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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313300
Species: Mus musculus
RGD Object: Gene
Symbol: Mdm2
Name: transformed mouse 3T3 cell double minute 2
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdm2increases expressionEXP 6480464CTDFluorouracil results in increased expression of MDM2 mRNAPMID:16949053
Mdm2increases expressionISOMDM2 (Homo sapiens)6480464CTDFluorouracil results in increased expression of MDM2 mRNA; Fluorouracil results in increased expression of MDM2 protein; Fluorouracil results in increased expression of MDM2 protein modified formPMID:14665630 PMID:15546879 PMID:16557594 PMID:17982676 PMID:18096571 PMID:19098008 PMID:22525470 PMID:28785074 PMID:30177839
Mdm2increases phosphorylationISOMDM2 (Homo sapiens)6480464CTDFluorouracil results in increased phosphorylation of MDM2 proteinPMID:25744307
Mdm2multiple interactionsISOMDM2 (Homo sapiens)6480464CTDCadmium Chloride affects the reaction [Fluorouracil results in increased phosphorylation of MDM2 protein]; Fluorouracil promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of MDM2 protein]; TP53 protein promotes the reaction [Fluorouracil promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of MDM2 protein]]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of MDM2 mRNA]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of MDM2 protein]PMID:15546879 PMID:17982676 PMID:25744307
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