Kat6b (lysine acetyltransferase 6B)

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Gene: Kat6b (lysine acetyltransferase 6B) Rattus norvegicus

Analyze

Symbol:

Kat6b

Name:

lysine acetyltransferase 6B

RGD ID:

1566399

Description:

Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; histone H3K14 acetyltransferase activity; and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in bipolar disorder; blepharophimosis-intellectual disability syndrome, SBBYS type; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B); PARTICIPATES IN histone modification pathway; INTERACTS WITH 4,4'-sulfonyldiphenol; atrazine; bisphenol A.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

histone acetyltransferase KAT6B; K(lysine) acetyltransferase 6B; LOC305681; RGD1566399; similar to MYST histone acetyltransferase monocytic leukemia 4

RGD Orthologs

Human

Mouse

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KAT6B (lysine acetyltransferase 6B)	HGNC	Ensembl, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Kat6b (K(lysine) acetyltransferase 6B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KAT6B (lysine acetyltransferase 6B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KAT6B (lysine acetyltransferase 6B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kat6b (lysine acetyltransferase 6B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KAT6B (lysine acetyltransferase 6B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KAT6B (lysine acetyltransferase 6B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kat6b (lysine acetyltransferase 6B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KAT6B (lysine acetyltransferase 6B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kat6b (K(lysine) acetyltransferase 6B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kat6b (K(lysine) acetyltransferase 6B)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	enok	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SAS3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	2,638,885 - 2,811,977 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	2,639,200 - 2,812,316 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	15	2,811,933 - 2,966,833 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	2,813,537 - 2,966,576 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	2,792,817 - 2,960,466 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	15	1,779,554 - 1,945,321 (+)	NCBI		Celera
Cytogenetic Map	15	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Arachnodactyly (ISO)

bipolar disorder (ISO)

blepharophimosis (ISO)

blepharophimosis-intellectual disability syndrome, SBBYS type (ISO)

brain small vessel disease 1 (ISO)

breast cancer (ISO)

CAKUT (ISO)

Cerebral Hemorrhage (ISO)

craniosynostosis (ISO)

cryptorchidism (ISO)

epilepsy (ISO)

genetic disease (ISO)

Genitopatellar Syndrome (ISO)

Hereditary Angiopathy with Nephropathy, Aneurysms, and Muscle Cramps (ISO)

high grade glioma (ISO)

hypospadias (ISO)

intellectual disability (ISO)

juvenile rheumatoid arthritis (ISO)

KBG syndrome (ISO)

leiomyoma (ISO)

nephronophthisis (ISO)

Neurodevelopmental Disorders (ISO)

Noonan syndrome (ISO,ISS)

Pontine Microangiopathy and Leukoencephalopathy, Autosomal Dominant (ISO)

porencephaly (ISO)

renal hypoplasia (ISO)

retinal arterial tortuosity (ISO)

Telecanthus (ISO)

vesicoureteral reflux (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(S)-nicotine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (EXP)

adefovir pivoxil (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

bleomycin A5 (ISO)

bortezomib (ISO)

butanal (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chloroacetaldehyde (ISO)

choline (ISO)

cidofovir anhydrous (ISO)

cisplatin (ISO)

clothianidin (ISO)

D-glucose (ISO)

diarsenic trioxide (ISO)

diclofenac (ISO)

dicrotophos (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

gallic acid (ISO)

glucose (ISO)

ifosfamide (ISO)

L-methionine (ISO)

N,N-diethyl-m-toluamide (EXP)

nickel atom (ISO)

nicotine (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

permethrin (EXP)

phenobarbital (ISO)

PhIP (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

pyrimidifen (ISO)

sarin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to leukemia inhibitory factor (ISO)

chromatin remodeling (ISO)

histone acetylation (ISO)

histone H3 acetylation (ISO)

negative regulation of DNA-templated transcription (ISO)

nucleosome assembly (IEA)

positive regulation of DNA-templated transcription (ISO)

positive regulation of transcription by RNA polymerase II (IDA)

regulation of DNA-templated transcription (ISO)

Cellular Component

MOZ/MORF histone acetyltransferase complex (IBA,ISO)

nucleosome (IEA)

nucleus (IDA)

nucleus (ISO)

Molecular Function

acetyltransferase activity (ISO)

DNA binding (IEA)

histone acetyltransferase activity (ISO)

histone H3K14 acetyltransferase activity (ISO)

metal ion binding (IEA)

peptide-lysine-N-acetyltransferase activity (ISO)

protein binding (ISO)

protein-containing complex binding (IPI)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

transcription coactivator activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome.	Clayton-Smith J, etal., Am J Hum Genet. 2011 Nov 11;89(5):675-81. doi: 10.1016/j.ajhg.2011.10.008.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.	Kraft M, etal., J Clin Invest. 2011 Sep;121(9):3479-91. doi: 10.1172/JCI43428. Epub 2011 Aug 1.
4.	Identification of novel loci for bipolar I disorder in a multi-stage genome-wide association study.	Kuo PH, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:58-64. doi: 10.1016/j.pnpbp.2014.01.003. Epub 2014 Jan 18.
5.	Can unknown predisposition in familial breast cancer be family-specific?	Lynch H, etal., Breast J. 2013 Sep-Oct;19(5):520-8. doi: 10.1111/tbj.12145. Epub 2013 Jun 26.
6.	Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF.	Moore SD, etal., Cancer Res. 2004 Aug 15;64(16):5570-7.
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	Physical and functional HAT/HDAC interplay regulates protein acetylation balance.	Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	De novo mutations of the gene encoding the histone acetyltransferase KAT6B cause Genitopatellar syndrome.	Simpson MA, etal., Am J Hum Genet. 2012 Feb 10;90(2):290-4. doi: 10.1016/j.ajhg.2011.11.024. Epub 2012 Jan 19.
12.	Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.	Surapureddi S, etal., Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11836-41.

Additional References at PubMed

PMID:10497217	PMID:10821753	PMID:11965546	PMID:16387653	PMID:18794358	PMID:20439489

Genomics

Comparative Map Data

Kat6b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	2,638,885 - 2,811,977 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	2,639,200 - 2,812,316 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	15	2,811,933 - 2,966,833 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	2,813,537 - 2,966,576 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	2,792,817 - 2,960,466 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	15	1,779,554 - 1,945,321 (+)	NCBI		Celera
Cytogenetic Map	15	p16	NCBI

KAT6B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	74,824,936 - 75,032,624 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	10	74,824,927 - 75,032,624 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	76,585,013 - 76,792,382 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	76,256,385 - 76,462,645 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	76,268,463 - 76,460,810	NCBI
Celera	10	69,874,402 - 70,080,888 (+)	NCBI		Celera
Cytogenetic Map	10	q22.2	NCBI
HuRef	10	70,584,503 - 70,790,954 (+)	NCBI		HuRef
CHM1_1	10	76,868,040 - 77,074,125 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	75,698,775 - 75,906,154 (+)	NCBI		T2T-CHM13v2.0

Kat6b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	21,549,284 - 21,722,546 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	21,531,502 - 21,722,546 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	21,499,216 - 21,672,478 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	21,481,434 - 21,672,478 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	22,319,076 - 22,491,355 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	20,288,420 - 20,460,685 (+)	NCBI		MGSCv36	mm8
Celera	14	17,881,664 - 18,055,053 (+)	NCBI		Celera
Cytogenetic Map	14	A3	NCBI

KAT6B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	10	74,020,143 - 74,225,546 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	74,035,496 - 74,223,975 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	10	71,354,585 - 71,561,572 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

KAT6B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	25,131,580 - 25,303,355 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	25,131,844 - 25,301,825 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	25,253,256 - 25,438,393 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	25,399,632 - 25,585,839 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	25,400,521 - 25,584,563 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	25,295,642 - 25,481,027 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	25,495,394 - 25,681,653 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	25,850,710 - 26,037,089 (+)	NCBI		UU_Cfam_GSD_1.0

Kat6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	55,816,974 - 56,005,037 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936521	4,309,694 - 4,496,904 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936521	4,309,699 - 4,497,755 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KAT6B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	77,404,136 - 77,597,673 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	77,390,790 - 77,597,674 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	83,529,553 - 83,722,784 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KAT6B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	56,340,579 - 56,525,809 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	56,340,026 - 56,536,512 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	16,828,363 - 17,063,158 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kat6b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	8,204,943 - 8,392,724 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	8,204,266 - 8,391,328 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Kat6b
671 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	108
Count of miRNA genes:	47
Interacting mature miRNAs:	53
Transcripts:	ENSRNOT00000017383, ENSRNOT00000070893
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	29912054	Rat
8552920	Pigfal8	Plasma insulin-like growth factor 1 level QTL 8	3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	15	1	34723002	Rat
8694361	Abfw6	Abdominal fat weight QTL 6	10.2	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	15	1	34723002	Rat
9589149	Insul29	Insulin level QTL 29	9.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	15	1	34723002	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
5684946	Bss98	Bone structure and strength QTL 98	3.9	0.0026	tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	15	1058250	14481294	Rat
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	colorectal tumor number (CMO:0001794)	15	2266368	22711984	Rat
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	15	2266368	22711984	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat

Markers in Region

D15Wox1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	2,673,264 - 2,673,438 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	2,845,089 - 2,845,262	NCBI	Rnor6.0
Rnor_5.0	15	2,824,359 - 2,824,532	UniSTS	Rnor5.0
Celera	15	1,911,633 - 1,911,806	UniSTS
RH 3.4 Map	15	45.2	RGD
RH 3.4 Map	15	45.2	UniSTS
RH 2.0 Map	15	0.0	RGD
Cytogenetic Map	15	p16	UniSTS

AW534476

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	2,641,202 - 2,641,354 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	2,814,251 - 2,814,402	NCBI	Rnor6.0
Rnor_5.0	15	2,795,135 - 2,795,286	UniSTS	Rnor5.0
Celera	15	1,942,852 - 1,943,003	UniSTS
RH 3.4 Map	15	45.2	UniSTS
Cytogenetic Map	15	p16	UniSTS

RH139049

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	2,794,908 - 2,795,038 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	2,966,654 - 2,966,783	NCBI	Rnor6.0
Rnor_5.0	15	2,945,451 - 2,945,580	UniSTS	Rnor5.0
RGSC_v3.4	15	2,999,019 - 2,999,148	UniSTS	RGSC3.4
Celera	15	1,792,727 - 1,792,856	UniSTS
RH 3.4 Map	15	49.2	UniSTS
Cytogenetic Map	15	p16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	10	14	2	13	2			74	22	33	11
Low		33	43	39	6	39	8	11		13	8		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008767347	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093713	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093714	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093715	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093716	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000017383 ⟹ ENSRNOP00000017383

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	15	2,813,540 - 2,966,576 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000070893 ⟹ ENSRNOP00000064386

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	2,639,200 - 2,812,316 (-)	Ensembl
Rnor_6.0 Ensembl	15	2,813,537 - 2,966,576 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107992 ⟹ ENSRNOP00000097238

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	2,639,200 - 2,810,956 (-)	Ensembl

RefSeq Acc Id:

XM_039093707 ⟹ XP_038949635

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	2,638,885 - 2,811,664 (-)	NCBI

RefSeq Acc Id:

XM_039093708 ⟹ XP_038949636

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	2,638,886 - 2,810,549 (-)	NCBI

RefSeq Acc Id:

XM_039093709 ⟹ XP_038949637

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	2,638,885 - 2,809,999 (-)	NCBI

RefSeq Acc Id:

XM_039093710 ⟹ XP_038949638

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	2,638,886 - 2,811,977 (-)	NCBI

RefSeq Acc Id:

XM_039093711 ⟹ XP_038949639

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	2,638,885 - 2,811,664 (-)	NCBI

RefSeq Acc Id:

XM_039093712 ⟹ XP_038949640

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	2,638,885 - 2,811,664 (-)	NCBI

RefSeq Acc Id:

XM_039093713 ⟹ XP_038949641

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	2,638,885 - 2,811,664 (-)	NCBI

RefSeq Acc Id:

XM_039093714 ⟹ XP_038949642

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	2,638,885 - 2,811,664 (-)	NCBI

RefSeq Acc Id:

XM_039093715 ⟹ XP_038949643

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	2,638,885 - 2,695,259 (-)	NCBI

RefSeq Acc Id:

XM_039093716 ⟹ XP_038949644

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	2,638,885 - 2,692,541 (-)	NCBI

RefSeq Acc Id:

XM_039093717 ⟹ XP_038949645

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	2,638,885 - 2,689,101 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_038949635	(Get FASTA)	NCBI Sequence Viewer
	XP_038949636	(Get FASTA)	NCBI Sequence Viewer
	XP_038949637	(Get FASTA)	NCBI Sequence Viewer
	XP_038949638	(Get FASTA)	NCBI Sequence Viewer
	XP_038949639	(Get FASTA)	NCBI Sequence Viewer
	XP_038949640	(Get FASTA)	NCBI Sequence Viewer
	XP_038949641	(Get FASTA)	NCBI Sequence Viewer
	XP_038949642	(Get FASTA)	NCBI Sequence Viewer
	XP_038949643	(Get FASTA)	NCBI Sequence Viewer
	XP_038949644	(Get FASTA)	NCBI Sequence Viewer
	XP_038949645	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000064386 ⟸ ENSRNOT00000070893

RefSeq Acc Id:

ENSRNOP00000017383 ⟸ ENSRNOT00000017383

RefSeq Acc Id:	XP_038949642 ⟸ XM_039093714
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038949641 ⟸ XM_039093713
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038949640 ⟸ XM_039093712
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038949639 ⟸ XM_039093711
- Peptide Label:	isoform X2
- UniProtKB:	M0R4T9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038949635 ⟸ XM_039093707
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GLZ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038949637 ⟸ XM_039093709
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GLZ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038949643 ⟸ XM_039093715
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038949644 ⟸ XM_039093716
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038949645 ⟸ XM_039093717
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_038949638 ⟸ XM_039093710
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GLZ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038949636 ⟸ XM_039093708
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GLZ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000097238 ⟸ ENSRNOT00000107992

Protein Domains

H15 MYST-type HAT PHD-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0R4T9-F1-model_v2	AlphaFold	M0R4T9	1-1850	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1566399	AgrOrtholog
BioCyc Gene	G2FUF-14586	BioCyc
Ensembl Genes	ENSRNOG00000012850	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000064386	ENTREZGENE
	ENSRNOP00000064386.3	UniProtKB/TrEMBL
	ENSRNOP00000097238	ENTREZGENE
	ENSRNOP00000097238.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000070893	ENTREZGENE
	ENSRNOT00000070893.3	UniProtKB/TrEMBL
	ENSRNOT00000107992	ENTREZGENE
	ENSRNOT00000107992.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	3.40.630.30	UniProtKB/TrEMBL
	N-acetyl transferase-like	UniProtKB/TrEMBL
InterPro	Acyl_CoA_acyltransferase	UniProtKB/TrEMBL
	HAT_MYST-type	UniProtKB/TrEMBL
	Histone_H1/H5_H15	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
	Zf-MYST	UniProtKB/TrEMBL
	Znf_FYVE_PHD	UniProtKB/TrEMBL
	Znf_PHD	UniProtKB/TrEMBL
	Znf_PHD-finger	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
NCBI Gene	305681	ENTREZGENE
PANTHER	HISTONE ACETYLTRANSFERASE	UniProtKB/TrEMBL
	HISTONE ACETYLTRANSFERASE KAT6B	UniProtKB/TrEMBL
Pfam	MOZ_SAS	UniProtKB/TrEMBL
	PHD	UniProtKB/TrEMBL
	zf-MYST	UniProtKB/TrEMBL
PhenoGen	Kat6b	PhenoGen
PROSITE	H15	UniProtKB/TrEMBL
	MYST_HAT	UniProtKB/TrEMBL
	ZF_PHD_2	UniProtKB/TrEMBL
SMART	H15	UniProtKB/TrEMBL
	PHD	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
	SSF55729	UniProtKB/TrEMBL
	SSF57903	UniProtKB/TrEMBL
UniProt	A0A8I6GLZ3	ENTREZGENE, UniProtKB/TrEMBL
	M0R4T9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Kat6b	lysine acetyltransferase 6B	Kat6b	K(lysine) acetyltransferase 6B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-07-25	Kat6b	K(lysine) acetyltransferase 6B	RGD1566399	similar to MYST histone acetyltransferase monocytic leukemia 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-02	RGD1566399	similar to MYST histone acetyltransferase monocytic leukemia 4	LOC688634	similar to Histone acetyltransferase MYST4 (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein)	Data Merged	1643240	APPROVED
2008-04-30	RGD1566399	similar to MYST histone acetyltransferase monocytic leukemia 4	RGD1566399_predicted	similar to MYST histone acetyltransferase monocytic leukemia 4 (predicted)	'predicted' is removed	2292626	APPROVED
2006-11-19	LOC688634	similar to Histone acetyltransferase MYST4 (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein)			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-07	RGD1566399_predicted	similar to MYST histone acetyltransferase monocytic leukemia 4 (predicted)	LOC305681	similar to MYST histone acetyltransferase monocytic leukemia 4	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC305681	similar to MYST histone acetyltransferase monocytic leukemia 4			Symbol and Name status set to provisional	70820	PROVISIONAL

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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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