MDM2 (MDM2 proto-oncogene) - Rat Genome Database

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Gene: MDM2 (MDM2 proto-oncogene) Pan paniscus
Analyze
Symbol: MDM2
Name: MDM2 proto-oncogene
RGD ID: 11965096
Description: ENCODES a protein that exhibits p53 binding (ortholog); peroxisome proliferator activated receptor binding (ortholog); receptor serine/threonine kinase binding (ortholog); INVOLVED IN atrial septum development (ortholog); atrioventricular valve morphogenesis (ortholog); blood vessel development (ortholog); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute myeloid leukemia (ortholog); biliary tract benign neoplasm (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase Mdm2; Mdm2, p53 E3 ubiquitin protein ligase homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21076,824,907 - 76,859,369 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11276,824,089 - 76,858,786 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01266,322,340 - 66,357,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11269,102,083 - 69,133,278 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1269,102,084 - 69,133,278 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid fibril formation  (IEA)
apoptotic process  (IEA)
atrial septum development  (IEA,ISO)
atrioventricular valve morphogenesis  (IEA,ISO)
blood vessel development  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
cardiac septum morphogenesis  (IEA,ISO)
cellular response to actinomycin D  (IEA)
cellular response to alkaloid  (ISO)
cellular response to antibiotic  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to gamma radiation  (IEA)
cellular response to growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (IEA)
cellular response to organic cyclic compound  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to UV-C  (ISO)
cellular response to vitamin B1  (ISO)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  (IEA)
endocardial cushion morphogenesis  (IEA,ISO)
establishment of protein localization  (IEA)
fibroblast activation  (ISO)
heart development  (IEA,ISO)
heart valve development  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IEA)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (IEA)
negative regulation of neuron projection development  (ISO)
negative regulation of protein processing  (ISO)
negative regulation of signal transduction by p53 class mediator  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
positive regulation of cell cycle  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of mitotic cell cycle  (IEA)
positive regulation of muscle cell differentiation  (IEA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of protein export from nucleus  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA)
protein autoubiquitination  (IEA)
protein destabilization  (IEA)
protein localization to nucleus  (IEA)
protein ubiquitination  (IEA,ISO)
protein-containing complex assembly  (IEA)
protein-containing complex organization  (IEA)
proteolysis involved in protein catabolic process  (IEA)
regulation of biological quality  (IEA)
regulation of cell cycle  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of heart rate  (IEA,ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (ISO)
regulation of protein catabolic process  (IEA)
regulation of protein catabolic process at postsynapse, modulating synaptic transmission  (ISO)
response to antibiotic  (IEA)
response to cocaine  (ISO)
response to ether  (ISO)
response to formaldehyde  (ISO)
response to iron ion  (ISO)
response to magnesium ion  (ISO)
response to steroid hormone  (ISO)
response to toxic substance  (ISO)
response to water-immersion restraint stress  (ISO)
response to xenobiotic stimulus  (ISO)
traversing start control point of mitotic cell cycle  (IEA,ISO)
ubiquitin-dependent protein catabolic process  (IEA,ISO)
ventricular septum development  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MDM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21076,824,907 - 76,859,369 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11276,824,089 - 76,858,786 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01266,322,340 - 66,357,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11269,102,083 - 69,133,278 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1269,102,084 - 69,133,278 (+)Ensemblpanpan1.1panPan2
MDM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381268,808,172 - 68,850,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1268,808,177 - 68,845,544 (+)EnsemblGRCh38hg38GRCh38
GRCh371269,201,952 - 69,244,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361267,488,247 - 67,520,481 (+)NCBINCBI36Build 36hg18NCBI36
Build 341267,488,246 - 67,520,481NCBI
Celera1268,865,796 - 68,903,026 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1266,252,410 - 66,289,884 (+)NCBIHuRef
CHM1_11269,170,604 - 69,207,918 (+)NCBICHM1_1
T2T-CHM13v2.01268,784,018 - 68,830,265 (+)NCBIT2T-CHM13v2.0
Mdm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910117,524,780 - 117,546,663 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10117,524,780 - 117,546,663 (-)EnsemblGRCm39 Ensembl
GRCm3810117,688,875 - 117,710,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,688,875 - 117,710,758 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710117,125,961 - 117,147,772 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610117,091,898 - 117,113,709 (-)NCBIMGSCv36mm8
Celera10119,626,758 - 119,648,336 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.32NCBI
Mdm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8755,176,558 - 55,201,757 (-)NCBIGRCr8
mRatBN7.2753,290,660 - 53,315,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,290,664 - 53,314,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx755,197,377 - 55,221,597 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,400,491 - 57,424,715 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,178,368 - 57,202,590 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,719,060 - 60,743,618 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,719,066 - 60,743,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0760,719,023 - 60,743,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4756,996,694 - 57,020,926 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1757,018,654 - 57,054,110 (-)NCBI
Celera750,062,029 - 50,086,121 (-)NCBICelera
Cytogenetic Map7q22NCBI
Mdm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545815,263,739 - 15,286,808 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545815,264,028 - 15,287,290 (+)NCBIChiLan1.0ChiLan1.0
MDM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11010,936,288 - 10,963,118 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1010,893,719 - 10,962,596 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1010,869,091 - 10,894,634 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01011,060,051 - 11,086,867 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1011,016,172 - 11,087,383 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11010,928,429 - 10,953,972 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01011,174,449 - 11,199,967 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01011,296,600 - 11,322,142 (+)NCBIUU_Cfam_GSD_1.0
Mdm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494547,377,991 - 47,400,191 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365456,709,903 - 6,732,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl533,105,759 - 33,137,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1533,105,717 - 33,137,602 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2535,889,682 - 35,921,569 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MDM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11164,434,203 - 64,465,490 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1164,434,261 - 64,469,890 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037181,237,754 - 181,268,657 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000042087   ⟹   ENSPPAP00000019328
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1269,102,084 - 69,133,278 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042098   ⟹   ENSPPAP00000019339
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1269,102,402 - 69,132,532 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042102   ⟹   ENSPPAP00000019343
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1269,103,120 - 69,132,532 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042106   ⟹   ENSPPAP00000019347
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1269,103,120 - 69,132,532 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042109   ⟹   ENSPPAP00000019350
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1269,103,120 - 69,132,532 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042111   ⟹   ENSPPAP00000019352
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1269,103,120 - 69,132,532 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042112   ⟹   ENSPPAP00000019353
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1269,103,120 - 69,132,532 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042115   ⟹   ENSPPAP00000019355
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1269,103,120 - 69,132,532 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042117   ⟹   ENSPPAP00000019357
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1269,103,120 - 69,132,532 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000042118   ⟹   ENSPPAP00000019358
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1269,103,120 - 69,132,532 (+)Ensembl
RefSeq Acc Id: XM_003808717   ⟹   XP_003808765
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21076,824,907 - 76,859,369 (+)NCBI
NHGRI_mPanPan11276,824,089 - 76,858,786 (+)NCBI
Mhudiblu_PPA_v01266,322,340 - 66,357,010 (+)NCBI
PanPan1.11269,102,085 - 69,133,278 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055095882   ⟹   XP_054951857
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21076,827,733 - 76,859,369 (+)NCBI
NHGRI_mPanPan11276,824,128 - 76,858,786 (+)NCBI
RefSeq Acc Id: XM_055095884   ⟹   XP_054951859
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21076,833,090 - 76,859,369 (+)NCBI
NHGRI_mPanPan11276,829,487 - 76,858,786 (+)NCBI
RefSeq Acc Id: XM_063593542   ⟹   XP_063449612
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21076,833,140 - 76,859,369 (+)NCBI
RefSeq Acc Id: XP_003808765   ⟸   XM_003808717
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AQ86 (UniProtKB/TrEMBL),   A0A2R9APP6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000019343   ⟸   ENSPPAT00000042102
Ensembl Acc Id: ENSPPAP00000019347   ⟸   ENSPPAT00000042106
Ensembl Acc Id: ENSPPAP00000019350   ⟸   ENSPPAT00000042109
Ensembl Acc Id: ENSPPAP00000019355   ⟸   ENSPPAT00000042115
Ensembl Acc Id: ENSPPAP00000019358   ⟸   ENSPPAT00000042118
Ensembl Acc Id: ENSPPAP00000019357   ⟸   ENSPPAT00000042117
Ensembl Acc Id: ENSPPAP00000019353   ⟸   ENSPPAT00000042112
Ensembl Acc Id: ENSPPAP00000019352   ⟸   ENSPPAT00000042111
Ensembl Acc Id: ENSPPAP00000019328   ⟸   ENSPPAT00000042087
Ensembl Acc Id: ENSPPAP00000019339   ⟸   ENSPPAT00000042098
RefSeq Acc Id: XP_054951857   ⟸   XM_055095882
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054951859   ⟸   XM_055095884
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063449612   ⟸   XM_063593542
- Peptide Label: isoform X2
Protein Domains
DM2   RanBP2-type   RING-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032775 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000042087.1 UniProtKB/TrEMBL
  ENSPPAT00000042098.1 UniProtKB/TrEMBL
  ENSPPAT00000042102.1 UniProtKB/TrEMBL
  ENSPPAT00000042106.1 UniProtKB/TrEMBL
  ENSPPAT00000042109.1 UniProtKB/TrEMBL
  ENSPPAT00000042111.1 UniProtKB/TrEMBL
  ENSPPAT00000042112.1 UniProtKB/TrEMBL
  ENSPPAT00000042115.1 UniProtKB/TrEMBL
  ENSPPAT00000042117.1 UniProtKB/TrEMBL
  ENSPPAT00000042118.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.245.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  Zn-finger domain of Sec23/24 UniProtKB/TrEMBL
InterPro Mdm2 UniProtKB/TrEMBL
  MDM2_mRING-HC-C2H2C4 UniProtKB/TrEMBL
  p53_neg-reg_MDM_2/4 UniProtKB/TrEMBL
  SWIB_MDM2_dom_sf UniProtKB/TrEMBL
  SWIB_MDM2_domain UniProtKB/TrEMBL
  Znf_RanBP2 UniProtKB/TrEMBL
  Znf_RanBP2_sf UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report pps:100968756 UniProtKB/TrEMBL
NCBI Gene MDM2 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MDM2 UniProtKB/TrEMBL
  OS05G0521000 PROTEIN UniProtKB/TrEMBL
Pfam SWIB UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
  zf-RanBP UniProtKB/TrEMBL
PIRSF MDM2 UniProtKB/TrEMBL
  p53_MDM_2/4 UniProtKB/TrEMBL
PROSITE SWIB_MDM2 UniProtKB/TrEMBL
  ZF_RANBP2_1 UniProtKB/TrEMBL
  ZF_RANBP2_2 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF47592 UniProtKB/TrEMBL
  SSF90209 UniProtKB/TrEMBL
UniProt A0A2R9APP6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9APQ2_PANPA UniProtKB/TrEMBL
  A0A2R9APQ8_PANPA UniProtKB/TrEMBL
  A0A2R9AQ86 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AQ99_PANPA UniProtKB/TrEMBL
  A0A2R9AQB0_PANPA UniProtKB/TrEMBL
  A0A2R9AQB6_PANPA UniProtKB/TrEMBL
  A0A2R9AUA5_PANPA UniProtKB/TrEMBL
  A0A2R9AUB0_PANPA UniProtKB/TrEMBL
  A0A2R9AWI5_PANPA UniProtKB/TrEMBL