GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mdm2 | affects expression | EXP | | 6480464 | CTD | Methotrexate affects the expression of MDM2 mRNA | PMID:18502557 | Mdm2 | increases expression | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | Methotrexate results in increased expression of MDM2 mRNA; Methotrexate results in increased expression of MDM2 protein | PMID:17637740 PMID:21678067 PMID:24449571 | Mdm2 | multiple interactions | ISO | MDM2 (Homo sapiens) | 6480464 | CTD | Methotrexate results in increased activity of and results in increased expression of MDM2 protein; nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]; TP53 affects the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]] | PMID:21624110 | | ||||||||||||||||||||||
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