Tp53 (tumor protein p53) - Rat Genome Database

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Gene: Tp53 (tumor protein p53) Rattus norvegicus
Symbol: Tp53
Name: tumor protein p53
RGD ID: 3889
Description: Enables several functions, including MDM2/MDM4 family protein binding activity; transmembrane transporter binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to triglyceride; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Part of RNA polymerase II transcription regulator complex and chromatin. Colocalizes with PML body. Used to study disease of cellular proliferation (multiple) and oral mucosa leukoplakia. Biomarker of several diseases, including dilated cardiomyopathy; gastrointestinal system cancer (multiple); ischemia; oral mucosa leukoplakia; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and open-angle glaucoma (multiple). Orthologous to human TP53 (tumor protein p53); PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; non-small cell lung carcinoma pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (-)-anisomycin.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cellular tumor antigen p53; MGC112612; p53; transformation related protein 53; Trp53; tumor protein p53 (Li-Fraumeni syndrome); tumor suppressor p53
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Tp53-ps3   p53-ps  
Allele / Splice: Tp53em3Mcwi   Tp53m1Kyo   Tp53tm1(EGFP-Pac)Qly   Tp53em1Sage  
Genetic Models: SD-Tp53em3Mcwi SD-Tp53em1Sage STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc F344-Tp53m1Kyo
Is Marker For: Strains:   STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc   F344-Tp53m1Kyo  
Candidate Gene For: Hcar1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21054,300,070 - 54,311,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,300,048 - 54,311,524 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,962,496 - 58,973,951 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01058,451,039 - 58,462,496 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01053,958,739 - 53,970,151 (+)NCBIRnor_WKY
Rnor_6.01056,186,299 - 56,198,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,187,020 - 56,198,449 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,932,658 - 55,944,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,399,721 - 56,411,150 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,413,290 - 56,424,751 (+)NCBI
Celera1053,454,375 - 53,465,803 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)