Mdm2 (transformed mouse 3T3 cell double minute 2) - Rat Genome Database

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Gene: Mdm2 (transformed mouse 3T3 cell double minute 2) Mus musculus
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Symbol: Mdm2
Name: transformed mouse 3T3 cell double minute 2
RGD ID: 1313300
MGI Page MGI
Description: Enables p53 binding activity and ubiquitin protein ligase activity. Involved in apoptotic process and positive regulation of muscle cell differentiation. Acts upstream of or within several processes, including blood vessel remodeling; circulatory system development; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700007J15Rik; AA415488; double minute 2 protein; E3 ubiquitin-protein ligase Mdm2; Mdm-2; oncoprotein Mdm2; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910117,524,780 - 117,546,663 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10117,524,780 - 117,546,663 (-)EnsemblGRCm39 Ensembl
GRCm3810117,688,875 - 117,710,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,688,875 - 117,710,758 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710117,125,961 - 117,147,772 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610117,091,898 - 117,113,709 (-)NCBIMGSCv36mm8
Celera10119,626,758 - 119,648,336 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (ISO)
10-Hydroxycamptothecin  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-nitrofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (EXP)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
alpha-naphthoflavone  (ISO)
alvocidib  (ISO)
amifostine  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
amsacrine  (ISO)
androstane  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azoxystrobin  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
brassinolide  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP,ISO)
cantharidin  (ISO)
capsaicin  (ISO)
Carbadox  (ISO)
carbamazepine  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chrysene  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP)
cryptolepine  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
DAPT  (ISO)
DDT  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
diclofenac  (ISO)
dieldrin  (ISO)
diepoxybutane  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ellipticine  (ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
EUK-134  (ISO)
fenbendazole  (ISO)
fenofibrate  (ISO)
fipronil  (ISO)
flavanones  (ISO)
flucytosine  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
furosemide  (ISO)
ganciclovir  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glyphosate  (ISO)
GW 501516  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyurea  (EXP,ISO)
ifosfamide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irinotecan  (ISO)
isoflurane  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
leptomycin B  (ISO)
Leucomalachite green  (ISO)
linalool  (ISO)
lipopolysaccharide  (EXP)
lupeol  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mancozeb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methyl caffeate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP)
mitomycin C  (EXP,ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (EXP)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitenpyram  (ISO)
Nodularin  (ISO)
Nutlin-3  (EXP,ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
Octicizer  (ISO)
ortho-Aminoazotoluene  (EXP)
ouabain  (ISO)
oxaliplatin  (ISO)
oxfendazole  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
Paraoxon-methyl  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (ISO)
PCB138  (ISO)
PD123319  (ISO)
pentachlorophenol  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
PhIP  (ISO)
phlorizin  (EXP)
phosphoramide mustard  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(vinylpyrrolidone)  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
promethazine  (ISO)
propanal  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rotenone  (ISO)
ruthenium atom  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sorafenib  (ISO)
staurosporine  (ISO)
succimer  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
tauroursodeoxycholic acid  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
theaflavin  (EXP)
thioacetamide  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
trovafloxacin  (EXP)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid fibril formation  (ISO)
apoptotic process  (IDA,ISO)
atrial septum development  (IGI)
atrioventricular valve morphogenesis  (IGI)
blood vessel development  (IMP)
blood vessel remodeling  (IMP)
cardiac septum morphogenesis  (IGI)
cellular response to actinomycin D  (ISO)
cellular response to alkaloid  (ISO)
cellular response to antibiotic  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to gamma radiation  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to organic substance  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to UV-C  (ISO)
cellular response to vitamin B1  (ISO)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  (ISO)
endocardial cushion morphogenesis  (IGI,IMP)
establishment of protein localization  (ISO)
fibroblast activation  (ISO)
heart development  (IGI,IMP)
heart valve development  (IGI)
localization  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of protein processing  (ISO)
negative regulation of signal transduction by p53 class mediator  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of cell cycle  (IGI)
positive regulation of gene expression  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of muscle cell differentiation  (IMP)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein export from nucleus  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein autoubiquitination  (ISO)
protein destabilization  (ISO)
protein localization to nucleus  (ISO)
protein ubiquitination  (ISO)
protein-containing complex assembly  (ISO)
proteolysis involved in protein catabolic process  (ISO)
regulation of cell cycle  (ISO)
regulation of gene expression  (IMP)
regulation of heart rate  (IGI)
regulation of protein catabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to antibiotic  (ISO)
response to cocaine  (ISO)
response to ether  (ISO)
response to formaldehyde  (ISO)
response to iron ion  (ISO)
response to magnesium ion  (ISO)
response to morphine  (ISO)
response to steroid hormone  (ISO)
response to toxic substance  (ISO)
response to water-immersion restraint stress  (ISO)
response to xenobiotic stimulus  (ISO)
traversing start control point of mitotic cell cycle  (IDA)
ubiquitin-dependent protein catabolic process  (IDA,IMP,ISO)
ventricular septum development  (IGI)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal blood circulation  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hematopoietic system physiology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
anemia  (IAGP)
cerebellum hypoplasia  (IAGP)
cleft palate  (IAGP)
decreased apoptosis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased cellular sensitivity to ionizing radiation  (IAGP)
decreased cerebellar granule cell number  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased fetal size  (IAGP)
decreased granulocyte number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased immature B cell number  (IAGP)
decreased kidney weight  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased liver weight  (IAGP)
decreased locomotor activity  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased mortality induced by ionizing radiation  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased spleen weight  (IAGP)
decreased T cell number  (IAGP)
decreased telomere length  (IAGP)
decreased thymocyte apoptosis  (IAGP)
decreased thymocyte number  (IAGP)
decreased thymus weight  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
empty decidua capsularis  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged Peyer's patches  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IAGP)
exencephaly  (IAGP)
hemorrhage  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased carcinoma incidence  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased cell proliferation  (IAGP)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased fibroblast proliferation  (IAGP)
increased fibrosarcoma incidence  (IAGP)
increased foot pad pigmentation  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased leiomyosarcoma incidence  (IAGP)
increased lipoma incidence  (IAGP)
increased liver adenocarcinoma incidence  (IAGP)
increased liver adenoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased mortality induced by gamma-irradiation  (IAGP)
increased mortality induced by ionizing radiation  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased salivary gland tumor incidence  (IAGP)
increased sarcoma incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased tumor incidence  (IAGP)
kinked tail  (IAGP)
no abnormal phenotype detected  (IAGP)
pallor  (IAGP)
pancytopenia  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
small cerebellum  (IAGP)
small heart  (IAGP)
small thymus  (IAGP)
spleen atrophy  (IAGP)
spleen hyperplasia  (IAGP)
spleen hypoplasia  (IAGP)
thin myocardium  (IAGP)
thrombocytopenia  (IAGP)
thymus atrophy  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 gene. Chang B, etal., Hum Mol Genet. 2008 Dec 15;17(24):3929-41. doi: 10.1093/hmg/ddn295. Epub 2008 Sep 18.
2. Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer. Dong M, etal., World J Gastroenterol. 2005 Apr 14;11(14):2162-5.
3. Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis. Dongiovanni P, etal., Am J Pathol. 2010 Feb;176(2):1006-17. Epub 2009 Dec 17.
4. Long-term effects of hypothermia on neuronal cell death and the concentration of apoptotic proteins after incomplete cerebral ischemia and reperfusion in rats. Eberspacher E, etal., Acta Anaesthesiol Scand. 2005 Apr;49(4):477-87.
5. The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia. Faderl S, etal., Cancer. 2000 Nov 1;89(9):1976-82.
6. Characterizing the role of MDM2 in diethylnitrosamine induced acute liver damage and development of pre-neoplastic lesions. Finnberg N, etal., Carcinogenesis. 2004 Jan;25(1):113-22. Epub 2003 Oct 10.
7. MDM2 SNP309 associates with accelerated pancreatic adenocarcinoma formation. Grochola LF, etal., Pancreas. 2010 Jan;39(1):76-80.
8. Inhibition of MDM2 attenuates neointimal hyperplasia via suppression of vascular proliferation and inflammation. Hashimoto T, etal., Cardiovasc Res. 2011 Sep 1;91(4):711-9. doi: 10.1093/cvr/cvr108. Epub 2011 Apr 14.
9. Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis. Ishikawa A, etal., Hum Pathol. 2004 Dec;35(12):1505-14.
10. Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome. Jarnagin WR, etal., J Clin Oncol. 2006 Mar 1;24(7):1152-60.
11. Experimental priapism is associated with increased oxidative stress and activation of protein degradation pathways in corporal tissue. Kanika ND, etal., Int J Impot Res. 2010 Nov-Dec;22(6):363-73. doi: 10.1038/ijir.2010.27. Epub 2010 Nov 18.
12. Nonresponsiveness of cerebral p53-MDM2 functional circuit in newborn rat pups rendered IUGR via uteroplacental insufficiency. Ke X, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Apr;288(4):R1038-45. Epub 2004 Nov 24.
13. Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer. Kriegmair MC, etal., Anticancer Res. 2016 Oct;36(10):5205-5213. doi: 10.21873/anticanres.11091.
14. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
15. The complexity of p53 stabilization and activation. Lavin MF and Gueven N, Cell Death Differ. 2006 Jun;13(6):941-50.
16. A molecular basis for the efficacy of magnesium treatment following traumatic brain injury in rats. Lee JS, etal., J Neurotrauma. 2004 May;21(5):549-61.
17. Up-regulation of Smurf1 after spinal cord injury in adult rats. Li D, etal., J Mol Histol. 2013 Aug;44(4):381-90. doi: 10.1007/s10735-013-9499-2. Epub 2013 Apr 18.
18. REGgamma deficiency promotes premature aging via the casein kinase 1 pathway. Li L, etal., Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11005-10. doi: 10.1073/pnas.1308497110. Epub 2013 Jun 13.
19. Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy. Li Q and Lozano G, Clin Cancer Res. 2013 Jan 1;19(1):34-41. doi: 10.1158/1078-0432.CCR-12-0053. Epub 2012 Dec 21.
20. MDM2 promoter polymorphism and p53 codon 72 polymorphism in chronic myeloid leukemia: the association between MDM2 promoter genotype and disease susceptibility, age of onset, and blast-free survival in chronic phase patients receiving imatinib. Liu YC, etal., Mol Carcinog. 2014 Dec;53(12):951-9. doi: 10.1002/mc.22061. Epub 2013 Jul 2.
21. Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. Ma B, etal., PLoS One. 2013 May 2;8(5):e56580. doi: 10.1371/journal.pone.0056580. Print 2013.
22. Lack of association between MDM2 SNP309 and TP53 Arg72Pro polymorphisms with clinical outcomes in myelodysplastic syndrome. Machado-Neto JA, etal., Neoplasma. 2012;59(5):530-5. doi: 10.4149/neo_2012_068.
23. MGDs mouse GO annotations MGD data from the GO Consortium
24. MGD IEA MGD IEA
25. p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning. Mocanu MM and Yellon DM, FEBS Lett. 2003 Dec 4;555(2):302-6.
26. Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors. Murray SA, etal., J Cell Biochem. 2005 Aug 1;95(5):875-84.
27. Inflammatory cells regulate p53 and caspases in acute pancreatitis. Nakamura Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Oct 22.
28. Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1beta/ErbB in response to myocardial infarction resulting in worsening heart failure. Odiete O, etal., Cardiovasc Diabetol. 2013 Mar 27;12:52. doi: 10.1186/1475-2840-12-52.
29. MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in breast cancer patients treated with 5-FU/epirubicin/cyclophosphamide. Okishiro M, etal., Breast Cancer Res Treat. 2012 Apr;132(3):947-53. doi: 10.1007/s10549-011-1637-5. Epub 2011 Jun 25.
30. Amplification of a gene encoding a p53-associated protein in human sarcomas. Oliner JD, etal., Nature. 1992 Jul 2;358(6381):80-3.
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
33. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. Mouse MP Annotation Import Pipeline RGD automated import pipeline
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Lose dose genistein inhibits glucocorticoid receptor and ischemic brain injury in female rats. Shi R, etal., Neurochem Int. 2014 Jan;65:14-22. doi: 10.1016/j.neuint.2013.12.002. Epub 2013 Dec 12.
37. Selective increase in the association of the beta2 adrenergic receptor, beta Arrestin-1 and p53 with Mdm2 in the ventral hippocampus one month after underwater trauma. Sood R, etal., Behav Brain Res. 2013 Mar 1;240:26-8. doi: 10.1016/j.bbr.2012.11.009. Epub 2012 Nov 20.
38. Multiple mouse chromosomal loci for dynein-based motility. Vaughan KT, etal., Genomics 1996 Aug 15;36(1):29-38.
39. MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced grade III/IV neutropenia in Chinese extensive-stage small-cell lung cancer patients. Wang X, etal., Oncol Res Treat. 2014;37(4):176-80. doi: 10.1159/000360785. Epub 2014 Mar 20.
40. p53 polymorphisms: cancer implications. Whibley C, etal., Nat Rev Cancer. 2009 Feb;9(2):95-107.
41. Identifying a hyperkeratosis signature in autosomal recessive congenital ichthyosis: Mdm2 inhibition prevents hyperkeratosis in a rat ARCI model. Youssef G, etal., J Invest Dermatol. 2014 Mar;134(3):858-61. doi: 10.1038/jid.2013.374. Epub 2013 Sep 4.
42. A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival. Zheng S, etal., Genes Dev. 2013 Jul 1;27(13):1462-72. doi: 10.1101/gad.213686.113. Epub 2013 Jun 24.
Additional References at PubMed
PMID:1535557   PMID:1552940   PMID:2026149   PMID:3474784   PMID:7472488   PMID:7477326   PMID:7477327   PMID:7651732   PMID:7671812   PMID:7849395   PMID:7936657   PMID:7958853  
PMID:8058315   PMID:8152809   PMID:8247544   PMID:8440237   PMID:8449492   PMID:8660994   PMID:8674108   PMID:8838799   PMID:8889548   PMID:8895579   PMID:8917101   PMID:8943068  
PMID:9087426   PMID:9126384   PMID:9144426   PMID:9153395   PMID:9153396   PMID:9171369   PMID:9241268   PMID:9285554   PMID:9294611   PMID:9380404   PMID:9419352   PMID:9486848  
PMID:9632782   PMID:9651526   PMID:9653180   PMID:9732264   PMID:9843989   PMID:9861017   PMID:10050879   PMID:10065155   PMID:10075719   PMID:10077639   PMID:10099828   PMID:10202144  
PMID:10205143   PMID:10321734   PMID:10341712   PMID:10349636   PMID:10365438   PMID:10419603   PMID:10436023   PMID:10523842   PMID:10597303   PMID:10611322   PMID:10706102   PMID:10713175  
PMID:10721693   PMID:10754200   PMID:10822382   PMID:10906133   PMID:10921903   PMID:10922068   PMID:10982879   PMID:10995391   PMID:11013216   PMID:11042159   PMID:11076861   PMID:11100897  
PMID:11172041   PMID:11217851   PMID:11245988   PMID:11335127   PMID:11423996   PMID:11431694   PMID:11528400   PMID:11588219   PMID:11606464   PMID:11697899   PMID:11718560   PMID:11857802  
PMID:11857803   PMID:11861407   PMID:11948180   PMID:11953423   PMID:11983168   PMID:12032854   PMID:12080472   PMID:12115603   PMID:12138177   PMID:12145204   PMID:12154087   PMID:12162806  
PMID:12167164   PMID:12167711   PMID:12232053   PMID:12297306   PMID:12466851   PMID:12477932   PMID:12488444   PMID:12493762   PMID:12509446   PMID:12520002   PMID:12529324   PMID:12547516  
PMID:12556559   PMID:12606552   PMID:12628936   PMID:12702724   PMID:12730202   PMID:12754350   PMID:12904583   PMID:12927808   PMID:12944468   PMID:14522887   PMID:14555234   PMID:14555661  
PMID:14610273   PMID:14610316   PMID:14612455   PMID:14673154   PMID:14691545   PMID:14695178   PMID:14729946   PMID:14767071   PMID:14769800   PMID:15024700   PMID:15029243   PMID:15090541  
PMID:15102471   PMID:15144954   PMID:15162501   PMID:15172967   PMID:15195100   PMID:15242646   PMID:15306695   PMID:15361844   PMID:15364927   PMID:15467748   PMID:15485902   PMID:15577914  
PMID:15577944   PMID:15607981   PMID:15618518   PMID:15619621   PMID:15678128   PMID:15703839   PMID:15734743   PMID:15747579   PMID:15750633   PMID:15878778   PMID:15878855   PMID:15989966  
PMID:16018998   PMID:16022282   PMID:16027727   PMID:16055726   PMID:16107883   PMID:16122802   PMID:16129783   PMID:16141072   PMID:16141073   PMID:16199867   PMID:16354690   PMID:16391230  
PMID:16491126   PMID:16492743   PMID:16492744   PMID:16533949   PMID:16543935   PMID:16579792   PMID:16616333   PMID:16624822   PMID:16702947   PMID:16729027   PMID:16737965   PMID:16884701  
PMID:17006543   PMID:17018606   PMID:17086174   PMID:17105817   PMID:17110379   PMID:17116689   PMID:17157790   PMID:17170761   PMID:17245556   PMID:17329361   PMID:17349959   PMID:17406677  
PMID:17420250   PMID:17426254   PMID:17468107   PMID:17476283   PMID:17526734   PMID:17591690   PMID:17616658   PMID:17823617   PMID:17828300   PMID:17893884   PMID:17896003   PMID:17936559  
PMID:17936560   PMID:17967808   PMID:18204439   PMID:18206965   PMID:18287559   PMID:18309296   PMID:18317451   PMID:18359851   PMID:18451149   PMID:18483220   PMID:18498130   PMID:18541670  
PMID:18566590   PMID:18567799   PMID:18614532   PMID:18636077   PMID:18665269   PMID:18695251   PMID:18723444   PMID:18799693   PMID:18923161   PMID:19032150   PMID:19033443   PMID:19090619  
PMID:19132120   PMID:19151705   PMID:19247369   PMID:19321440   PMID:19380490   PMID:19447627   PMID:19491200   PMID:19521340   PMID:19536131   PMID:19541625   PMID:19556538   PMID:19573810  
PMID:19580521   PMID:19590512   PMID:19630168   PMID:19649205   PMID:19732750   PMID:19833129   PMID:19842060   PMID:19950214   PMID:19965665   PMID:20019182   PMID:20124454   PMID:20362536  
PMID:20386595   PMID:20478998   PMID:20542919   PMID:20588255   PMID:20592017   PMID:20598683   PMID:20619429   PMID:20639885   PMID:20657550   PMID:20671749   PMID:20697359   PMID:20818388  
PMID:20832750   PMID:20832751   PMID:20849854   PMID:20855528   PMID:20921405   PMID:21040902   PMID:21060154   PMID:21081496   PMID:21169420   PMID:21183956   PMID:21211512   PMID:21213101  
PMID:21267068   PMID:21285512   PMID:21317535   PMID:21334322   PMID:21350561   PMID:21389118   PMID:21402876   PMID:21420949   PMID:21437245   PMID:21557332   PMID:21674502   PMID:21677750  
PMID:21724834   PMID:21730132   PMID:21730163   PMID:21738215   PMID:21747166   PMID:21747916   PMID:21788341   PMID:21804542   PMID:21849563   PMID:21852537   PMID:21855805   PMID:21857681  
PMID:21873635   PMID:21949095   PMID:21986500   PMID:22094330   PMID:22095636   PMID:22173032   PMID:22216266   PMID:22237799   PMID:22262167   PMID:22262176   PMID:22297670   PMID:22318725  
PMID:22378045   PMID:22388350   PMID:22560297   PMID:22624716   PMID:22666487   PMID:22714890   PMID:22734001   PMID:22737255   PMID:22789538   PMID:22805162   PMID:22821713   PMID:22835827  
PMID:22843172   PMID:22889954   PMID:22905258   PMID:22907436   PMID:22975381   PMID:22998186   PMID:23029416   PMID:23115126   PMID:23149414   PMID:23238568   PMID:23251530   PMID:23260144  
PMID:23333058   PMID:23401854   PMID:23580573   PMID:23682023   PMID:23749457   PMID:23770245   PMID:23935987   PMID:23973961   PMID:24013501   PMID:24163099   PMID:24167073   PMID:24174547  
PMID:24240685   PMID:24339722   PMID:24413081   PMID:24440154   PMID:24488098   PMID:24567357   PMID:24598047   PMID:24608433   PMID:24751726   PMID:24758576   PMID:24777531   PMID:24789767  
PMID:24804778   PMID:24872453   PMID:24980433   PMID:24982421   PMID:25057989   PMID:25117711   PMID:25144937   PMID:25168242   PMID:25263199   PMID:25301064   PMID:25349197   PMID:25435368  
PMID:25501825   PMID:25624478   PMID:25720496   PMID:25732823   PMID:25751059   PMID:25799988   PMID:25976245   PMID:25981963   PMID:25987256   PMID:26025930   PMID:26192438   PMID:26228571  
PMID:26255629   PMID:26334721   PMID:26470726   PMID:26494859   PMID:26565902   PMID:26598619   PMID:26748827   PMID:26764128   PMID:26883797   PMID:27000207   PMID:27042854   PMID:27113764  
PMID:27194168   PMID:27256803   PMID:27265727   PMID:27271257   PMID:27362806   PMID:27364741   PMID:27402081   PMID:27568562   PMID:27617574   PMID:27758855   PMID:27825169   PMID:27829155  
PMID:27869164   PMID:27882940   PMID:27912078   PMID:27956626   PMID:28025327   PMID:28049824   PMID:28100501   PMID:28118981   PMID:28122227   PMID:28166445   PMID:28181574   PMID:28193895  
PMID:28276606   PMID:28436570   PMID:28454724   PMID:28576884   PMID:28745540   PMID:28878120   PMID:28925402   PMID:29016848   PMID:29039579   PMID:29123033   PMID:29192902   PMID:29267372  
PMID:29364875   PMID:29371613   PMID:29452639   PMID:29581288   PMID:29691476   PMID:29704532   PMID:29903771   PMID:29950602   PMID:29975682   PMID:29992578   PMID:30011084   PMID:30012555  
PMID:30111642   PMID:30131393   PMID:30175854   PMID:30260703   PMID:30292394   PMID:30355102   PMID:30545932   PMID:30578299   PMID:30790589   PMID:30858352   PMID:30872705   PMID:30879903  
PMID:31018144   PMID:31178404   PMID:31313490   PMID:31364731   PMID:31409715   PMID:31472117   PMID:31483066   PMID:31534052   PMID:31557161   PMID:31662450   PMID:31749402   PMID:31767619  
PMID:31907996   PMID:32199946   PMID:32464196   PMID:32548123   PMID:32635537   PMID:32703236   PMID:32755395   PMID:32775003   PMID:32856486   PMID:33277368   PMID:33323382   PMID:33334825  
PMID:33468664   PMID:33601405   PMID:33637564   PMID:33767425   PMID:33894310   PMID:33905247   PMID:34242585   PMID:34257081   PMID:34303799   PMID:34480939   PMID:34628485   PMID:34750429  
PMID:34845330   PMID:34974536   PMID:35078816   PMID:35220830   PMID:35234168   PMID:35320355   PMID:35524581   PMID:35582848   PMID:35588102   PMID:35593225   PMID:35672379   PMID:35864088  
PMID:36012294   PMID:36198274  


Genomics

Comparative Map Data
Mdm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910117,524,780 - 117,546,663 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10117,524,780 - 117,546,663 (-)EnsemblGRCm39 Ensembl
GRCm3810117,688,875 - 117,710,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,688,875 - 117,710,758 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710117,125,961 - 117,147,772 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610117,091,898 - 117,113,709 (-)NCBIMGSCv36mm8
Celera10119,626,758 - 119,648,336 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.32NCBI
MDM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381268,808,172 - 68,850,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1268,808,177 - 68,845,544 (+)EnsemblGRCh38hg38GRCh38
GRCh371269,201,952 - 69,244,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361267,488,247 - 67,520,481 (+)NCBINCBI36Build 36hg18NCBI36
Build 341267,488,246 - 67,520,481NCBI
Celera1268,865,796 - 68,903,026 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1266,252,410 - 66,289,884 (+)NCBIHuRef
CHM1_11269,170,604 - 69,207,918 (+)NCBICHM1_1
T2T-CHM13v2.01268,787,755 - 68,830,265 (+)NCBIT2T-CHM13v2.0
Mdm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2753,290,660 - 53,315,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,290,664 - 53,314,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,197,377 - 55,221,597 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0757,400,491 - 57,424,715 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0757,178,368 - 57,202,590 (-)NCBIRnor_WKY
Rnor_6.0760,719,060 - 60,743,618 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,719,066 - 60,743,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0760,719,023 - 60,743,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4756,996,694 - 57,020,926 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1757,018,654 - 57,054,110 (-)NCBI
Celera750,062,029 - 50,086,121 (-)NCBICelera
Cytogenetic Map7q22NCBI
Mdm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545815,263,739 - 15,286,808 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545815,264,028 - 15,287,290 (+)NCBIChiLan1.0ChiLan1.0
MDM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11269,102,083 - 69,133,278 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1269,102,084 - 69,133,278 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01266,322,340 - 66,357,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MDM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11010,936,288 - 10,963,118 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1010,893,719 - 10,962,596 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1010,869,091 - 10,894,634 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01011,060,051 - 11,086,867 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1011,016,172 - 11,087,383 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11010,928,429 - 10,953,972 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01011,174,449 - 11,199,967 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01011,296,600 - 11,322,142 (+)NCBIUU_Cfam_GSD_1.0
Mdm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494547,377,991 - 47,400,191 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365456,709,903 - 6,732,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl533,105,759 - 33,137,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1533,105,717 - 33,137,602 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2535,889,682 - 35,921,569 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MDM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11164,434,203 - 64,465,490 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1164,434,261 - 64,469,890 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037181,237,754 - 181,268,657 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir143mmu-miR-143-3pOncomiRDBexternal_infoNANA22330136
Mir215mmu-miR-215-5pOncomiRDBexternal_infoNANA20951946
Mir194-1mmu-miR-194-5pOncomiRDBexternal_infoNANA20951946
Mir194-2mmu-miR-194-5pOncomiRDBexternal_infoNANA20951946
Mir192mmu-miR-192-5pOncomiRDBexternal_infoNANA20951946
Mir32mmu-miR-32-5pOncomiRDBexternal_infoNANA22431589
Mir25mmu-miR-25-3pOncomiRDBexternal_infoNANA22431589

Predicted Target Of
Summary Value
Count of predictions:1786
Count of miRNA genes:614
Interacting mature miRNAs:771
Transcripts:ENSMUST00000020408, ENSMUST00000105263, ENSMUST00000126022, ENSMUST00000131627, ENSMUST00000132277, ENSMUST00000137102, ENSMUST00000147823, ENSMUST00000151725, ENSMUST00000155285
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084079650122041528Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084079650122041528Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84079650122041528Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84079650122041528Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084079650122041528Mouse
1357638Cia29_mcollagen induced arthritis 29 (mouse)Not determined1085454982118497353Mouse
1300797Sluc22_msusceptibility to lung cancer 22 (mouse)Not determined1086713608120713756Mouse
1300908Insq4_minsulin QTL 4 (mouse)Not determined1086909085120909229Mouse
1301520Uvbi1_mUVB induced immunosuppression 1 (mouse)Not determined1086909085120909229Mouse
1300921Skl4_mskeletal size (tail length) 4 (mouse)Not determined1088088254122088391Mouse
4142386Tgq20_mtriglyceride QTL 20 (mouse)Not determined88836456122836456Mouse
1301758Fcsa3_mfemoral cross-sectional area 3 (mouse)Not determined1089927651123927754Mouse
11039516Ltpr5_mLeishmania tropica response 5 (mouse)1090506901125575232Mouse
13208554Lgth11_mbody length 11 (mouse)1090835862120835905Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
27226725Tibw1_mtibia width 1, proximal, 5 week (mouse)10102735861123235905Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
4141269Ipng2_mimprinted postnatal growth 2 (mouse)Not determined105088254118497353Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse
27226722Tibw7_mtibia width 7, proximal, 16 week (mouse)10108635861125435869Mouse
27095902Scvln11_msacral vertebrae length 2, 10 week (mouse)10110035861125435869Mouse
11353822Insq12_minsulin QTL 12 (mouse)10110453347125515907Mouse
11353823Homaq2_mhomeostatic model assessment QTL 2 (mouse)10110453347125515907Mouse
10412078Hylaq3_mHyperlocomotor activity related QTL 3 (mouse)Not determined10111568226117986649Mouse
26884391Skwq11_mskull length QTL 11, 16 week (mouse)10113535905121635905Mouse
26884433Zlq2_mzygomatic length QTL 2, 5 week (mouse)10113535905125735869Mouse
26884383Bzwq3_mbi-zygomatic width QTL 3, 5 week (mouse)10114235905122735905Mouse
13506931Recrq11_mrecombination rate in male meiosis QTL 11 (mouse)10114335905123635905Mouse
26884377Skwq3_mskull length QTL 3, 5 week (mouse)10114635905122735905Mouse
1300796Lmr5_mleishmaniasis resistance 5 (mouse)Not determined10116220635122179828Mouse

Markers in Region
RH124271  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810117,688,996 - 117,689,179UniSTSGRCm38
MGSCv3710117,126,052 - 117,126,235UniSTSGRCm37
Celera10119,626,849 - 119,627,032UniSTS
Cytogenetic Map10C1-C3UniSTS
UniSTS:236466  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810117,689,874 - 117,689,958UniSTSGRCm38
MGSCv3710117,126,930 - 117,127,014UniSTSGRCm37
Celera10119,627,713 - 119,627,797UniSTS
Cytogenetic Map10C1-C3UniSTS
D0S2246  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810117,709,697 - 117,709,780UniSTSGRCm38
MGSCv3710117,146,753 - 117,146,836UniSTSGRCm37
Celera10119,647,317 - 119,647,400UniSTS
Cytogenetic Map10C1-C3UniSTS
Mdm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810117,690,297 - 117,690,483UniSTSGRCm38
MGSCv3710117,127,353 - 117,127,539UniSTSGRCm37
Celera10119,628,136 - 119,628,322UniSTS
Cytogenetic Map10C1-C3UniSTS
cM Map1066.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001288586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF320762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK005723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP767471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY323121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN703560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ344919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U40145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U47934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X74980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000020408   ⟹   ENSMUSP00000020408
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,524,780 - 117,546,663 (-)Ensembl
GRCm38.p6 Ensembl10117,688,875 - 117,710,758 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105263   ⟹   ENSMUSP00000100898
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,524,780 - 117,546,663 (-)Ensembl
GRCm38.p6 Ensembl10117,688,875 - 117,710,758 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126022
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,531,946 - 117,546,616 (-)Ensembl
GRCm38.p6 Ensembl10117,696,041 - 117,710,711 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131627
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,526,148 - 117,527,425 (-)Ensembl
GRCm38.p6 Ensembl10117,690,243 - 117,691,520 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132277
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,526,014 - 117,546,590 (-)Ensembl
GRCm38.p6 Ensembl10117,690,109 - 117,710,685 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137102
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,530,839 - 117,545,983 (-)Ensembl
GRCm38.p6 Ensembl10117,694,934 - 117,710,078 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147823
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,538,164 - 117,546,197 (-)Ensembl
GRCm38.p6 Ensembl10117,702,259 - 117,710,292 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151725
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,545,623 - 117,546,619 (-)Ensembl
GRCm38.p6 Ensembl10117,709,718 - 117,710,714 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155285   ⟹   ENSMUSP00000137039
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10117,524,800 - 117,545,927 (-)Ensembl
GRCm38.p6 Ensembl10117,688,895 - 117,710,022 (-)Ensembl
RefSeq Acc Id: NM_001288586   ⟹   NP_001275515
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910117,524,780 - 117,546,663 (-)NCBI
GRCm3810117,688,875 - 117,710,758 (-)NCBI
Celera10119,626,728 - 119,648,378 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010786   ⟹   NP_034916
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910117,524,780 - 117,546,663 (-)NCBI
GRCm3810117,688,875 - 117,710,758 (-)NCBI
MGSCv3710117,125,961 - 117,147,772 (-)RGD
Celera10119,626,728 - 119,648,378 (-)NCBI
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017313822   ⟹   XP_017169311
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910117,524,797 - 117,537,464 (-)NCBI
GRCm3810117,688,892 - 117,701,559 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155661   ⟹   XP_036011554
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910117,524,797 - 117,545,927 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034916   ⟸   NM_010786
- Peptide Label: isoform 1
- UniProtKB: Q91XK7 (UniProtKB/Swiss-Prot),   P23804 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001275515   ⟸   NM_001288586
- Peptide Label: isoform 2
- UniProtKB: P23804 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017169311   ⟸   XM_017313822
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000100898   ⟸   ENSMUST00000105263
RefSeq Acc Id: ENSMUSP00000020408   ⟸   ENSMUST00000020408
RefSeq Acc Id: ENSMUSP00000137039   ⟸   ENSMUST00000155285
RefSeq Acc Id: XP_036011554   ⟸   XM_036155661
- Peptide Label: isoform X1
Protein Domains
RanBP2-type   RING-type   SWIB/MDM2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23804-F1-model_v2 AlphaFold P23804 1-489 view protein structure

Promoters
RGD ID:6819579
Promoter ID:MM_KWN:5704
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000049465
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610117,128,091 - 117,129,392 (-)MPROMDB
RGD ID:6819578
Promoter ID:MM_KWN:5705
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000105263,   OTTMUST00000049452,   OTTMUST00000049456,   OTTMUST00000049457,   OTTMUST00000049458,   OTTMUST00000049459,   OTTMUST00000049464,   UC007HDL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610117,147,041 - 117,148,747 (-)MPROMDB
RGD ID:8673334
Promoter ID:EPDNEW_M14698
Type:initiation region
Name:Mdm2_1
Description:Mus musculus transformed mouse 3T3 cell double minute 2 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810117,710,687 - 117,710,747EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96952 AgrOrtholog
Ensembl Genes ENSMUSG00000020184 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000020408 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000100898 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000137039.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020408 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000105263 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000155285.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.245.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Mdm2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MDM2_E3_ligase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MDM2_mRING-HC-C2H2C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53_neg-reg_MDM_2/4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SWIB_MDM2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SWIB_MDM2_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RanBP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RanBP2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17246 UniProtKB/Swiss-Prot
MGD MGI:96952 ENTREZGENE
NCBI Gene 17246 ENTREZGENE
PANTHER PTHR13844:SF15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SWIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-RanBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mdm2 PhenoGen
PIRSF MDM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53_MDM_2/4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SWIB_MDM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RANBP2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RANBP2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90209 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt J3QP04_MOUSE UniProtKB/TrEMBL
  MDM2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q2L9A9_MOUSE UniProtKB/TrEMBL
  Q3TVL4_MOUSE UniProtKB/TrEMBL
  Q569X0_MOUSE UniProtKB/TrEMBL
  Q91XK7 ENTREZGENE
UniProt Secondary Q61040 UniProtKB/Swiss-Prot
  Q64330 UniProtKB/Swiss-Prot
  Q91XK7 UniProtKB/Swiss-Prot