabolic process  (ISO)
regulation of gene expression  (ISO)
regulation of ketone metabolic process  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to nutrient  (ISO)
wound healing  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ppara
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,307,219 - 30,359,500 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495541330,306,563 - 30,366,245 (+)NCBIChiLan1.0ChiLan1.0
PPARA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382246,150,526 - 46,243,756 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2246,149,924 - 46,243,755 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh372246,546,429 - 46,639,653 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,925,163 - 45,018,317 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342244,893,181 - 44,937,060NCBI
Celera2230,453,877 - 30,547,038 (+)NCBICelera
Cytogenetic Map22q13.31ENTREZGENE
HuRef2229,490,745 - 29,583,687 (+)NCBIHuRef
CHM1_12246,506,503 - 46,598,389 (+)NCBICHM1_1
T2T-CHM13v2.02246,635,225 - 46,728,457 (+)NCBIT2T-CHM13v2.0
Ppara
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,619,112 - 85,691,052 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1585,618,656 - 85,687,067 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381585,734,910 - 85,806,851 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,734,983 - 85,802,819 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371585,565,994 - 85,637,281 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361585,563,542 - 85,630,585 (+)NCBIMGSCv36mm8
Celera1587,868,281 - 87,938,913 (+)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.42NCBI
Ppara
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87118,712,261 - 118,780,723 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7118,712,412 - 118,780,714 (+)EnsemblGRCr8
mRatBN7.27116,832,405 - 116,900,878 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,832,756 - 116,895,346 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7118,583,352 - 118,646,124 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,808,966 - 120,871,752 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,778,539 - 120,841,315 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd7120,748,091 - 120,810,877 (+)NCBI
Lyon_Normotensive7121,693,926 - 121,756,763 (+)NCBI
Lyon_Hypertensive7121,819,819 - 121,882,650 (+)NCBI
F344_StmMcwi7120,312,037 - 120,374,844 (+)NCBI
Rnor_6.07126,618,872 - 126,687,282 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,619,196 - 126,681,752 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.07126,330,559 - 126,397,441 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47123,729,774 - 123,807,090 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7113,125,201 - 113,187,404 (+)NCBICelera
RGSC_v3.17123,764,003 - 123,841,320 (+)NCBI
RH 3.4 Map7922.4RGD
Cytogenetic Map7q34NCBI
PPARA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22355,981,175 - 56,072,797 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12258,679,171 - 58,770,754 (+)NCBINHGRI_mPanPan1
PanPan1.12245,218,364 - 45,302,970 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2245,218,364 - 45,302,970 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
PPARA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11019,934,020 - 20,006,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1019,934,165 - 20,006,146 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1019,862,969 - 19,928,467 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01020,667,818 - 20,740,885 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1020,668,580 - 20,740,947 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11020,394,544 - 20,460,174 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01020,707,323 - 20,772,988 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01020,889,156 - 20,954,630 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppara
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap162,892,428 - 2,953,235 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_0244049453,665,412 - 3,725,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366293,672,460 - 3,725,626 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366293,672,445 - 3,725,645 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl53,300,741 - 3,364,239 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.153,302,755 - 3,321,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25470,097 - 488,440 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPARA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1194,593,880 - 4,695,280 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_0236661593,466 - 79,995 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11928,614,892 - 28,709,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1928,615,413 - 28,708,763 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Ppara
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247523,646,499 - 3,702,553 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247523,650,922 - 3,701,672 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl52,691,360 - 2,742,512 (-)Ensembl
Ppara
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11255,087,375 - 255,151,125 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000025442   ⟹   ENSCLAP00000025196
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541330,307,219 - 30,359,500 (+)Ensembl
RefSeq Acc Id: XM_005379496   ⟹   XP_005379553
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541330,307,219 - 30,366,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005379497   ⟹   XP_005379554
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541330,307,219 - 30,366,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005379498   ⟹   XP_005379555
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541330,306,571 - 30,366,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005379499   ⟹   XP_005379556
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541330,306,563 - 30,366,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005379500   ⟹   XP_005379557
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541330,344,523 - 30,366,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013511380   ⟹   XP_013366834
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541330,344,243 - 30,366,245 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005379556   ⟸   XM_005379499
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YUY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005379555   ⟸   XM_005379498
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YUY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005379553   ⟸   XM_005379496
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YUY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005379554   ⟸   XM_005379497
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YUY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005379557   ⟸   XM_005379500
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013366834   ⟸   XM_013511380
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSCLAP00000025196   ⟸   ENSCLAT00000025442
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000017301 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000025442 ENTREZGENE
  ENSCLAT00000025442.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro 1Cnucl_rcpt UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hormone_rcpt_NR1 UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  PPAR-alpha UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene Ppara ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
  PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS PROXISOMEPAR UniProtKB/TrEMBL
  PROXISOMPAAR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A8C2YUY2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Ppara  peroxisome proliferator activated receptor alpha    peroxisome proliferator-activated receptor alpha  Symbol and/or name change 5135510 APPROVED