RGD Reference Report - Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer. - Rat Genome Database

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Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer.

Authors: Kriegmair, Maximilian Christian  Balk, Matthias  Wirtz, Ralph  Steidler, Annette  Weis, Cleo-Aron  Breyer, Johannes  Hartmann, Arndt  Bolenz, Christian  Erben, Philipp 
Citation: Kriegmair MC, etal., Anticancer Res. 2016 Oct;36(10):5205-5213. doi: 10.21873/anticanres.11091.
RGD ID: 13602098
Pubmed: PMID:27798881   (View Abstract at PubMed)
DOI: DOI:10.21873/anticanres.11091   (Journal Full-text)


AIM: To evaluate the prognostic role of the p53-upstream inhibitors MDM2, MDM4 and its splice variant MDM4-S in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC).
MATERIALS AND METHODS: mRNA Expression levels of MDM2, MDM4 and MDM4-S were assessed by quantitative real-time polymerase chain reaction (qRT-PCR) in 75 RC samples. Logistic regression analyses identified predictors of recurrence-free (RFS) and cancer-specific survival (CSS).
RESULTS: High expression was found in 42% (MDM2), 27% (MDMD4) and 91% (MDM4-S) of tumor specimens. Increased MDM2 expression was significantly associated with higher tumor stage (p=0.05) and lymphovascular invasion (LVI) (p=0.041). In the univariate analysis, low MDM4 expression (hazard ratio (HR)=5.93; p=0.002; HR=3.00; p=0.047), but not MDM2 (HR=1.63; p=0.222; HR=1.59; p=0.27), were associated with RFS and CSS. In the multivariate analysis, the combination of low MDM4 and high MDM2 was significant for RFS and CSS (HR=14.9; p=0.001; HR=5.63; p=0.019).
CONCLUSION: The combination of MDM2 and MDM4 expression is an independent predictor in patients undergoing RC for MIBC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
urinary bladder cancer severityIEP 13602098mRNA:increased expression:bladderRGD 
urinary bladder cancer severityISOMDM2 (Homo sapiens)13602098; 13602098mRNA:increased expression:bladderRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mdm2  (MDM2 proto-oncogene)

Genes (Mus musculus)
Mdm2  (transformed mouse 3T3 cell double minute 2)

Genes (Homo sapiens)
MDM2  (MDM2 proto-oncogene)


Additional Information