Tp53 (tumor protein p53) - Rat Genome Database

Name: Tp53
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Tp53 (tumor protein p53) Rattus norvegicus

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Symbol:

Tp53

Name:

tumor protein p53

RGD ID:

3889

Description:

Enables several functions, including MDM2/MDM4 family protein binding activity; transmembrane transporter binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to triglyceride; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Part of RNA polymerase II transcription regulator complex and chromatin. Colocalizes with PML body. Used to study disease of cellular proliferation (multiple) and oral mucosa leukoplakia. Biomarker of several diseases, including dilated cardiomyopathy; gastrointestinal system cancer (multiple); ischemia; oral mucosa leukoplakia; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and open-angle glaucoma (multiple). Orthologous to human TP53 (tumor protein p53); PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; non-small cell lung carcinoma pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (-)-anisomycin.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

cellular tumor antigen p53; MGC112612; p53; transformation related protein 53; Trp53; tumor protein p53 (Li-Fraumeni syndrome); tumor suppressor p53

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TP53 (tumor protein p53)	HGNC	EggNOG, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Trp53 (transformation related protein 53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tp53 (tumor protein p53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TP53 (tumor protein p53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TP53 (tumor protein p53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tp53 (tumor protein p53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TP53 (tumor protein p53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TP53 (tumor protein p53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tp53 (tumor protein p53)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Trp53 (transformation related protein 53)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TP53 (tumor protein p53)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	tp53 (tumor protein p53)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	p53	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tp53	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Related Pseudogenes:

Tp53-ps3 p53-ps

Allele / Splice:

Tp53^em3Mcwi Tp53^m1Kyo Tp53^{tm1(EGFP-Pac)Qly} Tp53^em1Sage

Genetic Models:

SD-Tp53^em3Mcwi SD-Tp53^em1Sage STOCK-Tp53^{tm1(EGFP-Pac)Qly}/Rrrc F344-Tp53^m1Kyo

Is Marker For:

Strains: STOCK-Tp53^{tm1(EGFP-Pac)Qly}/Rrrc F344-Tp53^m1Kyo

Candidate Gene For:

Hcar1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	54,300,070 - 54,311,525 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	54,300,048 - 54,311,524 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	58,962,496 - 58,973,951 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	58,451,039 - 58,462,496 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	53,958,739 - 53,970,151 (+)	NCBI	Rnor_WKY
Rnor_6.0	10	56,186,299 - 56,198,449 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	56,187,020 - 56,198,449 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	55,932,658 - 55,944,087 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	56,399,721 - 56,411,150 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	56,413,290 - 56,424,751 (+)	NCBI
Celera	10	53,454,375 - 53,465,803 (+)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

JBrowse:

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Model

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Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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