Kat6b (lysine acetyltransferase 6B) - Rat Genome Database

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Gene: Kat6b (lysine acetyltransferase 6B) Rattus norvegicus
Analyze
Symbol: Kat6b
Name: lysine acetyltransferase 6B
RGD ID: 1566399
Description: Predicted to enable histone H3K14 acetyltransferase activity and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Human ortholog(s) of this gene implicated in Ohdo syndrome, SBBYS variant; bipolar disorder; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B); PARTICIPATES IN histone modification pathway; INTERACTS WITH 17beta-estradiol; 4,4'-sulfonyldiphenol; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: histone acetyltransferase KAT6B; K(lysine) acetyltransferase 6B; LOC305681; RGD1566399; similar to MYST histone acetyltransferase monocytic leukemia 4
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,688,535 - 2,861,443 (-)NCBIGRCr8
mRatBN7.2152,638,885 - 2,811,977 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,639,200 - 2,812,316 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0152,811,933 - 2,966,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,813,537 - 2,966,576 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0152,792,817 - 2,960,466 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera151,779,554 - 1,945,321 (+)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A5  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
choline  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
glucose  (ISO)
ifosfamide  (ISO)
L-methionine  (ISO)
methoxychlor  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
PhIP  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pyrimidifen  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Whole-exome-sequencing identifies mutations in histone acetyltransferase gene KAT6B in individuals with the Say-Barber-Biesecker variant of Ohdo syndrome. Clayton-Smith J, etal., Am J Hum Genet. 2011 Nov 11;89(5):675-81. doi: 10.1016/j.ajhg.2011.10.008.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice. Kraft M, etal., J Clin Invest. 2011 Sep;121(9):3479-91. doi: 10.1172/JCI43428. Epub 2011 Aug 1.
4. Identification of novel loci for bipolar I disorder in a multi-stage genome-wide association study. Kuo PH, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:58-64. doi: 10.1016/j.pnpbp.2014.01.003. Epub 2014 Jan 18.
5. Can unknown predisposition in familial breast cancer be family-specific? Lynch H, etal., Breast J. 2013 Sep-Oct;19(5):520-8. doi: 10.1111/tbj.12145. Epub 2013 Jun 26.
6. Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. Moore SD, etal., Cancer Res. 2004 Aug 15;64(16):5570-7.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. De novo mutations of the gene encoding the histone acetyltransferase KAT6B cause Genitopatellar syndrome. Simpson MA, etal., Am J Hum Genet. 2012 Feb 10;90(2):290-4. doi: 10.1016/j.ajhg.2011.11.024. Epub 2012 Jan 19.
12. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Surapureddi S, etal., Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11836-41.
Additional References at PubMed
PMID:10497217   PMID:10821753   PMID:11965546   PMID:16387653   PMID:18794358   PMID:20439489  


Genomics

Comparative Map Data
Kat6b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,688,535 - 2,861,443 (-)NCBIGRCr8
mRatBN7.2152,638,885 - 2,811,977 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,639,200 - 2,812,316 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0152,811,933 - 2,966,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,813,537 - 2,966,576 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0152,792,817 - 2,960,466 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera151,779,554 - 1,945,321 (+)NCBICelera
Cytogenetic Map15p16NCBI
KAT6B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381074,824,936 - 75,032,624 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1074,824,927 - 75,032,624 (+)EnsemblGRCh38hg38GRCh38
GRCh371076,585,013 - 76,792,382 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361076,256,385 - 76,462,645 (+)NCBINCBI36Build 36hg18NCBI36
Build 341076,268,463 - 76,460,810NCBI
Celera1069,874,402 - 70,080,888 (+)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1070,584,503 - 70,790,954 (+)NCBIHuRef
CHM1_11076,868,040 - 77,074,125 (+)NCBICHM1_1
T2T-CHM13v2.01075,698,186 - 75,906,154 (+)NCBIT2T-CHM13v2.0
Kat6b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391421,549,284 - 21,722,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1421,531,502 - 21,722,546 (+)EnsemblGRCm39 Ensembl
GRCm381421,499,216 - 21,672,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1421,481,434 - 21,672,478 (+)EnsemblGRCm38mm10GRCm38
MGSCv371422,319,076 - 22,491,355 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361420,288,420 - 20,460,685 (+)NCBIMGSCv36mm8
Celera1417,881,664 - 18,055,053 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.73NCBI
KAT6B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2886,982,465 - 87,189,469 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11086,987,799 - 87,194,794 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01071,354,585 - 71,561,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11074,020,143 - 74,225,546 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1074,035,496 - 74,223,975 (+)Ensemblpanpan1.1panPan2
KAT6B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1425,131,580 - 25,303,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl425,131,844 - 25,301,825 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha425,253,256 - 25,438,393 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0425,399,632 - 25,585,839 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl425,400,521 - 25,584,563 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1425,295,642 - 25,481,027 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0425,495,394 - 25,681,653 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0425,850,710 - 26,037,089 (+)NCBIUU_Cfam_GSD_1.0
Kat6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721355,816,974 - 56,005,037 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365214,309,694 - 4,496,904 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365214,309,699 - 4,497,755 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KAT6B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1477,404,136 - 77,597,673 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11477,390,790 - 77,597,674 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21483,529,553 - 83,722,784 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KAT6B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1956,340,579 - 56,525,809 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl956,340,026 - 56,536,512 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604816,828,363 - 17,063,158 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kat6b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247548,204,943 - 8,392,724 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247548,204,266 - 8,391,328 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kat6b
837 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:47
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000017383, ENSRNOT00000070893
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat

Markers in Region
D15Wox1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,673,264 - 2,673,438 (+)MAPPERmRatBN7.2
Rnor_6.0152,845,089 - 2,845,262NCBIRnor6.0
Rnor_5.0152,824,359 - 2,824,532UniSTSRnor5.0
Celera151,911,633 - 1,911,806UniSTS
RH 3.4 Map1545.2RGD
RH 3.4 Map1545.2UniSTS
RH 2.0 Map150.0RGD
Cytogenetic Map15p16UniSTS
AW534476  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,641,202 - 2,641,354 (+)MAPPERmRatBN7.2
Rnor_6.0152,814,251 - 2,814,402NCBIRnor6.0
Rnor_5.0152,795,135 - 2,795,286UniSTSRnor5.0
Celera151,942,852 - 1,943,003UniSTS
RH 3.4 Map1545.2UniSTS
Cytogenetic Map15p16UniSTS
RH139049  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,794,908 - 2,795,038 (+)MAPPERmRatBN7.2
Rnor_6.0152,966,654 - 2,966,783NCBIRnor6.0
Rnor_5.0152,945,451 - 2,945,580UniSTSRnor5.0
RGSC_v3.4152,999,019 - 2,999,148UniSTSRGSC3.4
Celera151,792,727 - 1,792,856UniSTS
RH 3.4 Map1549.2UniSTS
Cytogenetic Map15p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001433087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017383   ⟹   ENSRNOP00000017383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl152,813,540 - 2,966,576 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000070893   ⟹   ENSRNOP00000064386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,639,200 - 2,812,316 (-)Ensembl
Rnor_6.0 Ensembl152,813,537 - 2,966,576 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107992   ⟹   ENSRNOP00000097238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,639,200 - 2,810,956 (-)Ensembl
RefSeq Acc Id: XM_039093707   ⟹   XP_038949635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,861,008 (-)NCBI
mRatBN7.2152,638,885 - 2,811,664 (-)NCBI
RefSeq Acc Id: XM_039093708   ⟹   XP_038949636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,859,861 (-)NCBI
mRatBN7.2152,638,886 - 2,810,549 (-)NCBI
RefSeq Acc Id: XM_039093709   ⟹   XP_038949637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,859,316 (-)NCBI
mRatBN7.2152,638,885 - 2,809,999 (-)NCBI
RefSeq Acc Id: XM_039093710   ⟹   XP_038949638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,861,443 (-)NCBI
mRatBN7.2152,638,886 - 2,811,977 (-)NCBI
RefSeq Acc Id: XM_039093711   ⟹   XP_038949639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,860,971 (-)NCBI
mRatBN7.2152,638,885 - 2,811,664 (-)NCBI
RefSeq Acc Id: XM_039093712   ⟹   XP_038949640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,861,014 (-)NCBI
mRatBN7.2152,638,885 - 2,811,664 (-)NCBI
RefSeq Acc Id: XM_039093713   ⟹   XP_038949641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,860,971 (-)NCBI
mRatBN7.2152,638,885 - 2,811,664 (-)NCBI
RefSeq Acc Id: XM_039093716   ⟹   XP_038949644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,741,862 (-)NCBI
mRatBN7.2152,638,885 - 2,692,541 (-)NCBI
RefSeq Acc Id: XM_063274839   ⟹   XP_063130909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,859,861 (-)NCBI
RefSeq Acc Id: XM_063274840   ⟹   XP_063130910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,753,104 (-)NCBI
RefSeq Acc Id: XM_063274841   ⟹   XP_063130911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,859,861 (-)NCBI
RefSeq Acc Id: XM_063274842   ⟹   XP_063130912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,859,861 (-)NCBI
RefSeq Acc Id: XM_063274843   ⟹   XP_063130913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,688,535 - 2,859,861 (-)NCBI
Ensembl Acc Id: ENSRNOP00000064386   ⟸   ENSRNOT00000070893
Ensembl Acc Id: ENSRNOP00000017383   ⟸   ENSRNOT00000017383
RefSeq Acc Id: XP_038949641   ⟸   XM_039093713
- Peptide Label: isoform X5
- UniProtKB: A6KKS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949640   ⟸   XM_039093712
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038949639   ⟸   XM_039093711
- Peptide Label: isoform X2
- UniProtKB: A6KKS4 (UniProtKB/TrEMBL),   M0R4T9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949635   ⟸   XM_039093707
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949637   ⟸   XM_039093709
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949644   ⟸   XM_039093716
- Peptide Label: isoform X7
- UniProtKB: A6KKS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949638   ⟸   XM_039093710
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLZ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949636   ⟸   XM_039093708
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLZ3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097238   ⟸   ENSRNOT00000107992
RefSeq Acc Id: XP_063130913   ⟸   XM_063274843
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063130912   ⟸   XM_063274842
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063130911   ⟸   XM_063274841
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063130909   ⟸   XM_063274839
- Peptide Label: isoform X2
- UniProtKB: M0R4T9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130910   ⟸   XM_063274840
- Peptide Label: isoform X3
Protein Domains
H15   MYST-type HAT   PHD-type   SAMD1-like winged helix (WH)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4T9-F1-model_v2 AlphaFold M0R4T9 1-1850 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566399 AgrOrtholog
BioCyc Gene G2FUF-14586 BioCyc
Ensembl Genes ENSRNOG00000012850 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070893.3 UniProtKB/TrEMBL
  ENSRNOT00000107992.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  3.40.630.30 UniProtKB/TrEMBL
  N-acetyl transferase-like UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  HAT_MYST-type UniProtKB/TrEMBL
  Histone_H1/H5_H15 UniProtKB/TrEMBL
  MYST_HAT UniProtKB/TrEMBL
  SAMD1-like_WH UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
  Zf-MYST UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene Kat6b ENTREZGENE
PANTHER HISTONE ACETYLTRANSFERASE UniProtKB/TrEMBL
  HISTONE ACETYLTRANSFERASE KAT6B UniProtKB/TrEMBL
Pfam Linker_histone UniProtKB/TrEMBL
  MOZ_SAS UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  SAMD1_WH UniProtKB/TrEMBL
  zf-MYST UniProtKB/TrEMBL
PhenoGen Kat6b PhenoGen
PROSITE H15 UniProtKB/TrEMBL
  MYST_HAT UniProtKB/TrEMBL
  SAMD1_WH UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012850 RatGTEx
SMART H15 UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF55729 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
UniProt A0A8I6GLZ3 ENTREZGENE, UniProtKB/TrEMBL
  A6KKS4 ENTREZGENE, UniProtKB/TrEMBL
  M0R4T9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Kat6b  lysine acetyltransferase 6B  Kat6b  K(lysine) acetyltransferase 6B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-25 Kat6b  K(lysine) acetyltransferase 6B  RGD1566399  similar to MYST histone acetyltransferase monocytic leukemia 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-02 RGD1566399  similar to MYST histone acetyltransferase monocytic leukemia 4  LOC688634  similar to Histone acetyltransferase MYST4 (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein)  Data merged from RGD:1586466 1643240 APPROVED
2008-04-30 RGD1566399  similar to MYST histone acetyltransferase monocytic leukemia 4   RGD1566399_predicted  similar to MYST histone acetyltransferase monocytic leukemia 4 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC688634  similar to Histone acetyltransferase MYST4 (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1566399_predicted  similar to MYST histone acetyltransferase monocytic leukemia 4 (predicted)  LOC305681  similar to MYST histone acetyltransferase monocytic leukemia 4  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC305681  similar to MYST histone acetyltransferase monocytic leukemia 4      Symbol and Name status set to provisional 70820 PROVISIONAL