(+)-catechin decreases expression ISO MDM2 (Homo sapiens) 6480464 Catechin results in decreased expression of MDM2 mRNA CTD PMID:23706674 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MDM2 mRNA] CTD PMID:31150632 (-)-demecolcine increases expression ISO MDM2 (Homo sapiens) 6480464 Demecolcine results in increased expression of MDM2 mRNA CTD PMID:23649840 (-)-epigallocatechin 3-gallate multiple interactions ISO Mdm2 (Mus musculus) 6480464 [epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ... CTD PMID:23717041 (S)-naringenin multiple interactions ISO MDM2 (Homo sapiens) 6480464 [naringenin co-treated with bisphenol A] results in increased expression of MDM2 mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of MDM2 mRNA CTD PMID:36235125 (S)-naringenin increases expression ISO MDM2 (Homo sapiens) 6480464 naringenin metabolite results in increased expression of MDM2 mRNA CTD PMID:36235125 (S)-nicotine multiple interactions ISO MDM2 (Homo sapiens) 6480464 [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein and [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expression ISO Mdm2 (Mus musculus) 6480464 o and p'-DDT affects the expression of MDM2 mRNA CTD PMID:18925944 1,10-phenanthroline increases expression ISO MDM2 (Homo sapiens) 6480464 1 and 10-phenanthroline results in increased expression of MDM2 mRNA CTD PMID:19502547 1,2-dimethylhydrazine multiple interactions ISO Mdm2 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of MDM2 mRNA CTD PMID:22206623 1-nitropyrene increases expression ISO MDM2 (Homo sapiens) 6480464 1-nitropyrene results in increased expression of MDM2 mRNA more ... CTD PMID:10837373 and PMID:22044530 1-nitropyrene multiple interactions ISO MDM2 (Homo sapiens) 6480464 nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form] more ... CTD PMID:10837373 and PMID:22044530 10-Hydroxycamptothecin affects response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 protein affects the susceptibility to 10-hydroxycamptothecin CTD PMID:13130078 17alpha-ethynylestradiol increases expression ISO MDM2 (Homo sapiens) 6480464 Ethinyl Estradiol results in increased expression of MDM2 mRNA alternative form and Ethinyl Estradiol results in increased expression of MDM2 protein CTD PMID:12168835 17alpha-ethynylestradiol increases expression ISO Mdm2 (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of MDM2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDM2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO Mdm2 (Mus musculus) 6480464 Ethinyl Estradiol affects the expression of MDM2 mRNA CTD PMID:17555576 17beta-estradiol increases expression ISO MDM2 (Homo sapiens) 6480464 Estradiol results in increased expression of MDM2 mRNA alternative form and Estradiol results in increased expression of MDM2 protein CTD PMID:12168835 17beta-estradiol increases expression ISO Mdm2 (Mus musculus) 6480464 Estradiol results in increased expression of MDM2 mRNA and Estradiol results in increased expression of MDM2 protein CTD PMID:23684557 17beta-estradiol multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Estradiol co-treated with Parathion] results in increased expression of MDM2 mRNA and [Estradiol co-treated with TGFB1 protein] results in decreased expression of MDM2 mRNA CTD PMID:17622325 and PMID:30165855 17beta-estradiol decreases phosphorylation ISO Mdm2 (Mus musculus) 6480464 Estradiol results in decreased phosphorylation of MDM2 protein CTD PMID:22314386 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one increases expression ISO MDM2 (Homo sapiens) 6480464 1H-(1 more ... CTD PMID:16288207 2,2',3,3',6,6'-hexachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:20840854 2,2',4,4',5,5'-hexachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 and PMID:20840854 2,2',4,4'-tetrachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 2,2',4,5-tetrachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 2,2',5,5'-tetrachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one increases expression ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:21647879 2,3,3',4,4',5,5'-Heptachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO MDM2 (Homo sapiens) 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]] more ... CTD PMID:19578757 and PMID:22044530 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Mdm2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA CTD PMID:12167310 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Mdm2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of MDM2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation EXP 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of MDM2 protein CTD PMID:15459018 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein] and Tetrachlorodibenzodioxin results in increased expression of and results in increased phosphorylation of and results in increased activity of MDM2 protein CTD PMID:15459018 2,3,7,8-tetrachlorodibenzodioxine increases degradation EXP 6480464 Tetrachlorodibenzodioxin results in increased degradation of MDM2 protein CTD PMID:15459018 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDM2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of MDM2 protein CTD PMID:19751709 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO MDM2 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA CTD PMID:19578757 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO MDM2 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of MDM2 mRNA CTD PMID:16039398 2,4-dinitrotoluene affects expression EXP 6480464 2 and 4-dinitrotoluene affects the expression of MDM2 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2 and 6-dinitrotoluene affects the expression of MDM2 mRNA CTD PMID:21346803 2-acetamidofluorene multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein CTD PMID:11003613 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of MDM2 mRNA and 2-Acetylaminofluorene results in increased expression of MDM2 protein CTD PMID:19167416 more ... 2-acetamidofluorene increases expression ISO Mdm2 (Mus musculus) 6480464 2-Acetylaminofluorene results in increased expression of MDM2 mRNA CTD PMID:21607683 2-nitrofluorene increases expression EXP 6480464 2-nitrofluorene results in increased expression of MDM2 mRNA CTD PMID:14600272 more ... 3,3',4,4',5-pentachlorobiphenyl increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 3 more ... CTD PMID:19751709 and PMID:20840854 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO MDM2 (Homo sapiens) 6480464 3 more ... CTD PMID:20840854 3,3'-diindolylmethane decreases expression ISO Mdm2 (Mus musculus) 6480464 3 and 3'-diindolylmethane analog results in decreased expression of MDM2 mRNA CTD PMID:26593444 3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine increases expression ISO MDM2 (Homo sapiens) 6480464 3 more ... CTD PMID:23810796 3-phenylprop-2-enal increases expression ISO MDM2 (Homo sapiens) 6480464 cinnamaldehyde results in increased expression of MDM2 mRNA CTD PMID:19000754 4,4'-diaminodiphenylmethane increases expression ISO Mdm2 (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in increased expression of MDM2 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol increases methylation ISO Mdm2 (Mus musculus) 6480464 bis(4-hydroxyphenyl)sulfone results in increased methylation of MDM2 promoter CTD PMID:33297965 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MDM2 mRNA CTD PMID:14600272 more ... 4-hydroperoxycyclophosphamide increases expression ISO MDM2 (Homo sapiens) 6480464 perfosfamide results in increased expression of MDM2 CTD PMID:18034189 4-hydroxyphenyl retinamide decreases expression ISO MDM2 (Homo sapiens) 6480464 Fenretinide results in decreased expression of MDM2 mRNA CTD PMID:16570282 4-hydroxyphenyl retinamide increases expression ISO Mdm2 (Mus musculus) 6480464 Fenretinide results in increased expression of MDM2 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine affects expression ISO MDM2 (Homo sapiens) 6480464 Decitabine affects the expression of MDM2 mRNA CTD PMID:17145863 5-azacytidine increases expression ISO MDM2 (Homo sapiens) 6480464 Azacitidine results in increased expression of MDM2 mRNA CTD PMID:20823114 5-fluorouracil increases expression ISO Mdm2 (Mus musculus) 6480464 Fluorouracil results in increased expression of MDM2 mRNA CTD PMID:16949053 5-fluorouracil increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Fluorouracil results in increased phosphorylation of MDM2 protein CTD PMID:25744307 5-fluorouracil increases expression ISO MDM2 (Homo sapiens) 6480464 Fluorouracil results in increased expression of MDM2 mRNA more ... CTD PMID:14665630 more ... 5-fluorouracil multiple interactions ISO MDM2 (Homo sapiens) 6480464 Cadmium Chloride affects the reaction [Fluorouracil results in increased phosphorylation of MDM2 protein] more ... CTD PMID:15546879 more ... 7,12-dimethyltetraphene multiple interactions ISO Mdm2 (Mus musculus) 6480464 [epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ... CTD PMID:23717041 7,12-dimethyltetraphene increases expression ISO Mdm2 (Mus musculus) 6480464 9 more ... CTD PMID:23717041 and PMID:32553695 acetamide increases expression EXP 6480464 acetamide results in increased expression of MDM2 mRNA CTD PMID:31881176 acetylsalicylic acid decreases expression ISO MDM2 (Homo sapiens) 6480464 Aspirin results in decreased expression of MDM2 mRNA CTD PMID:20457246 adefovir pivoxil increases expression ISO MDM2 (Homo sapiens) 6480464 adefovir dipivoxil results in increased expression of MDM2 mRNA CTD PMID:25596134 aflatoxin B1 affects expression ISO MDM2 (Homo sapiens) 6480464 Aflatoxin B1 affects the expression of MDM2 protein CTD PMID:20106945 aflatoxin B1 increases expression ISO MDM2 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of MDM2 mRNA CTD PMID:21632981 more ... aflatoxin B1 decreases methylation ISO MDM2 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of MDM2 gene CTD PMID:27153756 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of MDM2 mRNA CTD PMID:14600272 more ... aflatoxin B1 increases expression ISO Mdm2 (Mus musculus) 6480464 Aflatoxin B1 results in increased expression of MDM2 mRNA CTD PMID:19770486 aflatoxin M1 decreases expression ISO MDM2 (Homo sapiens) 6480464 Aflatoxin M1 results in decreased expression of MDM2 mRNA CTD PMID:30928695 alpha-naphthoflavone multiple interactions ISO MDM2 (Homo sapiens) 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]] and alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA] CTD PMID:19578757 alvocidib decreases expression ISO MDM2 (Homo sapiens) 6480464 alvocidib results in decreased expression of MDM2 mRNA and alvocidib results in decreased expression of MDM2 protein CTD PMID:12589031 amifostine decreases expression ISO MDM2 (Homo sapiens) 6480464 Amifostine results in decreased expression of MDM2 mRNA CTD PMID:14555708 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of MDM2 mRNA and Ammonium Chloride results in increased expression of MDM2 protein CTD PMID:12420312 and PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of MDM2 mRNA CTD PMID:30779732 amphibole asbestos decreases expression ISO MDM2 (Homo sapiens) 6480464 Asbestos and Amphibole results in decreased expression of MDM2 protein CTD PMID:20855422 amsacrine decreases response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 promoter SNP results in decreased susceptibility to Amsacrine CTD PMID:17575151 androstane multiple interactions ISO Mdm2 (Mus musculus) 6480464 Androstanols inhibits the reaction [DDT results in increased expression of MDM2 mRNA] CTD PMID:23684557 antimycin A increases expression ISO MDM2 (Homo sapiens) 6480464 Antimycin A results in increased expression of MDM2 mRNA CTD PMID:33512557 arsane affects response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 SNP affects the susceptibility to Arsenic CTD PMID:21982800 arsane affects methylation ISO MDM2 (Homo sapiens) 6480464 Arsenic affects the methylation of MDM2 gene CTD PMID:25304211 arsenic atom affects response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 SNP affects the susceptibility to Arsenic CTD PMID:21982800 arsenic atom affects methylation ISO MDM2 (Homo sapiens) 6480464 Arsenic affects the methylation of MDM2 gene CTD PMID:25304211 arsenite(3-) multiple interactions ISO MDM2 (Homo sapiens) 6480464 [[[arsenite results in increased activity of PRKDC protein] which results in increased phosphorylation of and results in increased activity of MAPK9 protein] promotes the reaction [MAPK9 protein binds to TP53 protein]] inhibits the reaction [MDM2 results in increased degradation of and results in decreased stability of TP53 protein] more ... CTD PMID:22366412 more ... arsenite(3-) increases expression ISO MDM2 (Homo sapiens) 6480464 arsenite results in increased expression of MDM2 mRNA more ... CTD PMID:30177839 and PMID:34425169 arsenous acid decreases expression ISO MDM2 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of MDM2 mRNA CTD PMID:20458559 arsenous acid multiple interactions EXP 6480464 pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA] CTD PMID:17487067 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of MDM2 mRNA CTD PMID:17487067 arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of MDM2 mRNA CTD PMID:21145380 arsenous acid increases expression ISO MDM2 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of MDM2 mRNA CTD PMID:20862710 more ... aspartame multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA CTD PMID:23783067 atorvastatin calcium increases expression ISO MDM2 (Homo sapiens) 6480464 Atorvastatin results in increased expression of MDM2 protein CTD PMID:29630879 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of MDM2 gene CTD PMID:28931070 and PMID:35440735 avobenzone increases expression ISO MDM2 (Homo sapiens) 6480464 avobenzone results in increased expression of MDM2 mRNA CTD PMID:31016361 azoxystrobin increases expression ISO MDM2 (Homo sapiens) 6480464 azoxystrobin results in increased expression of MDM2 protein CTD PMID:32339800 benzene multiple interactions ISO Mdm2 (Mus musculus) 6480464 TRP53 protein affects the reaction [Benzene results in increased expression of MDM2 mRNA] CTD PMID:11896287 benzene increases expression ISO Mdm2 (Mus musculus) 6480464 Benzene results in increased expression of MDM2 mRNA CTD PMID:11896287 more ... benzene multiple interactions ISO MDM2 (Homo sapiens) 6480464 MDM2 gene polymorphism affects the reaction [CDKN2A gene polymorphism affects the susceptibility to Benzene] CTD PMID:19596022 benzene multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA CTD PMID:17905399 benzo[a]pyrene increases expression ISO MDM2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of MDM2 mRNA more ... CTD PMID:10837373 more ... benzo[a]pyrene decreases expression ISO MDM2 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of MDM2 mRNA CTD PMID:30562542 benzo[a]pyrene multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 benzo[a]pyrene increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased phosphorylation of MDM2 protein CTD PMID:20840854 and PMID:25744307 benzo[a]pyrene increases expression ISO Mdm2 (Mus musculus) 6480464 Benzo(a)pyrene metabolite results in increased expression of MDM2 mRNA and Benzo(a)pyrene results in increased expression of MDM2 mRNA CTD PMID:18656336 more ... benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of MDM2 protein CTD PMID:21467743 benzo[a]pyrene multiple interactions ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:10837373 more ... benzo[a]pyrene diol epoxide I increases expression ISO MDM2 (Homo sapiens) 6480464 7 more ... CTD PMID:20382639 more ... benzo[b]fluoranthene increases expression ISO Mdm2 (Mus musculus) 6480464 benzo(b)fluoranthene results in increased expression of MDM2 mRNA CTD PMID:26377693 benzo[b]fluoranthene multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 beta-naphthoflavone increases phosphorylation EXP 6480464 beta-Naphthoflavone results in increased phosphorylation of MDM2 protein CTD PMID:26558467 biphenyl-4-amine increases expression ISO MDM2 (Homo sapiens) 6480464 4-biphenylamine results in increased expression of MDM2 mRNA CTD PMID:32905825 biphenyl-4-amine multiple interactions ISO MDM2 (Homo sapiens) 6480464 TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA] CTD PMID:32905825 bis(2-chloroethyl) sulfide affects expression EXP 6480464 Mustard Gas affects the expression of MDM2 mRNA CTD PMID:15651846 bis(2-chloroethyl) sulfide increases expression ISO MDM2 (Homo sapiens) 6480464 Mustard Gas results in increased expression of MDM2 mRNA CTD PMID:33491125 bis(2-chloroethyl) sulfide increases expression ISO Mdm2 (Mus musculus) 6480464 Mustard Gas results in increased expression of MDM2 mRNA CTD PMID:15674843 and PMID:18955075 bis(2-ethylhexyl) phthalate increases expression ISO MDM2 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of MDM2 mRNA CTD PMID:31163220 bis(2-ethylhexyl) phthalate decreases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in decreased phosphorylation of MDM2 protein CTD PMID:31163220 bisphenol A increases expression ISO Mdm2 (Mus musculus) 6480464 bisphenol A results in increased expression of MDM2 mRNA CTD PMID:26063408 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of MDM2 mRNA CTD PMID:30816183 more ... bisphenol A increases expression ISO MDM2 (Homo sapiens) 6480464 bisphenol A analog results in increased expression of MDM2 mRNA and bisphenol A results in increased expression of MDM2 mRNA CTD PMID:29275510 and PMID:32387340 bisphenol A affects expression ISO MDM2 (Homo sapiens) 6480464 bisphenol A affects the expression of MDM2 mRNA CTD PMID:30903817 bisphenol A multiple interactions ISO MDM2 (Homo sapiens) 6480464 [naringenin co-treated with bisphenol A] results in increased expression of MDM2 mRNA more ... CTD PMID:24831732 and PMID:36235125 bisphenol A increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 bisphenol A results in increased phosphorylation of MDM2 protein CTD PMID:24831732 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of MDM2 mRNA CTD PMID:25181051 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of MDM2 mRNA CTD PMID:26982218 bisphenol F increases expression ISO Mdm2 (Mus musculus) 6480464 bisphenol F results in increased expression of MDM2 mRNA CTD PMID:35387338 bortezomib multiple interactions ISO MDM2 (Homo sapiens) 6480464 [CASP8 protein results in increased activity of CASP3 protein] affects the reaction [Bortezomib results in increased cleavage of MDM2 protein] and Bortezomib promotes the reaction [TP53 protein binds to MDM2 protein] CTD PMID:12393500 bortezomib increases cleavage ISO MDM2 (Homo sapiens) 6480464 Bortezomib results in increased cleavage of MDM2 protein CTD PMID:12393500 bortezomib affects expression ISO MDM2 (Homo sapiens) 6480464 Bortezomib affects the expression of MDM2 protein CTD PMID:12393500 brassinolide decreases expression ISO MDM2 (Homo sapiens) 6480464 brassinolide results in decreased expression of MDM2 protein CTD PMID:20833159 cadmium atom decreases expression EXP 6480464 Cadmium results in decreased expression of MDM2 mRNA CTD PMID:21467746 cadmium atom increases expression ISO Mdm2 (Mus musculus) 6480464 Cadmium results in increased expression of MDM2 mRNA CTD PMID:22666406 cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of MDM2 mRNA CTD PMID:22110744 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of MDM2 mRNA CTD PMID:31077537 cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of MDM2 mRNA CTD PMID:31077537 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of MDM2 mRNA CTD PMID:23405080 cadmium dichloride multiple interactions ISO MDM2 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MDM2 protein] more ... CTD PMID:25744307 cadmium dichloride increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Cadmium Chloride results in increased phosphorylation of MDM2 protein CTD PMID:25744307 cadmium dichloride increases expression ISO Mdm2 (Mus musculus) 6480464 Cadmium Chloride results in increased expression of MDM2 mRNA CTD PMID:11958953 more ... cadmium dichloride increases phosphorylation ISO Mdm2 (Mus musculus) 6480464 Cadmium Chloride results in increased phosphorylation of MDM2 protein CTD PMID:20525538 and PMID:22314386 cadmium dichloride multiple interactions ISO Mdm2 (Mus musculus) 6480464 Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein] more ... CTD PMID:11958953 and PMID:12135628 caffeine decreases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Caffeine results in decreased phosphorylation of MDM2 protein CTD PMID:35688186 camptothecin increases expression ISO MDM2 (Homo sapiens) 6480464 Camptothecin results in increased expression of MDM2 protein CTD PMID:17555331 cannabidiol multiple interactions ISO Mdm2 (Mus musculus) 6480464 [lipopolysaccharide and E coli O55-B5 co-treated with Cannabidiol] results in increased expression of MDM2 mRNA CTD PMID:30742662 cannabidiol increases expression ISO MDM2 (Homo sapiens) 6480464 Cannabidiol results in increased expression of MDM2 mRNA CTD PMID:27932991 and PMID:30713602 cannabidiol increases expression ISO Mdm2 (Mus musculus) 6480464 Cannabidiol results in increased expression of MDM2 mRNA CTD PMID:30742662 cantharidin decreases expression ISO MDM2 (Homo sapiens) 6480464 Cantharidin results in decreased expression of MDM2 mRNA CTD PMID:31945315 capsaicin multiple interactions ISO MDM2 (Homo sapiens) 6480464 Capsaicin promotes the reaction [resveratrol results in decreased expression of MDM2 protein] more ... CTD PMID:19846903 capsaicin increases expression ISO MDM2 (Homo sapiens) 6480464 Capsaicin results in increased expression of MDM2 mRNA CTD PMID:19502594 capsaicin decreases expression ISO MDM2 (Homo sapiens) 6480464 Capsaicin results in decreased expression of MDM2 protein CTD PMID:19846903 Carbadox increases expression EXP 6480464 Carbadox results in increased expression of MDM2 mRNA CTD PMID:26558467 carbamazepine affects expression ISO MDM2 (Homo sapiens) 6480464 Carbamazepine affects the expression of MDM2 mRNA CTD PMID:25979313 carbonyl cyanide p-trifluoromethoxyphenylhydrazone decreases expression ISO MDM2 (Homo sapiens) 6480464 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of MDM2 mRNA CTD PMID:16039398 chlorambucil increases expression ISO MDM2 (Homo sapiens) 6480464 Chlorambucil results in increased expression of MDM2 mRNA CTD PMID:17476690 chloroacetaldehyde increases expression ISO MDM2 (Homo sapiens) 6480464 chloroacetaldehyde results in increased expression of MDM2 mRNA CTD PMID:25596134 chloroethene affects response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 polymorphism affects the susceptibility to Vinyl Chloride CTD PMID:24464562 chloroprene increases expression ISO Mdm2 (Mus musculus) 6480464 Chloroprene results in increased expression of MDM2 mRNA CTD PMID:23125180 chlorpromazine increases expression EXP 6480464 Chlorpromazine results in increased expression of MDM2 mRNA CTD PMID:25596134 chlorpyrifos increases expression ISO MDM2 (Homo sapiens) 6480464 Chlorpyrifos results in increased expression of MDM2 mRNA CTD PMID:30981936 chlorpyrifos decreases expression ISO Mdm2 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of MDM2 mRNA CTD PMID:37019170 choline multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MDM2 gene CTD PMID:20938992 chrysene multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 cidofovir anhydrous affects expression ISO MDM2 (Homo sapiens) 6480464 Cidofovir affects the expression of MDM2 mRNA CTD PMID:25596134 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of MDM2 mRNA CTD PMID:24880025 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of MDM2 mRNA and Cisplatin results in decreased expression of MDM2 protein CTD PMID:35842499 cisplatin multiple interactions EXP 6480464 Cisplatin promotes the reaction [NFE2L2 protein results in increased expression of MDM2 mRNA] more ... CTD PMID:35842499 cisplatin increases expression ISO Mdm2 (Mus musculus) 6480464 Cisplatin results in increased expression of MDM2 mRNA and Cisplatin results in increased expression of MDM2 protein CTD PMID:21151649 more ... cisplatin multiple interactions ISO Mdm2 (Mus musculus) 6480464 Cisplatin promotes the reaction [TRP53 protein results in increased expression of MDM2] more ... CTD PMID:21552291 and PMID:35842499 cisplatin increases expression ISO MDM2 (Homo sapiens) 6480464 Cisplatin results in increased expression of MDM2 mRNA and Cisplatin results in increased expression of MDM2 protein CTD PMID:16797627 more ... cisplatin multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Cisplatin co-treated with eprenetapopt co-treated with Oxygen deficiency] results in increased expression of MDM2 mRNA more ... CTD PMID:21509038 more ... clofibrate multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA] CTD PMID:17585979 cobalt atom increases expression ISO MDM2 (Homo sapiens) 6480464 Cobalt results in increased expression of MDM2 mRNA CTD PMID:24068677 cobalt atom multiple interactions ISO MDM2 (Homo sapiens) 6480464 TP53 protein affects the reaction [Cobalt results in increased expression of MDM2 mRNA] CTD PMID:24068677 cobalt dichloride increases expression ISO MDM2 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of MDM2 protein CTD PMID:19714248 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of MDM2 mRNA CTD PMID:24386269 cobalt dichloride multiple interactions ISO MDM2 (Homo sapiens) 6480464 MDM2 protein promotes the reaction [cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]] CTD PMID:19714248 copper atom increases expression ISO Mdm2 (Mus musculus) 6480464 Copper results in increased expression of MDM2 mRNA CTD PMID:16629173 copper atom multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of MDM2 mRNA CTD PMID:30911355 copper(0) increases expression ISO Mdm2 (Mus musculus) 6480464 Copper results in increased expression of MDM2 mRNA CTD PMID:16629173 copper(0) multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of MDM2 mRNA CTD PMID:30911355 corn oil decreases expression EXP 6480464 Corn Oil results in decreased expression of MDM2 mRNA CTD PMID:22760963 coumarin decreases expression ISO MDM2 (Homo sapiens) 6480464 coumarin analog results in decreased expression of MDM2 mRNA CTD PMID:32578917 crocidolite asbestos decreases expression ISO Mdm2 (Mus musculus) 6480464 Asbestos and Crocidolite results in decreased expression of MDM2 mRNA CTD PMID:29279043 cryptolepine increases expression ISO MDM2 (Homo sapiens) 6480464 cryptolepine results in increased expression of MDM2 mRNA and cryptolepine results in increased expression of MDM2 protein CTD PMID:16120219 curcumin decreases expression ISO MDM2 (Homo sapiens) 6480464 [Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA more ... CTD PMID:17332326 curcumin increases expression ISO MDM2 (Homo sapiens) 6480464 Curcumin analog results in increased expression of MDM2 mRNA CTD PMID:26409325 curcumin multiple interactions ISO MDM2 (Homo sapiens) 6480464 Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein] CTD PMID:24831732 cyclosporin A increases expression ISO MDM2 (Homo sapiens) 6480464 Cyclosporine results in increased expression of MDM2 mRNA CTD PMID:20106945 more ... cylindrospermopsin increases expression ISO MDM2 (Homo sapiens) 6480464 cylindrospermopsin results in increased expression of MDM2 mRNA CTD PMID:21607682 cylindrospermopsin multiple interactions ISO MDM2 (Homo sapiens) 6480464 [4 and 4'-hexafluorisopropylidene diphenol co-treated with cylindrospermopsin] results in increased expression of MDM2 mRNA CTD PMID:32244372 cyproconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA and [cyproconazole co-treated with epoxiconazole] results in increased expression of MDM2 mRNA CTD PMID:29038839 DAPT increases expression ISO MDM2 (Homo sapiens) 6480464 N-(N-(3 and 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein CTD PMID:25005833 DAPT multiple interactions ISO MDM2 (Homo sapiens) 6480464 Hydrogen Peroxide inhibits the reaction [N-(N-(3 and 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein] CTD PMID:25005833 DDT multiple interactions ISO Mdm2 (Mus musculus) 6480464 Androstanols inhibits the reaction [DDT results in increased expression of MDM2 mRNA] CTD PMID:23684557 DDT increases expression ISO Mdm2 (Mus musculus) 6480464 DDT results in increased expression of MDM2 mRNA and DDT results in increased expression of MDM2 protein CTD PMID:23684557 deguelin increases expression ISO MDM2 (Homo sapiens) 6480464 deguelin results in increased expression of MDM2 mRNA CTD PMID:33512557 deoxynivalenol increases expression ISO MDM2 (Homo sapiens) 6480464 deoxynivalenol results in increased expression of MDM2 mRNA CTD PMID:31863870 diallyl disulfide multiple interactions EXP 6480464 [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of MDM2 mRNA CTD PMID:31077537 diallyl trisulfide decreases expression ISO MDM2 (Homo sapiens) 6480464 diallyl trisulfide results in decreased expression of MDM2 protein CTD PMID:24415872 diallyl trisulfide increases degradation ISO MDM2 (Homo sapiens) 6480464 diallyl trisulfide results in increased degradation of MDM2 protein CTD PMID:23754639 diarsenic trioxide multiple interactions EXP 6480464 pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA] CTD PMID:17487067 diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of MDM2 mRNA CTD PMID:21145380 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of MDM2 mRNA CTD PMID:17487067 diarsenic trioxide decreases expression ISO MDM2 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of MDM2 mRNA CTD PMID:20458559 diarsenic trioxide increases expression ISO MDM2 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of MDM2 mRNA CTD PMID:20862710 more ... diazinon affects expression EXP 6480464 Diazinon affects the expression of MDM2 mRNA CTD PMID:22546817 dibenz[a,h]anthracene increases expression ISO Mdm2 (Mus musculus) 6480464 1 more ... CTD PMID:26377693 diclofenac decreases expression EXP 6480464 Diclofenac results in decreased expression of MDM2 mRNA CTD PMID:17202759 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of MDM2 mRNA CTD PMID:22546817 diepoxybutane multiple interactions ISO MDM2 (Homo sapiens) 6480464 diepoxybutane inhibits the reaction [TP53 protein binds to MDM2 protein] CTD PMID:20024960 diethylstilbestrol affects mutagenesis ISO Mdm2 (Mus musculus) 6480464 Diethylstilbestrol affects the mutagenesis of MDM2 gene CTD PMID:7916985 diethylstilbestrol decreases expression ISO Mdm2 (Mus musculus) 6480464 Diethylstilbestrol results in decreased expression of MDM2 mRNA CTD PMID:21041162 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of MDM2 mRNA CTD PMID:15890375 diethylstilbestrol increases expression ISO Mdm2 (Mus musculus) 6480464 Diethylstilbestrol results in increased expression of MDM2 mRNA CTD PMID:15545218 dimethylarsinic acid increases expression EXP 6480464 Cacodylic Acid results in increased expression of MDM2 mRNA CTD PMID:17481689 dimethylarsinic acid multiple interactions ISO MDM2 (Homo sapiens) 6480464 [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of MDM2 mRNA CTD PMID:23192986 dioxygen multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Cisplatin co-treated with eprenetapopt co-treated with Oxygen deficiency] results in increased expression of MDM2 mRNA more ... CTD PMID:19578757 and PMID:29690507 dioxygen multiple interactions ISO Mdm2 (Mus musculus) 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of MDM2 mRNA CTD PMID:30529165 dioxygen increases expression ISO MDM2 (Homo sapiens) 6480464 Oxygen deficiency results in increased expression of MDM2 mRNA and Oxygen deficiency results in increased expression of MDM2 protein CTD PMID:19502547 more ... disodium selenite increases expression ISO MDM2 (Homo sapiens) 6480464 Sodium Selenite results in increased expression of MDM2 mRNA CTD PMID:24383545 dorsomorphin multiple interactions ISO MDM2 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin multiple interactions ISO MDM2 (Homo sapiens) 6480464 Doxorubicin inhibits the reaction [TP53 protein binds to MDM2 protein] more ... CTD PMID:17935137 more ... doxorubicin affects expression ISO Mdm2 (Mus musculus) 6480464 Doxorubicin affects the expression of MDM2 mRNA CTD PMID:29653124 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of MDM2 mRNA CTD PMID:12187937 more ... doxorubicin increases expression ISO MDM2 (Homo sapiens) 6480464 Doxorubicin results in increased expression of MDM2 mRNA and Doxorubicin results in increased expression of MDM2 protein CTD PMID:14665630 more ... doxorubicin decreases response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 protein results in decreased susceptibility to Doxorubicin CTD PMID:26317544 doxorubicin affects expression ISO MDM2 (Homo sapiens) 6480464 Doxorubicin affects the expression of MDM2 mRNA CTD PMID:25529476 and PMID:29803840 doxorubicin increases expression ISO Mdm2 (Mus musculus) 6480464 Doxorubicin results in increased expression of MDM2 mRNA CTD PMID:14766674 more ... doxorubicin multiple interactions ISO Mdm2 (Mus musculus) 6480464 pifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA] CTD PMID:14766674 doxorubicin increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Doxorubicin results in increased phosphorylation of MDM2 protein CTD PMID:17935137 ellipticine decreases response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 promoter SNP results in decreased susceptibility to ellipticine CTD PMID:17575151 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of MDM2 mRNA CTD PMID:29391264 epoxiconazole increases expression EXP 6480464 epoxiconazole results in increased expression of MDM2 mRNA CTD PMID:29038839 epoxiconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA and [cyproconazole co-treated with epoxiconazole] results in increased expression of MDM2 mRNA CTD PMID:29038839 ethanol decreases expression ISO Mdm2 (Mus musculus) 6480464 Ethanol results in decreased expression of MDM2 mRNA CTD PMID:22535522 ethyl methanesulfonate increases expression ISO MDM2 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of MDM2 mRNA CTD PMID:23649840 etoposide increases expression ISO MDM2 (Homo sapiens) 6480464 Etoposide results in increased expression of MDM2 mRNA more ... CTD PMID:16120219 more ... etoposide decreases expression ISO MDM2 (Homo sapiens) 6480464 Etoposide results in decreased expression of MDM2 protein CTD PMID:26259609 etoposide increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Etoposide results in increased phosphorylation of MDM2 protein CTD PMID:17935137 and PMID:25744307 etoposide increases expression EXP 6480464 Etoposide results in increased expression of MDM2 protein CTD PMID:15459018 etoposide multiple interactions EXP 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein] CTD PMID:15459018 etoposide decreases response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 promoter SNP results in decreased susceptibility to Etoposide CTD PMID:17575151 etoposide multiple interactions ISO MDM2 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] more ... CTD PMID:17575151 more ... EUK-134 multiple interactions ISO MDM2 (Homo sapiens) 6480464 EUK-134 inhibits the reaction [Hydrogen Peroxide results in decreased expression of MDM2 protein] and EUK-134 inhibits the reaction [Vitamin K 3 results in decreased expression of MDM2 protein] CTD PMID:25005833 fenbendazole increases expression EXP 6480464 Fenbendazole results in increased expression of MDM2 mRNA CTD PMID:23411599 fenofibrate decreases expression EXP 6480464 Fenofibrate results in decreased expression of MDM2 mRNA CTD PMID:25596134 fipronil increases expression EXP 6480464 fipronil results in increased expression of MDM2 mRNA CTD PMID:23962444 flavanones increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Flavanones results in increased phosphorylation of MDM2 protein CTD PMID:21616090 flucytosine increases expression ISO MDM2 (Homo sapiens) 6480464 Flucytosine results in increased expression of MDM2 protein CTD PMID:15592511 fluoranthene multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of MDM2 mRNA CTD PMID:17690111 flutamide increases expression EXP 6480464 Flutamide results in increased expression of MDM2 mRNA CTD PMID:24136188 folic acid affects expression ISO MDM2 (Homo sapiens) 6480464 Folic Acid affects the expression of MDM2 mRNA CTD PMID:16361273 folic acid multiple interactions ISO Mdm2 (Mus musculus) 6480464 [1 more ... CTD PMID:20938992 and PMID:22206623 formaldehyde increases expression EXP 6480464 Formaldehyde results in increased expression of MDM2 mRNA and Formaldehyde results in increased expression of MDM2 protein CTD PMID:18045764 formaldehyde increases expression ISO MDM2 (Homo sapiens) 6480464 Formaldehyde results in increased expression of MDM2 mRNA and Formaldehyde results in increased expression of MDM2 protein CTD PMID:18045764 and PMID:23649840 formononetin increases expression EXP 6480464 formononetin results in increased expression of MDM2 protein CTD PMID:28414026 fumonisin B1 multiple interactions ISO MDM2 (Homo sapiens) 6480464 fumonisin B1 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA] and fumonisin B1 inhibits the reaction [AGT protein results in increased expression of MDM2 protein] CTD PMID:18206046 furan increases expression EXP 6480464 furan results in increased expression of MDM2 mRNA CTD PMID:22079235 furosemide affects expression EXP 6480464 Furosemide affects the expression of MDM2 mRNA CTD PMID:17497460 ganciclovir increases expression ISO MDM2 (Homo sapiens) 6480464 Ganciclovir results in increased expression of MDM2 protein CTD PMID:15592511 geldanamycin increases expression ISO MDM2 (Homo sapiens) 6480464 geldanamycin results in increased expression of MDM2 mRNA CTD PMID:26705709 gemcitabine increases expression ISO MDM2 (Homo sapiens) 6480464 Gemcitabine results in increased expression of MDM2 mRNA CTD PMID:17039268 gemcitabine decreases expression ISO MDM2 (Homo sapiens) 6480464 Gemcitabine results in decreased expression of MDM2 mRNA CTD PMID:20103597 genistein decreases expression ISO Mdm2 (Mus musculus) 6480464 Genistein results in decreased expression of MDM2 mRNA CTD PMID:21048042 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of MDM2 mRNA CTD PMID:22061828 and PMID:33387578 glyphosate decreases expression ISO MDM2 (Homo sapiens) 6480464 glyphosate results in decreased expression of MDM2 mRNA CTD PMID:31295307 gold atom decreases expression ISO MDM2 (Homo sapiens) 6480464 Gold analog results in decreased expression of MDM2 mRNA CTD PMID:36057382 gold(0) decreases expression ISO MDM2 (Homo sapiens) 6480464 Gold analog results in decreased expression of MDM2 mRNA CTD PMID:36057382 GW 501516 multiple interactions EXP 6480464 MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein] CTD PMID:19103650 hydrogen peroxide multiple interactions ISO MDM2 (Homo sapiens) 6480464 EUK-134 inhibits the reaction [Hydrogen Peroxide results in decreased expression of MDM2 protein] more ... CTD PMID:21552291 and PMID:25005833 hydrogen peroxide increases expression ISO MDM2 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of MDM2 mRNA CTD PMID:21751221 hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of MDM2 mRNA CTD PMID:14689451 and PMID:27525270 hydrogen peroxide multiple interactions EXP 6480464 [Quercetin co-treated with Hydrogen Peroxide] results in increased expression of MDM2 mRNA more ... CTD PMID:14689451 and PMID:27525270 hydrogen peroxide decreases expression ISO MDM2 (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of MDM2 protein CTD PMID:25005833 hydrogen peroxide multiple interactions ISO Mdm2 (Mus musculus) 6480464 Hydrogen Peroxide promotes the reaction [TRP53 protein results in increased expression of MDM2] CTD PMID:21552291 hydroquinone increases expression ISO MDM2 (Homo sapiens) 6480464 hydroquinone results in increased expression of MDM2 mRNA CTD PMID:29221148 hydroxyurea increases expression ISO MDM2 (Homo sapiens) 6480464 Hydroxyurea results in increased expression of MDM2 mRNA CTD PMID:18647660 hydroxyurea increases expression ISO Mdm2 (Mus musculus) 6480464 Hydroxyurea results in increased expression of MDM2 mRNA CTD PMID:16356682 hydroxyurea affects expression ISO Mdm2 (Mus musculus) 6480464 Hydroxyurea affects the expression of MDM2 protein CTD PMID:16356682 ifosfamide increases expression ISO MDM2 (Homo sapiens) 6480464 Ifosfamide results in increased expression of MDM2 mRNA CTD PMID:25596134 Indeno[1,2,3-cd]pyrene increases expression ISO MDM2 (Homo sapiens) 6480464 indeno(1 more ... CTD PMID:32251684 irinotecan increases expression ISO MDM2 (Homo sapiens) 6480464 Irinotecan metabolite results in increased expression of MDM2 mRNA and Irinotecan results in increased expression of MDM2 mRNA CTD PMID:15956246 isoflurane decreases expression EXP 6480464 Isoflurane results in decreased expression of MDM2 mRNA CTD PMID:16978161 kojic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MDM2 mRNA CTD PMID:18544905 L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of MDM2 protein] CTD PMID:21262251 L-methionine multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MDM2 gene CTD PMID:20938992 leflunomide increases expression ISO MDM2 (Homo sapiens) 6480464 leflunomide results in increased expression of MDM2 mRNA CTD PMID:28988120 leptomycin B increases expression ISO MDM2 (Homo sapiens) 6480464 leptomycin B results in increased expression of MDM2 mRNA CTD PMID:20803015 Leucomalachite green increases phosphorylation EXP 6480464 leucomalachite green results in increased phosphorylation of MDM2 protein CTD PMID:26558467 linalool increases expression ISO MDM2 (Homo sapiens) 6480464 linalool results in increased expression of MDM2 mRNA CTD PMID:19922762 lipopolysaccharide multiple interactions ISO Mdm2 (Mus musculus) 6480464 Indirubin E804 inhibits the reaction [Lipopolysaccharides results in increased expression of MDM2 mRNA] CTD PMID:23107598 lipopolysaccharide increases expression ISO MDM2 (Homo sapiens) 6480464 Lipopolysaccharides results in increased expression of MDM2 mRNA CTD PMID:35953652 lipopolysaccharide increases expression ISO Mdm2 (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of MDM2 mRNA CTD PMID:10975854 and PMID:23107598 lupeol multiple interactions ISO MDM2 (Homo sapiens) 6480464 lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 luteolin increases expression EXP 6480464 Luteolin results in increased expression of MDM2 mRNA CTD PMID:31201582 luteolin multiple interactions EXP 6480464 Luteolin promotes the reaction [Hydrogen Peroxide results in increased expression of MDM2 mRNA] CTD PMID:27525270 LY294002 increases expression ISO MDM2 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of MDM2 protein CTD PMID:16412023 mancozeb multiple interactions ISO MDM2 (Homo sapiens) 6480464 lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 mancozeb increases expression ISO MDM2 (Homo sapiens) 6480464 mancozeb results in increased expression of MDM2 mRNA CTD PMID:27235710 manganese atom multiple interactions EXP 6480464 [Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein and PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein] CTD PMID:25791630 manganese atom decreases expression EXP 6480464 Manganese results in decreased expression of MDM2 protein CTD PMID:25791630 manganese(0) decreases expression EXP 6480464 Manganese results in decreased expression of MDM2 protein CTD PMID:25791630 manganese(0) multiple interactions EXP 6480464 [Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein and PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein] CTD PMID:25791630 manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of MDM2 mRNA CTD PMID:28801915 menadione decreases expression ISO MDM2 (Homo sapiens) 6480464 Vitamin K 3 results in decreased expression of MDM2 protein CTD PMID:25005833 menadione multiple interactions ISO MDM2 (Homo sapiens) 6480464 EUK-134 inhibits the reaction [Vitamin K 3 results in decreased expression of MDM2 protein] CTD PMID:25005833 mercury dibromide increases expression ISO MDM2 (Homo sapiens) 6480464 mercuric bromide results in increased expression of MDM2 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO MDM2 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA CTD PMID:27188386 mercury dichloride decreases expression ISO Mdm2 (Mus musculus) 6480464 Mercuric Chloride results in decreased expression of MDM2 mRNA CTD PMID:23202902 metformin increases expression EXP 6480464 Metformin results in increased expression of MDM2 mRNA CTD PMID:25596134 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of MDM2 mRNA CTD PMID:22584684 methapyrilene increases phosphorylation EXP 6480464 Methapyrilene results in increased phosphorylation of MDM2 protein CTD PMID:26558467 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of MDM2 mRNA CTD PMID:15890375 more ... methotrexate multiple interactions ISO MDM2 (Homo sapiens) 6480464 Methotrexate results in increased activity of and results in increased expression of MDM2 protein more ... CTD PMID:21624110 methotrexate affects expression ISO Mdm2 (Mus musculus) 6480464 Methotrexate affects the expression of MDM2 mRNA CTD PMID:18502557 methotrexate increases expression ISO MDM2 (Homo sapiens) 6480464 Methotrexate results in increased expression of MDM2 mRNA and Methotrexate results in increased expression of MDM2 protein CTD PMID:17637740 more ... methyl caffeate affects binding ISO MDM2 (Homo sapiens) 6480464 methyl caffeate binds to MDM2 protein CTD PMID:26415618 methyl methanesulfonate increases expression ISO MDM2 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of MDM2 mRNA and Methyl Methanesulfonate results in increased expression of MDM2 protein CTD PMID:23649840 and PMID:25078064 methylarsonic acid increases expression EXP 6480464 monomethylarsonic acid results in increased expression of MDM2 mRNA CTD PMID:17481689 methylarsonic acid multiple interactions ISO MDM2 (Homo sapiens) 6480464 [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of MDM2 mRNA CTD PMID:23192986 methylmercury chloride decreases expression ISO Mdm2 (Mus musculus) 6480464 methylmercuric chloride results in decreased expression of MDM2 mRNA CTD PMID:23202902 methylmercury chloride increases expression ISO MDM2 (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of MDM2 mRNA CTD PMID:28001369 methylmercury(1+) multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA CTD PMID:17905399 microcystin-LR decreases expression EXP 6480464 cyanoginosin LR results in decreased expression of MDM2 protein CTD PMID:31157505 microcystin-LR decreases expression ISO Mdm2 (Mus musculus) 6480464 cyanoginosin LR results in decreased expression of MDM2 mRNA and cyanoginosin LR results in decreased expression of MDM2 protein CTD PMID:28414124 mifepristone increases expression ISO Mdm2 (Mus musculus) 6480464 Mifepristone results in increased expression of MDM2 mRNA CTD PMID:12605714 mitomycin C multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Mitomycin results in increased stability of TP53 protein] which results in increased expression of MDM2 mRNA CTD PMID:20536192 mitomycin C increases expression ISO MDM2 (Homo sapiens) 6480464 Mitomycin results in increased expression of MDM2 protein CTD PMID:18096571 mitomycin C increases expression ISO Mdm2 (Mus musculus) 6480464 Mitomycin results in increased expression of MDM2 mRNA CTD PMID:25270620 mitoxantrone decreases response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 promoter SNP results in decreased susceptibility to Mitoxantrone CTD PMID:17575151 mono(2-ethylhexyl) phthalate decreases expression ISO MDM2 (Homo sapiens) 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of MDM2 protein CTD PMID:24706461 monocrotaline multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 monosodium L-glutamate multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Fats and Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA CTD PMID:23783067 motexafin gadolinium multiple interactions ISO MDM2 (Homo sapiens) 6480464 motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA] CTD PMID:16357179 motexafin gadolinium increases expression ISO MDM2 (Homo sapiens) 6480464 motexafin gadolinium results in increased expression of MDM2 mRNA CTD PMID:16357179 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine increases expression ISO MDM2 (Homo sapiens) 6480464 N more ... CTD PMID:33645215 N-acetylsphingosine decreases expression ISO MDM2 (Homo sapiens) 6480464 N-acetylsphingosine results in decreased expression of MDM2 mRNA and N-acetylsphingosine results in decreased expression of MDM2 protein CTD PMID:18206046 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO Mdm2 (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MDM2 mRNA CTD PMID:20061341 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO MDM2 (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] CTD PMID:17575151 N-ethyl-N-nitrosourea increases expression EXP 6480464 Ethylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:15954086 N-ethyl-N-nitrosourea increases expression ISO Mdm2 (Mus musculus) 6480464 Ethylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:19100860 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO MDM2 (Homo sapiens) 6480464 Methylnitronitrosoguanidine results in increased expression of MDM2 mRNA CTD PMID:12634122 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO Mdm2 (Mus musculus) 6480464 Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein] CTD PMID:12135628 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO Mdm2 (Mus musculus) 6480464 Methylnitronitrosoguanidine results in increased expression of MDM2 protein CTD PMID:12135628 N-methyl-N-nitrosourea increases expression EXP 6480464 Methylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:28688903 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein and [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MDM2 mRNA CTD PMID:11003613 and PMID:18544905 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of MDM2 mRNA and Diethylnitrosamine results in increased expression of MDM2 protein CTD PMID:14555611 more ... N-nitrosodiethylamine multiple interactions ISO Mdm2 (Mus musculus) 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MDM2 mRNA] CTD PMID:17854601 N-nitrosodiethylamine increases expression ISO Mdm2 (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of MDM2 mRNA and Diethylnitrosamine results in increased expression of MDM2 protein CTD PMID:17854601 more ... N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of MDM2 mRNA CTD PMID:14600272 and PMID:15890375 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of MDM2 mRNA and N-nitrosomorpholine results in increased expression of MDM2 protein CTD PMID:14587038 and PMID:19716841 N-Vinyl-2-pyrrolidone multiple interactions EXP 6480464 [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of MDM2 mRNA CTD PMID:22037397 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of MDM2 mRNA CTD PMID:24136188 nickel atom increases expression ISO MDM2 (Homo sapiens) 6480464 Nickel results in increased expression of MDM2 mRNA CTD PMID:24068677 nickel atom multiple interactions ISO MDM2 (Homo sapiens) 6480464 TP53 protein affects the reaction [Nickel results in increased expression of MDM2 mRNA] CTD PMID:24068677 nickel dichloride increases expression ISO MDM2 (Homo sapiens) 6480464 nickel chloride results in increased expression of MDM2 mRNA CTD PMID:23566959 and PMID:28552779 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of MDM2 mRNA CTD PMID:22546817 nickel dichloride multiple interactions ISO MDM2 (Homo sapiens) 6480464 TP53 protein affects the reaction [nickel chloride results in increased expression of MDM2 mRNA] CTD PMID:23566959 nicotinamide increases expression ISO MDM2 (Homo sapiens) 6480464 Niacinamide results in increased expression of MDM2 mRNA CTD PMID:16998810 nicotine multiple interactions ISO MDM2 (Homo sapiens) 6480464 [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein and [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of MDM2 mRNA CTD PMID:24136188 nitenpyram increases expression ISO MDM2 (Homo sapiens) 6480464 nitenpyram results in increased expression of MDM2 mRNA CTD PMID:35568224 Nodularin increases expression ISO MDM2 (Homo sapiens) 6480464 nodularin results in increased expression of MDM2 mRNA CTD PMID:30562542 Nutlin-3 multiple interactions ISO MDM2 (Homo sapiens) 6480464 [nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]] which results in increased activity of TP53 protein more ... CTD PMID:16439685 more ... Nutlin-3 decreases expression ISO MDM2 (Homo sapiens) 6480464 nutlin 3 results in decreased expression of MDM2 protein CTD PMID:35213076 Nutlin-3 increases expression ISO Mdm2 (Mus musculus) 6480464 nutlin 3 results in increased expression of MDM2 mRNA CTD PMID:16949053 Nutlin-3 increases expression ISO MDM2 (Homo sapiens) 6480464 nutlin 3 results in increased expression of MDM2 mRNA more ... CTD PMID:16014563 more ... O-methyleugenol increases expression EXP 6480464 methyleugenol results in increased expression of MDM2 mRNA CTD PMID:26011634 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of MDM2 mRNA CTD PMID:23358140 ochratoxin A decreases expression ISO MDM2 (Homo sapiens) 6480464 ochratoxin A results in decreased expression of MDM2 mRNA CTD PMID:30763683 Octicizer increases expression ISO MDM2 (Homo sapiens) 6480464 2-ethylhexyldiphenylphosphate results in increased expression of MDM2 mRNA CTD PMID:30981936 ortho-Aminoazotoluene increases expression ISO Mdm2 (Mus musculus) 6480464 o-Aminoazotoluene results in increased expression of MDM2 mRNA CTD PMID:15346788 ouabain multiple interactions ISO MDM2 (Homo sapiens) 6480464 Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein CTD PMID:31436044 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of MDM2 mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MDM2 mRNA CTD PMID:25729387 oxfendazole decreases phosphorylation EXP 6480464 oxfendazole results in decreased phosphorylation of MDM2 protein CTD PMID:26558467 oxfendazole increases expression EXP 6480464 oxfendazole results in increased expression of MDM2 mRNA CTD PMID:26558467 p-chloromercuribenzoic acid increases expression ISO MDM2 (Homo sapiens) 6480464 p-Chloromercuribenzoic Acid results in increased expression of MDM2 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO MDM2 (Homo sapiens) 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA CTD PMID:27188386 paclitaxel decreases response to substance ISO MDM2 (Homo sapiens) 6480464 MDM2 protein results in decreased susceptibility to Paclitaxel CTD PMID:13130078 palmatine affects binding ISO MDM2 (Homo sapiens) 6480464 palmatine binds to MDM2 protein CTD PMID:35997646 paracetamol multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA] CTD PMID:17585979 paracetamol increases expression ISO MDM2 (Homo sapiens) 6480464 Acetaminophen results in increased expression of MDM2 mRNA CTD PMID:22230336 paracetamol decreases expression ISO MDM2 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of MDM2 mRNA CTD PMID:21420995 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of MDM2 mRNA CTD PMID:21807079 paracetamol increases phosphorylation EXP 6480464 Acetaminophen results in increased phosphorylation of MDM2 protein CTD PMID:16330492 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of MDM2 mRNA CTD PMID:17202762 and PMID:33387578 paracetamol multiple interactions EXP 6480464 Acetaminophen promotes the reaction [MDM2 protein binds to TP53 protein] CTD PMID:16330492 paracetamol affects expression ISO Mdm2 (Mus musculus) 6480464 Acetaminophen affects the expression of MDM2 mRNA CTD PMID:17562736 paracetamol increases expression ISO Mdm2 (Mus musculus) 6480464 Acetaminophen results in increased expression of MDM2 mRNA CTD PMID:26056430 Paraoxon-methyl increases expression ISO MDM2 (Homo sapiens) 6480464 methylparaoxon results in increased expression of MDM2 mRNA CTD PMID:18418871 paraquat multiple interactions ISO Mdm2 (Mus musculus) 6480464 GPX1 protein affects the reaction [Paraquat affects the expression of MDM2 mRNA] CTD PMID:12654481 paraquat increases expression EXP 6480464 Paraquat results in increased expression of MDM2 mRNA CTD PMID:32680482 paraquat increases expression ISO MDM2 (Homo sapiens) 6480464 Paraquat results in increased expression of MDM2 mRNA CTD PMID:20883675 and PMID:34097952 parathion multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Estradiol co-treated with Parathion] results in increased expression of MDM2 mRNA CTD PMID:17622325 parathion-methyl increases expression ISO MDM2 (Homo sapiens) 6480464 Methyl Parathion results in increased expression of MDM2 mRNA CTD PMID:18418871 PCB138 increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 2 more ... CTD PMID:19751709 PD123319 multiple interactions ISO MDM2 (Homo sapiens) 6480464 PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA] and PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein] CTD PMID:18206046 pentachlorophenol increases expression ISO Mdm2 (Mus musculus) 6480464 Pentachlorophenol results in increased expression of MDM2 mRNA CTD PMID:23892564 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of MDM2 mRNA CTD PMID:19162173 phenobarbital increases expression ISO Mdm2 (Mus musculus) 6480464 Phenobarbital results in increased expression of MDM2 mRNA CTD PMID:19482888 more ... phenobarbital multiple interactions ISO Mdm2 (Mus musculus) 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MDM2 mRNA] and NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of MDM2 mRNA] CTD PMID:19482888 phenobarbital increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Phenobarbital results in increased phosphorylation of MDM2 protein CTD PMID:19751709 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of MDM2 mRNA CTD PMID:25145657 phenylmercury acetate increases expression ISO MDM2 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of MDM2 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO MDM2 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA CTD PMID:27188386 phenytoin multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 PhIP increases expression ISO MDM2 (Homo sapiens) 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of MDM2 protein CTD PMID:15635149 phlorizin decreases expression ISO Mdm2 (Mus musculus) 6480464 Phlorhizin results in decreased expression of MDM2 mRNA CTD PMID:22538082 phosphoramide mustard increases expression EXP 6480464 phosphoramide mustard results in increased expression of MDM2 mRNA CTD PMID:26708502 picoxystrobin increases expression ISO MDM2 (Homo sapiens) 6480464 picoxystrobin results in increased expression of MDM2 mRNA CTD PMID:33512557 piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of MDM2 mRNA CTD PMID:15890375 and PMID:22484513 pirinixic acid multiple interactions EXP 6480464 MDM2 protein affects the reaction [pirinixic acid results in increased activity of PPARA protein] more ... CTD PMID:19103650 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of MDM2 mRNA CTD PMID:15890375 and PMID:19162173 platycodin D decreases expression ISO MDM2 (Homo sapiens) 6480464 platycodin D results in decreased expression of MDM2 protein CTD PMID:25431082 and PMID:27432230 platycodin D multiple interactions ISO MDM2 (Homo sapiens) 6480464 MDM2 protein inhibits the reaction [platycodin D results in increased expression of FOXO3 protein] CTD PMID:25431082 poly(vinylpyrrolidone) multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein and [Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA CTD PMID:27387714 potassium bromate increases expression ISO MDM2 (Homo sapiens) 6480464 potassium bromate results in increased expression of MDM2 mRNA CTD PMID:30559759 potassium dichromate multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of MDM2 protein] CTD PMID:21262251 potassium dichromate decreases expression EXP 6480464 Potassium Dichromate results in decreased expression of MDM2 protein CTD PMID:21262251 pravastatin increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Pravastatin results in increased phosphorylation of MDM2 protein CTD PMID:15625077 pravastatin increases expression EXP 6480464 Pravastatin results in increased expression of MDM2 protein CTD PMID:15625077 pravastatin multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Pravastatin results in increased phosphorylation of MDM2 protein] which results in increased degradation of TP53 protein more ... CTD PMID:15625077 pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of MDM2 mRNA CTD PMID:19162173 prochloraz multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA CTD PMID:29038839 procymidone decreases expression EXP 6480464 procymidone results in decreased expression of MDM2 mRNA CTD PMID:15686871 promethazine increases phosphorylation EXP 6480464 Promethazine results in increased phosphorylation of MDM2 protein CTD PMID:26558467 propanal increases expression ISO MDM2 (Homo sapiens) 6480464 propionaldehyde results in increased expression of MDM2 mRNA CTD PMID:26079696 PX-866 decreases phosphorylation ISO MDM2 (Homo sapiens) 6480464 PX-866 results in decreased phosphorylation of MDM2 protein CTD PMID:27017931 PX-866 multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of MDM2 protein CTD PMID:27017931 quercetin multiple interactions ISO MDM2 (Homo sapiens) 6480464 Quercetin results in decreased phosphorylation of and results in decreased expression of MDM2 protein CTD PMID:17973296 quercetin increases expression ISO MDM2 (Homo sapiens) 6480464 Quercetin results in increased expression of MDM2 mRNA CTD PMID:21632981 more ... quercetin multiple interactions EXP 6480464 [Quercetin co-treated with Hydrogen Peroxide] results in increased expression of MDM2 mRNA CTD PMID:27525270 quercetin decreases expression ISO MDM2 (Homo sapiens) 6480464 Quercetin results in decreased expression of MDM2 protein CTD PMID:21933852 quercetin increases expression EXP 6480464 Quercetin results in increased expression of MDM2 mRNA CTD PMID:31201582 raloxifene multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of MDM2 protein CTD PMID:27017931 reactive oxygen species multiple interactions ISO MDM2 (Homo sapiens) 6480464 [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of MDM2 protein CTD PMID:27634759 resveratrol multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of MDM2 mRNA more ... CTD PMID:15542774 more ... resveratrol increases expression ISO MDM2 (Homo sapiens) 6480464 resveratrol results in increased expression of MDM2 mRNA CTD PMID:15280659 more ... resveratrol multiple interactions ISO Mdm2 (Mus musculus) 6480464 [resveratrol results in increased phosphorylation of TRP53 protein] inhibits the reaction [TRP53 protein binds to MDM2 protein] CTD PMID:11245472 resveratrol decreases expression ISO MDM2 (Homo sapiens) 6480464 resveratrol results in decreased expression of MDM2 mRNA and resveratrol results in decreased expression of MDM2 protein CTD PMID:16998810 more ... resveratrol increases expression ISO Mdm2 (Mus musculus) 6480464 resveratrol results in increased expression of MDM2 mRNA and resveratrol results in increased expression of MDM2 protein CTD PMID:11245472 more ... resveratrol affects expression ISO Mdm2 (Mus musculus) 6480464 resveratrol affects the expression of MDM2 protein CTD PMID:16369916 rifampicin multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 rotenone increases expression ISO MDM2 (Homo sapiens) 6480464 Rotenone results in increased expression of MDM2 mRNA CTD PMID:33512557 ruthenium atom decreases expression ISO MDM2 (Homo sapiens) 6480464 Ruthenium results in decreased expression of MDM2 protein CTD PMID:17210701 S-(1,2-dichlorovinyl)-L-cysteine increases expression ISO MDM2 (Homo sapiens) 6480464 S-(1 and 2-dichlorovinyl)cysteine results in increased expression of MDM2 mRNA CTD PMID:36576512 SB 431542 multiple interactions ISO MDM2 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide increases expression ISO Mdm2 (Mus musculus) 6480464 Silicon Dioxide results in increased expression of MDM2 mRNA CTD PMID:19073995 silver atom multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein and [Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA CTD PMID:27387714 silver atom decreases expression ISO MDM2 (Homo sapiens) 6480464 Silver results in decreased expression of MDM2 mRNA CTD PMID:26014281 silver(0) multiple interactions ISO MDM2 (Homo sapiens) 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein and [Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA CTD PMID:27387714 silver(0) decreases expression ISO MDM2 (Homo sapiens) 6480464 Silver results in decreased expression of MDM2 mRNA CTD PMID:26014281 simvastatin increases phosphorylation ISO MDM2 (Homo sapiens) 6480464 Simvastatin results in increased phosphorylation of MDM2 protein CTD PMID:15625077 simvastatin multiple interactions ISO MDM2 (Homo sapiens) 6480464 Simvastatin promotes the reaction [Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]] CTD PMID:15625077 sirolimus multiple interactions ISO MDM2 (Homo sapiens) 6480464 EIF4E protein inhibits the reaction [Sirolimus results in decreased expression of MDM2 protein] more ... CTD PMID:15625077 more ... sirolimus decreases expression ISO MDM2 (Homo sapiens) 6480464 Sirolimus results in decreased expression of MDM2 protein CTD PMID:19560264 sodium arsenate increases expression ISO Mdm2 (Mus musculus) 6480464 sodium arsenate results in increased expression of MDM2 mRNA CTD PMID:11353140 sodium arsenite multiple interactions ISO MDM2 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of MDM2 protein] more ... CTD PMID:20375080 more ... sodium arsenite affects expression ISO MDM2 (Homo sapiens) 6480464 sodium arsenite affects the expression of MDM2 mRNA CTD PMID:29319823 sodium arsenite increases expression ISO Mdm2 (Mus musculus) 6480464 sodium arsenite results in increased expression of MDM2 mRNA CTD PMID:11353140 and PMID:20477944 sodium arsenite decreases expression ISO Mdm2 (Mus musculus) 6480464 sodium arsenite results in decreased expression of MDM2 protein CTD PMID:16166651 sodium arsenite increases expression ISO MDM2 (Homo sapiens) 6480464 sodium arsenite results in increased expression of MDM2 mRNA more ... CTD PMID:11813266 more ... sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of MDM2 mRNA CTD PMID:11960910 and PMID:22110744 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of MDM2 mRNA CTD PMID:25993096 sorafenib increases expression ISO MDM2 (Homo sapiens) 6480464 sorafenib results in increased expression of MDM2 mRNA CTD PMID:26409325 staurosporine multiple interactions ISO MDM2 (Homo sapiens) 6480464 Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]] CTD PMID:15542774 succimer multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MDM2 mRNA CTD PMID:26378955 sunitinib increases expression ISO MDM2 (Homo sapiens) 6480464 Sunitinib results in increased expression of MDM2 mRNA CTD PMID:31533062 T-2 toxin increases expression EXP 6480464 T-2 Toxin results in increased expression of MDM2 mRNA CTD PMID:26141394 T-2 toxin increases expression ISO MDM2 (Homo sapiens) 6480464 T-2 Toxin results in increased expression of MDM2 mRNA CTD PMID:31863870 tamoxifen affects expression ISO Mdm2 (Mus musculus) 6480464 Tamoxifen affects the expression of MDM2 mRNA CTD PMID:17555576 tamoxifen decreases expression ISO MDM2 (Homo sapiens) 6480464 Tamoxifen results in decreased expression of MDM2 mRNA CTD PMID:34821461 tanespimycin increases degradation ISO MDM2 (Homo sapiens) 6480464 tanespimycin results in increased degradation of MDM2 protein CTD PMID:17157164 tauroursodeoxycholic acid increases expression EXP 6480464 ursodoxicoltaurine results in increased expression of MDM2 mRNA CTD PMID:15885361 tebufenpyrad increases expression ISO MDM2 (Homo sapiens) 6480464 4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of MDM2 mRNA CTD PMID:33512557 tert-butyl hydroperoxide increases expression ISO MDM2 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of MDM2 mRNA CTD PMID:27509014 testosterone decreases expression ISO Mdm2 (Mus musculus) 6480464 Testosterone results in decreased expression of MDM2 mRNA CTD PMID:20403060 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MDM2 mRNA] CTD PMID:31150632 tetrachloromethane increases expression ISO Mdm2 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of MDM2 mRNA CTD PMID:31919559 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of MDM2 mRNA CTD PMID:31150632 tetraphene multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 theaflavin multiple interactions ISO Mdm2 (Mus musculus) 6480464 [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ... CTD PMID:23717041 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of MDM2 mRNA CTD PMID:18619722 more ... thioacetamide increases phosphorylation EXP 6480464 Thioacetamide results in increased phosphorylation of MDM2 protein CTD PMID:26558467 thymoquinone decreases expression ISO MDM2 (Homo sapiens) 6480464 thymoquinone results in decreased expression of MDM2 protein CTD PMID:31433961 and PMID:34627931 titanium dioxide increases expression ISO MDM2 (Homo sapiens) 6480464 titanium dioxide results in increased expression of MDM2 mRNA CTD PMID:21067279 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MDM2 mRNA CTD PMID:25729387 topotecan multiple interactions ISO MDM2 (Homo sapiens) 6480464 [N-(oxo-5 more ... CTD PMID:23376119 topotecan increases expression EXP 6480464 Topotecan results in increased expression of MDM2 mRNA CTD PMID:25729387 trichloroethene affects expression ISO Mdm2 (Mus musculus) 6480464 Trichloroethylene affects the expression of MDM2 mRNA CTD PMID:21135412 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of MDM2 mRNA CTD PMID:33387578 trichloroethene multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA CTD PMID:17905399 trichostatin A affects expression ISO MDM2 (Homo sapiens) 6480464 trichostatin A affects the expression of MDM2 mRNA CTD PMID:28542535 triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of MDM2 mRNA CTD PMID:30589522 Triptolide increases expression ISO Mdm2 (Mus musculus) 6480464 triptolide results in increased expression of MDM2 mRNA CTD PMID:32835833 triptonide affects expression ISO Mdm2 (Mus musculus) 6480464 triptonide affects the expression of MDM2 mRNA CTD PMID:33045310 trovafloxacin multiple interactions ISO Mdm2 (Mus musculus) 6480464 [trovafloxacin co-treated with lipopolysaccharide and E coli O55-B5] results in increased expression of MDM2 mRNA CTD PMID:18930950 trovafloxacin increases expression ISO Mdm2 (Mus musculus) 6480464 trovafloxacin results in increased expression of MDM2 mRNA CTD PMID:35537566 urethane multiple interactions ISO Mdm2 (Mus musculus) 6480464 [Urethane co-treated with Freund's Adjuvant] results in increased expression of MDM2 mRNA CTD PMID:12400877 ursodeoxycholic acid multiple interactions EXP 6480464 [Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]] which results in increased degradation of TP53 protein more ... CTD PMID:14514686 more ... ursodeoxycholic acid increases expression EXP 6480464 Ursodeoxycholic Acid results in increased expression of MDM2 mRNA CTD PMID:15885361 ursodeoxycholic acid multiple interactions ISO MDM2 (Homo sapiens) 6480464 MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased ubiquitination of TP53 protein] CTD PMID:20807506 valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of MDM2 mRNA CTD PMID:24136188 valproic acid increases expression ISO MDM2 (Homo sapiens) 6480464 Valproic Acid results in increased expression of MDM2 mRNA CTD PMID:23179753 valproic acid decreases expression ISO MDM2 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of MDM2 mRNA CTD PMID:28001369 valproic acid affects expression ISO MDM2 (Homo sapiens) 6480464 Valproic Acid affects the expression of MDM2 mRNA CTD PMID:25979313 vincristine increases expression ISO MDM2 (Homo sapiens) 6480464 Vincristine results in increased expression of MDM2 mRNA CTD PMID:23649840 vincristine decreases expression ISO MDM2 (Homo sapiens) 6480464 Vincristine results in decreased expression of MDM2 mRNA CTD PMID:16001973 vorinostat decreases expression ISO MDM2 (Homo sapiens) 6480464 vorinostat results in decreased expression of MDM2 mRNA CTD PMID:27188386 wortmannin multiple interactions ISO MDM2 (Homo sapiens) 6480464 wortmannin promotes the reaction [Doxorubicin results in increased phosphorylation of MDM2 protein] and wortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein] CTD PMID:17935137 zidovudine increases expression ISO MDM2 (Homo sapiens) 6480464 Zidovudine results in increased expression of MDM2 protein CTD PMID:16797627 zinc acetate multiple interactions ISO MDM2 (Homo sapiens) 6480464 motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA] CTD PMID:16357179 zinc acetate increases expression ISO MDM2 (Homo sapiens) 6480464 Zinc Acetate results in increased expression of MDM2 mRNA CTD PMID:16357179 zinc atom multiple interactions ISO MDM2 (Homo sapiens) 6480464 Zinc binds to and results in increased folding of MDM2 protein more ... CTD PMID:16965791 zinc atom increases ubiquitination ISO MDM2 (Homo sapiens) 6480464 Zinc results in increased ubiquitination of MDM2 protein CTD PMID:16965791 zinc atom affects expression ISO MDM2 (Homo sapiens) 6480464 Zinc affects the expression of MDM2 protein CTD PMID:16636310 zinc pyrithione increases expression ISO MDM2 (Homo sapiens) 6480464 pyrithione zinc results in increased expression of MDM2 mRNA CTD PMID:21424779 zinc(0) multiple interactions ISO MDM2 (Homo sapiens) 6480464 Zinc binds to and results in increased folding of MDM2 protein more ... CTD PMID:16965791 zinc(0) affects expression ISO MDM2 (Homo sapiens) 6480464 Zinc affects the expression of MDM2 protein CTD PMID:16636310 zinc(0) increases ubiquitination ISO MDM2 (Homo sapiens) 6480464 Zinc results in increased ubiquitination of MDM2 protein CTD PMID:16965791