Tp53 (tumor protein p53) - Rat Genome Database

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Gene: Tp53 (tumor protein p53) Rattus norvegicus
Symbol: Tp53
Name: tumor protein p53
RGD ID: 3889
Description: Enables several functions, including MDM2/MDM4 family protein binding activity; protein C-terminus binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of smooth muscle cell proliferation; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Located in several cellular components, including chromatin; cytosol; and mitochondrion. Part of RNA polymerase II transcription regulator complex. Used to study disease of cellular proliferation (multiple) and oral mucosa leukoplakia. Biomarker of several diseases, including dilated cardiomyopathy; gastrointestinal system cancer (multiple); ischemia; oral mucosa leukoplakia; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and open-angle glaucoma (multiple). Orthologous to human TP53 (tumor protein p53); PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; non-small cell lung carcinoma pathway; INTERACTS WITH (+)-schisandrin B; (-)-anisomycin; (-)-citrinin.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cellular tumor antigen p53; MGC112612; p53; transformation related protein 53; Trp53; tumor protein p53 (Li-Fraumeni syndrome); tumor suppressor p53
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC100151773   p53-ps  
Allele / Splice: Tp53em3Mcwi   Tp53m1Kyo   Tp53tm1(EGFP-Pac)Qly   Tp53em1Sage  
Genetic Models: SD-Tp53em1Sage STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc F344-Tp53m1Kyo SD-Tp53em3Mcwi
Is Marker For: Strains:   STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc   F344-Tp53m1Kyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21054,300,070 - 54,311,525 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1054,300,048 - 54,311,524 (+)Ensembl
Rnor_6.01056,186,299 - 56,198,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,187,020 - 56,198,449 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,932,658 - 55,944,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,399,721 - 56,411,150 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11056,413,290 - 56,424,751 (+)NCBI
Celera1053,454,375 - 53,465,803 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)