Mdm2 (transformed mouse 3T3 cell double minute 2) - Rat Genome Database

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Gene: Mdm2 (transformed mouse 3T3 cell double minute 2) Mus musculus
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Symbol: Mdm2
Name: transformed mouse 3T3 cell double minute 2
RGD ID: 1313300
MGI Page MGI
Description: Enables p53 binding activity and ubiquitin protein ligase activity. Involved in apoptotic process and positive regulation of muscle cell differentiation. Acts upstream of or within several processes, including blood vessel remodeling; circulatory system development; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700007J15Rik; AA415488; double minute 2 protein; E3 ubiquitin-protein ligase Mdm2; Mdm-2; oncoprotein Mdm2; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910117,524,780 - 117,546,663 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10117,524,780 - 117,546,663 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810117,688,875 - 117,710,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,688,875 - 117,710,758 (-)Ensemblmm10GRCm38
MGSCv3710117,125,961 - 117,147,772 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610117,091,898 - 117,113,709 (-)NCBIMGSCv36mm8
Celera10119,626,758 - 119,648,336 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,10-phenanthroline  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-nitropyrene  (ISO)
10-Hydroxycamptothecin  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-nitrofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (EXP)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
alpha-naphthoflavone  (ISO)
alvocidib  (ISO)
amifostine  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
amsacrine  (ISO)
androstane  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azoxystrobin  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
brassinolide  (ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP,ISO)
cantharidin  (ISO)
capsaicin  (ISO)
Carbadox  (ISO)
carbamazepine  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
chrysene  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clofibrate  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corn oil  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP)
cryptolepine  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
DAPT  (ISO)
DDT  (EXP)
deguelin  (ISO)
DENSPM  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
diclofenac  (ISO)
dieldrin  (EXP,ISO)
diepoxybutane  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
eflornithine  (ISO)
ellipticine  (ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
escitalopram  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
EUK-134  (ISO)
fenbendazole  (ISO)
fenofibrate  (ISO)
fipronil  (ISO)
flavanones  (ISO)
flucytosine  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formononetin  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
furosemide  (ISO)
ganciclovir  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
GW 501516  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyurea  (EXP,ISO)
Icaritin  (ISO)
ifosfamide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irinotecan  (ISO)
isoflurane  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
leptomycin B  (ISO)
Leucomalachite green  (ISO)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lupeol  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mancozeb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methyl caffeate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP)
mitomycin C  (EXP,ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (EXP)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitenpyram  (ISO)
Nodularin  (ISO)
Nutlin-3  (EXP,ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
Octicizer  (ISO)
okadaic acid  (ISO)
ortho-Aminoazotoluene  (EXP)
ouabain  (ISO)
oxaliplatin  (ISO)
oxfendazole  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
palmatine  (ISO)
paracetamol  (EXP,ISO)
Paraoxon-methyl  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (ISO)
PCB138  (ISO)
PD123319  (ISO)
pentachlorophenol  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
PhIP  (ISO)
phlorizin  (EXP)
phosphoramide mustard  (ISO)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(vinylpyrrolidone)  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
promethazine  (ISO)
propanal  (ISO)
PX-866  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rotenone  (ISO)
ruthenium atom  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selinexor  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sorafenib  (ISO)
staurosporine  (ISO)
succimer  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
tauroursodeoxycholic acid  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
theaflavin  (EXP)
thioacetamide  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
triptonide  (EXP)
trovafloxacin  (EXP)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid fibril formation  (IEA,ISO)
apoptotic process  (IDA,IEA,ISO)
atrial septum development  (IEA,IGI)
atrioventricular valve morphogenesis  (IEA,IGI)
blood vessel development  (IMP)
blood vessel remodeling  (IMP)
cardiac septum morphogenesis  (IGI)
cellular response to actinomycin D  (IEA,ISO)
cellular response to alkaloid  (IEA,ISO)
cellular response to antibiotic  (IEA,ISO)
cellular response to estrogen stimulus  (IEA,ISO)
cellular response to gamma radiation  (IEA,ISO)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to hypoxia  (IEA)
cellular response to peptide hormone stimulus  (IEA,ISO)
cellular response to UV-C  (IEA,ISO)
cellular response to vitamin B1  (IEA,ISO)
DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
endocardial cushion morphogenesis  (IEA,IGI,IMP)
establishment of protein localization  (IEA,ISO)
fibroblast activation  (IEA,ISO)
heart development  (IGI,IMP)
heart valve development  (IGI)
negative regulation of apoptotic process  (IBA,IEA,ISO)
negative regulation of apoptotic signaling pathway  (IEA,ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (IEA,ISO)
negative regulation of neuron projection development  (IEA,ISO)
negative regulation of protein processing  (IEA,ISO)
negative regulation of signal transduction by p53 class mediator  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of cell cycle  (IGI)
positive regulation of gene expression  (IEA,ISO)
positive regulation of mitotic cell cycle  (IBA,IEA,ISO)
positive regulation of muscle cell differentiation  (IMP)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of protein export from nucleus  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell migration  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO)
protein autoubiquitination  (IEA,ISO)
protein destabilization  (IEA,ISO)
protein localization to nucleus  (IEA,ISO)
protein ubiquitination  (IEA,ISO,ISS)
protein-containing complex assembly  (IEA,ISO)
proteolysis involved in protein catabolic process  (IEA,ISO)
regulation of cell cycle  (IEA,ISO)
regulation of gene expression  (IEA,IMP)
regulation of heart rate  (IEA,IGI)
regulation of postsynaptic neurotransmitter receptor internalization  (IEA,ISO)
regulation of protein catabolic process  (IEA,ISO)
regulation of protein catabolic process at postsynapse, modulating synaptic transmission  (IEA,ISO)
response to antibiotic  (IEA)
response to cocaine  (IEA,ISO)
response to ether  (IEA,ISO)
response to formaldehyde  (IEA,ISO)
response to iron ion  (IEA,ISO)
response to magnesium ion  (IEA,ISO)
response to steroid hormone  (IEA,ISO)
response to toxic substance  (IEA,ISO)
response to water-immersion restraint stress  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
signal transduction by p53 class mediator  (ISO)
traversing start control point of mitotic cell cycle  (IDA)
ubiquitin-dependent protein catabolic process  (IBA,IDA,IEA,IMP,ISO)
ventricular septum development  (IEA,IGI)

Cellular Component
centriolar satellite  (IEA,ISO)
cytoplasm  (IBA,IDA,IEA,ISO)
cytosol  (IEA,ISO,TAS)
glutamatergic synapse  (IEA,ISO)
nuclear body  (IEA,ISO)
nucleolus  (IBA,IDA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IDA,IEA,ISO)
postsynaptic density  (IEA,ISO)
protein-containing complex  (IEA,ISO)
transcription repressor complex  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal blood circulation  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hematopoietic system physiology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
anemia  (IAGP)
cerebellum hypoplasia  (IAGP)
cleft palate  (IAGP)
decreased apoptosis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased cellular sensitivity to ionizing radiation  (IAGP)
decreased cerebellar granule cell number  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased fetal size  (IAGP)
decreased granulocyte number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased immature B cell number  (IAGP)
decreased kidney weight  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased liver weight  (IAGP)
decreased locomotor activity  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased mortality induced by ionizing radiation  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased spleen weight  (IAGP)
decreased T cell number  (IAGP)
decreased telomere length  (IAGP)
decreased thymocyte apoptosis  (IAGP)
decreased thymocyte number  (IAGP)
decreased thymus weight  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
empty decidua capsularis  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged Peyer's patches  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IAGP)
exencephaly  (IAGP)
hemorrhage  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased carcinoma incidence  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased cell proliferation  (IAGP)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased fibroblast proliferation  (IAGP)
increased fibrosarcoma incidence  (IAGP)
increased foot pad pigmentation  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased leiomyosarcoma incidence  (IAGP)
increased lipoma incidence  (IAGP)
increased liver adenocarcinoma incidence  (IAGP)
increased liver adenoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased mortality induced by gamma-irradiation  (IAGP)
increased mortality induced by ionizing radiation  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased salivary gland tumor incidence  (IAGP)
increased sarcoma incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased tumor incidence  (IAGP)
kinked tail  (IAGP)
no abnormal phenotype detected  (IAGP)
pallor  (IAGP)
pancytopenia  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
small cerebellum  (IAGP)
small heart  (IAGP)
small thymus  (IAGP)
spleen atrophy  (IAGP)
spleen hyperplasia  (IAGP)
spleen hypoplasia  (IAGP)
thin myocardium  (IAGP)
thrombocytopenia  (IAGP)
thymus atrophy  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 gene. Chang B, etal., Hum Mol Genet. 2008 Dec 15;17(24):3929-41. doi: 10.1093/hmg/ddn295. Epub 2008 Sep 18.
2. Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer. Dong M, etal., World J Gastroenterol. 2005 Apr 14;11(14):2162-5.
3. Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis. Dongiovanni P, etal., Am J Pathol. 2010 Feb;176(2):1006-17. Epub 2009 Dec 17.
4. Long-term effects of hypothermia on neuronal cell death and the concentration of apoptotic proteins after incomplete cerebral ischemia and reperfusion in rats. Eberspacher E, etal., Acta Anaesthesiol Scand. 2005 Apr;49(4):477-87.
5. The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia. Faderl S, etal., Cancer. 2000 Nov 1;89(9):1976-82.
6. Characterizing the role of MDM2 in diethylnitrosamine induced acute liver damage and development of pre-neoplastic lesions. Finnberg N, etal., Carcinogenesis. 2004 Jan;25(1):113-22. Epub 2003 Oct 10.
7. MDM2 SNP309 associates with accelerated pancreatic adenocarcinoma formation. Grochola LF, etal., Pancreas. 2010 Jan;39(1):76-80.
8. ZEB2, interacting with MDM2, contributes to the dysfuntion of brain microvascular endothelial cells and brain injury after intracerebral hemorrhage. Guo Q, etal., Cell Cycle. 2021 Sep;20(17):1692-1707. doi: 10.1080/15384101.2021.1959702. Epub 2021 Aug 2.
9. Inhibition of MDM2 attenuates neointimal hyperplasia via suppression of vascular proliferation and inflammation. Hashimoto T, etal., Cardiovasc Res. 2011 Sep 1;91(4):711-9. doi: 10.1093/cvr/cvr108. Epub 2011 Apr 14.
10. Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis. Ishikawa A, etal., Hum Pathol. 2004 Dec;35(12):1505-14.
11. Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome. Jarnagin WR, etal., J Clin Oncol. 2006 Mar 1;24(7):1152-60.
12. Experimental priapism is associated with increased oxidative stress and activation of protein degradation pathways in corporal tissue. Kanika ND, etal., Int J Impot Res. 2010 Nov-Dec;22(6):363-73. doi: 10.1038/ijir.2010.27. Epub 2010 Nov 18.
13. Nonresponsiveness of cerebral p53-MDM2 functional circuit in newborn rat pups rendered IUGR via uteroplacental insufficiency. Ke X, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Apr;288(4):R1038-45. Epub 2004 Nov 24.
14. Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer. Kriegmair MC, etal., Anticancer Res. 2016 Oct;36(10):5205-5213. doi: 10.21873/anticanres.11091.
15. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
16. The complexity of p53 stabilization and activation. Lavin MF and Gueven N, Cell Death Differ. 2006 Jun;13(6):941-50.
17. A molecular basis for the efficacy of magnesium treatment following traumatic brain injury in rats. Lee JS, etal., J Neurotrauma. 2004 May;21(5):549-61.
18. Up-regulation of Smurf1 after spinal cord injury in adult rats. Li D, etal., J Mol Histol. 2013 Aug;44(4):381-90. doi: 10.1007/s10735-013-9499-2. Epub 2013 Apr 18.
19. REGgamma deficiency promotes premature aging via the casein kinase 1 pathway. Li L, etal., Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11005-10. doi: 10.1073/pnas.1308497110. Epub 2013 Jun 13.
20. Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy. Li Q and Lozano G, Clin Cancer Res. 2013 Jan 1;19(1):34-41. doi: 10.1158/1078-0432.CCR-12-0053. Epub 2012 Dec 21.
21. MDM2 promoter polymorphism and p53 codon 72 polymorphism in chronic myeloid leukemia: the association between MDM2 promoter genotype and disease susceptibility, age of onset, and blast-free survival in chronic phase patients receiving imatinib. Liu YC, etal., Mol Carcinog. 2014 Dec;53(12):951-9. doi: 10.1002/mc.22061. Epub 2013 Jul 2.
22. Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. Ma B, etal., PLoS One. 2013 May 2;8(5):e56580. doi: 10.1371/journal.pone.0056580. Print 2013.
23. Lack of association between MDM2 SNP309 and TP53 Arg72Pro polymorphisms with clinical outcomes in myelodysplastic syndrome. Machado-Neto JA, etal., Neoplasma. 2012;59(5):530-5. doi: 10.4149/neo_2012_068.
24. MGDs mouse GO annotations MGD data from the GO Consortium
25. MGD IEA MGD IEA
26. p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning. Mocanu MM and Yellon DM, FEBS Lett. 2003 Dec 4;555(2):302-6.
27. Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors. Murray SA, etal., J Cell Biochem. 2005 Aug 1;95(5):875-84.
28. Inflammatory cells regulate p53 and caspases in acute pancreatitis. Nakamura Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Oct 22.
29. Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1beta/ErbB in response to myocardial infarction resulting in worsening heart failure. Odiete O, etal., Cardiovasc Diabetol. 2013 Mar 27;12:52. doi: 10.1186/1475-2840-12-52.
30. MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in breast cancer patients treated with 5-FU/epirubicin/cyclophosphamide. Okishiro M, etal., Breast Cancer Res Treat. 2012 Apr;132(3):947-53. doi: 10.1007/s10549-011-1637-5. Epub 2011 Jun 25.
31. Amplification of a gene encoding a p53-associated protein in human sarcomas. Oliner JD, etal., Nature. 1992 Jul 2;358(6381):80-3.
32. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
35. Mouse MP Annotation Import Pipeline RGD automated import pipeline
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Lose dose genistein inhibits glucocorticoid receptor and ischemic brain injury in female rats. Shi R, etal., Neurochem Int. 2014 Jan;65:14-22. doi: 10.1016/j.neuint.2013.12.002. Epub 2013 Dec 12.
38. Selective increase in the association of the beta2 adrenergic receptor, beta Arrestin-1 and p53 with Mdm2 in the ventral hippocampus one month after underwater trauma. Sood R, etal., Behav Brain Res. 2013 Mar 1;240:26-8. doi: 10.1016/j.bbr.2012.11.009. Epub 2012 Nov 20.
39. Multiple mouse chromosomal loci for dynein-based motility. Vaughan KT, etal., Genomics 1996 Aug 15;36(1):29-38.
40. MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced grade III/IV neutropenia in Chinese extensive-stage small-cell lung cancer patients. Wang X, etal., Oncol Res Treat. 2014;37(4):176-80. doi: 10.1159/000360785. Epub 2014 Mar 20.
41. p53 polymorphisms: cancer implications. Whibley C, etal., Nat Rev Cancer. 2009 Feb;9(2):95-107.
42. Identifying a hyperkeratosis signature in autosomal recessive congenital ichthyosis: Mdm2 inhibition prevents hyperkeratosis in a rat ARCI model. Youssef G, etal., J Invest Dermatol. 2014 Mar;134(3):858-61. doi: 10.1038/jid.2013.374. Epub 2013 Sep 4.
43. A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival. Zheng S, etal., Genes Dev. 2013 Jul 1;27(13):1462-72. doi: 10.1101/gad.213686.113. Epub 2013 Jun 24.
Additional References at PubMed
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Genomics

Comparative Map Data
Mdm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910117,524,780 - 117,546,663 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10117,524,780 - 117,546,663 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810117,688,875 - 117,710,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,688,875 - 117,710,758 (-)Ensemblmm10GRCm38
MGSCv3710117,125,961 - 117,147,772 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610117,091,898 - 117,113,709 (-)NCBIMGSCv36mm8
Celera10119,626,758 - 119,648,336 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.32NCBI
MDM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381268,808,172 - 68,850,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1268,808,177 - 68,845,544 (+)Ensemblhg38GRCh38
GRCh371269,201,952 - 69,244,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361267,488,247 - 67,520,481 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341267,488,246 - 67,520,481NCBI
Celera1268,865,796 - 68,903,026 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1266,252,410 - 66,289,884 (+)NCBIHuRef
CHM1_11269,170,604 - 69,207,918 (+)NCBICHM1_1
T2T-CHM13v2.01268,784,018 - 68,830,265 (+)NCBIT2T-CHM13v2.0
Mdm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8755,176,558 - 55,201,757 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl755,176,560 - 55,200,791 (-)EnsemblGRCr8
mRatBN7.2753,290,660 - 53,315,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,290,664 - 53,314,915 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx755,197,377 - 55,221,597 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,400,491 - 57,424,715 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,178,368 - 57,202,590 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,719,060 - 60,743,618 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,719,066 - 60,743,328 (-)Ensemblrn6Rnor6.0
Rnor_5.0760,719,023 - 60,743,581 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4756,996,694 - 57,020,926 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera750,062,029 - 50,086,121 (-)NCBICelera
RGSC_v3.1757,018,654 - 57,054,110 (-)NCBI
Cytogenetic Map7q22NCBI
Mdm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545815,263,739 - 15,286,808 (+)Ensembl
ChiLan1.0NW_00495545815,264,028 - 15,287,290 (+)NCBIChiLan1.0ChiLan1.0
MDM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21076,824,907 - 76,859,369 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11276,824,089 - 76,858,786 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01266,322,340 - 66,357,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11269,102,083 - 69,133,278 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1269,102,084 - 69,133,278 (+)EnsemblpanPan2panpan1.1
MDM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11010,936,288 - 10,963,118 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1010,893,719 - 10,962,596 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1010,869,091 - 10,894,634 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01011,060,051 - 11,086,867 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1011,016,172 - 11,087,383 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11010,928,429 - 10,953,972 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01011,174,449 - 11,199,967 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01011,296,600 - 11,322,142 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mdm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494547,377,991 - 47,400,191 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365456,709,903 - 6,732,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl533,105,759 - 33,137,739 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1533,105,717 - 33,137,602 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2535,889,682 - 35,921,569 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MDM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11164,434,203 - 64,465,490 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1164,434,261 - 64,469,890 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037181,237,754 - 181,268,657 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Mdm2
824 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1786
Count of miRNA genes:614
Interacting mature miRNAs:771
Transcripts:ENSMUST00000020408, ENSMUST00000105263, ENSMUST00000126022, ENSMUST00000131627, ENSMUST00000132277, ENSMUST00000137102, ENSMUST00000147823, ENSMUST00000151725, ENSMUST00000155285
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301520Uvbi1_mUVB induced immunosuppression 1 (mouse)Not determined1086909085120909229Mouse
26884377Skwq3_mskull length QTL 3, 5 week (mouse)10114635905122735905Mouse
26884383Bzwq3_mbi-zygomatic width QTL 3, 5 week (mouse)10114235905122735905Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
4142386Tgq20_mtriglyceride QTL 20 (mouse)Not determined88836456122836456Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084079650122041528Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084079650122041528Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84079650122041528Mouse
13208554Lgth11_mbody length 11 (mouse)1090835862120835905Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
1300921Skl4_mskeletal size (tail length) 4 (mouse)Not determined1088088254122088391Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
1300797Sluc22_msusceptibility to lung cancer 22 (mouse)Not determined1086713608120713756Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1300796Lmr5_mleishmaniasis resistance 5 (mouse)Not determined10116220635122179828Mouse
10412078Hylaq3_mHyperlocomotor activity related QTL 3 (mouse)Not determined10111568226117986649Mouse
11039516Ltpr5_mLeishmania tropica response 5 (mouse)1090506901125575232Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
26884391Skwq11_mskull length QTL 11, 16 week (mouse)10113535905121635905Mouse
13506931Recrq11_mrecombination rate in male meiosis QTL 11 (mouse)10114335905123635905Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
1300908Insq4_minsulin QTL 4 (mouse)Not determined1086909085120909229Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
27095902Scvln11_msacral vertebrae length 2, 10 week (mouse)10110035861125435869Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084079650122041528Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
26884433Zlq2_mzygomatic length QTL 2, 5 week (mouse)10113535905125735869Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
1357638Cia29_mcollagen induced arthritis 29 (mouse)Not determined1085454982118497353Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
4141269Ipng2_mimprinted postnatal growth 2 (mouse)Not determined105088254118497353Mouse
1301758Fcsa3_mfemoral cross-sectional area 3 (mouse)Not determined1089927651123927754Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
11353823Homaq2_mhomeostatic model assessment QTL 2 (mouse)10110453347125515907Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
11353822Insq12_minsulin QTL 12 (mouse)10110453347125515907Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84079650122041528Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226725Tibw1_mtibia width 1, proximal, 5 week (mouse)10102735861123235905Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
27226722Tibw7_mtibia width 7, proximal, 16 week (mouse)10108635861125435869Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse

Markers in Region
RH124271  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810117,688,996 - 117,689,179UniSTSGRCm38
MGSCv3710117,126,052 - 117,126,235UniSTSGRCm37
Celera10119,626,849 - 119,627,032UniSTS
Cytogenetic Map10C1-C3UniSTS
UniSTS:236466  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810117,689,874 - 117,689,958UniSTSGRCm38
MGSCv3710117,126,930 - 117,127,014UniSTSGRCm37
Celera10119,627,713 - 119,627,797UniSTS
Cytogenetic Map10C1-C3UniSTS
D0S2246  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810117,709,697 - 117,709,780UniSTSGRCm38
MGSCv3710117,146,753 - 117,146,836UniSTSGRCm37
Celera10119,647,317 - 119,647,400UniSTS
Cytogenetic Map10C1-C3UniSTS
Mdm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810117,690,297 - 117,690,483UniSTSGRCm38
MGSCv3710117,127,353 - 117,127,539UniSTSGRCm37
Celera10119,628,136 - 119,628,322UniSTS
Cytogenetic Map10C1-C3UniSTS
cM Map1066.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001288586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF320762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK005723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP767471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY323121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN703560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ344919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U40145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U47934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X74980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000020408   ⟹   ENSMUSP00000020408
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,524,780 - 117,546,663 (-)Ensembl
GRCm38.p6 Ensembl10117,688,875 - 117,710,758 (-)Ensembl
Ensembl Acc Id: ENSMUST00000105263   ⟹   ENSMUSP00000100898
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,524,780 - 117,546,663 (-)Ensembl
GRCm38.p6 Ensembl10117,688,875 - 117,710,758 (-)Ensembl
Ensembl Acc Id: ENSMUST00000126022
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,531,946 - 117,546,616 (-)Ensembl
GRCm38.p6 Ensembl10117,696,041 - 117,710,711 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131627
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,526,148 - 117,527,425 (-)Ensembl
GRCm38.p6 Ensembl10117,690,243 - 117,691,520 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132277
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,526,014 - 117,546,590 (-)Ensembl
GRCm38.p6 Ensembl10117,690,109 - 117,710,685 (-)Ensembl
Ensembl Acc Id: ENSMUST00000137102
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,530,839 - 117,545,983 (-)Ensembl
GRCm38.p6 Ensembl10117,694,934 - 117,710,078 (-)Ensembl
Ensembl Acc Id: ENSMUST00000147823
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,538,164 - 117,546,197 (-)Ensembl
GRCm38.p6 Ensembl10117,702,259 - 117,710,292 (-)Ensembl
Ensembl Acc Id: ENSMUST00000151725
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,545,623 - 117,546,619 (-)Ensembl
GRCm38.p6 Ensembl10117,709,718 - 117,710,714 (-)Ensembl
Ensembl Acc Id: ENSMUST00000155285   ⟹   ENSMUSP00000137039
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,524,800 - 117,545,927 (-)Ensembl
GRCm38.p6 Ensembl10117,688,895 - 117,710,022 (-)Ensembl
RefSeq Acc Id: NM_001288586   ⟹   NP_001275515
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910117,524,780 - 117,546,663 (-)NCBI
GRCm3810117,688,875 - 117,710,758 (-)NCBI
Celera10119,626,728 - 119,648,378 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010786   ⟹   NP_034916
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910117,524,780 - 117,546,663 (-)NCBI
GRCm3810117,688,875 - 117,710,758 (-)NCBI
MGSCv3710117,125,961 - 117,147,772 (-)RGD
Celera10119,626,728 - 119,648,378 (-)NCBI
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017313822   ⟹   XP_017169311
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910117,524,797 - 117,537,464 (-)NCBI
GRCm3810117,688,892 - 117,701,559 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155661   ⟹   XP_036011554
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910117,524,797 - 117,545,927 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001275515 (Get FASTA)   NCBI Sequence Viewer  
  NP_001415540 (Get FASTA)   NCBI Sequence Viewer  
  NP_001415541 (Get FASTA)   NCBI Sequence Viewer  
  NP_001415542 (Get FASTA)   NCBI Sequence Viewer  
  NP_001415543 (Get FASTA)   NCBI Sequence Viewer  
  NP_001415544 (Get FASTA)   NCBI Sequence Viewer  
  NP_001415545 (Get FASTA)   NCBI Sequence Viewer  
  NP_001415546 (Get FASTA)   NCBI Sequence Viewer  
  NP_034916 (Get FASTA)   NCBI Sequence Viewer  
  XP_017169311 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011554 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA91167 (Get FASTA)   NCBI Sequence Viewer  
  AAB09030 (Get FASTA)   NCBI Sequence Viewer  
  AAB09031 (Get FASTA)   NCBI Sequence Viewer  
  AAH50902 (Get FASTA)   NCBI Sequence Viewer  
  AAH92270 (Get FASTA)   NCBI Sequence Viewer  
  ABC70327 (Get FASTA)   NCBI Sequence Viewer  
  BAB23502 (Get FASTA)   NCBI Sequence Viewer  
  BAC40470 (Get FASTA)   NCBI Sequence Viewer  
  BAE35604 (Get FASTA)   NCBI Sequence Viewer  
  CAA41684 (Get FASTA)   NCBI Sequence Viewer  
  EDL21843 (Get FASTA)   NCBI Sequence Viewer  
  EDL21844 (Get FASTA)   NCBI Sequence Viewer  
  EDL21845 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000020408
  ENSMUSP00000020408.9
  ENSMUSP00000100898
  ENSMUSP00000100898.2
GenBank Protein P23804 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_034916   ⟸   NM_010786
- Peptide Label: isoform 1
- UniProtKB: Q64330 (UniProtKB/Swiss-Prot),   Q61040 (UniProtKB/Swiss-Prot),   Q91XK7 (UniProtKB/Swiss-Prot),   P23804 (UniProtKB/Swiss-Prot),   Q3TVL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001275515   ⟸   NM_001288586
- Peptide Label: isoform 2
- UniProtKB: Q3TVL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169311   ⟸   XM_017313822
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000100898   ⟸   ENSMUST00000105263
Ensembl Acc Id: ENSMUSP00000020408   ⟸   ENSMUST00000020408
Ensembl Acc Id: ENSMUSP00000137039   ⟸   ENSMUST00000155285
RefSeq Acc Id: XP_036011554   ⟸   XM_036155661
- Peptide Label: isoform X1
Protein Domains
DM2   RanBP2-type   RING-type   SWIB/MDM2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23804-F1-model_v2 AlphaFold P23804 1-489 view protein structure

Promoters
RGD ID:6819579
Promoter ID:MM_KWN:5704
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000049465
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610117,128,091 - 117,129,392 (-)MPROMDB
RGD ID:6819578
Promoter ID:MM_KWN:5705
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000105263,   OTTMUST00000049452,   OTTMUST00000049456,   OTTMUST00000049457,   OTTMUST00000049458,   OTTMUST00000049459,   OTTMUST00000049464,   UC007HDL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610117,147,041 - 117,148,747 (-)MPROMDB
RGD ID:8673334
Promoter ID:EPDNEW_M14698
Type:initiation region
Name:Mdm2_1
Description:Mus musculus transformed mouse 3T3 cell double minute 2 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810117,710,687 - 117,710,747EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96952 AgrOrtholog
Ensembl Genes ENSMUSG00000020184 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020408 ENTREZGENE
  ENSMUST00000020408.16 UniProtKB/Swiss-Prot
  ENSMUST00000105263 ENTREZGENE
  ENSMUST00000105263.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.245.10 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
  Zn-finger domain of Sec23/24 UniProtKB/Swiss-Prot
InterPro Mdm2 UniProtKB/Swiss-Prot
  MDM2_mRING-HC-C2H2C4 UniProtKB/Swiss-Prot
  p53_neg-reg_MDM_2/4 UniProtKB/Swiss-Prot
  SWIB_MDM2_dom_sf UniProtKB/Swiss-Prot
  SWIB_MDM2_domain UniProtKB/Swiss-Prot
  Znf_RanBP2 UniProtKB/Swiss-Prot
  Znf_RanBP2_sf UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
KEGG Report mmu:17246 UniProtKB/Swiss-Prot
MGD MGI:96952 ENTREZGENE
NCBI Gene 17246 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MDM2 UniProtKB/Swiss-Prot
  OS05G0521000 PROTEIN UniProtKB/Swiss-Prot
Pfam SWIB UniProtKB/Swiss-Prot
  zf-C3HC4_3 UniProtKB/Swiss-Prot
  zf-RanBP UniProtKB/Swiss-Prot
PhenoGen Mdm2 PhenoGen
PIRSF MDM2 UniProtKB/Swiss-Prot
  p53_MDM_2/4 UniProtKB/Swiss-Prot
PROSITE SWIB_MDM2 UniProtKB/Swiss-Prot
  ZF_RANBP2_1 UniProtKB/Swiss-Prot
  ZF_RANBP2_2 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  SSF47592 UniProtKB/Swiss-Prot
  SSF90209 UniProtKB/Swiss-Prot
UniProt J3QP04_MOUSE UniProtKB/TrEMBL
  MDM2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q2L9A9_MOUSE UniProtKB/TrEMBL
  Q3TVL4 ENTREZGENE, UniProtKB/TrEMBL
  Q569X0_MOUSE UniProtKB/TrEMBL
  Q61040 ENTREZGENE
  Q64330 ENTREZGENE
  Q91XK7 ENTREZGENE
UniProt Secondary Q61040 UniProtKB/Swiss-Prot
  Q64330 UniProtKB/Swiss-Prot
  Q91XK7 UniProtKB/Swiss-Prot