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Gene: Mdm2 (transformed mouse 3T3 cell double minute 2) Mus musculus
Symbol: Mdm2
Name: transformed mouse 3T3 cell double minute 2
Description: Exhibits p53 binding activity; scaffold protein binding activity; and ubiquitin protein ligase activity. Involved in several processes, including blood vessel remodeling; circulatory system development; and traversing start control point of mitotic cell cycle. Localizes to the cytoplasm and nucleolus. Predicted to colocalize with the nuclear body. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma multiforme; ichthyosis; and sarcoma. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; respiratory system; and sensory organ. Orthologous to human MDM2 (MDM2 proto-oncogene); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1700007J15Rik; AA415488; double minute 2 protein; E3 ubiquitin-protein ligase Mdm2; Mdm-2; oncoprotein Mdm2; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2
Homo sapiens (human) : MDM2 (MDM2 proto-oncogene)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mdm2 (MDM2 proto-oncogene)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mdm2 (MDM2 proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : MDM2 (MDM2 proto-oncogene)
Canis lupus familiaris (dog) : MDM2 (MDM2 proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mdm2 (MDM2 proto-oncogene)
Sus scrofa (pig) : MDM2 (MDM2 proto-oncogene)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3810117,688,875 - 117,710,758 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710117,125,961 - 117,147,772 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610117,091,898 - 117,113,709 (-)NCBImm8
Celera10119,626,728 - 119,648,378 (-)NCBICelera
Cytogenetic Map10 D2NCBI
cM Map1066.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mdm2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313300
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.