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Gene: Mdm2 (transformed mouse 3T3 cell double minute 2) Mus musculus
Symbol: Mdm2
Name: transformed mouse 3T3 cell double minute 2
RGD ID: 1313300
Description: Exhibits p53 binding activity; scaffold protein binding activity; and ubiquitin protein ligase activity. Predicted to contribute to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including blood vessel remodeling; circulatory system development; and traversing start control point of mitotic cell cycle. Localizes to cytoplasm and nucleolus. Predicted to colocalize with nuclear body. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma multiforme; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1700007J15Rik; AA415488; double minute 2 protein; E3 ubiquitin-protein ligase Mdm2; Mdm-2; oncoprotein Mdm2; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2
Homo sapiens (human) : MDM2 (MDM2 proto-oncogene)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mdm2 (MDM2 proto-oncogene)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mdm2 (MDM2 proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : MDM2 (MDM2 proto-oncogene)
Canis lupus familiaris (dog) : MDM2 (MDM2 proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mdm2 (MDM2 proto-oncogene)
Sus scrofa (pig) : MDM2 (MDM2 proto-oncogene)
Chlorocebus sabaeus (African green monkey) : MDM2 (MDM2 proto-oncogene)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910117,524,780 - 117,546,663 (-)NCBI
GRCm3810117,688,875 - 117,710,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,688,875 - 117,710,758 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710117,125,961 - 117,147,772 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610117,091,898 - 117,113,709 (-)NCBImm8
Celera10119,626,758 - 119,648,336 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mdm2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313300
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.