(+)-catechin decreases expression ISO RGD:1313299 6480464 Catechin results in decreased expression of MDM2 mRNA CTD PMID:23706674 (+)-schisandrin B multiple interactions ISO RGD:1305332 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MDM2 mRNA] CTD PMID:31150632 (-)-demecolcine increases expression ISO RGD:1313299 6480464 Demecolcine results in increased expression of MDM2 mRNA CTD PMID:23649840 (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ... CTD PMID:23717041 (S)-nicotine multiple interactions ISO RGD:1313299 6480464 [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein, [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expression EXP 6480464 o, p'-DDT affects the expression of MDM2 mRNA CTD PMID:18925944 1,10-phenanthroline increases expression ISO RGD:1313299 6480464 1, 10-phenanthroline results in increased expression of MDM2 mRNA CTD PMID:19502547 1,2-dimethylhydrazine multiple interactions EXP 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of MDM2 mRNA CTD PMID:22206623 1-nitropyrene increases expression ISO RGD:1313299 6480464 1-nitropyrene results in increased expression of MDM2 mRNA more ... CTD PMID:10837373 , PMID:22044530 1-nitropyrene multiple interactions ISO RGD:1313299 6480464 nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form] more ... CTD PMID:10837373 , PMID:22044530 10-Hydroxycamptothecin affects response to substance ISO RGD:1313299 6480464 MDM2 protein affects the susceptibility to 10-hydroxycamptothecin CTD PMID:13130078 17alpha-ethynylestradiol increases expression ISO RGD:1313299 6480464 Ethinyl Estradiol results in increased expression of MDM2 mRNA alternative form, Ethinyl Estradiol results in increased expression of MDM2 protein CTD PMID:12168835 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of MDM2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDM2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of MDM2 mRNA CTD PMID:17555576 17beta-estradiol increases expression ISO RGD:1313299 6480464 Estradiol results in increased expression of MDM2 mRNA alternative form, Estradiol results in increased expression of MDM2 protein CTD PMID:12168835 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of MDM2 mRNA, Estradiol results in increased expression of MDM2 protein CTD PMID:23684557 17beta-estradiol multiple interactions ISO RGD:1313299 6480464 [Estradiol co-treated with Parathion] results in increased expression of MDM2 mRNA, [Estradiol co-treated with TGFB1 protein] results in decreased expression of MDM2 mRNA CTD PMID:17622325 , PMID:30165855 17beta-estradiol decreases phosphorylation EXP 6480464 Estradiol results in decreased phosphorylation of MDM2 protein CTD PMID:22314386 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one increases expression ISO RGD:1313299 6480464 1H-(1 more ... CTD PMID:16288207 2,2',3,3',6,6'-hexachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 2 more ... CTD PMID:19751709 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1313299 6480464 2 more ... CTD PMID:20840854 2,2',4,4',5,5'-hexachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 2 more ... CTD PMID:19751709 , PMID:20840854 2,2',4,4'-tetrachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 2 more ... CTD PMID:19751709 2,2',4,5-tetrachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 2 more ... CTD PMID:19751709 2,2',5,5'-tetrachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 2 more ... CTD PMID:19751709 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one increases expression ISO RGD:1313299 6480464 2 more ... CTD PMID:21647879 2,3,3',4,4',5,5'-Heptachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 2 more ... CTD PMID:19751709 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1313299 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]] more ... CTD PMID:19578757 , PMID:22044530 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1305332 6480464 Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA CTD PMID:12167310 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of MDM2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation ISO RGD:1305332 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of MDM2 protein CTD PMID:15459018 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1305332 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein], Tetrachlorodibenzodioxin results in increased expression of and results in increased phosphorylation of and results in increased activity of MDM2 protein CTD PMID:15459018 2,3,7,8-tetrachlorodibenzodioxine increases degradation ISO RGD:1305332 6480464 Tetrachlorodibenzodioxin results in increased degradation of MDM2 protein CTD PMID:15459018 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDM2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation ISO RGD:1313299 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of MDM2 protein CTD PMID:19751709 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1313299 6480464 Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA CTD PMID:19578757 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1313299 6480464 Tetrachlorodibenzodioxin results in decreased expression of MDM2 mRNA CTD PMID:16039398 2,4-dinitrotoluene affects expression ISO RGD:1305332 6480464 2, 4-dinitrotoluene affects the expression of MDM2 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:1305332 6480464 2, 6-dinitrotoluene affects the expression of MDM2 mRNA CTD PMID:21346803 2-acetamidofluorene multiple interactions ISO RGD:1305332 6480464 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein CTD PMID:11003613 2-acetamidofluorene increases expression ISO RGD:1305332 6480464 2-Acetylaminofluorene results in increased expression of MDM2 mRNA, 2-Acetylaminofluorene results in increased expression of MDM2 protein CTD PMID:19167416 more ... 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of MDM2 mRNA CTD PMID:21607683 2-nitrofluorene increases expression ISO RGD:1305332 6480464 2-nitrofluorene results in increased expression of MDM2 mRNA CTD PMID:14600272 more ... 3,3',4,4',5-pentachlorobiphenyl increases phosphorylation ISO RGD:1313299 6480464 3 more ... CTD PMID:19751709 , PMID:20840854 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO RGD:1313299 6480464 3 more ... CTD PMID:20840854 3,3'-diindolylmethane decreases expression EXP 6480464 3, 3'-diindolylmethane analog results in decreased expression of MDM2 mRNA CTD PMID:26593444 3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine increases expression ISO RGD:1313299 6480464 3 more ... CTD PMID:23810796 3-phenylprop-2-enal increases expression ISO RGD:1313299 6480464 cinnamaldehyde results in increased expression of MDM2 mRNA CTD PMID:19000754 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of MDM2 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol increases methylation EXP 6480464 bis(4-hydroxyphenyl)sulfone results in increased methylation of MDM2 promoter CTD PMID:33297965 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression ISO RGD:1305332 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MDM2 mRNA CTD PMID:14600272 more ... 4-hydroperoxycyclophosphamide increases expression ISO RGD:1313299 6480464 perfosfamide results in increased expression of MDM2 CTD PMID:18034189 4-hydroxyphenyl retinamide decreases expression ISO RGD:1313299 6480464 Fenretinide results in decreased expression of MDM2 mRNA CTD PMID:16570282 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of MDM2 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine affects expression ISO RGD:1313299 6480464 Decitabine affects the expression of MDM2 mRNA CTD PMID:17145863 5-azacytidine increases expression ISO RGD:1313299 6480464 Azacitidine results in increased expression of MDM2 mRNA CTD PMID:20823114 5-fluorouracil increases expression EXP 6480464 Fluorouracil results in increased expression of MDM2 mRNA CTD PMID:16949053 5-fluorouracil increases phosphorylation ISO RGD:1313299 6480464 Fluorouracil results in increased phosphorylation of MDM2 protein CTD PMID:25744307 5-fluorouracil increases expression ISO RGD:1313299 6480464 Fluorouracil results in increased expression of MDM2 mRNA more ... CTD PMID:14665630 more ... 5-fluorouracil multiple interactions ISO RGD:1313299 6480464 Cadmium Chloride affects the reaction [Fluorouracil results in increased phosphorylation of MDM2 protein] more ... CTD PMID:15546879 more ... 7,12-dimethyltetraphene increases expression EXP 6480464 9 more ... CTD PMID:23717041 , PMID:32553695 7,12-dimethyltetraphene multiple interactions EXP 6480464 [epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ... CTD PMID:23717041 acetamide increases expression ISO RGD:1305332 6480464 acetamide results in increased expression of MDM2 mRNA CTD PMID:31881176 acetylsalicylic acid decreases expression ISO RGD:1313299 6480464 Aspirin results in decreased expression of MDM2 mRNA CTD PMID:20457246 adefovir pivoxil increases expression ISO RGD:1313299 6480464 adefovir dipivoxil results in increased expression of MDM2 mRNA CTD PMID:25596134 aflatoxin B1 affects expression ISO RGD:1313299 6480464 Aflatoxin B1 affects the expression of MDM2 protein CTD PMID:20106945 aflatoxin B1 increases expression ISO RGD:1313299 6480464 Aflatoxin B1 results in increased expression of MDM2 mRNA CTD PMID:21632981 more ... aflatoxin B1 decreases methylation ISO RGD:1313299 6480464 Aflatoxin B1 results in decreased methylation of MDM2 gene CTD PMID:27153756 aflatoxin B1 increases expression ISO RGD:1305332 6480464 Aflatoxin B1 results in increased expression of MDM2 mRNA CTD PMID:14600272 more ... aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of MDM2 mRNA CTD PMID:19770486 aflatoxin M1 decreases expression ISO RGD:1313299 6480464 Aflatoxin M1 results in decreased expression of MDM2 mRNA CTD PMID:30928695 alpha-naphthoflavone multiple interactions ISO RGD:1313299 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]], alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA] CTD PMID:19578757 alvocidib decreases expression ISO RGD:1313299 6480464 alvocidib results in decreased expression of MDM2 mRNA, alvocidib results in decreased expression of MDM2 protein CTD PMID:12589031 amifostine decreases expression ISO RGD:1313299 6480464 Amifostine results in decreased expression of MDM2 mRNA CTD PMID:14555708 ammonium chloride increases expression ISO RGD:1305332 6480464 Ammonium Chloride results in increased expression of MDM2 mRNA, Ammonium Chloride results in increased expression of MDM2 protein CTD PMID:12420312 , PMID:16483693 amphetamine increases expression ISO RGD:1305332 6480464 Amphetamine results in increased expression of MDM2 mRNA CTD PMID:30779732 amphibole asbestos decreases expression ISO RGD:1313299 6480464 Asbestos, Amphibole results in decreased expression of MDM2 protein CTD PMID:20855422 amsacrine decreases response to substance ISO RGD:1313299 6480464 MDM2 promoter SNP results in decreased susceptibility to Amsacrine CTD PMID:17575151 androstane multiple interactions EXP 6480464 Androstanols inhibits the reaction [DDT results in increased expression of MDM2 mRNA] CTD PMID:23684557 antimycin A increases expression ISO RGD:1313299 6480464 Antimycin A results in increased expression of MDM2 mRNA CTD PMID:33512557 arsane affects response to substance ISO RGD:1313299 6480464 MDM2 SNP affects the susceptibility to Arsenic CTD PMID:21982800 arsane affects methylation ISO RGD:1313299 6480464 Arsenic affects the methylation of MDM2 gene CTD PMID:25304211 arsenic atom affects response to substance ISO RGD:1313299 6480464 MDM2 SNP affects the susceptibility to Arsenic CTD PMID:21982800 arsenic atom affects methylation ISO RGD:1313299 6480464 Arsenic affects the methylation of MDM2 gene CTD PMID:25304211 arsenite(3-) multiple interactions ISO RGD:1313299 6480464 [[[arsenite results in increased activity of PRKDC protein] which results in increased phosphorylation of and results in increased activity of MAPK9 protein] promotes the reaction [MAPK9 protein binds to TP53 protein]] inhibits the reaction [MDM2 results in increased degradation of and results in decreased stability of TP53 protein] more ... CTD PMID:22366412 more ... arsenite(3-) increases expression ISO RGD:1313299 6480464 arsenite results in increased expression of MDM2 mRNA more ... CTD PMID:30177839 , PMID:34425169 arsenous acid decreases expression ISO RGD:1305332 6480464 Arsenic Trioxide results in decreased expression of MDM2 mRNA CTD PMID:21145380 arsenous acid increases expression ISO RGD:1313299 6480464 Arsenic Trioxide results in increased expression of MDM2 mRNA CTD PMID:20862710 more ... arsenous acid multiple interactions ISO RGD:1305332 6480464 pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA] CTD PMID:17487067 arsenous acid decreases expression ISO RGD:1313299 6480464 Arsenic Trioxide results in decreased expression of MDM2 mRNA CTD PMID:20458559 arsenous acid increases expression ISO RGD:1305332 6480464 Arsenic Trioxide results in increased expression of MDM2 mRNA CTD PMID:17487067 aspartame multiple interactions EXP 6480464 [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA CTD PMID:23783067 atorvastatin calcium increases expression ISO RGD:1313299 6480464 Atorvastatin results in increased expression of MDM2 protein CTD PMID:29630879 atrazine affects methylation ISO RGD:1305332 6480464 Atrazine affects the methylation of MDM2 gene CTD PMID:28931070 avobenzone increases expression ISO RGD:1313299 6480464 avobenzone results in increased expression of MDM2 mRNA CTD PMID:31016361 azoxystrobin increases expression ISO RGD:1313299 6480464 azoxystrobin results in increased expression of MDM2 protein CTD PMID:32339800 benzene multiple interactions EXP 6480464 TRP53 protein affects the reaction [Benzene results in increased expression of MDM2 mRNA] CTD PMID:11896287 benzene increases expression EXP 6480464 Benzene results in increased expression of MDM2 mRNA CTD PMID:11896287 more ... benzene multiple interactions ISO RGD:1313299 6480464 MDM2 gene polymorphism affects the reaction [CDKN2A gene polymorphism affects the susceptibility to Benzene] CTD PMID:19596022 benzene multiple interactions ISO RGD:1305332 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA CTD PMID:17905399 benzo[a]pyrene increases expression ISO RGD:1313299 6480464 Benzo(a)pyrene results in increased expression of MDM2 mRNA more ... CTD PMID:10837373 more ... benzo[a]pyrene decreases expression ISO RGD:1313299 6480464 Benzo(a)pyrene results in decreased expression of MDM2 mRNA CTD PMID:30562542 benzo[a]pyrene increases phosphorylation ISO RGD:1313299 6480464 Benzo(a)pyrene results in increased phosphorylation of MDM2 protein CTD PMID:20840854 , PMID:25744307 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene metabolite results in increased expression of MDM2 mRNA, Benzo(a)pyrene results in increased expression of MDM2 mRNA CTD PMID:18656336 more ... benzo[a]pyrene decreases expression ISO RGD:1305332 6480464 Benzo(a)pyrene results in decreased expression of MDM2 protein CTD PMID:21467743 benzo[a]pyrene multiple interactions ISO RGD:1313299 6480464 2 more ... CTD PMID:10837373 more ... benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1313299 6480464 7 more ... CTD PMID:20382639 more ... benzo[b]fluoranthene increases expression EXP 6480464 benzo(b)fluoranthene results in increased expression of MDM2 mRNA CTD PMID:26377693 benzo[b]fluoranthene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 beta-naphthoflavone increases phosphorylation ISO RGD:1305332 6480464 beta-Naphthoflavone results in increased phosphorylation of MDM2 protein CTD PMID:26558467 biphenyl-4-amine multiple interactions ISO RGD:1313299 6480464 TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA] CTD PMID:32905825 biphenyl-4-amine increases expression ISO RGD:1313299 6480464 4-biphenylamine results in increased expression of MDM2 mRNA CTD PMID:32905825 bis(2-chloroethyl) sulfide affects expression ISO RGD:1305332 6480464 Mustard Gas affects the expression of MDM2 mRNA CTD PMID:15651846 bis(2-chloroethyl) sulfide increases expression ISO RGD:1313299 6480464 Mustard Gas results in increased expression of MDM2 mRNA CTD PMID:33491125 bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of MDM2 mRNA CTD PMID:15674843 , PMID:18955075 bis(2-ethylhexyl) phthalate decreases phosphorylation ISO RGD:1313299 6480464 Diethylhexyl Phthalate results in decreased phosphorylation of MDM2 protein CTD PMID:31163220 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1313299 6480464 Diethylhexyl Phthalate results in increased expression of MDM2 mRNA CTD PMID:31163220 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of MDM2 mRNA CTD PMID:26063408 bisphenol A increases expression ISO RGD:1305332 6480464 bisphenol A results in increased expression of MDM2 mRNA CTD PMID:30816183 more ... bisphenol A affects expression ISO RGD:1313299 6480464 bisphenol A affects the expression of MDM2 mRNA CTD PMID:30903817 bisphenol A increases expression ISO RGD:1313299 6480464 bisphenol A analog results in increased expression of MDM2 mRNA, bisphenol A results in increased expression of MDM2 mRNA CTD PMID:29275510 , PMID:32387340 bisphenol A multiple interactions ISO RGD:1313299 6480464 Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein] CTD PMID:24831732 bisphenol A increases phosphorylation ISO RGD:1313299 6480464 bisphenol A results in increased phosphorylation of MDM2 protein CTD PMID:24831732 bisphenol A affects expression ISO RGD:1305332 6480464 bisphenol A affects the expression of MDM2 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1305332 6480464 bisphenol A results in decreased expression of MDM2 mRNA CTD PMID:26982218 bortezomib multiple interactions ISO RGD:1313299 6480464 [CASP8 protein results in increased activity of CASP3 protein] affects the reaction [Bortezomib results in increased cleavage of MDM2 protein], Bortezomib promotes the reaction [TP53 protein binds to MDM2 protein] CTD PMID:12393500 bortezomib increases cleavage ISO RGD:1313299 6480464 Bortezomib results in increased cleavage of MDM2 protein CTD PMID:12393500 bortezomib affects expression ISO RGD:1313299 6480464 Bortezomib affects the expression of MDM2 protein CTD PMID:12393500 brassinolide decreases expression ISO RGD:1313299 6480464 brassinolide results in decreased expression of MDM2 protein CTD PMID:20833159 cadmium atom decreases expression ISO RGD:1305332 6480464 Cadmium results in decreased expression of MDM2 mRNA CTD PMID:21467746 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of MDM2 mRNA CTD PMID:22666406 cadmium dichloride affects expression ISO RGD:1305332 6480464 Cadmium Chloride affects the expression of MDM2 mRNA CTD PMID:22110744 cadmium dichloride multiple interactions ISO RGD:1305332 6480464 [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of MDM2 mRNA CTD PMID:31077537 cadmium dichloride decreases expression ISO RGD:1305332 6480464 Cadmium Chloride results in decreased expression of MDM2 mRNA CTD PMID:31077537 cadmium dichloride increases expression ISO RGD:1305332 6480464 Cadmium Chloride results in increased expression of MDM2 mRNA CTD PMID:23405080 cadmium dichloride increases phosphorylation ISO RGD:1313299 6480464 Cadmium Chloride results in increased phosphorylation of MDM2 protein CTD PMID:25744307 cadmium dichloride multiple interactions ISO RGD:1313299 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MDM2 protein] more ... CTD PMID:25744307 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of MDM2 mRNA CTD PMID:11958953 more ... cadmium dichloride increases phosphorylation EXP 6480464 Cadmium Chloride results in increased phosphorylation of MDM2 protein CTD PMID:20525538 , PMID:22314386 cadmium dichloride multiple interactions EXP 6480464 Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein] more ... CTD PMID:11958953 , PMID:12135628 caffeine decreases phosphorylation ISO RGD:1313299 6480464 Caffeine results in decreased phosphorylation of MDM2 protein CTD PMID:35688186 camptothecin increases expression ISO RGD:1313299 6480464 Camptothecin results in increased expression of MDM2 protein CTD PMID:17555331 cannabidiol increases expression EXP 6480464 Cannabidiol results in increased expression of MDM2 mRNA CTD PMID:30742662 cannabidiol increases expression ISO RGD:1313299 6480464 Cannabidiol results in increased expression of MDM2 mRNA CTD PMID:27932991 , PMID:30713602 cannabidiol multiple interactions EXP 6480464 [lipopolysaccharide, E coli O55-B5 co-treated with Cannabidiol] results in increased expression of MDM2 mRNA CTD PMID:30742662 cantharidin decreases expression ISO RGD:1313299 6480464 Cantharidin results in decreased expression of MDM2 mRNA CTD PMID:31945315 capsaicin multiple interactions ISO RGD:1313299 6480464 Capsaicin promotes the reaction [resveratrol results in decreased expression of MDM2 protein] more ... CTD PMID:19846903 capsaicin increases expression ISO RGD:1313299 6480464 Capsaicin results in increased expression of MDM2 mRNA CTD PMID:19502594 capsaicin decreases expression ISO RGD:1313299 6480464 Capsaicin results in decreased expression of MDM2 protein CTD PMID:19846903 Carbadox increases expression ISO RGD:1305332 6480464 Carbadox results in increased expression of MDM2 mRNA CTD PMID:26558467 carbamazepine affects expression ISO RGD:1313299 6480464 Carbamazepine affects the expression of MDM2 mRNA CTD PMID:25979313 carbonyl cyanide p-trifluoromethoxyphenylhydrazone decreases expression ISO RGD:1313299 6480464 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of MDM2 mRNA CTD PMID:16039398 chlorambucil increases expression ISO RGD:1313299 6480464 Chlorambucil results in increased expression of MDM2 mRNA CTD PMID:17476690 chloroacetaldehyde increases expression ISO RGD:1313299 6480464 chloroacetaldehyde results in increased expression of MDM2 mRNA CTD PMID:25596134 chloroethene affects response to substance ISO RGD:1313299 6480464 MDM2 polymorphism affects the susceptibility to Vinyl Chloride CTD PMID:24464562 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of MDM2 mRNA CTD PMID:23125180 chlorpromazine increases expression ISO RGD:1305332 6480464 Chlorpromazine results in increased expression of MDM2 mRNA CTD PMID:25596134 chlorpyrifos increases expression ISO RGD:1313299 6480464 Chlorpyrifos results in increased expression of MDM2 mRNA CTD PMID:30981936 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MDM2 gene CTD PMID:20938992 chrysene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 cidofovir anhydrous affects expression ISO RGD:1313299 6480464 Cidofovir affects the expression of MDM2 mRNA CTD PMID:25596134 cisplatin increases expression ISO RGD:1305332 6480464 Cisplatin results in increased expression of MDM2 mRNA CTD PMID:24880025 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of MDM2 mRNA CTD PMID:21151649 more ... cisplatin multiple interactions EXP 6480464 Cisplatin promotes the reaction [TRP53 protein results in increased expression of MDM2] CTD PMID:21552291 cisplatin increases expression ISO RGD:1313299 6480464 Cisplatin results in increased expression of MDM2 mRNA, Cisplatin results in increased expression of MDM2 protein CTD PMID:16797627 more ... cisplatin multiple interactions ISO RGD:1313299 6480464 [Cisplatin co-treated with eprenetapopt co-treated with Oxygen deficiency] results in increased expression of MDM2 mRNA more ... CTD PMID:21509038 more ... clofibrate multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA] CTD PMID:17585979 cobalt atom increases expression ISO RGD:1313299 6480464 Cobalt results in increased expression of MDM2 mRNA CTD PMID:24068677 cobalt atom multiple interactions ISO RGD:1313299 6480464 TP53 protein affects the reaction [Cobalt results in increased expression of MDM2 mRNA] CTD PMID:24068677 cobalt dichloride increases expression ISO RGD:1313299 6480464 cobaltous chloride results in increased expression of MDM2 protein CTD PMID:19714248 cobalt dichloride increases expression ISO RGD:1305332 6480464 cobaltous chloride results in increased expression of MDM2 mRNA CTD PMID:24386269 cobalt dichloride multiple interactions ISO RGD:1313299 6480464 MDM2 protein promotes the reaction [cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]] CTD PMID:19714248 copper atom increases expression EXP 6480464 Copper results in increased expression of MDM2 mRNA CTD PMID:16629173 copper atom multiple interactions ISO RGD:1313299 6480464 [Chelating Agents binds to Copper] which results in increased expression of MDM2 mRNA CTD PMID:30911355 copper(0) increases expression EXP 6480464 Copper results in increased expression of MDM2 mRNA CTD PMID:16629173 copper(0) multiple interactions ISO RGD:1313299 6480464 [Chelating Agents binds to Copper] which results in increased expression of MDM2 mRNA CTD PMID:30911355 coumarin decreases expression ISO RGD:1313299 6480464 coumarin analog results in decreased expression of MDM2 mRNA CTD PMID:32578917 crocidolite asbestos decreases expression EXP 6480464 Asbestos, Crocidolite results in decreased expression of MDM2 mRNA CTD PMID:29279043 cryptolepine increases expression ISO RGD:1313299 6480464 cryptolepine results in increased expression of MDM2 mRNA, cryptolepine results in increased expression of MDM2 protein CTD PMID:16120219 curcumin decreases expression ISO RGD:1313299 6480464 [Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA more ... CTD PMID:17332326 curcumin increases expression ISO RGD:1313299 6480464 Curcumin analog results in increased expression of MDM2 mRNA CTD PMID:26409325 curcumin multiple interactions ISO RGD:1313299 6480464 Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein] CTD PMID:24831732 cyclosporin A increases expression ISO RGD:1313299 6480464 Cyclosporine results in increased expression of MDM2 mRNA CTD PMID:20106945 more ... cylindrospermopsin increases expression ISO RGD:1313299 6480464 cylindrospermopsin results in increased expression of MDM2 mRNA CTD PMID:21607682 cylindrospermopsin multiple interactions ISO RGD:1313299 6480464 [4, 4'-hexafluorisopropylidene diphenol co-treated with cylindrospermopsin] results in increased expression of MDM2 mRNA CTD PMID:32244372 cyproconazole multiple interactions ISO RGD:1305332 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA, [cyproconazole co-treated with epoxiconazole] results in increased expression of MDM2 mRNA CTD PMID:29038839 DAPT multiple interactions ISO RGD:1313299 6480464 Hydrogen Peroxide inhibits the reaction [N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein] CTD PMID:25005833 DAPT increases expression ISO RGD:1313299 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein CTD PMID:25005833 DDT multiple interactions EXP 6480464 Androstanols inhibits the reaction [DDT results in increased expression of MDM2 mRNA] CTD PMID:23684557 DDT increases expression EXP 6480464 DDT results in increased expression of MDM2 mRNA, DDT results in increased expression of MDM2 protein CTD PMID:23684557 deguelin increases expression ISO RGD:1313299 6480464 deguelin results in increased expression of MDM2 mRNA CTD PMID:33512557 deoxynivalenol increases expression ISO RGD:1313299 6480464 deoxynivalenol results in increased expression of MDM2 mRNA CTD PMID:31863870 diallyl disulfide multiple interactions ISO RGD:1305332 6480464 [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of MDM2 mRNA CTD PMID:31077537 diallyl trisulfide decreases expression ISO RGD:1313299 6480464 diallyl trisulfide results in decreased expression of MDM2 protein CTD PMID:24415872 diallyl trisulfide increases degradation ISO RGD:1313299 6480464 diallyl trisulfide results in increased degradation of MDM2 protein CTD PMID:23754639 diarsenic trioxide decreases expression ISO RGD:1313299 6480464 Arsenic Trioxide results in decreased expression of MDM2 mRNA CTD PMID:20458559 diarsenic trioxide increases expression ISO RGD:1313299 6480464 Arsenic Trioxide results in increased expression of MDM2 mRNA CTD PMID:20862710 more ... diarsenic trioxide multiple interactions ISO RGD:1305332 6480464 pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA] CTD PMID:17487067 diarsenic trioxide decreases expression ISO RGD:1305332 6480464 Arsenic Trioxide results in decreased expression of MDM2 mRNA CTD PMID:21145380 diarsenic trioxide increases expression ISO RGD:1305332 6480464 Arsenic Trioxide results in increased expression of MDM2 mRNA CTD PMID:17487067 diazinon affects expression ISO RGD:1305332 6480464 Diazinon affects the expression of MDM2 mRNA CTD PMID:22546817 dibenz[a,h]anthracene increases expression EXP 6480464 1 more ... CTD PMID:26377693 diclofenac decreases expression ISO RGD:1305332 6480464 Diclofenac results in decreased expression of MDM2 mRNA CTD PMID:17202759 dieldrin affects expression ISO RGD:1305332 6480464 Dieldrin affects the expression of MDM2 mRNA CTD PMID:22546817 diepoxybutane multiple interactions ISO RGD:1313299 6480464 diepoxybutane inhibits the reaction [TP53 protein binds to MDM2 protein] CTD PMID:20024960 diethylstilbestrol affects mutagenesis EXP 6480464 Diethylstilbestrol affects the mutagenesis of MDM2 gene CTD PMID:7916985 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of MDM2 mRNA CTD PMID:21041162 diethylstilbestrol increases expression ISO RGD:1305332 6480464 Diethylstilbestrol results in increased expression of MDM2 mRNA CTD PMID:15890375 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of MDM2 mRNA CTD PMID:15545218 dimethylarsinic acid increases expression ISO RGD:1305332 6480464 Cacodylic Acid results in increased expression of MDM2 mRNA CTD PMID:17481689 dimethylarsinic acid multiple interactions ISO RGD:1313299 6480464 [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of MDM2 mRNA CTD PMID:23192986 dioxygen multiple interactions ISO RGD:1313299 6480464 [Cisplatin co-treated with eprenetapopt co-treated with Oxygen deficiency] results in increased expression of MDM2 mRNA more ... CTD PMID:19578757 , PMID:29690507 dioxygen multiple interactions EXP 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of MDM2 mRNA CTD PMID:30529165 dioxygen increases expression ISO RGD:1313299 6480464 Oxygen deficiency results in increased expression of MDM2 mRNA, Oxygen deficiency results in increased expression of MDM2 protein CTD PMID:19502547 more ... disodium selenite increases expression ISO RGD:1313299 6480464 Sodium Selenite results in increased expression of MDM2 mRNA CTD PMID:24383545 dorsomorphin multiple interactions ISO RGD:1313299 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin multiple interactions ISO RGD:1313299 6480464 Doxorubicin inhibits the reaction [TP53 protein binds to MDM2 protein] more ... CTD PMID:17935137 more ... doxorubicin affects expression EXP 6480464 Doxorubicin affects the expression of MDM2 mRNA CTD PMID:29653124 doxorubicin increases expression ISO RGD:1305332 6480464 Doxorubicin results in increased expression of MDM2 mRNA CTD PMID:12187937 more ... doxorubicin decreases response to substance ISO RGD:1313299 6480464 MDM2 protein results in decreased susceptibility to Doxorubicin CTD PMID:26317544 doxorubicin increases expression ISO RGD:1313299 6480464 Doxorubicin results in increased expression of MDM2 mRNA, Doxorubicin results in increased expression of MDM2 protein CTD PMID:14665630 more ... doxorubicin affects expression ISO RGD:1313299 6480464 Doxorubicin affects the expression of MDM2 mRNA CTD PMID:25529476 , PMID:29803840 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of MDM2 mRNA CTD PMID:14766674 more ... doxorubicin multiple interactions EXP 6480464 pifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA] CTD PMID:14766674 doxorubicin increases phosphorylation ISO RGD:1313299 6480464 Doxorubicin results in increased phosphorylation of MDM2 protein CTD PMID:17935137 ellipticine decreases response to substance ISO RGD:1313299 6480464 MDM2 promoter SNP results in decreased susceptibility to ellipticine CTD PMID:17575151 endosulfan increases expression ISO RGD:1305332 6480464 Endosulfan results in increased expression of MDM2 mRNA CTD PMID:29391264 epoxiconazole multiple interactions ISO RGD:1305332 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA, [cyproconazole co-treated with epoxiconazole] results in increased expression of MDM2 mRNA CTD PMID:29038839 epoxiconazole increases expression ISO RGD:1305332 6480464 epoxiconazole results in increased expression of MDM2 mRNA CTD PMID:29038839 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of MDM2 mRNA CTD PMID:22535522 ethyl methanesulfonate increases expression ISO RGD:1313299 6480464 Ethyl Methanesulfonate results in increased expression of MDM2 mRNA CTD PMID:23649840 etoposide increases expression ISO RGD:1313299 6480464 Etoposide results in increased expression of MDM2 mRNA more ... CTD PMID:16120219 more ... etoposide decreases expression ISO RGD:1313299 6480464 Etoposide results in decreased expression of MDM2 protein CTD PMID:26259609 etoposide increases phosphorylation ISO RGD:1313299 6480464 Etoposide results in increased phosphorylation of MDM2 protein CTD PMID:17935137 , PMID:25744307 etoposide increases expression ISO RGD:1305332 6480464 Etoposide results in increased expression of MDM2 protein CTD PMID:15459018 etoposide multiple interactions ISO RGD:1305332 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein] CTD PMID:15459018 etoposide decreases response to substance ISO RGD:1313299 6480464 MDM2 promoter SNP results in decreased susceptibility to Etoposide CTD PMID:17575151 etoposide multiple interactions ISO RGD:1313299 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] more ... CTD PMID:17575151 more ... EUK-134 multiple interactions ISO RGD:1313299 6480464 EUK-134 inhibits the reaction [Hydrogen Peroxide results in decreased expression of MDM2 protein], EUK-134 inhibits the reaction [Vitamin K 3 results in decreased expression of MDM2 protein] CTD PMID:25005833 fenbendazole increases expression ISO RGD:1305332 6480464 Fenbendazole results in increased expression of MDM2 mRNA CTD PMID:23411599 fenofibrate decreases expression ISO RGD:1305332 6480464 Fenofibrate results in decreased expression of MDM2 mRNA CTD PMID:25596134 fipronil increases expression ISO RGD:1305332 6480464 fipronil results in increased expression of MDM2 mRNA CTD PMID:23962444 flavanones increases phosphorylation ISO RGD:1313299 6480464 Flavanones results in increased phosphorylation of MDM2 protein CTD PMID:21616090 flucytosine increases expression ISO RGD:1313299 6480464 Flucytosine results in increased expression of MDM2 protein CTD PMID:15592511 fluoranthene multiple interactions ISO RGD:1313299 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of MDM2 mRNA CTD PMID:17690111 flutamide increases expression ISO RGD:1305332 6480464 Flutamide results in increased expression of MDM2 mRNA CTD PMID:24136188 folic acid affects expression ISO RGD:1313299 6480464 Folic Acid affects the expression of MDM2 mRNA CTD PMID:16361273 folic acid multiple interactions EXP 6480464 [1 more ... CTD PMID:20938992 , PMID:22206623 formaldehyde increases expression ISO RGD:1305332 6480464 Formaldehyde results in increased expression of MDM2 mRNA, Formaldehyde results in increased expression of MDM2 protein CTD PMID:18045764 formaldehyde increases expression ISO RGD:1313299 6480464 Formaldehyde results in increased expression of MDM2 mRNA, Formaldehyde results in increased expression of MDM2 protein CTD PMID:18045764 , PMID:23649840 formononetin increases expression ISO RGD:1305332 6480464 formononetin results in increased expression of MDM2 protein CTD PMID:28414026 fumonisin B1 multiple interactions ISO RGD:1313299 6480464 fumonisin B1 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA], fumonisin B1 inhibits the reaction [AGT protein results in increased expression of MDM2 protein] CTD PMID:18206046 furan increases expression ISO RGD:1305332 6480464 furan results in increased expression of MDM2 mRNA CTD PMID:22079235 furosemide affects expression ISO RGD:1305332 6480464 Furosemide affects the expression of MDM2 mRNA CTD PMID:17497460 ganciclovir increases expression ISO RGD:1313299 6480464 Ganciclovir results in increased expression of MDM2 protein CTD PMID:15592511 geldanamycin increases expression ISO RGD:1313299 6480464 geldanamycin results in increased expression of MDM2 mRNA CTD PMID:26705709 gemcitabine decreases expression ISO RGD:1313299 6480464 gemcitabine results in decreased expression of MDM2 mRNA CTD PMID:20103597 gemcitabine increases expression ISO RGD:1313299 6480464 gemcitabine results in increased expression of MDM2 mRNA CTD PMID:17039268 genistein decreases expression EXP 6480464 Genistein results in decreased expression of MDM2 mRNA CTD PMID:21048042 gentamycin increases expression ISO RGD:1305332 6480464 Gentamicins results in increased expression of MDM2 mRNA CTD PMID:22061828 , PMID:33387578 glyphosate decreases expression ISO RGD:1313299 6480464 glyphosate results in decreased expression of MDM2 mRNA CTD PMID:31295307 GW 501516 multiple interactions ISO RGD:1305332 6480464 MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein] CTD PMID:19103650 hydrogen peroxide multiple interactions ISO RGD:1313299 6480464 EUK-134 inhibits the reaction [Hydrogen Peroxide results in decreased expression of MDM2 protein] more ... CTD PMID:21552291 , PMID:25005833 hydrogen peroxide increases expression ISO RGD:1313299 6480464 Hydrogen Peroxide results in increased expression of MDM2 mRNA CTD PMID:21751221 hydrogen peroxide increases expression ISO RGD:1305332 6480464 Hydrogen Peroxide results in increased expression of MDM2 mRNA CTD PMID:14689451 , PMID:27525270 hydrogen peroxide multiple interactions ISO RGD:1305332 6480464 [Quercetin co-treated with Hydrogen Peroxide] results in increased expression of MDM2 mRNA more ... CTD PMID:14689451 , PMID:27525270 hydrogen peroxide decreases expression ISO RGD:1313299 6480464 Hydrogen Peroxide results in decreased expression of MDM2 protein CTD PMID:25005833 hydrogen peroxide multiple interactions EXP 6480464 Hydrogen Peroxide promotes the reaction [TRP53 protein results in increased expression of MDM2] CTD PMID:21552291 hydroquinone increases expression ISO RGD:1313299 6480464 hydroquinone results in increased expression of MDM2 mRNA CTD PMID:29221148 hydroxyurea increases expression ISO RGD:1313299 6480464 Hydroxyurea results in increased expression of MDM2 mRNA CTD PMID:18647660 hydroxyurea increases expression EXP 6480464 Hydroxyurea results in increased expression of MDM2 mRNA CTD PMID:16356682 hydroxyurea affects expression EXP 6480464 Hydroxyurea affects the expression of MDM2 protein CTD PMID:16356682 ifosfamide increases expression ISO RGD:1313299 6480464 Ifosfamide results in increased expression of MDM2 mRNA CTD PMID:25596134 Indeno[1,2,3-cd]pyrene increases expression ISO RGD:1313299 6480464 indeno(1 more ... CTD PMID:32251684 irinotecan increases expression ISO RGD:1313299 6480464 Irinotecan metabolite results in increased expression of MDM2 mRNA, Irinotecan results in increased expression of MDM2 mRNA CTD PMID:15956246 isoflurane decreases expression ISO RGD:1305332 6480464 Isoflurane results in decreased expression of MDM2 mRNA CTD PMID:16978161 kojic acid multiple interactions ISO RGD:1305332 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MDM2 mRNA CTD PMID:18544905 L-ascorbic acid multiple interactions ISO RGD:1305332 6480464 Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of MDM2 protein] CTD PMID:21262251 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MDM2 gene CTD PMID:20938992 leflunomide increases expression ISO RGD:1313299 6480464 leflunomide results in increased expression of MDM2 mRNA CTD PMID:28988120 leptomycin B increases expression ISO RGD:1313299 6480464 leptomycin B results in increased expression of MDM2 mRNA CTD PMID:20803015 Leucomalachite green increases phosphorylation ISO RGD:1305332 6480464 leucomalachite green results in increased phosphorylation of MDM2 protein CTD PMID:26558467 linalool increases expression ISO RGD:1313299 6480464 linalool results in increased expression of MDM2 mRNA CTD PMID:19922762 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of MDM2 mRNA CTD PMID:10975854 , PMID:23107598 lipopolysaccharide multiple interactions EXP 6480464 Indirubin E804 inhibits the reaction [Lipopolysaccharides results in increased expression of MDM2 mRNA] CTD PMID:23107598 lupeol multiple interactions ISO RGD:1313299 6480464 lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 luteolin increases expression ISO RGD:1305332 6480464 Luteolin results in increased expression of MDM2 mRNA CTD PMID:31201582 luteolin multiple interactions ISO RGD:1305332 6480464 Luteolin promotes the reaction [Hydrogen Peroxide results in increased expression of MDM2 mRNA] CTD PMID:27525270 LY294002 increases expression ISO RGD:1313299 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of MDM2 protein CTD PMID:16412023 mancozeb multiple interactions ISO RGD:1313299 6480464 lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 mancozeb increases expression ISO RGD:1313299 6480464 mancozeb results in increased expression of MDM2 mRNA CTD PMID:27235710 manganese atom multiple interactions ISO RGD:1305332 6480464 [Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein, PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein] CTD PMID:25791630 manganese atom decreases expression ISO RGD:1305332 6480464 Manganese results in decreased expression of MDM2 protein CTD PMID:25791630 manganese(0) multiple interactions ISO RGD:1305332 6480464 [Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein, PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein] CTD PMID:25791630 manganese(0) decreases expression ISO RGD:1305332 6480464 Manganese results in decreased expression of MDM2 protein CTD PMID:25791630 manganese(II) chloride increases expression ISO RGD:1305332 6480464 manganese chloride results in increased expression of MDM2 mRNA CTD PMID:28801915 menadione decreases expression ISO RGD:1313299 6480464 Vitamin K 3 results in decreased expression of MDM2 protein CTD PMID:25005833 menadione multiple interactions ISO RGD:1313299 6480464 EUK-134 inhibits the reaction [Vitamin K 3 results in decreased expression of MDM2 protein] CTD PMID:25005833 mercury dibromide increases expression ISO RGD:1313299 6480464 mercuric bromide results in increased expression of MDM2 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:1313299 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA CTD PMID:27188386 mercury dichloride decreases expression EXP 6480464 Mercuric Chloride results in decreased expression of MDM2 mRNA CTD PMID:23202902 metformin increases expression ISO RGD:1305332 6480464 Metformin results in increased expression of MDM2 mRNA CTD PMID:25596134 methapyrilene decreases expression ISO RGD:1305332 6480464 Methapyrilene results in decreased expression of MDM2 mRNA CTD PMID:22584684 methapyrilene increases expression ISO RGD:1305332 6480464 Methapyrilene results in increased expression of MDM2 mRNA CTD PMID:15890375 more ... methapyrilene increases phosphorylation ISO RGD:1305332 6480464 Methapyrilene results in increased phosphorylation of MDM2 protein CTD PMID:26558467 methotrexate multiple interactions ISO RGD:1313299 6480464 Methotrexate results in increased activity of and results in increased expression of MDM2 protein more ... CTD PMID:21624110 methotrexate affects expression EXP 6480464 Methotrexate affects the expression of MDM2 mRNA CTD PMID:18502557 methotrexate increases expression ISO RGD:1313299 6480464 Methotrexate results in increased expression of MDM2 mRNA, Methotrexate results in increased expression of MDM2 protein CTD PMID:17637740 more ... methyl caffeate affects binding ISO RGD:1313299 6480464 methyl caffeate binds to MDM2 protein CTD PMID:26415618 methyl methanesulfonate increases expression ISO RGD:1313299 6480464 Methyl Methanesulfonate results in increased expression of MDM2 mRNA, Methyl Methanesulfonate results in increased expression of MDM2 protein CTD PMID:23649840 , PMID:25078064 methylarsonic acid increases expression ISO RGD:1305332 6480464 monomethylarsonic acid results in increased expression of MDM2 mRNA CTD PMID:17481689 methylarsonic acid multiple interactions ISO RGD:1313299 6480464 [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of MDM2 mRNA CTD PMID:23192986 methylmercury chloride decreases expression EXP 6480464 methylmercuric chloride results in decreased expression of MDM2 mRNA CTD PMID:23202902 methylmercury chloride increases expression ISO RGD:1313299 6480464 methylmercuric chloride results in increased expression of MDM2 mRNA CTD PMID:28001369 methylmercury(1+) multiple interactions ISO RGD:1305332 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA CTD PMID:17905399 microcystin-LR decreases expression EXP 6480464 cyanoginosin LR results in decreased expression of MDM2 mRNA, cyanoginosin LR results in decreased expression of MDM2 protein CTD PMID:28414124 microcystin-LR decreases expression ISO RGD:1305332 6480464 cyanoginosin LR results in decreased expression of MDM2 protein CTD PMID:31157505 mifepristone increases expression EXP 6480464 Mifepristone results in increased expression of MDM2 mRNA CTD PMID:12605714 mitomycin C multiple interactions ISO RGD:1313299 6480464 [Mitomycin results in increased stability of TP53 protein] which results in increased expression of MDM2 mRNA CTD PMID:20536192 mitomycin C increases expression ISO RGD:1313299 6480464 Mitomycin results in increased expression of MDM2 protein CTD PMID:18096571 mitomycin C increases expression EXP 6480464 Mitomycin results in increased expression of MDM2 mRNA CTD PMID:25270620 mitoxantrone decreases response to substance ISO RGD:1313299 6480464 MDM2 promoter SNP results in decreased susceptibility to Mitoxantrone CTD PMID:17575151 mono(2-ethylhexyl) phthalate decreases expression ISO RGD:1313299 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of MDM2 protein CTD PMID:24706461 monocrotaline multiple interactions EXP 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 monosodium L-glutamate multiple interactions EXP 6480464 [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA CTD PMID:23783067 motexafin gadolinium multiple interactions ISO RGD:1313299 6480464 motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA] CTD PMID:16357179 motexafin gadolinium increases expression ISO RGD:1313299 6480464 motexafin gadolinium results in increased expression of MDM2 mRNA CTD PMID:16357179 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine increases expression ISO RGD:1313299 6480464 N more ... CTD PMID:33645215 N-acetylsphingosine decreases expression ISO RGD:1313299 6480464 N-acetylsphingosine results in decreased expression of MDM2 mRNA, N-acetylsphingosine results in decreased expression of MDM2 protein CTD PMID:18206046 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MDM2 mRNA CTD PMID:20061341 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1313299 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]] CTD PMID:17575151 N-ethyl-N-nitrosourea increases expression ISO RGD:1305332 6480464 Ethylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:15954086 N-ethyl-N-nitrosourea increases expression EXP 6480464 Ethylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:19100860 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO RGD:1313299 6480464 Methylnitronitrosoguanidine results in increased expression of MDM2 mRNA CTD PMID:12634122 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein] CTD PMID:12135628 N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP 6480464 Methylnitronitrosoguanidine results in increased expression of MDM2 protein CTD PMID:12135628 N-methyl-N-nitrosourea increases expression ISO RGD:1305332 6480464 Methylnitrosourea results in increased expression of MDM2 mRNA CTD PMID:28688903 N-nitrosodiethylamine multiple interactions ISO RGD:1305332 6480464 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein, [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MDM2 mRNA CTD PMID:11003613 , PMID:18544905 N-nitrosodiethylamine increases expression ISO RGD:1305332 6480464 Diethylnitrosamine results in increased expression of MDM2 mRNA, Diethylnitrosamine results in increased expression of MDM2 protein CTD PMID:14555611 more ... N-nitrosodiethylamine multiple interactions EXP 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MDM2 mRNA] CTD PMID:17854601 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of MDM2 mRNA, Diethylnitrosamine results in increased expression of MDM2 protein CTD PMID:17854601 more ... N-nitrosodimethylamine increases expression ISO RGD:1305332 6480464 Dimethylnitrosamine results in increased expression of MDM2 mRNA CTD PMID:14600272 , PMID:15890375 N-nitrosomorpholine increases expression ISO RGD:1305332 6480464 N-nitrosomorpholine results in increased expression of MDM2 mRNA, N-nitrosomorpholine results in increased expression of MDM2 protein CTD PMID:14587038 , PMID:19716841 N-Vinyl-2-pyrrolidone multiple interactions ISO RGD:1305332 6480464 [N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of MDM2 mRNA CTD PMID:22037397 nefazodone increases expression ISO RGD:1305332 6480464 nefazodone results in increased expression of MDM2 mRNA CTD PMID:24136188 nickel atom increases expression ISO RGD:1313299 6480464 Nickel results in increased expression of MDM2 mRNA CTD PMID:24068677 nickel atom multiple interactions ISO RGD:1313299 6480464 TP53 protein affects the reaction [Nickel results in increased expression of MDM2 mRNA] CTD PMID:24068677 nickel dichloride increases expression ISO RGD:1313299 6480464 nickel chloride results in increased expression of MDM2 mRNA CTD PMID:23566959 , PMID:28552779 nickel dichloride affects expression ISO RGD:1305332 6480464 nickel chloride affects the expression of MDM2 mRNA CTD PMID:22546817 nickel dichloride multiple interactions ISO RGD:1313299 6480464 TP53 protein affects the reaction [nickel chloride results in increased expression of MDM2 mRNA] CTD PMID:23566959 nicotinamide increases expression ISO RGD:1313299 6480464 Niacinamide results in increased expression of MDM2 mRNA CTD PMID:16998810 nicotine multiple interactions ISO RGD:1313299 6480464 [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein, [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 nimesulide increases expression ISO RGD:1305332 6480464 nimesulide results in increased expression of MDM2 mRNA CTD PMID:24136188 nitenpyram increases expression ISO RGD:1313299 6480464 nitenpyram results in increased expression of MDM2 mRNA CTD PMID:35568224 Nodularin increases expression ISO RGD:1313299 6480464 nodularin results in increased expression of MDM2 mRNA CTD PMID:30562542 Nutlin-3 multiple interactions ISO RGD:1313299 6480464 [nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]] which results in increased activity of TP53 protein more ... CTD PMID:16439685 more ... Nutlin-3 decreases expression ISO RGD:1313299 6480464 nutlin 3 results in decreased expression of MDM2 protein CTD PMID:35213076 Nutlin-3 increases expression EXP 6480464 nutlin 3 results in increased expression of MDM2 mRNA CTD PMID:16949053 Nutlin-3 increases expression ISO RGD:1313299 6480464 nutlin 3 results in increased expression of MDM2 mRNA more ... CTD PMID:16014563 more ... O-methyleugenol increases expression ISO RGD:1305332 6480464 methyleugenol results in increased expression of MDM2 mRNA CTD PMID:26011634 ochratoxin A increases expression ISO RGD:1305332 6480464 ochratoxin A results in increased expression of MDM2 mRNA CTD PMID:23358140 ochratoxin A decreases expression ISO RGD:1313299 6480464 ochratoxin A results in decreased expression of MDM2 mRNA CTD PMID:30763683 Octicizer increases expression ISO RGD:1313299 6480464 2-ethylhexyldiphenylphosphate results in increased expression of MDM2 mRNA CTD PMID:30981936 ortho-Aminoazotoluene increases expression EXP 6480464 o-Aminoazotoluene results in increased expression of MDM2 mRNA CTD PMID:15346788 ouabain multiple interactions ISO RGD:1313299 6480464 Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein CTD PMID:31436044 oxaliplatin increases expression ISO RGD:1305332 6480464 oxaliplatin results in increased expression of MDM2 mRNA CTD PMID:25729387 oxaliplatin multiple interactions ISO RGD:1305332 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MDM2 mRNA CTD PMID:25729387 oxfendazole increases expression ISO RGD:1305332 6480464 oxfendazole results in increased expression of MDM2 mRNA CTD PMID:26558467 oxfendazole decreases phosphorylation ISO RGD:1305332 6480464 oxfendazole results in decreased phosphorylation of MDM2 protein CTD PMID:26558467 p-chloromercuribenzoic acid increases expression ISO RGD:1313299 6480464 p-Chloromercuribenzoic Acid results in increased expression of MDM2 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:1313299 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA CTD PMID:27188386 paclitaxel decreases response to substance ISO RGD:1313299 6480464 MDM2 protein results in decreased susceptibility to Paclitaxel CTD PMID:13130078 paracetamol multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA] CTD PMID:17585979 paracetamol increases expression ISO RGD:1313299 6480464 Acetaminophen results in increased expression of MDM2 mRNA CTD PMID:22230336 paracetamol decreases expression ISO RGD:1313299 6480464 Acetaminophen results in decreased expression of MDM2 mRNA CTD PMID:21420995 paracetamol decreases expression ISO RGD:1305332 6480464 Acetaminophen results in decreased expression of MDM2 mRNA CTD PMID:21807079 paracetamol increases phosphorylation ISO RGD:1305332 6480464 Acetaminophen results in increased phosphorylation of MDM2 protein CTD PMID:16330492 paracetamol increases expression ISO RGD:1305332 6480464 Acetaminophen results in increased expression of MDM2 mRNA CTD PMID:17202762 , PMID:33387578 paracetamol multiple interactions ISO RGD:1305332 6480464 Acetaminophen promotes the reaction [MDM2 protein binds to TP53 protein] CTD PMID:16330492 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of MDM2 mRNA CTD PMID:17562736 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of MDM2 mRNA CTD PMID:26056430 Paraoxon-methyl increases expression ISO RGD:1313299 6480464 methylparaoxon results in increased expression of MDM2 mRNA CTD PMID:18418871 paraquat multiple interactions EXP 6480464 GPX1 protein affects the reaction [Paraquat affects the expression of MDM2 mRNA] CTD PMID:12654481 paraquat increases expression ISO RGD:1305332 6480464 Paraquat results in increased expression of MDM2 mRNA CTD PMID:32680482 paraquat increases expression ISO RGD:1313299 6480464 Paraquat results in increased expression of MDM2 mRNA CTD PMID:20883675 , PMID:34097952 parathion multiple interactions ISO RGD:1313299 6480464 [Estradiol co-treated with Parathion] results in increased expression of MDM2 mRNA CTD PMID:17622325 parathion-methyl increases expression ISO RGD:1313299 6480464 Methyl Parathion results in increased expression of MDM2 mRNA CTD PMID:18418871 PCB138 increases phosphorylation ISO RGD:1313299 6480464 2 more ... CTD PMID:19751709 PD123319 multiple interactions ISO RGD:1313299 6480464 PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA], PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein] CTD PMID:18206046 pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of MDM2 mRNA CTD PMID:23892564 perfluorooctanoic acid increases expression ISO RGD:1305332 6480464 perfluorooctanoic acid results in increased expression of MDM2 mRNA CTD PMID:19162173 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of MDM2 mRNA CTD PMID:19482888 more ... phenobarbital multiple interactions EXP 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MDM2 mRNA], NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of MDM2 mRNA] CTD PMID:19482888 phenobarbital increases phosphorylation ISO RGD:1313299 6480464 Phenobarbital results in increased phosphorylation of MDM2 protein CTD PMID:19751709 phenobarbital increases expression ISO RGD:1305332 6480464 Phenobarbital results in increased expression of MDM2 mRNA CTD PMID:25145657 phenylmercury acetate increases expression ISO RGD:1313299 6480464 Phenylmercuric Acetate results in increased expression of MDM2 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1313299 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA CTD PMID:27188386 phenytoin multiple interactions EXP 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 PhIP increases expression ISO RGD:1313299 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of MDM2 protein CTD PMID:15635149 phlorizin decreases expression EXP 6480464 Phlorhizin results in decreased expression of MDM2 mRNA CTD PMID:22538082 phosphoramide mustard increases expression ISO RGD:1305332 6480464 phosphoramide mustard results in increased expression of MDM2 mRNA CTD PMID:26708502 picoxystrobin increases expression ISO RGD:1313299 6480464 picoxystrobin results in increased expression of MDM2 mRNA CTD PMID:33512557 piperonyl butoxide increases expression ISO RGD:1305332 6480464 Piperonyl Butoxide results in increased expression of MDM2 mRNA CTD PMID:15890375 , PMID:22484513 pirinixic acid multiple interactions ISO RGD:1305332 6480464 MDM2 protein affects the reaction [pirinixic acid results in increased activity of PPARA protein] more ... CTD PMID:19103650 pirinixic acid increases expression ISO RGD:1305332 6480464 pirinixic acid results in increased expression of MDM2 mRNA CTD PMID:15890375 , PMID:19162173 platycodin D decreases expression ISO RGD:1313299 6480464 platycodin D results in decreased expression of MDM2 protein CTD PMID:25431082 , PMID:27432230 platycodin D multiple interactions ISO RGD:1313299 6480464 MDM2 protein inhibits the reaction [platycodin D results in increased expression of FOXO3 protein] CTD PMID:25431082 poly(vinylpyrrolidone) multiple interactions ISO RGD:1313299 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein, [Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA CTD PMID:27387714 potassium bromate increases expression ISO RGD:1313299 6480464 potassium bromate results in increased expression of MDM2 mRNA CTD PMID:30559759 potassium dichromate multiple interactions ISO RGD:1305332 6480464 Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of MDM2 protein] CTD PMID:21262251 potassium dichromate decreases expression ISO RGD:1305332 6480464 Potassium Dichromate results in decreased expression of MDM2 protein CTD PMID:21262251 pravastatin increases phosphorylation ISO RGD:1313299 6480464 Pravastatin results in increased phosphorylation of MDM2 protein CTD PMID:15625077 pravastatin increases expression ISO RGD:1305332 6480464 Pravastatin results in increased expression of MDM2 protein CTD PMID:15625077 pravastatin multiple interactions ISO RGD:1313299 6480464 [Pravastatin results in increased phosphorylation of MDM2 protein] which results in increased degradation of TP53 protein more ... CTD PMID:15625077 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:1305332 6480464 Pregnenolone Carbonitrile results in increased expression of MDM2 mRNA CTD PMID:19162173 prochloraz multiple interactions ISO RGD:1305332 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA CTD PMID:29038839 procymidone decreases expression ISO RGD:1305332 6480464 procymidone results in decreased expression of MDM2 mRNA CTD PMID:15686871 promethazine increases phosphorylation ISO RGD:1305332 6480464 Promethazine results in increased phosphorylation of MDM2 protein CTD PMID:26558467 propanal increases expression ISO RGD:1313299 6480464 propionaldehyde results in increased expression of MDM2 mRNA CTD PMID:26079696 quercetin multiple interactions ISO RGD:1313299 6480464 Quercetin results in decreased phosphorylation of and results in decreased expression of MDM2 protein CTD PMID:17973296 quercetin increases expression ISO RGD:1313299 6480464 Quercetin results in increased expression of MDM2 mRNA CTD PMID:21632981 more ... quercetin multiple interactions ISO RGD:1305332 6480464 [Quercetin co-treated with Hydrogen Peroxide] results in increased expression of MDM2 mRNA CTD PMID:27525270 quercetin decreases expression ISO RGD:1313299 6480464 Quercetin results in decreased expression of MDM2 protein CTD PMID:21933852 quercetin increases expression ISO RGD:1305332 6480464 Quercetin results in increased expression of MDM2 mRNA CTD PMID:31201582 reactive oxygen species multiple interactions ISO RGD:1313299 6480464 [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of MDM2 protein CTD PMID:27634759 resveratrol multiple interactions ISO RGD:1313299 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of MDM2 mRNA more ... CTD PMID:15542774 more ... resveratrol increases expression ISO RGD:1313299 6480464 resveratrol results in increased expression of MDM2 mRNA CTD PMID:15280659 more ... resveratrol multiple interactions EXP 6480464 [resveratrol results in increased phosphorylation of TRP53 protein] inhibits the reaction [TRP53 protein binds to MDM2 protein] CTD PMID:11245472 resveratrol decreases expression ISO RGD:1313299 6480464 resveratrol results in decreased expression of MDM2 mRNA, resveratrol results in decreased expression of MDM2 protein CTD PMID:16998810 more ... resveratrol increases expression EXP 6480464 resveratrol results in increased expression of MDM2 mRNA, resveratrol results in increased expression of MDM2 protein CTD PMID:11245472 more ... resveratrol affects expression EXP 6480464 resveratrol affects the expression of MDM2 protein CTD PMID:16369916 rifampicin multiple interactions EXP 6480464 [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA CTD PMID:21224054 rotenone increases expression ISO RGD:1313299 6480464 Rotenone results in increased expression of MDM2 mRNA CTD PMID:33512557 ruthenium atom decreases expression ISO RGD:1313299 6480464 Ruthenium results in decreased expression of MDM2 protein CTD PMID:17210701 SB 431542 multiple interactions ISO RGD:1313299 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of MDM2 mRNA CTD PMID:19073995 silver atom multiple interactions ISO RGD:1313299 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein, [Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA CTD PMID:27387714 silver atom decreases expression ISO RGD:1313299 6480464 Silver results in decreased expression of MDM2 mRNA CTD PMID:26014281 silver(0) multiple interactions ISO RGD:1313299 6480464 [Silver co-treated with Povidone] affects the expression of MDM2 protein, [Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA CTD PMID:27387714 silver(0) decreases expression ISO RGD:1313299 6480464 Silver results in decreased expression of MDM2 mRNA CTD PMID:26014281 simvastatin increases phosphorylation ISO RGD:1313299 6480464 Simvastatin results in increased phosphorylation of MDM2 protein CTD PMID:15625077 simvastatin multiple interactions ISO RGD:1313299 6480464 Simvastatin promotes the reaction [Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]] CTD PMID:15625077 sirolimus multiple interactions ISO RGD:1313299 6480464 EIF4E protein inhibits the reaction [Sirolimus results in decreased expression of MDM2 protein] more ... CTD PMID:15625077 more ... sirolimus decreases expression ISO RGD:1313299 6480464 Sirolimus results in decreased expression of MDM2 protein CTD PMID:19560264 sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of MDM2 mRNA CTD PMID:11353140 sodium arsenite multiple interactions ISO RGD:1313299 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of MDM2 protein] more ... CTD PMID:20375080 more ... sodium arsenite affects expression ISO RGD:1313299 6480464 sodium arsenite affects the expression of MDM2 mRNA CTD PMID:29319823 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of MDM2 mRNA CTD PMID:11353140 , PMID:20477944 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of MDM2 protein CTD PMID:16166651 sodium arsenite increases expression ISO RGD:1313299 6480464 sodium arsenite results in increased expression of MDM2 mRNA more ... CTD PMID:11813266 more ... sodium dichromate affects expression ISO RGD:1305332 6480464 sodium bichromate affects the expression of MDM2 mRNA CTD PMID:11960910 , PMID:22110744 sodium dichromate increases expression ISO RGD:1305332 6480464 sodium bichromate results in increased expression of MDM2 mRNA CTD PMID:25993096 sorafenib increases expression ISO RGD:1313299 6480464 sorafenib results in increased expression of MDM2 mRNA CTD PMID:26409325 staurosporine multiple interactions ISO RGD:1313299 6480464 Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]] CTD PMID:15542774 succimer multiple interactions EXP 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MDM2 mRNA CTD PMID:26378955 sunitinib increases expression ISO RGD:1313299 6480464 Sunitinib results in increased expression of MDM2 mRNA CTD PMID:31533062 T-2 toxin increases expression ISO RGD:1305332 6480464 T-2 Toxin results in increased expression of MDM2 mRNA CTD PMID:26141394 T-2 toxin increases expression ISO RGD:1313299 6480464 T-2 Toxin results in increased expression of MDM2 mRNA CTD PMID:31863870 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of MDM2 mRNA CTD PMID:17555576 tamoxifen decreases expression ISO RGD:1313299 6480464 Tamoxifen results in decreased expression of MDM2 mRNA CTD PMID:34821461 tanespimycin increases degradation ISO RGD:1313299 6480464 tanespimycin results in increased degradation of MDM2 protein CTD PMID:17157164 tauroursodeoxycholic acid increases expression ISO RGD:1305332 6480464 ursodoxicoltaurine results in increased expression of MDM2 mRNA CTD PMID:15885361 tebufenpyrad increases expression ISO RGD:1313299 6480464 4-chloro-N-((4-(1, 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of MDM2 mRNA CTD PMID:33512557 tert-butyl hydroperoxide increases expression ISO RGD:1313299 6480464 tert-Butylhydroperoxide results in increased expression of MDM2 mRNA CTD PMID:27509014 testosterone decreases expression EXP 6480464 Testosterone results in decreased expression of MDM2 mRNA CTD PMID:20403060 tetrachloromethane multiple interactions ISO RGD:1305332 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MDM2 mRNA] CTD PMID:31150632 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of MDM2 mRNA CTD PMID:31919559 tetrachloromethane increases expression ISO RGD:1305332 6480464 Carbon Tetrachloride results in increased expression of MDM2 mRNA CTD PMID:31150632 tetraphene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA CTD PMID:27858113 theaflavin multiple interactions EXP 6480464 [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ... CTD PMID:23717041 thioacetamide increases expression ISO RGD:1305332 6480464 Thioacetamide results in increased expression of MDM2 mRNA CTD PMID:18619722 more ... thioacetamide increases phosphorylation ISO RGD:1305332 6480464 Thioacetamide results in increased phosphorylation of MDM2 protein CTD PMID:26558467 thymoquinone decreases expression ISO RGD:1313299 6480464 thymoquinone results in decreased expression of MDM2 protein CTD PMID:31433961 , PMID:34627931 titanium dioxide increases expression ISO RGD:1313299 6480464 titanium dioxide results in increased expression of MDM2 mRNA CTD PMID:21067279 topotecan increases expression ISO RGD:1305332 6480464 Topotecan results in increased expression of MDM2 mRNA CTD PMID:25729387 topotecan multiple interactions ISO RGD:1313299 6480464 [N-(oxo-5 more ... CTD PMID:23376119 topotecan multiple interactions ISO RGD:1305332 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MDM2 mRNA CTD PMID:25729387 trichloroethene affects expression EXP 6480464 Trichloroethylene affects the expression of MDM2 mRNA CTD PMID:21135412 trichloroethene increases expression ISO RGD:1305332 6480464 Trichloroethylene results in increased expression of MDM2 mRNA CTD PMID:33387578 trichloroethene multiple interactions ISO RGD:1305332 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA CTD PMID:17905399 trichostatin A affects expression ISO RGD:1313299 6480464 trichostatin A affects the expression of MDM2 mRNA CTD PMID:28542535 triphenyl phosphate increases expression ISO RGD:1305332 6480464 triphenyl phosphate results in increased expression of MDM2 mRNA CTD PMID:30589522 Triptolide increases expression EXP 6480464 triptolide results in increased expression of MDM2 mRNA CTD PMID:32835833 triptonide affects expression EXP 6480464 triptonide affects the expression of MDM2 mRNA CTD PMID:33045310 trovafloxacin multiple interactions EXP 6480464 [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MDM2 mRNA CTD PMID:18930950 trovafloxacin increases expression EXP 6480464 trovafloxacin results in increased expression of MDM2 mRNA CTD PMID:35537566 urethane multiple interactions EXP 6480464 [Urethane co-treated with Freund's Adjuvant] results in increased expression of MDM2 mRNA CTD PMID:12400877 ursodeoxycholic acid multiple interactions ISO RGD:1305332 6480464 [Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]] which results in increased degradation of TP53 protein more ... CTD PMID:14514686 more ... ursodeoxycholic acid increases expression ISO RGD:1305332 6480464 Ursodeoxycholic Acid results in increased expression of MDM2 mRNA CTD PMID:15885361 ursodeoxycholic acid multiple interactions ISO RGD:1313299 6480464 MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased ubiquitination of TP53 protein] CTD PMID:20807506 valdecoxib increases expression ISO RGD:1305332 6480464 valdecoxib results in increased expression of MDM2 mRNA CTD PMID:24136188 valproic acid increases expression ISO RGD:1313299 6480464 Valproic Acid results in increased expression of MDM2 mRNA CTD PMID:23179753 valproic acid decreases expression ISO RGD:1313299 6480464 Valproic Acid results in decreased expression of MDM2 mRNA CTD PMID:28001369 valproic acid affects expression ISO RGD:1313299 6480464 Valproic Acid affects the expression of MDM2 mRNA CTD PMID:25979313 vincristine increases expression ISO RGD:1313299 6480464 Vincristine results in increased expression of MDM2 mRNA CTD PMID:23649840 vincristine decreases expression ISO RGD:1313299 6480464 Vincristine results in decreased expression of MDM2 mRNA CTD PMID:16001973 vorinostat decreases expression ISO RGD:1313299 6480464 vorinostat results in decreased expression of MDM2 mRNA CTD PMID:27188386 wortmannin multiple interactions ISO RGD:1313299 6480464 wortmannin promotes the reaction [Doxorubicin results in increased phosphorylation of MDM2 protein], wortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein] CTD PMID:17935137 zidovudine increases expression ISO RGD:1313299 6480464 Zidovudine results in increased expression of MDM2 protein CTD PMID:16797627 zinc acetate multiple interactions ISO RGD:1313299 6480464 motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA] CTD PMID:16357179 zinc acetate increases expression ISO RGD:1313299 6480464 Zinc Acetate results in increased expression of MDM2 mRNA CTD PMID:16357179 zinc atom multiple interactions ISO RGD:1313299 6480464 Zinc binds to and results in increased folding of MDM2 protein more ... CTD PMID:16965791 zinc atom increases ubiquitination ISO RGD:1313299 6480464 Zinc results in increased ubiquitination of MDM2 protein CTD PMID:16965791 zinc atom affects expression ISO RGD:1313299 6480464 Zinc affects the expression of MDM2 protein CTD PMID:16636310 zinc pyrithione increases expression ISO RGD:1313299 6480464 pyrithione zinc results in increased expression of MDM2 mRNA CTD PMID:21424779 zinc(0) multiple interactions ISO RGD:1313299 6480464 Zinc binds to and results in increased folding of MDM2 protein more ... CTD PMID:16965791 zinc(0) affects expression ISO RGD:1313299 6480464 Zinc affects the expression of MDM2 protein CTD PMID:16636310 zinc(0) increases ubiquitination ISO RGD:1313299 6480464 Zinc results in increased ubiquitination of MDM2 protein CTD PMID:16965791
