Dut (deoxyuridine triphosphatase) - Rat Genome Database

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Gene: Dut (deoxyuridine triphosphatase) Rattus norvegicus
Analyze
Symbol: Dut
Name: deoxyuridine triphosphatase
RGD ID: 620849
Description: Enables several functions, including dUTP diphosphatase activity; peroxisome proliferator activated receptor binding activity; and pyrimidine deoxyribonucleotide binding activity. Involved in several processes, including liver development; pyrimidine deoxyribonucleotide metabolic process; and regulation of protein-containing complex assembly. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human DUT (deoxyuridine triphosphatase); PARTICIPATES IN pyrimidine metabolic pathway; beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deoxyuridine 5'-triphosphate nucleotidohydrolase; Deoxyuridinetriphosphatase (dUTPase); Dutp; dUTP pyrophosphatase; dUTPase; PIP4; PPAR-interacting protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Dut-ps   LOC100526819  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83132,952,258 - 132,963,433 (+)NCBIGRCr8
mRatBN7.23112,498,864 - 112,509,994 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3112,498,982 - 112,510,771 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3116,358,986 - 116,369,833 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03124,954,504 - 124,965,351 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03122,614,871 - 122,625,718 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03117,514,399 - 117,525,450 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3117,514,444 - 117,525,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03124,038,120 - 124,049,168 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43112,551,434 - 112,562,434 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13112,457,006 - 112,468,009 (+)NCBI
Celera3111,355,479 - 111,366,436 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bufalin  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
erythromycin estolate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
levofloxacin  (EXP)
limonene  (EXP)
maneb  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
ouabain  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiram  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (EXP,ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
mitochondrion  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha. Chu R, etal., J Biol Chem 1996 Nov 1;271(44):27670-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of candidate growth-regulating genes that are overexpressed in late gestation fetal liver in the rat. Gruppuso PA, etal., Biochim Biophys Acta. 2000 Dec 1;1494(3):242-7.
4. Purification and characterization of deoxyuridine triphosphate nucleotidohydrolase from anemic rat spleen: a trimer composition of the enzyme protein. Hokari S and Sakagishi Y, Arch Biochem Biophys. 1987 Mar;253(2):350-6.
5. Deoxyuridine triphosphate nucleotidohydrolase activity and its correlation with multiplication of erythroid cells in rat spleen. Hokari S, etal., Biochem Int. 1987 May;14(5):851-7.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Immunohistochemical detection of dUTPase in intracranial tumors. Romeike BF, etal., Pathol Res Pract. 2005;201(11):727-32. Epub 2005 Oct 19.
14. Reversible effect of calcium-binding protein regucalcin on the Ca(2+)-induced inhibition of deoxyuridine 5'-triphosphatase activity in rat liver cytosol. Yamaguchi M and Sakurai T, Mol Cell Biochem. 1992 Mar 4;110(1):25-9.
Additional References at PubMed
PMID:8631816   PMID:8889548   PMID:14651853   PMID:18614015   PMID:20458337   PMID:22658674   PMID:28073829  


Genomics

Comparative Map Data
Dut
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83132,952,258 - 132,963,433 (+)NCBIGRCr8
mRatBN7.23112,498,864 - 112,509,994 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3112,498,982 - 112,510,771 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3116,358,986 - 116,369,833 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03124,954,504 - 124,965,351 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03122,614,871 - 122,625,718 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03117,514,399 - 117,525,450 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3117,514,444 - 117,525,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03124,038,120 - 124,049,168 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43112,551,434 - 112,562,434 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13112,457,006 - 112,468,009 (+)NCBI
Celera3111,355,479 - 111,366,436 (+)NCBICelera
Cytogenetic Map3q36NCBI
DUT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381548,331,095 - 48,343,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1548,331,011 - 48,343,373 (+)EnsemblGRCh38hg38GRCh38
GRCh371548,623,292 - 48,635,570 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361546,410,913 - 46,422,862 (+)NCBINCBI36Build 36hg18NCBI36
Build 341546,411,721 - 46,422,855NCBI
Celera1525,516,088 - 25,528,037 (+)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1525,456,621 - 25,468,570 (+)NCBIHuRef
CHM1_11548,741,653 - 48,753,602 (+)NCBICHM1_1
T2T-CHM13v2.01546,139,356 - 46,151,634 (+)NCBIT2T-CHM13v2.0
Dut
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392125,089,168 - 125,100,969 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2125,089,110 - 125,100,528 (+)EnsemblGRCm39 Ensembl
GRCm382125,247,248 - 125,259,049 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2125,247,190 - 125,258,608 (+)EnsemblGRCm38mm10GRCm38
MGSCv372125,072,984 - 125,084,785 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362124,938,923 - 124,950,049 (+)NCBIMGSCv36mm8
Celera2126,491,099 - 126,502,875 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.33NCBI
Dut
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554095,574,694 - 5,584,134 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554095,574,810 - 5,584,135 (-)NCBIChiLan1.0ChiLan1.0
DUT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21637,571,636 - 37,582,801 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11541,753,022 - 41,764,193 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01527,280,025 - 27,292,003 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11545,604,061 - 45,616,022 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1545,603,807 - 45,616,022 (+)Ensemblpanpan1.1panPan2
DUT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13014,572,766 - 14,585,621 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3014,572,602 - 14,585,530 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3014,494,200 - 14,507,265 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03014,706,670 - 14,719,522 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3014,706,505 - 14,719,499 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13014,629,328 - 14,642,402 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03014,744,651 - 14,757,504 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03014,856,699 - 14,869,776 (+)NCBIUU_Cfam_GSD_1.0
Dut
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864092,822,523 - 92,833,400 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647110,670,604 - 10,681,356 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1123,450,858 - 123,462,245 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11123,451,207 - 123,462,267 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21137,480,904 - 137,492,062 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12634,941,775 - 34,954,184 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2634,940,702 - 34,953,166 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048106,175,656 - 106,187,091 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dut
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473111,378,944 - 11,388,057 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473111,378,882 - 11,388,677 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dut
111 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000009549
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
RH128566  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,368,930 - 48,369,114 (+)MAPPERmRatBN7.2
Rnor_6.0148,565,047 - 48,565,230NCBIRnor6.0
Rnor_5.0151,190,802 - 51,190,985UniSTSRnor5.0
RGSC_v3.4142,826,437 - 42,826,620UniSTSRGSC3.4
Celera144,160,979 - 44,161,162UniSTS
RH 3.4 Map1585.3UniSTS
Cytogenetic Map1q11UniSTS
Cytogenetic Map3q36UniSTS
D1Bda1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23112,509,632 - 112,509,834 (+)MAPPERmRatBN7.2
mRatBN7.2148,368,897 - 48,369,099 (-)MAPPERmRatBN7.2
mRatBN7.2148,368,897 - 48,369,099 (+)MAPPERmRatBN7.2
mRatBN7.23112,509,632 - 112,509,834 (-)MAPPERmRatBN7.2
Rnor_6.03117,525,088 - 117,525,289NCBIRnor6.0
Rnor_6.0148,565,014 - 48,565,215NCBIRnor6.0
Rnor_5.0151,190,817 - 51,191,018UniSTSRnor5.0
Rnor_5.03124,048,806 - 124,049,007UniSTSRnor5.0
RGSC_v3.43112,562,078 - 112,562,279UniSTSRGSC3.4
RGSC_v3.4142,826,404 - 42,826,605UniSTSRGSC3.4
Celera144,160,946 - 44,161,147UniSTS
Celera3111,366,080 - 111,366,281UniSTS
Cytogenetic Map1q11UniSTS
Cytogenetic Map3q36UniSTS
BF390230  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23112,509,559 - 112,509,730 (+)MAPPERmRatBN7.2
Rnor_6.03117,525,015 - 117,525,185NCBIRnor6.0
Rnor_5.03124,048,733 - 124,048,903UniSTSRnor5.0
RGSC_v3.43112,562,005 - 112,562,175UniSTSRGSC3.4
Celera3111,366,007 - 111,366,177UniSTS
RH 3.4 Map3982.9UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001040271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC139960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI705003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW530495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB325379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U64030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000009549   ⟹   ENSRNOP00000009549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3112,498,982 - 112,510,771 (+)Ensembl
Rnor_6.0 Ensembl3117,514,444 - 117,525,446 (+)Ensembl
RefSeq Acc Id: NM_001040271   ⟹   NP_001035361
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,899 - 132,963,430 (+)NCBI
mRatBN7.23112,499,458 - 112,509,989 (+)NCBI
Rnor_6.03117,514,913 - 117,525,444 (+)NCBI
Rnor_5.03124,038,120 - 124,049,168 (+)NCBI
RGSC_v3.43112,551,434 - 112,562,434 (+)RGD
Celera3111,355,948 - 111,366,436 (+)NCBI
Sequence:
RefSeq Acc Id: NM_053592   ⟹   NP_446044
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,430 - 132,963,430 (+)NCBI
mRatBN7.23112,498,989 - 112,509,989 (+)NCBI
Rnor_6.03117,514,444 - 117,525,444 (+)NCBI
Rnor_5.03124,038,120 - 124,049,168 (+)NCBI
RGSC_v3.43112,551,434 - 112,562,434 (+)RGD
Celera3111,355,479 - 111,366,436 (+)RGD
Sequence:
RefSeq Acc Id: XM_008762188   ⟹   XP_008760410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,258 - 132,963,433 (+)NCBI
mRatBN7.23112,498,955 - 112,509,994 (+)NCBI
Rnor_6.03117,514,406 - 117,525,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105649   ⟹   XP_038961577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,610 - 132,963,433 (+)NCBI
mRatBN7.23112,499,192 - 112,509,994 (+)NCBI
RefSeq Acc Id: XM_039105651   ⟹   XP_038961579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,961,587 - 132,963,433 (+)NCBI
mRatBN7.23112,501,312 - 112,509,994 (+)NCBI
RefSeq Acc Id: XM_063284325   ⟹   XP_063140395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,393 - 132,963,433 (+)NCBI
RefSeq Acc Id: XM_063284326   ⟹   XP_063140396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,388 - 132,962,620 (+)NCBI
RefSeq Acc Id: XM_063284327   ⟹   XP_063140397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,388 - 132,963,433 (+)NCBI
RefSeq Acc Id: XM_063284328   ⟹   XP_063140398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,393 - 132,963,433 (+)NCBI
RefSeq Acc Id: XM_063284329   ⟹   XP_063140399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,388 - 132,962,620 (+)NCBI
RefSeq Acc Id: XM_063284330   ⟹   XP_063140400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,389 - 132,963,433 (+)NCBI
RefSeq Acc Id: XM_063284331   ⟹   XP_063140401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,388 - 132,963,433 (+)NCBI
RefSeq Acc Id: XM_063284332   ⟹   XP_063140402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,269 - 132,961,425 (+)NCBI
RefSeq Acc Id: XM_063284333   ⟹   XP_063140403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,389 - 132,956,815 (+)NCBI
RefSeq Acc Id: XM_063284334   ⟹   XP_063140404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,390 - 132,956,814 (+)NCBI
RefSeq Acc Id: XM_063284335   ⟹   XP_063140405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,461 - 132,963,433 (+)NCBI
RefSeq Acc Id: XR_010064679
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,388 - 132,963,145 (+)NCBI
RefSeq Acc Id: XR_010064680
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,388 - 132,962,620 (+)NCBI
RefSeq Acc Id: XR_010064681
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83132,952,389 - 132,962,620 (+)NCBI
RefSeq Acc Id: NP_446044   ⟸   NM_053592
- Peptide Label: isoform 1
- UniProtKB: P70583 (UniProtKB/Swiss-Prot),   A6HPW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001035361   ⟸   NM_001040271
- Peptide Label: isoform 2
- UniProtKB: A6HPW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760410   ⟸   XM_008762188
- Peptide Label: isoform X7
- Sequence:
Ensembl Acc Id: ENSRNOP00000009549   ⟸   ENSRNOT00000009549
RefSeq Acc Id: XP_038961577   ⟸   XM_039105649
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038961579   ⟸   XM_039105651
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063140402   ⟸   XM_063284332
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063140397   ⟸   XM_063284327
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063140401   ⟸   XM_063284331
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063140396   ⟸   XM_063284326
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140399   ⟸   XM_063284329
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063140400   ⟸   XM_063284330
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063140403   ⟸   XM_063284333
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063140404   ⟸   XM_063284334
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063140395   ⟸   XM_063284325
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140398   ⟸   XM_063284328
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063140405   ⟸   XM_063284335
- Peptide Label: isoform X12
Protein Domains
dUTPase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70583-F1-model_v2 AlphaFold P70583 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692380
Promoter ID:EPDNEW_R2903
Type:initiation region
Name:Dut_1
Description:deoxyuridine triphosphatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03117,514,430 - 117,514,490EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620849 AgrOrtholog
BioCyc Gene G2FUF-48047 BioCyc
BioCyc Pathway PWY-7184 [pyrimidine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7206 [pyrimidine deoxyribonucleotides dephosphorylation] BioCyc
BioCyc Pathway Image PWY-7184 BioCyc
  PWY-7206 BioCyc
Ensembl Genes ENSRNOG00000007221 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055005141 UniProtKB/Swiss-Prot
  ENSRNOG00060019051 UniProtKB/Swiss-Prot
  ENSRNOG00065012683 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009549.3 UniProtKB/Swiss-Prot
  ENSRNOT00055008243 UniProtKB/Swiss-Prot
  ENSRNOT00060032993 UniProtKB/Swiss-Prot
  ENSRNOT00065020675 UniProtKB/Swiss-Prot
Gene3D-CATH 2.70.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro dUTPase UniProtKB/TrEMBL
  dUTPase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dUTPase-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dUTPase_1 UniProtKB/Swiss-Prot
  dUTPase_trimeric UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:497778 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 497778 ENTREZGENE
PANTHER DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE UniProtKB/Swiss-Prot
  DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE UniProtKB/TrEMBL
  DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE UniProtKB/TrEMBL
  PTHR11241 UniProtKB/Swiss-Prot
Pfam dUTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dut PhenoGen
RatGTEx ENSRNOG00000007221 RatGTEx
  ENSRNOG00055005141 RatGTEx
  ENSRNOG00060019051 RatGTEx
  ENSRNOG00065012683 RatGTEx
Superfamily-SCOP dUTPase-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HPW5 ENTREZGENE, UniProtKB/TrEMBL
  A6HPW6 ENTREZGENE, UniProtKB/TrEMBL
  DUT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Dut  deoxyuridine triphosphatase  Dutp    Symbol updated 1299863 APPROVED
2004-12-14 Dutp  deoxyuridine triphosphatase  Dut  Deoxyuridinetriphosphatase (dUTPase)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Dut        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA present in all tissues studied 728628
gene_homology protein shares 92% identity with human dUTPase 728628
gene_physical_interaction interacts with three isoforms of PPAR, but not retinoid X receptor or thyroid hormone receptor 728628
gene_process prevents PPAR/retinoid X receptor heterodimerization, inhibition of PPAR is ligand-independent 728628
gene_protein predicted protein contains 203 aa residues 728628