Tp53 (tumor protein p53) - Rat Genome Database

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Gene: Tp53 (tumor protein p53) Rattus norvegicus
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Symbol: Tp53
Name: tumor protein p53
RGD ID: 3889
Description: Enables several functions, including MDM2/MDM4 family protein binding activity; transmembrane transporter binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to polyamine macromolecule; regulation of apoptotic process; and regulation of macromolecule biosynthetic process. Located in PML body and chromatin. Part of RNA polymerase II transcription regulator complex. Used to study disease of cellular proliferation (multiple); oral mucosa leukoplakia; and traumatic brain injury. Biomarker of several diseases, including bronchopulmonary dysplasia; gastrointestinal system cancer (multiple); ischemia; oral mucosa leukoplakia; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53); PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; non-small cell lung carcinoma pathway; INTERACTS WITH (+)-catechin; (+)-dexrazoxane; (+)-schisandrin B.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cellular tumor antigen p53; MGC112612; p53; transformation related protein 53; Trp53; tumor protein p53 (Li-Fraumeni syndrome); tumor suppressor p53
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Tp53-ps1   Tp53-ps3  
Allele / Splice: Tp53em3Mcwi ; Tp53m1Kyo ; Tp53tm1(EGFP-Pac)Qly ; Tp53em1Sage
Genetic Models: SD-Tp53em3Mcwi ; SD-Tp53em1Sage ; STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc ; F344-Tp53m1Kyo
Is Marker For: Strains:   STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc   F344-Tp53m1Kyo  
Candidate Gene For: Hcar1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,798,871 - 54,810,300 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,798,851 - 54,810,299 (+)EnsemblGRCr8
mRatBN7.21054,300,070 - 54,311,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,300,048 - 54,311,524 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1058,962,496 - 58,973,951 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,451,039 - 58,462,496 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,958,739 - 53,970,151 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,186,299 - 56,198,449 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,187,020 - 56,198,449 (+)Ensemblrn6Rnor6.0
Rnor_5.01055,932,658 - 55,944,087 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41056,399,721 - 56,411,150 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1053,454,375 - 53,465,803 (+)NCBICelera
RGSC_v3.11056,413,290 - 56,424,751 (+)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Erythroleukemia  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute megakaryocytic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adenoma  (ISO)
Adrenal Cortex Neoplasms  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anaplastic astrocytoma  (ISO)
anaplastic thyroid carcinoma  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
Arsenic Poisoning  (ISO)
atherosclerosis  (ISO)
atypical teratoid rhabdoid tumor  (ISO)
autosomal recessive dyskeratosis congenita 3  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
Balkan nephropathy  (ISO)
basal cell carcinoma  (ISO)
bone development disease  (ISO)
Bone Marrow Failure Syndrome 5  (ISO)
Bone Marrow Neoplasms  (ISO)
bone osteosarcoma  (ISO)
brain ischemia  (ISO)
Brain Neoplasms  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO,ISS)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (IMP)
bronchopulmonary dysplasia  (IEP)
Calcification of Aortic Valve  (ISO)
calcinosis  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
carotid artery disease  (ISO)
cataract  (ISO)
Cecal Neoplasms  (ISO)
Central Nervous System Neoplasms  (ISO)
cervical adenocarcinoma  (ISO)
cervical cancer  (ISO)
cervical squamous cell carcinoma  (ISO)
CHARGE syndrome  (ISS)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma of middle ear  (ISO)
choroid plexus carcinoma  (ISO)
choroid plexus papilloma  (ISO)
Chromosome 17 Deletion  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell adenocarcinoma  (ISO)
clear cell renal cell carcinoma  (ISO)
colon carcinoma  (ISO)
Colon Diverticulum  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (IEP,ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital fibrosarcoma  (ISO)
congenital merosin-deficient muscular dystrophy 1A  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
coronary restenosis  (ISO)
Craniofacial Abnormalities  (ISO)
demyelinating disease  (ISO)
Diabetic Nephropathies  (IEP)
Diamond-Blackfan anemia  (ISO)
diffuse large B-cell lymphoma  (ISO,ISS)
diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  (ISO)
DiGeorge syndrome  (ISO)
dilated cardiomyopathy  (IEP)
disease of cellular proliferation  (IMP,ISO)
Disease Progression  (ISO)
Drug-induced Neutropenia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Ductal Carcinoma  (ISO)
ductal carcinoma in situ  (ISO)
dyskeratosis congenita  (ISS)
Emphysema  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial cancer  (ISS)
endometrial carcinoma  (IMP,ISO)
Endometrial Intraepithelial Neoplasia  (ISO)
Endometrial Neoplasms  (ISO)
esophageal cancer  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (IEP,ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IEP,ISO)
Experimental Neoplasms  (ISO)
Eye Neoplasms  (ISO)
familial melanoma  (ISO)
Familial Pancreatic Carcinoma  (ISO)
Female Infertility  (ISO)
gallbladder cancer  (ISO)
Gallbladder Neoplasms  (ISO)
gastric adenocarcinoma  (ISO)
glioblastoma  (ISO,ISS)
graft-versus-host disease  (ISO)
Graves' disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hematologic cancer  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hereditary Adrenocortical Carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypogonadism and Testicular Atrophy  (IMP)
ischemia  (IEP,ISO)
Kaposi's sarcoma  (ISO)
keratosis  (ISO)
Leber hereditary optic neuropathy  (ISO)
leukemia  (ISO)
Li-Fraumeni syndrome  (ISO,ISS)
Li-Fraumeni syndrome 1  (ISO)
Li-Fraumeni-Like Syndrome  (ISO)
Lip Neoplasms  (ISO)
Liver Neoplasms  (ISO)
low tension glaucoma  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (IMP,ISO)
lung non-small cell carcinoma  (ISO)
lung sarcomatoid carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoma  (ISO)
male infertility  (ISO)
malignant astrocytoma  (ISO)
malignant mesothelioma  (ISO)
marginal zone lymphoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
meninges sarcoma  (IMP)
Mesothelioma  (ISO)
mismatch repair cancer syndrome  (ISO)
mitochondrial metabolism disease  (ISO)
Mouth Neoplasms  (IEP,ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myelofibrosis  (ISO)
myeloid leukemia associated with Down Syndrome  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IEP)
nasal cavity cancer  (ISO)
Nasopharyngeal Neoplasms  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (IMP,ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
Nerve Sheath Neoplasms  (ISO)
nervous system disease  (ISO)
neuroblastoma  (ISO)
non-Hodgkin lymphoma  (ISO)
Odontogenic Myxoma  (ISO)
Oral Lichen Planus  (ISO)
oral mucosa leukoplakia  (IEP,IMP,ISO)
oral squamous cell carcinoma  (ISO)
oral submucous fibrosis  (ISO)
Oropharyngeal Neoplasms  (ISO)
osteosarcoma  (IMP,ISO,ISS)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
ovarian small cell carcinoma  (ISO)
ovary serous adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatic intraductal papillary-mucinous neoplasm  (ISO)
papillary thyroid carcinoma  (ISO)
paranasal sinus benign neoplasm  (ISO)
Parasitic Liver Diseases  (ISO)
Pediatric Adrenocortical Carcinoma  (ISO)
Penile Neoplasms  (ISO)
Phyllodes Tumor  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Pleural Effusion  (ISO)
Polyploidy  (ISO)
pre-malignant neoplasm  (IEP,ISO)
Premature Aging  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
primary open angle glaucoma  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Hereditary, 1  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pterygium  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
rhabdomyosarcoma  (ISO)
SAPHO syndrome  (ISO)
sarcoma  (IMP,ISO)
schizophrenia  (ISO)
serous cystadenocarcinoma  (ISO)
Sezary's disease  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Injuries  (IEP)
spondyloarthropathy  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
thymoma  (ISO)
Thymus Neoplasms  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (IEP,IMP,ISO)
tongue squamous cell carcinoma  (IEP)
transitional cell carcinoma  (ISO)
transthyretin amyloidosis  (ISO)
traumatic brain injury  (IMP)
Trigeminal Nerve Injuries  (IEP)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
Urogenital Neoplasms  (ISO)
Urologic Neoplasms  (ISO)
vascular dementia  (IEP)
Vulvar Lichen Sclerosus  (ISO)
Vulvar Neoplasms  (IEP,ISO)
xeroderma pigmentosum  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View