Mdm2 (MDM2 proto-oncogene) - Rat Genome Database

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Gene: Mdm2 (MDM2 proto-oncogene) Rattus norvegicus
Analyze
Symbol: Mdm2
Name: MDM2 proto-oncogene
RGD ID: 1305332
Description: Enables p53 binding activity; signaling receptor binding activity; and ubiquitin protein ligase activity. Involved in several processes, including cellular response to UV-C; cellular response to organonitrogen compound; and regulation of gene expression. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to colocalize with nuclear body. Used to study ichthyosis; post-traumatic stress disorder; and transient cerebral ischemia. Biomarker of breast cancer; intermittent claudication; liver disease; pancreatitis; and priapism. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; glioblastoma; hepatocellular carcinoma; pancreatic ductal carcinoma; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: double minute 2; E3 ubiquitin-protein ligase Mdm2; LOC314856; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; Mdm2 p53 binding protein homolog (mouse); MDM2 proto-oncogene, E3 ubiquitin protein ligase; p53 E3 ubiquitin protein ligase; transformed mouse 3T3 cell double minute 2; transformed mouse 3T3 cell double minute 2 homolog (mouse)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2753,290,660 - 53,315,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,290,664 - 53,314,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,197,377 - 55,221,597 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,400,491 - 57,424,715 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,178,368 - 57,202,590 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,719,060 - 60,743,618 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,719,066 - 60,743,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0760,719,023 - 60,743,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4756,996,694 - 57,020,926 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1757,018,654 - 57,054,110 (-)NCBI
Celera750,062,029 - 50,086,121 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
10-Hydroxycamptothecin  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
alpha-naphthoflavone  (ISO)
alvocidib  (ISO)
amifostine  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
amsacrine  (ISO)
androstane  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
azoxystrobin  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brassinolide  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
Carbadox  (EXP)
carbamazepine  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
corn oil  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cryptolepine  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (EXP)
DAPT  (ISO)
DDT  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
diallyl disulfide  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
diclofenac  (EXP)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ellipticine  (ISO)
endosulfan  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (EXP,ISO)
EUK-134  (ISO)
fenbendazole  (EXP)
fenofibrate  (EXP)
fipronil  (EXP)
flavanones  (ISO)
flucytosine  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (EXP)
ganciclovir  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 501516  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
ifosfamide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irinotecan  (ISO)
isoflurane  (EXP)
kojic acid  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
Leucomalachite green  (EXP)
linalool  (ISO)
lipopolysaccharide  (ISO)
lupeol  (ISO)
luteolin  (EXP)
LY294002  (ISO)
mancozeb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl caffeate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP,ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitenpyram  (ISO)
Nodularin  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (EXP,ISO)
Octicizer  (ISO)
ortho-Aminoazotoluene  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxfendazole  (EXP)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
palmatine  (ISO)
paracetamol  (EXP,ISO)
Paraoxon-methyl  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (ISO)
PCB138  (ISO)
PD123319  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phlorizin  (ISO)
phosphoramide mustard  (EXP)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
platycodin D  (ISO)
poly(vinylpyrrolidone)  (ISO)
potassium bromate  (ISO)
potassium dichromate  (EXP)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
promethazine  (EXP)
propanal  (ISO)
PX-866  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
ruthenium atom  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sorafenib  (ISO)
staurosporine  (ISO)
succimer  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tauroursodeoxycholic acid  (EXP)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid fibril formation  (ISO)
apoptotic process  (ISO)
atrial septum development  (ISO)
atrioventricular valve morphogenesis  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
cardiac septum morphogenesis  (ISO)
cellular response to actinomycin D  (ISO)
cellular response to alkaloid  (IEP)
cellular response to antibiotic  (IEP)
cellular response to estrogen stimulus  (IEP)
cellular response to gamma radiation  (ISO)
cellular response to growth factor stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to hypoxia  (ISO)
cellular response to organic cyclic compound  (IEP)
cellular response to organic substance  (IEP)
cellular response to peptide hormone stimulus  (IEP)
cellular response to UV-C  (IEP)
cellular response to vitamin B1  (IEP)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  (ISO)
endocardial cushion morphogenesis  (ISO)
establishment of protein localization  (ISO)
fibroblast activation  (IMP)
heart development  (ISO)
heart valve development  (ISO)
negative regulation of apoptotic process  (IBA,IMP)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of DNA-templated transcription  (IDA,ISO)
negative regulation of gene expression  (IMP)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
negative regulation of neuron projection development  (IMP)
negative regulation of protein processing  (IMP)
negative regulation of signal transduction by p53 class mediator  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of muscle cell differentiation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein export from nucleus  (IMP)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
protein autoubiquitination  (IEA,ISO)
protein destabilization  (ISO)
protein localization to nucleus  (ISO)
protein ubiquitination  (IBA,IDA,IMP,ISO)
protein-containing complex assembly  (ISO)
proteolysis involved in protein catabolic process  (ISO)
regulation of cell cycle  (ISO)
regulation of gene expression  (IBA,ISO)
regulation of heart rate  (ISO)
regulation of protein catabolic process  (ISO)
response to antibiotic  (ISO)
response to cocaine  (IEP)
response to ether  (IEP)
response to formaldehyde  (IEP)
response to iron ion  (IEP)
response to magnesium ion  (IEP)
response to steroid hormone  (IEP)
response to toxic substance  (IEP)
response to water-immersion restraint stress  (IDA)
response to xenobiotic stimulus  (IEP)
traversing start control point of mitotic cell cycle  (ISO)
ubiquitin-dependent protein catabolic process  (ISO)
ventricular septum development  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. Amaral JD, etal., J Biol Chem. 2007 Nov 23;282(47):34250-9. Epub 2007 Sep 19.
2. Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells. Bhattacharya S, etal., Cell Signal. 2009 Apr;21(4):509-22. Epub 2008 Dec 24.
3. Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes. Bitar MS, etal., Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E951-63. doi: 10.1152/ajpendo.00189.2013. Epub 2013 Aug 13.
4. FGF1 inhibits p53-dependent apoptosis and cell cycle arrest via an intracrine pathway. Bouleau S, etal., Oncogene. 2005 Nov 24;24(53):7839-49.
5. Induction of p53 expression and function by estrogen in osteoblasts. Bovenkerk S, etal., Calcif Tissue Int. 2003 Sep;73(3):274-80.
6. Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 gene. Chang B, etal., Hum Mol Genet. 2008 Dec 15;17(24):3929-41. doi: 10.1093/hmg/ddn295. Epub 2008 Sep 18.
7. PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2. Choy MK, etal., J Cell Physiol. 2010 Mar;222(3):635-9.
8. Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Colledge M, etal., Neuron. 2003 Oct 30;40(3):595-607.
9. Thyrotropin effects on ultraviolet radiation-dependent apoptosis in FRTL-5 cells. Del Terra E, etal., Thyroid. 2003 Aug;13(8):747-53.
10. Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer. Dong M, etal., World J Gastroenterol. 2005 Apr 14;11(14):2162-5.
11. Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis. Dongiovanni P, etal., Am J Pathol. 2010 Feb;176(2):1006-17. Epub 2009 Dec 17.
12. Long-term effects of hypothermia on neuronal cell death and the concentration of apoptotic proteins after incomplete cerebral ischemia and reperfusion in rats. Eberspacher E, etal., Acta Anaesthesiol Scand. 2005 Apr;49(4):477-87.
13. The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia. Faderl S, etal., Cancer. 2000 Nov 1;89(9):1976-82.
14. Characterizing the role of MDM2 in diethylnitrosamine induced acute liver damage and development of pre-neoplastic lesions. Finnberg N, etal., Carcinogenesis. 2004 Jan;25(1):113-22. Epub 2003 Oct 10.
15. The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization. Fumagalli M, etal., Glia. 2015 Dec;63(12):2327-39. doi: 10.1002/glia.22896. Epub 2015 Jul 31.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Regulation of peroxisome proliferator-activated receptor-alpha by MDM2. Gopinathan L, etal., Toxicol Sci. 2009 Mar;108(1):48-58. Epub 2008 Dec 22.
19. Delta(9)-tetrahydrocannabinol regulates the p53 post-translational modifiers Murine double minute 2 and the Small Ubiquitin MOdifier protein in the rat brain. Gowran A, etal., FEBS Lett. 2009 Nov 3;583(21):3412-8. Epub 2009 Oct 9.
20. MDM2 SNP309 associates with accelerated pancreatic adenocarcinoma formation. Grochola LF, etal., Pancreas. 2010 Jan;39(1):76-80.
21. ZEB2, interacting with MDM2, contributes to the dysfuntion of brain microvascular endothelial cells and brain injury after intracerebral hemorrhage. Guo Q, etal., Cell Cycle. 2021 Sep;20(17):1692-1707. doi: 10.1080/15384101.2021.1959702. Epub 2021 Aug 2.
22. Inhibition of MDM2 attenuates neointimal hyperplasia via suppression of vascular proliferation and inflammation. Hashimoto T, etal., Cardiovasc Res. 2011 Sep 1;91(4):711-9. doi: 10.1093/cvr/cvr108. Epub 2011 Apr 14.
23. Transcriptomics analysis of interactive effects of benzene, trichloroethylene and methyl mercury within binary and ternary mixtures on the liver and kidney following subchronic exposure in the rat. Hendriksen PJ, etal., Toxicol Appl Pharmacol. 2007 Dec 1;225(2):171-88. Epub 2007 Aug 29.
24. Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis. Ishikawa A, etal., Hum Pathol. 2004 Dec;35(12):1505-14.
25. Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome. Jarnagin WR, etal., J Clin Oncol. 2006 Mar 1;24(7):1152-60.
26. Up-regulation of murine double minute clone 2 (MDM2) gene expression in rat brain after morphine, heroin, and cocaine administrations. Jiang Y, etal., Neurosci Lett. 2003 Dec 11;352(3):216-20.
27. Experimental priapism is associated with increased oxidative stress and activation of protein degradation pathways in corporal tissue. Kanika ND, etal., Int J Impot Res. 2010 Nov-Dec;22(6):363-73. doi: 10.1038/ijir.2010.27. Epub 2010 Nov 18.
28. Nonresponsiveness of cerebral p53-MDM2 functional circuit in newborn rat pups rendered IUGR via uteroplacental insufficiency. Ke X, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Apr;288(4):R1038-45. Epub 2004 Nov 24.
29. Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer. Kriegmair MC, etal., Anticancer Res. 2016 Oct;36(10):5205-5213. doi: 10.21873/anticanres.11091.
30. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
31. The complexity of p53 stabilization and activation. Lavin MF and Gueven N, Cell Death Differ. 2006 Jun;13(6):941-50.
32. A molecular basis for the efficacy of magnesium treatment following traumatic brain injury in rats. Lee JS, etal., J Neurotrauma. 2004 May;21(5):549-61.
33. Identification of formaldehyde-responsive genes by suppression subtractive hybridization. Lee MH, etal., Toxicology. 2008 Jan 14;243(1-2):224-35. Epub 2007 Oct 22.
34. Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen. Lee YS, etal., J Pharmacol Exp Ther. 2006 Apr;317(1):202-8. Epub 2005 Dec 5.
35. Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin D. Lents NH, etal., Cell Cycle. 2008 Jun 1;7(11):1580-6. Epub 2008 Mar 24.
36. Up-regulation of Smurf1 after spinal cord injury in adult rats. Li D, etal., J Mol Histol. 2013 Aug;44(4):381-90. doi: 10.1007/s10735-013-9499-2. Epub 2013 Apr 18.
37. REGgamma deficiency promotes premature aging via the casein kinase 1 pathway. Li L, etal., Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11005-10. doi: 10.1073/pnas.1308497110. Epub 2013 Jun 13.
38. Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy. Li Q and Lozano G, Clin Cancer Res. 2013 Jan 1;19(1):34-41. doi: 10.1158/1078-0432.CCR-12-0053. Epub 2012 Dec 21.
39. SCYL1BP1 modulates neurite outgrowth and regeneration by regulating the Mdm2/p53 pathway. Liu Y, etal., Mol Biol Cell. 2012 Dec;23(23):4506-14. doi: 10.1091/mbc.E12-05-0362. Epub 2012 Oct 10.
40. MDM2 promoter polymorphism and p53 codon 72 polymorphism in chronic myeloid leukemia: the association between MDM2 promoter genotype and disease susceptibility, age of onset, and blast-free survival in chronic phase patients receiving imatinib. Liu YC, etal., Mol Carcinog. 2014 Dec;53(12):951-9. doi: 10.1002/mc.22061. Epub 2013 Jul 2.
41. Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. Ma B, etal., PLoS One. 2013 May 2;8(5):e56580. doi: 10.1371/journal.pone.0056580. Print 2013.
42. Lack of association between MDM2 SNP309 and TP53 Arg72Pro polymorphisms with clinical outcomes in myelodysplastic syndrome. Machado-Neto JA, etal., Neoplasma. 2012;59(5):530-5. doi: 10.4149/neo_2012_068.
43. MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 is activated in response to inhibited Akt signaling. Malmlof M, etal., J Biol Chem. 2007 Jan 26;282(4):2288-96. Epub 2006 Nov 15.
44. Inhibition of PP2A, but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells. Messner DJ, etal., J Cell Biochem. 2006 Sep 1;99(1):241-55.
45. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
46. p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning. Mocanu MM and Yellon DM, FEBS Lett. 2003 Dec 4;555(2):302-6.
47. Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors. Murray SA, etal., J Cell Biochem. 2005 Aug 1;95(5):875-84.
48. p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition. Nair VD, etal., J Biol Chem. 2006 Dec 22;281(51):39550-60. Epub 2006 Oct 23.
49. Inflammatory cells regulate p53 and caspases in acute pancreatitis. Nakamura Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Oct 22.
50. p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile. Nelson DM, etal., Toxicol Sci. 2006 Dec;94(2):272-80. Epub 2006 Sep 25.
51. Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1beta/ErbB in response to myocardial infarction resulting in worsening heart failure. Odiete O, etal., Cardiovasc Diabetol. 2013 Mar 27;12:52. doi: 10.1186/1475-2840-12-52.
52. MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in breast cancer patients treated with 5-FU/epirubicin/cyclophosphamide. Okishiro M, etal., Breast Cancer Res Treat. 2012 Apr;132(3):947-53. doi: 10.1007/s10549-011-1637-5. Epub 2011 Jun 25.
53. Amplification of a gene encoding a p53-associated protein in human sarcomas. Oliner JD, etal., Nature. 1992 Jul 2;358(6381):80-3.
54. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
55. The long-term effect of sevoflurane on neuronal cell damage and expression of apoptotic factors after cerebral ischemia and reperfusion in rats. Pape M, etal., Anesth Analg. 2006 Jul;103(1):173-9, table of contents.
56. Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H(2)O(2)-induced oxidative stress in neonatal rat cardiac myocytes. Pikkarainen S, etal., J Biol Chem. 2009 Oct 2;284(40):27195-210. Epub 2009 Jul 28.
57. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
58. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
59. GOA pipeline RGD automated data pipeline
60. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
61. Lose dose genistein inhibits glucocorticoid receptor and ischemic brain injury in female rats. Shi R, etal., Neurochem Int. 2014 Jan;65:14-22. doi: 10.1016/j.neuint.2013.12.002. Epub 2013 Dec 12.
62. Selective increase in the association of the beta2 adrenergic receptor, beta Arrestin-1 and p53 with Mdm2 in the ventral hippocampus one month after underwater trauma. Sood R, etal., Behav Brain Res. 2013 Mar 1;240:26-8. doi: 10.1016/j.bbr.2012.11.009. Epub 2012 Nov 20.
63. MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced grade III/IV neutropenia in Chinese extensive-stage small-cell lung cancer patients. Wang X, etal., Oncol Res Treat. 2014;37(4):176-80. doi: 10.1159/000360785. Epub 2014 Mar 20.
64. Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells. Wassmann S, etal., J Mol Cell Cardiol. 2007 Sep;43(3):301-7. Epub 2007 Jun 16.
65. p53 polymorphisms: cancer implications. Whibley C, etal., Nat Rev Cancer. 2009 Feb;9(2):95-107.
66. [The expression of p53, MDM2 and Ref1 gene in cultured retina neurons of SD rats treated with vitamin B1 and/or elevated pressure] Yang Z, etal., Yan Ke Xue Bao. 2004 Dec;20(4):259-63.
67. MDM2 mediates fibroblast activation and renal tubulointerstitial fibrosis via a p53-independent pathway. Ye C, etal., Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F760-F768. doi: 10.1152/ajprenal.00528.2016. Epub 2017 Jan 18.
68. Identifying a hyperkeratosis signature in autosomal recessive congenital ichthyosis: Mdm2 inhibition prevents hyperkeratosis in a rat ARCI model. Youssef G, etal., J Invest Dermatol. 2014 Mar;134(3):858-61. doi: 10.1038/jid.2013.374. Epub 2013 Sep 4.
69. A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival. Zheng S, etal., Genes Dev. 2013 Jul 1;27(13):1462-72. doi: 10.1101/gad.213686.113. Epub 2013 Jun 24.
Additional References at PubMed
PMID:8058315   PMID:8417333   PMID:9153395   PMID:9271120   PMID:9450543   PMID:9529249   PMID:10360174   PMID:10608892   PMID:10707090   PMID:10722742   PMID:10906133   PMID:11278372  
PMID:11718560   PMID:11983168   PMID:12145204   PMID:12154087   PMID:12630860   PMID:12915590   PMID:12927808   PMID:14767071   PMID:15053879   PMID:15195100   PMID:15199126   PMID:15314173  
PMID:15456867   PMID:15485902   PMID:15577914   PMID:15678128   PMID:15878855   PMID:16129783   PMID:16173922   PMID:16213212   PMID:16339144   PMID:16479015   PMID:16737965   PMID:16914427  
PMID:17142452   PMID:17159902   PMID:17237821   PMID:17290220   PMID:17310983   PMID:17591690   PMID:17936559   PMID:18382127   PMID:18560357   PMID:18566590   PMID:18614532   PMID:18784257  
PMID:19090619   PMID:19656744   PMID:20153724   PMID:20173098   PMID:20810912   PMID:20818388   PMID:21281824   PMID:21726810   PMID:21900752   PMID:22046440   PMID:22173032   PMID:22405968  
PMID:22493164   PMID:22821713   PMID:22835827   PMID:22869143   PMID:24003224   PMID:24120868   PMID:24506068   PMID:25058273   PMID:25063292   PMID:25417702   PMID:25720496   PMID:25912675  
PMID:28596723   PMID:28798142   PMID:29295817   PMID:29344658   PMID:30001240   PMID:30360646   PMID:30998966   PMID:31973811   PMID:35818191  


Genomics

Comparative Map Data
Mdm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2753,290,660 - 53,315,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,290,664 - 53,314,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,197,377 - 55,221,597 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,400,491 - 57,424,715 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,178,368 - 57,202,590 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,719,060 - 60,743,618 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,719,066 - 60,743,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0760,719,023 - 60,743,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4756,996,694 - 57,020,926 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1757,018,654 - 57,054,110 (-)NCBI
Celera750,062,029 - 50,086,121 (-)NCBICelera
Cytogenetic Map7q22NCBI
MDM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381268,808,172 - 68,850,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1268,808,177 - 68,845,544 (+)EnsemblGRCh38hg38GRCh38
GRCh371269,201,952 - 69,244,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361267,488,247 - 67,520,481 (+)NCBINCBI36Build 36hg18NCBI36
Build 341267,488,246 - 67,520,481NCBI
Celera1268,865,796 - 68,903,026 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1266,252,410 - 66,289,884 (+)NCBIHuRef
CHM1_11269,170,604 - 69,207,918 (+)NCBICHM1_1
T2T-CHM13v2.01268,784,018 - 68,830,265 (+)NCBIT2T-CHM13v2.0
Mdm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910117,524,780 - 117,546,663 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10117,524,780 - 117,546,663 (-)EnsemblGRCm39 Ensembl
GRCm3810117,688,875 - 117,710,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,688,875 - 117,710,758 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710117,125,961 - 117,147,772 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610117,091,898 - 117,113,709 (-)NCBIMGSCv36mm8
Celera10119,626,758 - 119,648,336 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.32NCBI
Mdm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545815,263,739 - 15,286,808 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545815,264,028 - 15,287,290 (+)NCBIChiLan1.0ChiLan1.0
MDM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11276,824,089 - 76,858,786 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01266,322,340 - 66,357,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11269,102,083 - 69,133,278 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1269,102,084 - 69,133,278 (+)Ensemblpanpan1.1panPan2
MDM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11010,936,288 - 10,963,118 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1010,893,719 - 10,962,596 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1010,869,091 - 10,894,634 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01011,060,051 - 11,086,867 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1011,016,172 - 11,087,383 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11010,928,429 - 10,953,972 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01011,174,449 - 11,199,967 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01011,296,600 - 11,322,142 (+)NCBIUU_Cfam_GSD_1.0
Mdm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494547,377,991 - 47,400,191 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365456,709,903 - 6,732,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl533,105,759 - 33,137,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1533,105,717 - 33,137,602 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2535,889,682 - 35,921,569 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MDM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11164,434,203 - 64,465,490 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1164,434,261 - 64,469,890 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037181,237,754 - 181,268,657 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Mdm2
174 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:759
Count of miRNA genes:296
Interacting mature miRNAs:376
Transcripts:ENSRNOT00000066767
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 51 35 19 35 8 11 74 35 41 11 8
Low 6 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066767   ⟹   ENSRNOP00000063449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,290,666 - 53,314,915 (-)Ensembl
Rnor_6.0 Ensembl760,719,066 - 60,743,328 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086116   ⟹   ENSRNOP00000069425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,290,664 - 53,314,909 (-)Ensembl
Rnor_6.0 Ensembl760,719,631 - 60,742,660 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096862   ⟹   ENSRNOP00000079885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,290,664 - 53,309,889 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102407   ⟹   ENSRNOP00000092330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,290,666 - 53,314,909 (-)Ensembl
RefSeq Acc Id: NM_001108099   ⟹   NP_001101569
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2753,290,666 - 53,314,915 (-)NCBI
Rnor_6.0760,719,066 - 60,743,328 (-)NCBI
Rnor_5.0760,719,023 - 60,743,581 (-)NCBI
RGSC_v3.4756,996,694 - 57,020,926 (-)RGD
Celera750,062,029 - 50,086,121 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241382   ⟹   XP_006241444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2753,290,660 - 53,315,205 (-)NCBI
Rnor_6.0760,719,060 - 60,743,618 (-)NCBI
Rnor_5.0760,719,023 - 60,743,581 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241383   ⟹   XP_006241445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2753,290,660 - 53,314,609 (-)NCBI
Rnor_6.0760,719,060 - 60,743,026 (-)NCBI
Rnor_5.0760,719,023 - 60,743,581 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079126   ⟹   XP_038935054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2753,290,660 - 53,314,737 (-)NCBI
RefSeq Acc Id: XM_039079127   ⟹   XP_038935055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2753,290,660 - 53,315,205 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001101569   ⟸   NM_001108099
- UniProtKB: D3ZVH5 (UniProtKB/TrEMBL),   A6IGT1 (UniProtKB/TrEMBL),   A0A8I6GK47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241444   ⟸   XM_006241382
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GK47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241445   ⟸   XM_006241383
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GK47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063449   ⟸   ENSRNOT00000066767
RefSeq Acc Id: ENSRNOP00000069425   ⟸   ENSRNOT00000086116
RefSeq Acc Id: XP_038935055   ⟸   XM_039079127
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JVC1 (UniProtKB/TrEMBL),   A0A8I6G5V3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935054   ⟸   XM_039079126
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G5V3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092330   ⟸   ENSRNOT00000102407
RefSeq Acc Id: ENSRNOP00000079885   ⟸   ENSRNOT00000096862
Protein Domains
DM2   RanBP2-type   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVC1-F1-model_v2 AlphaFold A0A0G2JVC1 1-483 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695222
Promoter ID:EPDNEW_R5740
Type:single initiation site
Name:Mdm2_1
Description:MDM2 proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5741  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0760,742,660 - 60,742,720EPDNEW
RGD ID:13695216
Promoter ID:EPDNEW_R5741
Type:initiation region
Name:Mdm2_2
Description:MDM2 proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5740  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0760,743,296 - 60,743,356EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305332 AgrOrtholog
BioCyc Gene G2FUF-33982 BioCyc
Ensembl Genes ENSRNOG00000006304 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066767 ENTREZGENE
  ENSRNOT00000066767.3 UniProtKB/TrEMBL
  ENSRNOT00000086116 ENTREZGENE
  ENSRNOT00000086116.2 UniProtKB/TrEMBL
  ENSRNOT00000096862.1 UniProtKB/TrEMBL
  ENSRNOT00000102407 ENTREZGENE
  ENSRNOT00000102407.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.245.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  Zn-finger domain of Sec23/24 UniProtKB/TrEMBL
InterPro Mdm2 UniProtKB/TrEMBL
  MDM2_mRING-HC-C2H2C4 UniProtKB/TrEMBL
  p53_neg-reg_MDM_2/4 UniProtKB/TrEMBL
  SWIB_MDM2_dom_sf UniProtKB/TrEMBL
  SWIB_MDM2_domain UniProtKB/TrEMBL
  Znf_RanBP2 UniProtKB/TrEMBL
  Znf_RanBP2_sf UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:314856 UniProtKB/TrEMBL
NCBI Gene 314856 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MDM2 UniProtKB/TrEMBL
  OS05G0521000 PROTEIN UniProtKB/TrEMBL
Pfam SWIB UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
  zf-RanBP UniProtKB/TrEMBL
PhenoGen Mdm2 PhenoGen
PIRSF MDM2 UniProtKB/TrEMBL
  p53_MDM_2/4 UniProtKB/TrEMBL
PROSITE SWIB_MDM2 UniProtKB/TrEMBL
  ZF_RANBP2_1 UniProtKB/TrEMBL
  ZF_RANBP2_2 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006304 RatGTEx
Superfamily-SCOP MDM2 UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
  SSF90209 UniProtKB/TrEMBL
UniProt A0A0G2JVC1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G5V3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GK47 ENTREZGENE, UniProtKB/TrEMBL
  A6IGT1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVH5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Mdm2  MDM2 proto-oncogene  Mdm2  MDM2 proto-oncogene, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-10 Mdm2  MDM2 proto-oncogene, E3 ubiquitin protein ligase  Mdm2  MDM2 oncogene, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-22 Mdm2  MDM2 oncogene, E3 ubiquitin protein ligase  Mdm2  p53 E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-05 Mdm2  p53 E3 ubiquitin protein ligase  Mdm2  Mdm2 p53 binding protein homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Mdm2  Mdm2 p53 binding protein homolog (mouse)  Mdm2  transformed mouse 3T3 cell double minute 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-17 Mdm2  transformed mouse 3T3 cell double minute 2  Mdm2_predicted  transformed mouse 3T3 cell double minute 2 homolog (mouse) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Mdm2_predicted  transformed mouse 3T3 cell double minute 2 homolog (mouse) (predicted)    transformed mouse 3T3 cell double minute 2 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Mdm2_predicted  transformed mouse 3T3 cell double minute 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED