(+)-catechin decreases expression ISO RGD:1313299 6480464 Catechin results in decreased expression of MDM2 mRNA CTD PMID:23706674 (-)-demecolcine increases expression ISO RGD:1313299 6480464 Demecolcine results in increased expression of MDM2 mRNA CTD PMID:23649840 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1313300 6480464 [epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA] CTD PMID:23717041 (RS)-amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of MDM2 mRNA CTD PMID:30779732 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MDM2 mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE increases expression EXP 6480464 Topotecan results in increased expression of MDM2 mRNA CTD PMID:25729387 (S)-nicotine multiple interactions ISO RGD:1313299 6480464 [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; more ... CTD PMID:30272249 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expression ISO RGD:1313300 6480464 o,p'-DDT affects the expression of MDM2 mRNA CTD PMID:18925944 1,10-phenanthroline increases expression ISO RGD:1313299 6480464 1,10-phenanthroline results in increased expression of MDM2 mRNA CTD PMID:19502547 1-nitropyrene increases expression ISO RGD:1313299 6480464 1-nitropyrene results in increased expression of MDM2 mRNA; more ... CTD PMID:10837373 PMID:22044530 1-nitropyrene multiple interactions ISO RGD:1313299 6480464 nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; more ... CTD PMID:10837373 PMID:22044530 10-Hydroxycamptothecin affects response to substance ISO RGD:1313299 6480464 MDM2 protein affects the susceptibility to 10-hydroxycamptothecin CTD PMID:13130078 17alpha-ethynylestradiol increases expression ISO RGD:1313299 6480464 Ethinyl Estradiol results in increased expression of MDM2 mRNA alternative form; more ... CTD PMID:12168835 17alpha-ethynylestradiol increases expression ISO RGD:1313300 6480464 Ethinyl Estradiol results in increased expression of MDM2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1313300 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDM2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:1313300 6480464 Ethinyl Estradiol affects the expression of MDM2 mRNA CTD PMID:17555576 17beta-estradiol increases expression ISO RGD:1313299 6480464 Estradiol results in increased expression of MDM2 mRNA alternative form; more ... CTD PMID:12168835 17beta-estradiol increases expression ISO RGD:1313300 6480464 Estradiol results in increased expression of MDM2 mRNA; more ... CTD PMID:23684557 17beta-estradiol multiple interactions ISO RGD:1313299 6480464 [Estradiol co-treated with Parathion] results in increased expression of MDM2 mRNA CTD PMID:17622325 17beta-estradiol decreases phosphorylation ISO RGD:1313300 6480464 Estradiol results in decreased phosphorylation of MDM2 protein CTD PMID:22314386 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one increases expression ISO RGD:1313299 6480464 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased expression of MDM2 protein CTD PMID:16288207 2,2',3,3',6,6'-hexachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 2,3,6,2',3',6'-hexachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1313299 6480464 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein] CTD PMID:20840854 2,2',4,4',5,5'-hexachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 PMID:20840854 2,2',4,4'-tetrachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 2,4,2',4'-tetrachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 2,2',4,5-tetrachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 2,4,4',5-tetrachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 2,2',5,5'-tetrachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 2,5,2',5'-tetrachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one increases expression ISO RGD:1313299 6480464 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of MDM2 CTD PMID:21647879 2,3,3',4,4',5,5'-Heptachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 2,2',3,3',4,4',5-heptachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1313299 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]]; more ... CTD PMID:19578757 PMID:22044530 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1313300 6480464 Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA CTD PMID:12167310 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1313300 6480464 Tetrachlorodibenzodioxin affects the expression of MDM2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation EXP 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of MDM2 protein CTD PMID:15459018 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein]; more ... CTD PMID:15459018 2,3,7,8-tetrachlorodibenzodioxine increases degradation EXP 6480464 Tetrachlorodibenzodioxin results in increased degradation of MDM2 protein CTD PMID:15459018 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1313300 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDM2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation ISO RGD:1313299 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of MDM2 protein CTD PMID:19751709 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1313299 6480464 Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA CTD PMID:19578757 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1313299 6480464 Tetrachlorodibenzodioxin results in decreased expression of MDM2 mRNA CTD PMID:16039398 2,4-dinitrotoluene affects expression EXP 6480464 2,4-dinitrotoluene affects the expression of MDM2 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2,6-dinitrotoluene affects the expression of MDM2 mRNA CTD PMID:21346803 2-acetamidofluorene multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein CTD PMID:11003613 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of MDM2 mRNA; more ... CTD PMID:19167416 more ... 2-acetamidofluorene increases expression ISO RGD:1313300 6480464 2-Acetylaminofluorene results in increased expression of MDM2 mRNA CTD PMID:21607683 2-nitrofluorene increases expression EXP 6480464 2-nitrofluorene results in increased expression of MDM2 mRNA CTD PMID:14600272 more ... 3,3',4,4',5-pentachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 PMID:20840854 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO RGD:1313299 6480464 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]; more ... CTD PMID:20840854 3,3'-diindolylmethane decreases expression ISO RGD:1313300 6480464 3,3'-diindolylmethane analog results in decreased expression of MDM2 mRNA CTD PMID:26593444 4,4'-diaminodiphenylmethane increases expression ISO RGD:1313300 6480464 4,4'-diaminodiphenylmethane results in increased expression of MDM2 mRNA CTD PMID:18648102 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MDM2 mRNA CTD PMID:14600272 more ... 4-hydroperoxycyclophosphamide increases expression ISO RGD:1313299 6480464 perfosfamide results in increased expression of MDM2 CTD PMID:18034189 4-hydroxyphenyl retinamide decreases expression ISO RGD:1313299 6480464 Fenretinide results in decreased expression of MDM2 mRNA CTD PMID:16570282 4-hydroxyphenyl retinamide increases expression ISO RGD:1313300 6480464 Fenretinide results in increased expression of MDM2 mRNA CTD PMID:28973697 5-azacytidine increases expression ISO RGD:1313299 6480464 Azacitidine results in increased expression of MDM2 mRNA CTD PMID:20823114 5-fluorouracil increases expression ISO RGD:1313300 6480464 Fluorouracil results in increased expression of MDM2 mRNA CTD PMID:16949053 5-fluorouracil increases phosphorylation ISO RGD:1313299 6480464 Fluorouracil results in increased phosphorylation of MDM2 protein CTD PMID:25744307 5-fluorouracil increases expression ISO RGD:1313299 6480464 Fluorouracil results in increased expression of MDM2 mRNA; more ... CTD PMID:14665630 more ... 5-fluorouracil multiple interactions ISO RGD:1313299 6480464 Cadmium Chloride affects the reaction [Fluorouracil results in increased phosphorylation of MDM2 protein]; more ... CTD PMID:15546879 more ... 7,12-dimethyltetraphene multiple interactions ISO RGD:1313300 6480464 [epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]; more ... CTD PMID:23717041 7,12-dimethyltetraphene increases expression ISO RGD:1313300 6480464 9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA CTD PMID:23717041 acetylsalicylic acid decreases expression ISO RGD:1313299 6480464 Aspirin results in decreased expression of MDM2 mRNA CTD PMID:20457246 adefovir pivoxil increases expression ISO RGD:1313299 6480464 adefovir dipivoxil results in increased expression of MDM2 mRNA CTD PMID:25596134 aflatoxin B1 affects expression ISO RGD:1313299 6480464 Aflatoxin B1 affects the expression of MDM2 protein CTD PMID:20106945 aflatoxin B1 increases expression ISO RGD:1313299 6480464 Aflatoxin B1 results in increased expression of MDM2 mRNA CTD PMID:21632981 more ... aflatoxin B1 decreases methylation ISO RGD:1313299 6480464 Aflatoxin B1 results in decreased methylation of MDM2 gene CTD PMID:27153756 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of MDM2 mRNA CTD PMID:14600272 more ... aflatoxin B1 increases expression ISO RGD:1313300 6480464 Aflatoxin B1 results in increased expression of MDM2 mRNA CTD PMID:19770486 alpha-naphthoflavone multiple interactions ISO RGD:1313299 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]]; more ... CTD PMID:19578757 alvocidib decreases expression ISO RGD:1313299 6480464 alvocidib results in decreased expression of MDM2 mRNA; more ... CTD PMID:12589031 amifostine decreases expression ISO RGD:1313299 6480464 Amifostine results in decreased expression of MDM2 mRNA CTD PMID:14555708 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of MDM2 mRNA; more ... CTD PMID:12420312 PMID:16483693 amphibole asbestos decreases expression ISO RGD:1313299 6480464 Asbestos, Amphibole results in decreased expression of MDM2 protein CTD PMID:20855422 amsacrine decreases response to substance ISO RGD:1313299 6480464 MDM2 promoter SNP results in decreased susceptibility to Amsacrine CTD PMID:17575151 androstane multiple interactions ISO RGD:1313300 6480464 Androstanols inhibits the reaction [DDT results in increased expression of MDM2 mRNA] CTD PMID:23684557 arsane affects response to substance ISO RGD:1313299 6480464 MDM2 SNP affects the susceptibility to Arsenic CTD PMID:21982800 arsane affects methylation ISO RGD:1313299 6480464 Arsenic affects the methylation of MDM2 gene CTD PMID:25304211 arsenic atom affects response to substance ISO RGD:1313299 6480464 MDM2 SNP affects the susceptibility to Arsenic CTD PMID:21982800 arsenic atom affects methylation ISO RGD:1313299 6480464 Arsenic affects the methylation of MDM2 gene CTD PMID:25304211 arsenic(3+) affects methylation ISO RGD:1313299 6480464 Arsenic affects the methylation of MDM2 gene CTD PMID:25304211 arsenic(3+) affects response to substance ISO RGD:1313299 6480464 MDM2 SNP affects the susceptibility to Arsenic CTD PMID:21982800 arsenite(3-) multiple interactions ISO RGD:1313299 6480464 [[[arsenite results in increased activity of PRKDC protein] which results in increased phosphorylation of and results in increased activity of MAPK9 protein] promotes the reaction [MAPK9 protein binds to TP53 protein]] inhibits the reaction [MDM2 results in increased degradation of and results in decreased stability of TP53 protein] CTD PMID:22366412 atorvastatin calcium increases expression ISO RGD:1313299 6480464 Atorvastatin results in increased expression of MDM2 protein CTD PMID:29630879 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of MDM2 gene CTD PMID:28931070 benzene multiple interactions ISO RGD:1313300 6480464 TRP53 protein affects the reaction [Benzene results in increased expression of MDM2 mRNA] CTD PMID:11896287 benzene increases expression ISO RGD:1313300 6480464 Benzene results in increased expression of MDM2 mRNA CTD PMID:11896287 more ... benzene multiple interactions ISO RGD:1313299 6480464 MDM2 gene polymorphism affects the reaction [CDKN2A gene polymorphism affects the susceptibility to Benzene] CTD PMID:19596022 benzene multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA CTD PMID:17905399 benzo[a]pyrene increases expression ISO RGD:1313299 6480464 Benzo(a)pyrene results in increased expression of MDM2 mRNA; more ... CTD PMID:10837373 more ... benzo[a]pyrene decreases expression ISO RGD:1313299 6480464 Benzo(a)pyrene results in decreased expression of MDM2 mRNA CTD PMID:30562542 benzo[a]pyrene multiple interactions ISO RGD:1313300 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 benzo[a]pyrene increases phosphorylation ISO RGD:1313299 6480464 Benzo(a)pyrene results in increased phosphorylation of MDM2 protein CTD PMID:20840854 PMID:25744307 benzo[a]pyrene increases expression ISO RGD:1313300 6480464 Benzo(a)pyrene results in increased expression of MDM2 mRNA CTD PMID:18656336 more ... benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of MDM2 protein CTD PMID:21467743 benzo[a]pyrene multiple interactions ISO RGD:1313299 6480464 2,4,4'-trichlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]; more ... CTD PMID:10837373 more ... benzo[a]pyrene diol epoxide I increases expression ISO RGD:1313299 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MDM2 mRNA CTD PMID:20382639 more ... benzo[b]fluoranthene increases expression ISO RGD:1313300 6480464 benzo(b)fluoranthene results in increased expression of MDM2 mRNA CTD PMID:26377693 benzo[b]fluoranthene multiple interactions ISO RGD:1313300 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 beta-naphthoflavone increases phosphorylation EXP 6480464 beta-Naphthoflavone results in increased phosphorylation of MDM2 protein CTD PMID:26558467 bis(2-chloroethyl) sulfide affects expression EXP 6480464 Mustard Gas affects the expression of MDM2 mRNA CTD PMID:15651846 bis(2-chloroethyl) sulfide increases expression ISO RGD:1313300 6480464 Mustard Gas results in increased expression of MDM2 mRNA CTD PMID:15674843 PMID:18955075 bisphenol A increases expression ISO RGD:1313300 6480464 bisphenol A results in increased expression of MDM2 mRNA CTD PMID:26063408 bisphenol A increases expression ISO RGD:1313299 6480464 bisphenol A results in increased expression of MDM2 mRNA CTD PMID:29275510 bisphenol A multiple interactions ISO RGD:1313299 6480464 Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein] CTD PMID:24831732 bisphenol A increases phosphorylation ISO RGD:1313299 6480464 bisphenol A results in increased phosphorylation of MDM2 protein CTD PMID:24831732 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of MDM2 mRNA CTD PMID:25181051 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of MDM2 mRNA CTD PMID:26982218 bortezomib multiple interactions ISO RGD:1313299 6480464 [CASP8 protein results in increased activity of CASP3 protein] affects the reaction [Bortezomib results in increased cleavage of MDM2 protein]; more ... CTD PMID:12393500 bortezomib increases cleavage ISO RGD:1313299 6480464 Bortezomib results in increased cleavage of MDM2 protein CTD PMID:12393500 bortezomib affects expression ISO RGD:1313299 6480464 Bortezomib affects the expression of MDM2 protein CTD PMID:12393500 brassinolide decreases expression ISO RGD:1313299 6480464 brassinolide results in decreased expression of MDM2 protein CTD PMID:20833159 cadmium atom decreases expression EXP 6480464 Cadmium results in decreased expression of MDM2 mRNA CTD PMID:21467746 cadmium atom increases expression ISO RGD:1313300 6480464 Cadmium results in increased expression of MDM2 mRNA CTD PMID:22666406 cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of MDM2 mRNA CTD PMID:22110744 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of MDM2 mRNA CTD PMID:23405080 cadmium dichloride multiple interactions ISO RGD:1313299 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MDM2 protein]; more ... CTD PMID:25744307 cadmium dichloride increases phosphorylation ISO RGD:1313299 6480464 Cadmium Chloride results in increased phosphorylation of MDM2 protein CTD PMID:25744307 cadmium dichloride increases expression ISO RGD:1313300 6480464 Cadmium Chloride results in increased expression of MDM2 mRNA CTD PMID:11958953 more ... cadmium dichloride increases phosphorylation ISO RGD:1313300 6480464 Cadmium Chloride results in increased phosphorylation of MDM2 protein CTD PMID:20525538 PMID:22314386 cadmium dichloride multiple interactions ISO RGD:1313300 6480464 Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein]; more ... CTD PMID:11958953 PMID:12135628 camptothecin increases expression ISO RGD:1313299 6480464 Camptothecin results in increased expression of MDM2 protein CTD PMID:17555331 capsaicin multiple interactions ISO RGD:1313299 6480464 Capsaicin promotes the reaction [resveratrol results in decreased expression of MDM2 protein]; more ... CTD PMID:19846903 capsaicin increases expression ISO RGD:1313299 6480464 Capsaicin results in increased expression of MDM2 mRNA CTD PMID:19502594 capsaicin decreases expression ISO RGD:1313299 6480464 Capsaicin results in decreased expression of MDM2 protein CTD PMID:19846903 carbamazepine affects expression ISO RGD:1313299 6480464 Carbamazepine affects the expression of MDM2 mRNA CTD PMID:25979313 carbonyl cyanide p-trifluoromethoxyphenylhydrazone decreases expression ISO RGD:1313299 6480464 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of MDM2 mRNA CTD PMID:16039398 catechin decreases expression ISO RGD:1313299 6480464 Catechin results in decreased expression of MDM2 mRNA CTD PMID:23706674 chlorambucil increases expression ISO RGD:1313299 6480464 Chlorambucil results in increased expression of MDM2 mRNA CTD PMID:17476690 chloroacetaldehyde increases expression ISO RGD:1313299 6480464 chloroacetaldehyde results in increased expression of MDM2 mRNA CTD PMID:25596134 chloroethene affects response to substance ISO RGD:1313299 6480464 MDM2 polymorphism affects the susceptibility to Vinyl Chloride CTD PMID:24464562 chloroprene increases expression ISO RGD:1313300 6480464 Chloroprene results in increased expression of MDM2 mRNA CTD PMID:23125180 chlorpromazine increases expression EXP 6480464 Chlorpromazine results in increased expression of MDM2 mRNA CTD PMID:25596134 choline multiple interactions ISO RGD:1313300 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MDM2 gene CTD PMID:20938992 chrysene multiple interactions ISO RGD:1313300 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of MDM2 mRNA CTD PMID:24880025 cisplatin increases expression ISO RGD:1313300 6480464 Cisplatin results in increased expression of MDM2 mRNA CTD PMID:21151649 more ... cisplatin multiple interactions ISO RGD:1313300 6480464 Cisplatin promotes the reaction [TRP53 protein results in increased expression of MDM2] CTD PMID:21552291 cisplatin increases expression ISO RGD:1313299 6480464 Cisplatin results in increased expression of MDM2 mRNA; more ... CTD PMID:16797627 more ... cisplatin multiple interactions ISO RGD:1313299 6480464 [Cisplatin co-treated with 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one co-treated with Oxygen deficiency] results in increased expression of MDM2 mRNA; more ... CTD PMID:21509038 more ... clofibrate multiple interactions ISO RGD:1313300 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA; more ... CTD PMID:17585979 cobalt atom increases expression ISO RGD:1313299 6480464 Cobalt results in increased expression of MDM2 mRNA CTD PMID:24068677 cobalt atom multiple interactions ISO RGD:1313299 6480464 TP53 protein affects the reaction [Cobalt results in increased expression of MDM2 mRNA] CTD PMID:24068677 cobalt dichloride increases expression ISO RGD:1313299 6480464 cobaltous chloride results in increased expression of MDM2 protein CTD PMID:19714248 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of MDM2 mRNA CTD PMID:24386269 cobalt dichloride multiple interactions ISO RGD:1313299 6480464 MDM2 protein promotes the reaction [cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]] CTD PMID:19714248 cobalt(2+) multiple interactions ISO RGD:1313299 6480464 TP53 protein affects the reaction [Cobalt results in increased expression of MDM2 mRNA] CTD PMID:24068677 cobalt(2+) increases expression ISO RGD:1313299 6480464 Cobalt results in increased expression of MDM2 mRNA CTD PMID:24068677 copper atom increases expression ISO RGD:1313300 6480464 Copper results in increased expression of MDM2 mRNA CTD PMID:16629173 copper(0) increases expression ISO RGD:1313300 6480464 Copper results in increased expression of MDM2 mRNA CTD PMID:16629173 copper(2+) increases expression ISO RGD:1313300 6480464 Copper results in increased expression of MDM2 mRNA CTD PMID:16629173 cryptolepine increases expression ISO RGD:1313299 6480464 cryptolepine results in increased expression of MDM2 mRNA; more ... CTD PMID:16120219 curcumin decreases expression ISO RGD:1313299 6480464 [Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; more ... CTD PMID:17332326 curcumin increases expression ISO RGD:1313299 6480464 Curcumin analog results in increased expression of MDM2 mRNA CTD PMID:26409325 curcumin multiple interactions ISO RGD:1313299 6480464 Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein] CTD PMID:24831732 cyclosporin A increases expression ISO RGD:1313299 6480464 Cyclosporine results in increased expression of MDM2 mRNA CTD PMID:20106945 more ... cylindrospermopsin increases expression ISO RGD:1313299 6480464 cylindrospermopsin results in increased expression of MDM2 mRNA CTD PMID:21607682 cyproconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA; more ... CTD PMID:29038839 DAPT increases expression ISO RGD:1313299 6480464 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein CTD PMID:25005833 DAPT multiple interactions ISO RGD:1313299 6480464 Hydrogen Peroxide inhibits the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein] CTD PMID:25005833 DDT multiple interactions ISO RGD:1313300 6480464 Androstanols inhibits the reaction [DDT results in increased expression of MDM2 mRNA] CTD PMID:23684557 DDT increases expression ISO RGD:1313300 6480464 DDT results in increased expression of MDM2 mRNA; more ... CTD PMID:23684557 diallyl trisulfide decreases expression ISO RGD:1313299 6480464 diallyl trisulfide results in decreased expression of MDM2 protein CTD PMID:24415872 diallyl trisulfide increases degradation ISO RGD:1313299 6480464 diallyl trisulfide results in increased degradation of MDM2 protein CTD PMID:23754639 diazinon affects expression EXP 6480464 Diazinon affects the expression of MDM2 mRNA CTD PMID:22546817 dibenz[a,h]anthracene increases expression ISO RGD:1313300 6480464 1,2,5,6-dibenzanthracene results in increased expression of MDM2 mRNA CTD PMID:26377693 diclofenac decreases expression EXP 6480464 Diclofenac results in decreased expression of MDM2 mRNA CTD PMID:17202759 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of MDM2 mRNA CTD PMID:22546817 diepoxybutane multiple interactions ISO RGD:1313299 6480464 diepoxybutane inhibits the reaction [TP53 protein binds to MDM2 protein] CTD PMID:20024960 diethylstilbestrol affects mutagenesis ISO RGD:1313300 6480464 Diethylstilbestrol affects the mutagenesis of MDM2 gene CTD PMID:7916985 diethylstilbestrol decreases expression ISO RGD:1313300 6480464 Diethylstilbestrol results in decreased expression of MDM2 mRNA CTD PMID:21041162 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of MDM2 mRNA CTD PMID:15890375 diethylstilbestrol increases expression ISO RGD:1313300 6480464 Diethylstilbestrol results in increased expression of MDM2 mRNA CTD PMID:15545218 dimethylarsinic acid increases expression EXP 6480464 Cacodylic Acid results in increased expression of MDM2 mRNA CTD PMID:17481689 dimethylarsinic acid multiple interactions ISO RGD:1313299 6480464 [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of MDM2 mRNA CTD PMID:23192986 dioxygen multiple interactions ISO RGD:1313299 6480464 [Cisplatin co-treated with 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one co-treated with Oxygen deficiency] results in increased expression of MDM2 mRNA; more ... CTD PMID:19578757 PMID:29690507 dioxygen multiple interactions ISO RGD:1313300 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of MDM2 mRNA CTD PMID:30529165 dioxygen increases expression ISO RGD:1313299 6480464 Oxygen deficiency results in increased expression of MDM2 mRNA; more ... CTD PMID:19502547 more ... disodium selenite increases expression ISO RGD:1313299 6480464 Sodium Selenite results in increased expression of MDM2 mRNA CTD PMID:24383545 dorsomorphin multiple interactions ISO RGD:1313299 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA; more ... CTD PMID:27188386 doxorubicin multiple interactions ISO RGD:1313299 6480464 Doxorubicin inhibits the reaction [TP53 protein binds to MDM2 protein]; more ... CTD PMID:17935137 more ... doxorubicin affects expression ISO RGD:1313300 6480464 Doxorubicin affects the expression of MDM2 mRNA CTD PMID:29653124 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of MDM2 mRNA CTD PMID:12187937 PMID:27255381 doxorubicin increases expression ISO RGD:1313299 6480464 Doxorubicin results in increased expression of MDM2 mRNA; more ... CTD PMID:14665630 more ... doxorubicin decreases response to substance ISO RGD:1313299 6480464 MDM2 protein results in decreased susceptibility to Doxorubicin CTD PMID:26317544 doxorubicin affects expression ISO RGD:1313299 6480464 Doxorubicin affects the expression of MDM2 mRNA CTD PMID:25529476 PMID:29803840 doxorubicin increases expression ISO RGD:1313300 6480464 Doxorubicin results in increased expression of MDM2 mRNA CTD PMID:14766674 PMID:16949053 doxorubicin multiple interactions ISO RGD:1313300 6480464 pifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA] CTD PMID:14766674 doxorubicin increases phosphorylation ISO RGD:1313299 6480464 Doxorubicin results in increased phosphorylation of MDM2 protein CTD PMID:17935137 ellipticine decreases response to substance ISO RGD:1313299 6480464 MDM2 promoter SNP results in decreased susceptibility to ellipticine CTD PMID:17575151 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of MDM2 mRNA CTD PMID:29391264 epoxiconazole increases expression EXP 6480464 epoxiconazole results in increased expression of MDM2 mRNA CTD PMID:29038839 epoxiconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA; more ... CTD PMID:29038839 ethanol decreases expression ISO RGD:1313300 6480464 Ethanol results in decreased expression of MDM2 mRNA CTD PMID:22535522 ethyl methanesulfonate increases expression ISO RGD:1313299 6480464 Ethyl Methanesulfonate results in increased expression of MDM2 mRNA CTD PMID:23649840 etoposide increases expression ISO RGD:1313299 6480464 Etoposide results in increased expression of MDM2 mRNA; more ... CTD PMID:16120219 more ... etoposide decreases expression ISO RGD:1313299 6480464 Etoposide results in decreased expression of MDM2 protein CTD PMID:26259609 etoposide increases phosphorylation ISO RGD:1313299 6480464 Etoposide results in increased phosphorylation of MDM2 protein CTD PMID:17935137 PMID:25744307 etoposide increases expression EXP 6480464 Etoposide results in increased expression of MDM2 protein CTD PMID:15459018 etoposide multiple interactions EXP 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein] CTD PMID:15459018 etoposide decreases response to substance ISO RGD:1313299 6480464 MDM2 promoter SNP results in decreased susceptibility to Etoposide CTD PMID:17575151 etoposide multiple interactions ISO RGD:1313299 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]]; more ... CTD PMID:17575151 more ... fenbendazole increases expression EXP 6480464 Fenbendazole results in increased expression of MDM2 mRNA CTD PMID:23411599 fenofibrate decreases expression EXP 6480464 Fenofibrate results in decreased expression of MDM2 mRNA CTD PMID:25596134 fipronil increases expression EXP 6480464 fipronil results in increased expression of MDM2 mRNA CTD PMID:23962444 flavanones increases phosphorylation ISO RGD:1313299 6480464 Flavanones results in increased phosphorylation of MDM2 protein CTD PMID:21616090 flucytosine increases expression ISO RGD:1313299 6480464 Flucytosine results in increased expression of MDM2 protein CTD PMID:15592511 fluoranthene multiple interactions ISO RGD:1313299 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of MDM2 mRNA CTD PMID:17690111 flutamide increases expression EXP 6480464 Flutamide results in increased expression of MDM2 mRNA CTD PMID:24136188 folic acid affects expression ISO RGD:1313299 6480464 Folic Acid affects the expression of MDM2 mRNA CTD PMID:16361273 folic acid multiple interactions ISO RGD:1313300 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MDM2 gene CTD PMID:20938992 formaldehyde increases expression EXP 6480464 Formaldehyde results in increased expression of MDM2 mRNA; more ... CTD PMID:18045764 formaldehyde increases expression ISO RGD:1313299 6480464 Formaldehyde results in increased expression of MDM2 mRNA; more ... CTD PMID:18045764 PMID:23649840 formononetin increases expression EXP 6480464 formononetin results in increased expression of MDM2 protein CTD PMID:28414026 fumonisin B1 multiple interactions ISO RGD:1313299 6480464 fumonisin B1 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; more ... CTD PMID:18206046 furan increases expression EXP 6480464 furan results in increased expression of MDM2 mRNA CTD PMID:22079235 furosemide affects expression EXP 6480464 Furosemide affects the expression of MDM2 mRNA CTD PMID:17497460 ganciclovir increases expression ISO RGD:1313299 6480464 Ganciclovir results in increased expression of MDM2 protein CTD PMID:15592511 geldanamycin increases expression ISO RGD:1313299 6480464 geldanamycin results in increased expression of MDM2 mRNA CTD PMID:26705709 gemcitabine decreases expression ISO RGD:1313299 6480464 gemcitabine results in decreased expression of MDM2 mRNA CTD PMID:20103597 gemcitabine increases expression ISO RGD:1313299 6480464 gemcitabine results in increased expression of MDM2 mRNA CTD PMID:17039268 genistein decreases expression ISO RGD:1313300 6480464 Genistein results in decreased expression of MDM2 mRNA CTD PMID:21048042 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of MDM2 mRNA CTD PMID:22061828 GW 501516 multiple interactions EXP 6480464 MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein] CTD PMID:19103650 hydrogen peroxide multiple interactions ISO RGD:1313299 6480464 EUK-134 inhibits the reaction [Hydrogen Peroxide results in decreased expression of MDM2 protein]; more ... CTD PMID:21552291 PMID:25005833 hydrogen peroxide increases expression ISO RGD:1313299 6480464 Hydrogen Peroxide results in increased expression of MDM2 mRNA CTD PMID:21751221 hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of MDM2 mRNA CTD PMID:14689451 PMID:27525270 hydrogen peroxide multiple interactions EXP 6480464 [Quercetin co-treated with Hydrogen Peroxide] results in increased expression of MDM2 mRNA; more ... CTD PMID:14689451 PMID:27525270 hydrogen peroxide decreases expression ISO RGD:1313299 6480464 Hydrogen Peroxide results in decreased expression of MDM2 protein CTD PMID:25005833 hydrogen peroxide multiple interactions ISO RGD:1313300 6480464 Hydrogen Peroxide promotes the reaction [TRP53 protein results in increased expression of MDM2] CTD PMID:21552291 hydroxyurea increases expression ISO RGD:1313299 6480464 Hydroxyurea results in increased expression of MDM2 mRNA CTD PMID:18647660 hydroxyurea increases expression ISO RGD:1313300 6480464 Hydroxyurea results in increased expression of MDM2 mRNA CTD PMID:16356682 hydroxyurea affects expression ISO RGD:1313300 6480464 Hydroxyurea affects the expression of MDM2 protein CTD PMID:16356682 ifosfamide increases expression ISO RGD:1313299 6480464 Ifosfamide results in increased expression of MDM2 mRNA CTD PMID:25596134 irinotecan increases expression ISO RGD:1313299 6480464 Irinotecan metabolite results in increased expression of MDM2 mRNA; more ... CTD PMID:15956246 isoflurane decreases expression EXP 6480464 Isoflurane results in decreased expression of MDM2 mRNA CTD PMID:16978161 kojic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MDM2 mRNA CTD PMID:18544905 L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of MDM2 protein] CTD PMID:21262251 L-methionine multiple interactions ISO RGD:1313300 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MDM2 gene CTD PMID:20938992 leflunomide increases expression ISO RGD:1313299 6480464 leflunomide results in increased expression of MDM2 mRNA CTD PMID:28988120 leptomycin B increases expression ISO RGD:1313299 6480464 leptomycin B results in increased expression of MDM2 mRNA CTD PMID:20803015 linalool increases expression ISO RGD:1313299 6480464 linalool results in increased expression of MDM2 mRNA CTD PMID:19922762 lipopolysaccharide multiple interactions ISO RGD:1313300 6480464 E804 bisindole inhibits the reaction [Lipopolysaccharides results in increased expression of MDM2 mRNA] CTD PMID:23107598 lipopolysaccharide increases expression ISO RGD:1313300 6480464 Lipopolysaccharides results in increased expression of MDM2 mRNA CTD PMID:10975854 PMID:23107598 lupeol multiple interactions ISO RGD:1313299 6480464 lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 luteolin multiple interactions EXP 6480464 Luteolin promotes the reaction [Hydrogen Peroxide results in increased expression of MDM2 mRNA] CTD PMID:27525270 mancozeb multiple interactions ISO RGD:1313299 6480464 lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 mancozeb increases expression ISO RGD:1313299 6480464 mancozeb results in increased expression of MDM2 mRNA CTD PMID:27235710 manganese atom multiple interactions EXP 6480464 [Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein; more ... CTD PMID:25791630 manganese atom decreases expression EXP 6480464 Manganese results in decreased expression of MDM2 protein CTD PMID:25791630 manganese(0) decreases expression EXP 6480464 Manganese results in decreased expression of MDM2 protein CTD PMID:25791630 manganese(0) multiple interactions EXP 6480464 [Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein; more ... CTD PMID:25791630 manganese(2+) decreases expression EXP 6480464 Manganese results in decreased expression of MDM2 protein CTD PMID:25791630 manganese(2+) multiple interactions EXP 6480464 [Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein; more ... CTD PMID:25791630 manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of MDM2 mRNA CTD PMID:28801915 menadione decreases expression ISO RGD:1313299 6480464 Vitamin K 3 results in decreased expression of MDM2 protein CTD PMID:25005833 menadione multiple interactions ISO RGD:1313299 6480464 EUK-134 inhibits the reaction [Vitamin K 3 results in decreased expression of MDM2 protein] CTD PMID:25005833 mercury dibromide increases expression ISO RGD:1313299 6480464 mercuric bromide results in increased expression of MDM2 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:1313299 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA CTD PMID:27188386 mercury dichloride decreases expression ISO RGD:1313300 6480464 Mercuric Chloride results in decreased expression of MDM2 mRNA CTD PMID:23202902 metformin increases expression EXP 6480464 Metformin results in increased expression of MDM2 mRNA CTD PMID:25596134 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of MDM2 mRNA CTD PMID:22584684 methapyrilene increases phosphorylation EXP 6480464 Methapyrilene results in increased phosphorylation of MDM2 protein CTD PMID:26558467 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of MDM2 mRNA CTD PMID:15890375 more ... methotrexate multiple interactions ISO RGD:1313299 6480464 Methotrexate results in increased activity of and results in increased expression of MDM2 protein; more ... CTD PMID:21624110 methotrexate affects expression ISO RGD:1313300 6480464 Methotrexate affects the expression of MDM2 mRNA CTD PMID:18502557 methotrexate increases expression ISO RGD:1313299 6480464 Methotrexate results in increased expression of MDM2 mRNA; more ... CTD PMID:17637740 more ... methyl caffeate affects binding ISO RGD:1313299 6480464 methyl caffeate binds to MDM2 protein CTD PMID:26415618 methyl methanesulfonate increases expression ISO RGD:1313299 6480464 Methyl Methanesulfonate results in increased expression of MDM2 mRNA; more ... CTD PMID:23649840 PMID:25078064 methylarsonic acid increases expression EXP 6480464 monomethylarsonic acid results in increased expression of MDM2 mRNA CTD PMID:17481689 methylarsonic acid multiple interactions ISO RGD:1313299 6480464 [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of MDM2 mRNA CTD PMID:23192986 methylmercury chloride decreases expression ISO RGD:1313300 6480464 methylmercuric chloride results in decreased expression of MDM2 mRNA CTD PMID:23202902 methylmercury chloride increases expression ISO RGD:1313299 6480464 methylmercuric chloride results in increased expression of MDM2 mRNA CTD PMID:28001369 methylmercury(1+) multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA CTD PMID:17905399 microcystin-LR decreases expression ISO RGD:1313300 6480464 cyanoginosin LR results in decreased expression of MDM2 mRNA; more ... CTD PMID:28414124 mifepristone increases expression ISO RGD:1313300 6480464 Mifepristone results in increased expression of MDM2 mRNA CTD PMID:12605714 mitomycin C multiple interactions ISO RGD:1313299 6480464 [Mitomycin results in increased stability of TP53 protein] which results in increased expression of MDM2 mRNA CTD PMID:20536192 mitomycin C increases expression ISO RGD:1313299 6480464 Mitomycin results in increased expression of MDM2 protein CTD PMID:18096571 mitomycin C increases expression ISO RGD:1313300 6480464 Mitomycin results in increased expression of MDM2 mRNA CTD PMID:25270620 mitoxantrone decreases response to substance ISO RGD:1313299 6480464 MDM2 promoter SNP results in decreased susceptibility to Mitoxantrone CTD PMID:17575151 mono(2-ethylhexyl) phthalate decreases expression ISO RGD:1313299 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of MDM2 protein CTD PMID:24706461 monocrotaline multiple interactions ISO RGD:1313300 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 motexafin gadolinium multiple interactions ISO RGD:1313299 6480464 motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA] CTD PMID:16357179 motexafin gadolinium increases expression ISO RGD:1313299 6480464 motexafin gadolinium results in increased expression of MDM2 mRNA CTD PMID:16357179 N-acetylsphingosine decreases expression ISO RGD:1313299 6480464 N-acetylsphingosine results in decreased expression of MDM2 mRNA; more ... CTD PMID:18206046 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO RGD:1313300 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MDM2 mRNA CTD PMID:20061341 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1313299 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] CTD PMID:17575151 N-ethyl-N-nitrosourea increases expression EXP 6480464 Ethylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:15954086 N-ethyl-N-nitrosourea increases expression ISO RGD:1313300 6480464 Ethylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:19100860 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO RGD:1313299 6480464 Methylnitronitrosoguanidine results in increased expression of MDM2 mRNA CTD PMID:12634122 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:1313300 6480464 Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein] CTD PMID:12135628 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO RGD:1313300 6480464 Methylnitronitrosoguanidine results in increased expression of MDM2 protein CTD PMID:12135628 N-methyl-N-nitrosourea increases expression EXP 6480464 Methylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:28688903 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein; more ... CTD PMID:11003613 PMID:18544905 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of MDM2 mRNA; more ... CTD PMID:14555611 more ... N-nitrosodiethylamine multiple interactions ISO RGD:1313300 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MDM2 mRNA] CTD PMID:17854601 N-nitrosodiethylamine increases expression ISO RGD:1313300 6480464 Diethylnitrosamine results in increased expression of MDM2 mRNA; more ... CTD PMID:17854601 more ... N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of MDM2 mRNA CTD PMID:14600272 PMID:15890375 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of MDM2 mRNA; more ... CTD PMID:14587038 PMID:19716841 N-Vinyl-2-pyrrolidone multiple interactions EXP 6480464 [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of MDM2 mRNA CTD PMID:22037397 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of MDM2 mRNA CTD PMID:24136188 nickel atom increases expression ISO RGD:1313299 6480464 Nickel results in increased expression of MDM2 mRNA CTD PMID:24068677 nickel atom multiple interactions ISO RGD:1313299 6480464 TP53 protein affects the reaction [Nickel results in increased expression of MDM2 mRNA] CTD PMID:24068677 nickel dichloride increases expression ISO RGD:1313299 6480464 nickel chloride results in increased expression of MDM2 mRNA CTD PMID:23566959 PMID:28552779 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of MDM2 mRNA CTD PMID:22546817 nickel dichloride multiple interactions ISO RGD:1313299 6480464 TP53 protein affects the reaction [nickel chloride results in increased expression of MDM2 mRNA] CTD PMID:23566959 nicotinamide increases expression ISO RGD:1313299 6480464 Niacinamide results in increased expression of MDM2 mRNA CTD PMID:16998810 nicotine multiple interactions ISO RGD:1313299 6480464 [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; more ... CTD PMID:30272249 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of MDM2 mRNA CTD PMID:24136188 Nodularin increases expression ISO RGD:1313299 6480464 nodularin results in increased expression of MDM2 mRNA CTD PMID:30562542 Nutlin-3 multiple interactions ISO RGD:1313299 6480464 [nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]] which results in increased activity of TP53 protein; more ... CTD PMID:16439685 more ... Nutlin-3 increases expression ISO RGD:1313300 6480464 nutlin 3 results in increased expression of MDM2 mRNA CTD PMID:16949053 Nutlin-3 increases expression ISO RGD:1313299 6480464 nutlin 3 results in increased expression of MDM2 mRNA; more ... CTD PMID:16014563 more ... O-methyleugenol increases expression EXP 6480464 methyleugenol results in increased expression of MDM2 mRNA CTD PMID:26011634 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of MDM2 mRNA CTD PMID:23358140 ortho-Aminoazotoluene increases expression ISO RGD:1313300 6480464 o-Aminoazotoluene results in increased expression of MDM2 mRNA CTD PMID:15346788 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of MDM2 mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MDM2 mRNA CTD PMID:25729387 oxfendazole decreases phosphorylation EXP 6480464 oxfendazole results in decreased phosphorylation of MDM2 protein CTD PMID:26558467 oxfendazole increases expression EXP 6480464 oxfendazole results in increased expression of MDM2 mRNA CTD PMID:26558467 p-chloromercuribenzoic acid increases expression ISO RGD:1313299 6480464 p-Chloromercuribenzoic Acid results in increased expression of MDM2 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:1313299 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA CTD PMID:27188386 paclitaxel decreases response to substance ISO RGD:1313299 6480464 MDM2 protein results in decreased susceptibility to Paclitaxel CTD PMID:13130078 paracetamol multiple interactions ISO RGD:1313300 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA; more ... CTD PMID:17585979 paracetamol increases expression ISO RGD:1313299 6480464 Acetaminophen results in increased expression of MDM2 mRNA CTD PMID:22230336 paracetamol decreases expression ISO RGD:1313299 6480464 Acetaminophen results in decreased expression of MDM2 mRNA CTD PMID:21420995 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of MDM2 mRNA CTD PMID:21807079 paracetamol increases phosphorylation EXP 6480464 Acetaminophen results in increased phosphorylation of MDM2 protein CTD PMID:16330492 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of MDM2 mRNA CTD PMID:17202762 paracetamol multiple interactions EXP 6480464 Acetaminophen promotes the reaction [MDM2 protein binds to TP53 protein] CTD PMID:16330492 paracetamol affects expression ISO RGD:1313300 6480464 Acetaminophen affects the expression of MDM2 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:1313300 6480464 Acetaminophen results in increased expression of MDM2 mRNA CTD PMID:26056430 paraquat multiple interactions ISO RGD:1313300 6480464 GPX1 protein affects the reaction [Paraquat affects the expression of MDM2 mRNA] CTD PMID:12654481 paraquat increases expression ISO RGD:1313299 6480464 Paraquat results in increased expression of MDM2 mRNA CTD PMID:20883675 parathion multiple interactions ISO RGD:1313299 6480464 [Estradiol co-treated with Parathion] results in increased expression of MDM2 mRNA CTD PMID:17622325 parathion-methyl increases expression ISO RGD:1313299 6480464 Methyl Parathion results in increased expression of MDM2 mRNA CTD PMID:18418871 PD123319 multiple interactions ISO RGD:1313299 6480464 PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; more ... CTD PMID:18206046 pentachlorophenol increases expression ISO RGD:1313300 6480464 Pentachlorophenol results in increased expression of MDM2 mRNA CTD PMID:23892564 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of MDM2 mRNA CTD PMID:19162173 phenobarbital increases expression ISO RGD:1313300 6480464 Phenobarbital results in increased expression of MDM2 mRNA CTD PMID:19482888 more ... phenobarbital multiple interactions ISO RGD:1313300 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MDM2 mRNA]; more ... CTD PMID:19482888 phenobarbital increases phosphorylation ISO RGD:1313299 6480464 Phenobarbital results in increased phosphorylation of MDM2 protein CTD PMID:19751709 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of MDM2 mRNA CTD PMID:25145657 phenylmercury acetate increases expression ISO RGD:1313299 6480464 Phenylmercuric Acetate results in increased expression of MDM2 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1313299 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA CTD PMID:27188386 phenytoin multiple interactions ISO RGD:1313300 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 PhIP increases expression ISO RGD:1313299 6480464 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MDM2 protein CTD PMID:15635149 phlorizin decreases expression ISO RGD:1313300 6480464 Phlorhizin results in decreased expression of MDM2 mRNA CTD PMID:22538082 phosphoramide mustard increases expression EXP 6480464 phosphoramide mustard results in increased expression of MDM2 mRNA CTD PMID:26708502 piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of MDM2 mRNA CTD PMID:15890375 PMID:22484513 pirinixic acid multiple interactions EXP 6480464 MDM2 protein affects the reaction [pirinixic acid results in increased activity of PPARA protein]; more ... CTD PMID:19103650 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of MDM2 mRNA CTD PMID:15890375 PMID:19162173 poly(vinylpyrrolidone) multiple interactions ISO RGD:1313299 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein; more ... CTD PMID:27387714 potassium dichromate multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of MDM2 protein] CTD PMID:21262251 potassium dichromate decreases expression EXP 6480464 Potassium Dichromate results in decreased expression of MDM2 protein CTD PMID:21262251 pravastatin increases phosphorylation ISO RGD:1313299 6480464 Pravastatin results in increased phosphorylation of MDM2 protein CTD PMID:15625077 pravastatin increases expression EXP 6480464 Pravastatin results in increased expression of MDM2 protein CTD PMID:15625077 pravastatin multiple interactions ISO RGD:1313299 6480464 [Pravastatin results in increased phosphorylation of MDM2 protein] which results in increased degradation of TP53 protein; more ... CTD PMID:15625077 pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of MDM2 mRNA CTD PMID:19162173 prochloraz multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA CTD PMID:29038839 procymidone decreases expression EXP 6480464 procymidone results in decreased expression of MDM2 mRNA CTD PMID:15686871 promethazine increases phosphorylation EXP 6480464 Promethazine results in increased phosphorylation of MDM2 protein CTD PMID:26558467 propanal increases expression ISO RGD:1313299 6480464 propionaldehyde results in increased expression of MDM2 mRNA CTD PMID:26079696 quercetin multiple interactions ISO RGD:1313299 6480464 Quercetin results in decreased phosphorylation of and results in decreased expression of MDM2 protein CTD PMID:17973296 quercetin increases expression ISO RGD:1313299 6480464 Quercetin results in increased expression of MDM2 mRNA CTD PMID:21632981 more ... quercetin multiple interactions EXP 6480464 [Quercetin co-treated with Hydrogen Peroxide] results in increased expression of MDM2 mRNA CTD PMID:27525270 quercetin decreases expression ISO RGD:1313299 6480464 Quercetin results in decreased expression of MDM2 protein CTD PMID:21933852 reactive oxygen species multiple interactions ISO RGD:1313299 6480464 [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of MDM2 protein CTD PMID:27634759 resveratrol multiple interactions ISO RGD:1313299 6480464 Capsaicin promotes the reaction [resveratrol results in decreased expression of MDM2 protein]; more ... CTD PMID:15542774 PMID:19846903 resveratrol increases expression ISO RGD:1313299 6480464 resveratrol results in increased expression of MDM2 mRNA CTD PMID:15280659 more ... resveratrol multiple interactions ISO RGD:1313300 6480464 [resveratrol results in increased phosphorylation of TRP53 protein] inhibits the reaction [TRP53 protein binds to MDM2 protein] CTD PMID:11245472 resveratrol decreases expression ISO RGD:1313299 6480464 resveratrol results in decreased expression of MDM2 mRNA; more ... CTD PMID:16998810 more ... resveratrol increases expression ISO RGD:1313300 6480464 resveratrol results in increased expression of MDM2 mRNA; more ... CTD PMID:11245472 more ... resveratrol affects expression ISO RGD:1313300 6480464 resveratrol affects the expression of MDM2 protein CTD PMID:16369916 rifampicin multiple interactions ISO RGD:1313300 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 ruthenium atom decreases expression ISO RGD:1313299 6480464 Ruthenium results in decreased expression of MDM2 protein CTD PMID:17210701 SB 431542 multiple interactions ISO RGD:1313299 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA; more ... CTD PMID:27188386 silicon dioxide increases expression ISO RGD:1313300 6480464 Silicon Dioxide results in increased expression of MDM2 mRNA CTD PMID:19073995 silver atom multiple interactions ISO RGD:1313299 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein; more ... CTD PMID:27387714 silver atom decreases expression ISO RGD:1313299 6480464 Silver results in decreased expression of MDM2 mRNA CTD PMID:26014281 silver(0) multiple interactions ISO RGD:1313299 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein; more ... CTD PMID:27387714 silver(0) decreases expression ISO RGD:1313299 6480464 Silver results in decreased expression of MDM2 mRNA CTD PMID:26014281 silver(1+) decreases expression ISO RGD:1313299 6480464 Silver results in decreased expression of MDM2 mRNA CTD PMID:26014281 silver(1+) multiple interactions ISO RGD:1313299 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein; more ... CTD PMID:27387714 simvastatin increases phosphorylation ISO RGD:1313299 6480464 Simvastatin results in increased phosphorylation of MDM2 protein CTD PMID:15625077 simvastatin multiple interactions ISO RGD:1313299 6480464 Simvastatin promotes the reaction [Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]] CTD PMID:15625077 sirolimus multiple interactions ISO RGD:1313299 6480464 EIF4E protein inhibits the reaction [Sirolimus results in decreased expression of MDM2 protein]; more ... CTD PMID:15625077 more ... sirolimus decreases expression ISO RGD:1313299 6480464 Sirolimus results in decreased expression of MDM2 protein CTD PMID:19560264 sodium arsenate increases expression ISO RGD:1313300 6480464 sodium arsenate results in increased expression of MDM2 mRNA CTD PMID:11353140 sodium arsenite multiple interactions ISO RGD:1313299 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of MDM2 protein]; more ... CTD PMID:20375080 more ... sodium arsenite affects expression ISO RGD:1313299 6480464 sodium arsenite affects the expression of MDM2 mRNA CTD PMID:29319823 sodium arsenite increases expression ISO RGD:1313300 6480464 sodium arsenite results in increased expression of MDM2 mRNA CTD PMID:11353140 PMID:20477944 sodium arsenite decreases expression ISO RGD:1313300 6480464 sodium arsenite results in decreased expression of MDM2 protein CTD PMID:16166651 sodium arsenite increases expression ISO RGD:1313299 6480464 sodium arsenite results in increased expression of MDM2 mRNA; more ... CTD PMID:11813266 more ... sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of MDM2 mRNA CTD PMID:11960910 PMID:22110744 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of MDM2 mRNA CTD PMID:25993096 sorafenib increases expression ISO RGD:1313299 6480464 sorafenib results in increased expression of MDM2 mRNA CTD PMID:26409325 staurosporine multiple interactions ISO RGD:1313299 6480464 Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]] CTD PMID:15542774 succimer multiple interactions ISO RGD:1313300 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MDM2 mRNA CTD PMID:26378955 T-2 Toxin increases expression EXP 6480464 T-2 Toxin results in increased expression of MDM2 mRNA CTD PMID:26141394 tamoxifen affects expression ISO RGD:1313300 6480464 Tamoxifen affects the expression of MDM2 mRNA CTD PMID:17555576 tanespimycin increases degradation ISO RGD:1313299 6480464 tanespimycin results in increased degradation of MDM2 protein CTD PMID:17157164 tauroursodeoxycholic acid increases expression EXP 6480464 tauroursodeoxycholic acid results in increased expression of MDM2 mRNA CTD PMID:15885361 tert-butyl hydroperoxide increases expression ISO RGD:1313299 6480464 tert-Butylhydroperoxide results in increased expression of MDM2 mRNA CTD PMID:27509014 testosterone decreases expression ISO RGD:1313300 6480464 Testosterone results in decreased expression of MDM2 mRNA CTD PMID:20403060 tetraphene multiple interactions ISO RGD:1313300 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 theaflavin multiple interactions ISO RGD:1313300 6480464 [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]; more ... CTD PMID:23717041 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of MDM2 mRNA CTD PMID:18619722 more ... thioacetamide increases phosphorylation EXP 6480464 Thioacetamide results in increased phosphorylation of MDM2 protein CTD PMID:26558467 titanium dioxide increases expression ISO RGD:1313299 6480464 titanium dioxide results in increased expression of MDM2 mRNA CTD PMID:21067279 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MDM2 mRNA CTD PMID:25729387 topotecan increases expression EXP 6480464 Topotecan results in increased expression of MDM2 mRNA CTD PMID:25729387 trichloroethene affects expression ISO RGD:1313300 6480464 Trichloroethylene affects the expression of MDM2 mRNA CTD PMID:21135412 trichloroethene multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA CTD PMID:17905399 trichostatin A affects expression ISO RGD:1313299 6480464 trichostatin A affects the expression of MDM2 mRNA CTD PMID:28542535 trovafloxacin multiple interactions ISO RGD:1313300 6480464 [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MDM2 mRNA CTD PMID:18930950 urethane multiple interactions ISO RGD:1313300 6480464 [Urethane co-treated with Freund's Adjuvant] results in increased expression of MDM2 mRNA CTD PMID:12400877 ursodeoxycholic acid multiple interactions EXP 6480464 [Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]] which results in increased degradation of TP53 protein; more ... CTD PMID:14514686 more ... ursodeoxycholic acid increases expression EXP 6480464 Ursodeoxycholic Acid results in increased expression of MDM2 mRNA CTD PMID:15885361 ursodeoxycholic acid multiple interactions ISO RGD:1313299 6480464 MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased ubiquitination of TP53 protein] CTD PMID:20807506 valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of MDM2 mRNA CTD PMID:24136188 valproic acid increases expression ISO RGD:1313299 6480464 Valproic Acid results in increased expression of MDM2 mRNA CTD PMID:23179753 valproic acid decreases expression ISO RGD:1313299 6480464 Valproic Acid results in decreased expression of MDM2 mRNA CTD PMID:28001369 valproic acid affects expression ISO RGD:1313299 6480464 Valproic Acid affects the expression of MDM2 mRNA CTD PMID:25979313 vincristine increases expression ISO RGD:1313299 6480464 Vincristine results in increased expression of MDM2 mRNA CTD PMID:23649840 vincristine decreases expression ISO RGD:1313299 6480464 Vincristine results in decreased expression of MDM2 mRNA CTD PMID:16001973 vorinostat decreases expression ISO RGD:1313299 6480464 vorinostat results in decreased expression of MDM2 mRNA CTD PMID:27188386 wortmannin multiple interactions ISO RGD:1313299 6480464 wortmannin promotes the reaction [Doxorubicin results in increased phosphorylation of MDM2 protein]; more ... CTD PMID:17935137 zidovudine increases expression ISO RGD:1313299 6480464 Zidovudine results in increased expression of MDM2 protein CTD PMID:16797627 zinc acetate multiple interactions ISO RGD:1313299 6480464 motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA] CTD PMID:16357179 zinc acetate increases expression ISO RGD:1313299 6480464 Zinc Acetate results in increased expression of MDM2 mRNA CTD PMID:16357179 zinc atom multiple interactions ISO RGD:1313299 6480464 Zinc binds to and results in increased folding of MDM2 protein; more ... CTD PMID:16965791 zinc atom increases ubiquitination ISO RGD:1313299 6480464 Zinc results in increased ubiquitination of MDM2 protein CTD PMID:16965791 zinc atom affects expression ISO RGD:1313299 6480464 Zinc affects the expression of MDM2 protein CTD PMID:16636310 zinc pyrithione increases expression ISO RGD:1313299 6480464 pyrithione zinc results in increased expression of MDM2 mRNA CTD PMID:21424779 zinc(0) multiple interactions ISO RGD:1313299 6480464 Zinc binds to and results in increased folding of MDM2 protein; more ... CTD PMID:16965791 zinc(0) affects expression ISO RGD:1313299 6480464 Zinc affects the expression of MDM2 protein CTD PMID:16636310 zinc(0) increases ubiquitination ISO RGD:1313299 6480464 Zinc results in increased ubiquitination of MDM2 protein CTD PMID:16965791
Biological Process amyloid fibril formation ISO RGD:1313299 1624291 RGD PMID:12630860 amyloid fibril formation IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 atrial septum development ISO RGD:1313300 1624291 MGI:MGI:107934 RGD MGI:MGI:5440773 PMID:22821713 atrial septum development IEA UniProtKB:P23804|ensembl:ENSMUSP00000020408 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 atrioventricular valve morphogenesis ISO RGD:1313300 1624291 MGI:MGI:107934 RGD MGI:MGI:5440773 PMID:22821713 atrioventricular valve morphogenesis IEA UniProtKB:P23804|ensembl:ENSMUSP00000020408 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 blood vessel development ISO RGD:1313300 1624291 MGI:MGI:2385439 RGD MGI:MGI:5440773 PMID:22821713 blood vessel development IEA UniProtKB:P23804|ensembl:ENSMUSP00000020408 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 blood vessel remodeling ISO RGD:1313300 1624291 MGI:MGI:2385439 RGD MGI:MGI:5440773 PMID:22821713 blood vessel remodeling IEA UniProtKB:P23804|ensembl:ENSMUSP00000020408 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cardiac septum morphogenesis ISO RGD:1313300 1624291 MGI:MGI:107934|MGI:MGI:98834 RGD MGI:MGI:5440773 PMID:22821713 cardiac septum morphogenesis IEA UniProtKB:P23804|ensembl:ENSMUSP00000020408 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to actinomycin D ISO RGD:1313299 1624291 RGD PMID:15314173 cellular response to actinomycin D IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to alkaloid IEP 2317366 camptothecin RGD cellular response to antibiotic IEP 2317371 chemotherapeutic anthracycline Adriamycin; more ... RGD cellular response to estrogen stimulus IEP 2317400 RGD cellular response to gamma radiation ISO RGD:1313299 1624291 RGD PMID:16213212 cellular response to gamma radiation IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to growth factor stimulus IEP 2317392 FGF1 RGD cellular response to hydrogen peroxide IEP 2317364 cardiac myocytes RGD cellular response to hypoxia ISO RGD:1313299 1624291 RGD PMID:20810912 cellular response to hypoxia IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to organic cyclic compound IEP 2317362 delta-9-tetrahydrocannabinol; more ... RGD cellular response to organic substance IEP 2317359 deferroxamine, pifithrin RGD cellular response to peptide hormone stimulus IEP 2317361 CCK-8 RGD cellular response to UV-C IEP 2317408 RGD cellular response to vitamin B1 IEP 2317394 RGD DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO RGD:1313299 1624291 RGD PMID:21726810 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 endocardial cushion morphogenesis ISO RGD:1313300 1624291 MGI:MGI:107934|MGI:MGI:2385439 RGD MGI:MGI:5440773 PMID:22821713 endocardial cushion morphogenesis IEA UniProtKB:P23804|ensembl:ENSMUSP00000020408 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 establishment of protein localization ISO RGD:1313299 1624291 RGD PMID:10360174 establishment of protein localization IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 heart development ISO RGD:1313300 1624291 MGI:MGI:107934|MGI:MGI:2385439|MGI:MGI:98834 RGD MGI:MGI:5440773 PMID:22821713 heart valve development ISO RGD:1313300 1624291 MGI:MGI:107934 RGD MGI:MGI:5440773 PMID:22821713 negative regulation of apoptotic process IMP 2317374 RGD negative regulation of cell cycle arrest ISO RGD:1313299 1624291 RGD PMID:9529249 negative regulation of cell cycle arrest IEA InterPro:IPR016495 1600115 GO_REF:0000002 InterPro GO_REF:0000002 negative regulation of cell cycle arrest IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP 2317361 caspase-2, caspase-3 RGD negative regulation of DNA damage response, signal transduction by p53 class mediator ISO RGD:1313299 1624291 RGD PMID:10360174 PMID:9529249 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of gene expression IMP 2317361 p53 RGD negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO RGD:1313299 1624291 RGD PMID:17310983 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of neuron projection development IMP 10412064 RGD negative regulation of protein processing IMP 2317364 caspase-3 RGD negative regulation of signal transduction by p53 class mediator ISO RGD:1313299 1624291 RGD PMID:16173922 negative regulation of transcription by RNA polymerase II ISO RGD:1313299 1624291 RGD PMID:17310983 PMID:9271120 negative regulation of transcription by RNA polymerase II IEA InterPro:IPR015459 1600115 GO_REF:0000002 InterPro GO_REF:0000002 negative regulation of transcription by RNA polymerase II IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription, DNA-templated IDA 2317368 RGD negative regulation of transcription, DNA-templated ISO RGD:1313299 1624291 RGD PMID:16479015 more ... peptidyl-lysine modification ISO RGD:1313299 1624291 RGD PMID:19372219 peptidyl-lysine modification IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell cycle ISO RGD:1313300 1624291 MGI:MGI:107738 RGD MGI:MGI:3511413 PMID:15485902 positive regulation of gene expression IMP 2317368 Ppara, ACO, Angptl4, ECH, FABP1, CYP4A1 RGD positive regulation of mitotic cell cycle ISO RGD:1313299 1624291 RGD PMID:17290220 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO RGD:1313299 1624291 RGD PMID:11278372 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein export from nucleus IMP 2317374 p53 RGD positive regulation of vascular associated smooth muscle cell migration IMP 10412065 RGD positive regulation of vascular smooth muscle cell proliferation IMP 10412065 RGD protein autoubiquitination ISO RGD:1313299 1624291 RGD PMID:16479015 PMID:17237821 protein autoubiquitination IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein destabilization ISO RGD:1313299 1624291 RGD PMID:10360174 more ... protein destabilization IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein localization to nucleus ISO RGD:1313299 1624291 RGD PMID:10360174 protein localization to nucleus IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein ubiquitination IMP 2316094 RGD protein ubiquitination IDA 2317402 PMID:14642282 UniProt protein ubiquitination ISO RGD:1313299 1624291 RGD PMID:15878855 more ... protein-containing complex assembly ISO RGD:1313299 1624291 RGD PMID:10608892 PMID:12915590 protein-containing complex assembly IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 proteolysis involved in cellular protein catabolic process ISO RGD:1313299 1624291 RGD PMID:25417702 regulation of gene expression ISO RGD:1313300 1624291 MGI:MGI:2385439 RGD MGI:MGI:5440773 PMID:22821713 regulation of heart rate ISO RGD:1313300 1624291 MGI:MGI:107934 RGD MGI:MGI:5440773 PMID:22821713 regulation of heart rate IEA UniProtKB:P23804|ensembl:ENSMUSP00000020408 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of protein catabolic process ISO RGD:1313299 1624291 RGD PMID:9153395 response to antibiotic ISO RGD:1313299 1624291 RGD PMID:20810912 response to cocaine IEP 2317407 RGD response to drug IEP 2317366 5-fluorouracil RGD response to ether IEP 2317388 anesthetic sevoflurane RGD response to formaldehyde IEP 2317372 RGD response to iron ion IEP 2317357 RGD response to magnesium ion IEP 2317397 RGD response to morphine IEP 2317407 RGD response to steroid hormone IEP 2317386 pregnenolone RGD response to toxic substance IEP 2317373 benzene, trichloroethylene, methyl mercury mixture RGD response to toxic substance IEP 2317390 okadaic acid RGD response to water-immersion restraint stress IDA 10412309 RGD traversing start control point of mitotic cell cycle ISO RGD:1313300 1624291 RGD MGI:MGI:2661697 PMID:10906133 traversing start control point of mitotic cell cycle IEA UniProtKB:P23804|ensembl:ENSMUSP00000020408 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ubiquitin-dependent protein catabolic process ISO RGD:1313300 1624291 RGD MGI:MGI:2384368 more ... ubiquitin-dependent protein catabolic process ISO RGD:1313299 1624291 UniProtKB:P21675 RGD PMID:11278372 more ... ubiquitin-dependent protein catabolic process IEA UniProtKB:P23804|ensembl:ENSMUSP00000020408 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ubiquitin-dependent protein catabolic process IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ventricular septum development ISO RGD:1313300 1624291 MGI:MGI:107934 RGD MGI:MGI:5440773 PMID:22821713 ventricular septum development IEA UniProtKB:P23804|ensembl:ENSMUSP00000020408 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cytoplasm ISO RGD:1313299 1624291 RGD PMID:15314173 PMID:21726810 cytoplasm ISO RGD:1313300 1624291 RGD MGI:MGI:3042317 more ... cytosol IDA 2317362 RGD nuclear body colocalizes_with ISO RGD:1313299 1624291 RGD PMID:10360174 nuclear body IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleolus ISO RGD:1313300 1624291 RGD MGI:MGI:2153973 more ... nucleolus IEA UniProtKB-SubCell:SL-0188 1600115 GO_REF:0000040 UniProt GO_REF:0000040 nucleolus ISO RGD:1313299 1624291 RGD PMID:10707090 more ... nucleoplasm ISO RGD:1313299 1624291 RGD PMID:10707090 PMID:12915590 nucleoplasm IEA UniProtKB-SubCell:SL-0190 1600115 GO_REF:0000040 UniProt GO_REF:0000040 nucleus IDA 2317378 Ser-166 phosphorylated Mdm2 RGD nucleus ISO RGD:1313299 1624291 RGD PMID:10360174 more ... nucleus ISO RGD:1313300 1624291 RGD MGI:MGI:2153973 more ... plasma membrane IDA 2317402 synaptic RGD protein-containing complex ISO RGD:1313299 1624291 RGD PMID:11718560 more ... protein-containing complex IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 synapse IDA 2317402 RGD Molecular Function 5S rRNA binding ISO RGD:1313299 1624291 RGD PMID:24120868 5S rRNA binding IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 disordered domain specific binding ISO RGD:1313299 1624291 UniProtKB:Q8N726 RGD PMID:12630860 disordered domain specific binding IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 enzyme binding ISO RGD:1313299 1624291 UniProtKB:O75604|UniProtKB:Q15392|UniProtKB:Q6PCD5|UniProtKB:Q93009 RGD PMID:15577914 more ... identical protein binding ISO RGD:1313299 1624291 UniProtKB:Q00987 RGD PMID:17159902 more ... identical protein binding IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ligase activity ISO RGD:1313299 1624291 RGD PMID:17142452 ligase activity IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000038 UniProt GO_REF:0000038 NEDD8 ligase activity ISO RGD:1313299 1624291 RGD PMID:18560357 NEDD8 ligase activity IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 p53 binding IPI RGD:3889 2316094 RGD p53 binding ISO RGD:1313299 1624291 UniProtKB:O15350|UniProtKB:P04637|UniProtKB:Q9H3D4 RGD PMID:15053879 more ... p53 binding IPI RGD:3889 9588563 RGD p53 binding ISO RGD:1313300 1624291 UniProtKB:P02340 RGD MGI:MGI:3529885 more ... peroxisome proliferator activated receptor binding IPI RGD:3369 2317368 PPARalpha RGD protein binding IPI RGD:2200 2317383 RGD protein binding IPI UniProtKB:P31016 2317402 PMID:14642282 UniProt protein binding IPI RGD:2280 9588563 RGD protein binding IPI RGD:61928 2317359 RGD protein binding ISO RGD:1313300 1624291 UniProtKB:O35618|UniProtKB:O88904|UniProtKB:P02340|UniProtKB:P19091|UniProtKB:P47962|UniProtKB:P53350|UniProtKB:P62830|UniProtKB:Q3UHD1|UniProtKB:Q5EBH1|UniProtKB:Q62108|UniProtKB:Q64364|UniProtKB:Q8BJS8|UniProtKB:Q8BSK8|UniProtKB:Q8BWG8|UniProtKB:Q9CXW4|UniProtKB:Q9DCE5 RGD MGI:MGI:2384368 more ... protein binding ISO RGD:1313299 1624291 UniProtKB:O15151|UniProtKB:O15297|UniProtKB:O15350|UniProtKB:O60858|UniProtKB:O75604|UniProtKB:O75832|UniProtKB:P03372|UniProtKB:P04271|UniProtKB:P04637|UniProtKB:P05412|UniProtKB:P06400|UniProtKB:P06703|UniProtKB:P06748|UniProtKB:P08069|UniProtKB:P0CG48|UniProtKB:P10275|UniProtKB:P15311|UniProtKB:P17535|UniProtKB:P19338|UniProtKB:P21675|UniProtKB:P23297|UniProtKB:P23396|UniProtKB:P25098|UniProtKB:P25788|UniProtKB:P26447|UniProtKB:P29034|UniProtKB:P29067|UniProtKB:P29084|UniProtKB:P29590|UniProtKB:P29590-5|UniProtKB:P31749|UniProtKB:P32121|UniProtKB:P42574|UniProtKB:P42677|UniProtKB:P46777|UniProtKB:P48729|UniProtKB:P48729-2|UniProtKB:P48730|UniProtKB:P49407|UniProtKB:P49674|UniProtKB:P49757|UniProtKB:P49789|UniProtKB:P53350|UniProtKB:P61289|UniProtKB:P61978|UniProtKB:P62081|UniProtKB:P62829|UniProtKB:P62913|UniProtKB:P68104|UniProtKB:P78352|UniProtKB:Q00688|UniProtKB:Q01105|UniProtKB:Q06486|UniProtKB:Q08499-6|UniProtKB:Q13362|UniProtKB:Q13616|UniProtKB:Q15466|UniProtKB:Q2HR73|UniProtKB:Q5T7V8|UniProtKB:Q61937|UniProtKB:Q62446|UniProtKB:Q6P5F9|UniProtKB:Q6PCD5|UniProtKB:Q71UM5|UniProtKB:Q7LG56|UniProtKB:Q7LG56-1|UniProtKB:Q8N488|UniProtKB:Q8N726|UniProtKB:Q8N726-1|UniProtKB:Q8N9B5|UniProtKB:Q92736|UniProtKB:Q93009|UniProtKB:Q96FW1|UniProtKB:Q96JB5|UniProtKB:Q96PM5|UniProtKB:Q9BVP2|UniProtKB:Q9CXW4|UniProtKB:Q9NS23|UniProtKB:Q9NS23-1|UniProtKB:Q9NVN8|UniProtKB:Q9UER7|UniProtKB:Q9UKB1|UniProtKB:Q9Y297 RGD PMID:10196247 more ... protein domain specific binding ISO RGD:1313299 1624291 UniProtKB:Q6K0P9 RGD PMID:16479015 protein N-terminus binding ISO RGD:1313299 1624291 UniProtKB:Q64364 RGD PMID:11718560 protein N-terminus binding IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 receptor serine/threonine kinase binding IPI RGD:2062 11076228 RGD ribonucleoprotein complex binding ISO RGD:1313299 1624291 RGD PMID:24120868 ribonucleoprotein complex binding IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 scaffold protein binding ISO RGD:1313300 1624291 UniProtKB:P32121 RGD MGI:MGI:5318022 PMID:19372219 scaffold protein binding IEA UniProtKB:P23804|ensembl:ENSMUSP00000020408 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 SUMO transferase activity ISO RGD:1313299 1624291 RGD PMID:21900752 ubiquitin binding IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ubiquitin binding ISO RGD:1313299 1624291 RGD PMID:29295817 ubiquitin protein ligase activity ISO RGD:1313300 1624291 RGD MGI:MGI:2384368 PMID:12145204 ubiquitin protein ligase activity IDA 2317402 PMID:14642282 UniProt ubiquitin protein ligase activity IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ubiquitin protein ligase activity IEA UniProtKB:P23804|ensembl:ENSMUSP00000020408 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ubiquitin protein ligase activity ISO RGD:1313299 1624291 RGD PMID:15314173 more ... ubiquitin protein ligase binding IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ubiquitin protein ligase binding ISO RGD:1313299 1624291 UniProtKB:Q8WZ73|UniProtKB:Q969K3|UniProtKB:Q9H992 RGD PMID:18382127 PMID:29295817 ubiquitin-protein transferase activity IMP 2316094 RGD ubiquitin-protein transferase activity ISO RGD:1313299 1624291 RGD PMID:20173098 PMID:9450543 ubiquitin-protein transferase activity ISO RGD:1313300 1624291 RGD MGI:MGI:3720993 PMID:17591690 zinc ion binding ISO RGD:1313299 1624291 RGD PMID:10722742 zinc ion binding IEA UniProtKB:Q00987|ensembl:ENSP00000258149 1600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
