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Gene: MDM2 (MDM2 proto-oncogene) Homo sapiens
Symbol: MDM2
Name: MDM2 proto-oncogene
Description: Exhibits several functions, including disordered domain specific binding activity; p53 binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including cellular protein metabolic process; negative regulation of signal transduction by p53 class mediator; and positive regulation of cell cycle. Localizes to the cytoplasm; nuclear lumen; and protein-containing complex. Colocalizes with the nuclear body. Implicated in chronic myeloid leukemia; glioblastoma multiforme; hepatocellular carcinoma; pancreatic ductal carcinoma; and sarcoma. Biomarker of acute myeloid leukemia; biliary tract disease (multiple); ichthyosis; pancreatic ductal carcinoma; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACTFS; double minute 2, human homolog of; double minute 2, human homolog of, p53-binding protein; E3 ubiquitin-protein ligase Mdm2; hdm2; HDM2 transcript variant MYO-1; HDM2 transcript variant MYO-18; HDM2 transcript variant MYO-20; HDM2 transcript variant MYO-24; HDM2 transcript variant MYO-25; HDM2 transcript variant MYO-26; HDM2 transcript variant MYO-32; HDM2 transcript variant MYO-4; HDMX; LSKB; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; MDM2 variant FB30; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; ubiquitin-protein ligase E3 Mdm2
Mus musculus (house mouse) : Mdm2 (transformed mouse 3T3 cell double minute 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mdm2 (MDM2 proto-oncogene)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mdm2 (MDM2 proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : MDM2 (MDM2 proto-oncogene)
Canis lupus familiaris (dog) : MDM2 (MDM2 proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mdm2 (MDM2 proto-oncogene)
Sus scrofa (pig) : MDM2 (MDM2 proto-oncogene)
Chlorocebus sabaeus (African green monkey) : MDM2 (MDM2 proto-oncogene)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1268,808,177 - 68,850,686 (+)EnsemblGRCh38hg38GRCh38
GRCh381268,808,149 - 68,850,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371269,201,952 - 69,239,324 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361267,488,247 - 67,520,481 (+)NCBINCBI36hg18NCBI36
Build 341267,488,246 - 67,520,481NCBI
Celera1268,865,796 - 68,903,026 (+)NCBI
Cytogenetic Map12q15NCBI
HuRef1266,252,410 - 66,289,884 (+)NCBIHuRef
CHM1_11269,170,604 - 69,207,918 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences