LOC103223491 (peroxisome proliferator-activated receptor alpha) - Rat Genome Database

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Gene: LOC103223491 (peroxisome proliferator-activated receptor alpha) Chlorocebus sabaeus
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Symbol: LOC103223491 (Ensembl: PPARA)
Name: peroxisome proliferator-activated receptor alpha (Ensembl:peroxisome proliferator activated receptor alpha)
RGD ID: 18369218
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH alcoholic hepatitis (ortholog); Alcoholic Liver Diseases (ortholog); anti-basement membrane glomerulonephritis (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: peroxisome proliferator activated receptor alpha; PPARA
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11928,614,892 - 28,709,272 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1928,615,413 - 28,708,763 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236661593,466 - 79,995 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to nicotine  (ISO)
cell differentiation  (IEA)
cellular response to fructose stimulus  (ISO)
cellular response to starvation  (IEA)
circadian regulation of gene expression  (IEA)
enamel mineralization  (IEA,ISO)
epidermis development  (IEA,ISO)
fatty acid metabolic process  (IEA,ISO)
gluconeogenesis  (IEA,ISO)
heart development  (ISO)
hormone-mediated signaling pathway  (IEA)
intracellular receptor signaling pathway  (IEA)
lipoprotein metabolic process  (ISO)
negative regulation of appetite  (IEA)
negative regulation of blood pressure  (ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of cholesterol storage  (IEA)
negative regulation of cytokine production involved in inflammatory response  (IEA)
negative regulation of glycolytic process  (IEA)
negative regulation of hepatocyte apoptotic process  (IEA)
negative regulation of inflammatory response  (IEA)
negative regulation of leukocyte cell-cell adhesion  (IEA)
negative regulation of macrophage derived foam cell differentiation  (IEA)
negative regulation of miRNA transcription  (IEA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
negative regulation of protein binding  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (IEA)
negative regulation of sequestering of triglyceride  (IEA)
negative regulation of signaling receptor activity  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA)
nitric oxide metabolic process  (ISO)
positive regulation of ATP biosynthetic process  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of fatty acid metabolic process  (IEA)
positive regulation of fatty acid oxidation  (IEA)
positive regulation of gluconeogenesis  (IEA,ISO)
positive regulation of lipid biosynthetic process  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of cellular ketone metabolic process  (IEA)
regulation of circadian rhythm  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of fatty acid metabolic process  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of lipid storage  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to ethanol  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
steroid hormone receptor signaling pathway  (IEA)
wound healing  (IEA,ISO)

Cellular Component
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics


Sequence


Ensembl Acc Id: ENSCSAT00000003340   ⟹   ENSCSAP00000001621
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1928,615,413 - 28,708,763 (+)Ensembl
RefSeq Acc Id: XM_037995569   ⟹   XP_037851497
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236661593,466 - 79,995 (-)NCBI
RefSeq Acc Id: XM_037995570   ⟹   XP_037851498
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236661593,466 - 79,721 (-)NCBI
RefSeq Acc Id: XM_037995571   ⟹   XP_037851499
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236661593,466 - 79,995 (-)NCBI
RefSeq Acc Id: XM_037995572   ⟹   XP_037851500
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236661593,466 - 79,720 (-)NCBI
RefSeq Acc Id: XM_037995573   ⟹   XP_037851501
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236661593,466 - 45,828 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037851497 (Get FASTA)   NCBI Sequence Viewer  
  XP_037851498 (Get FASTA)   NCBI Sequence Viewer  
  XP_037851499 (Get FASTA)   NCBI Sequence Viewer  
  XP_037851500 (Get FASTA)   NCBI Sequence Viewer  
  XP_037851501 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001621.1
Ensembl Acc Id: ENSCSAP00000001621   ⟸   ENSCSAT00000003340
RefSeq Acc Id: XP_037851499   ⟸   XM_037995571
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037851497   ⟸   XM_037995569
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037851498   ⟸   XM_037995570
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037851500   ⟸   XM_037995572
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037851501   ⟸   XM_037995573
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005307 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003340.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro 1Cnucl_rcpt UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hormone_rcpt_NR1 UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/TrEMBL
  PPAR-alpha UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene PPARA ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/TrEMBL
  PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS PROXISOMEPAR UniProtKB/TrEMBL
  PROXISOMPAAR UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt A0A0D9QZ32_CHLSB UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 LOC103223491  peroxisome proliferator-activated receptor alpha  PPARA  peroxisome proliferator activated receptor alpha  Symbol and/or name change 5135510 APPROVED