Nr1i3 (nuclear receptor subfamily 1, group I, member 3) - Rat Genome Database

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Gene: Nr1i3 (nuclear receptor subfamily 1, group I, member 3) Rattus norvegicus
Analyze
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
RGD ID: 621400
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Involved in osteoblast differentiation. Predicted to be located in cytosol and nucleoplasm. Biomarker of cholestasis. Orthologous to human NR1I3 (nuclear receptor subfamily 1 group I member 3); INTERACTS WITH (+)-artemisinin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CAR; constitutive androstane receptor; MGC108525; nuclear receptor constitutive active receptor; nuclear receptor subfamily 1 group I member 3; strain Fischer nuclear receptor (CAR)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nr1i3em1Sage  
Genetic Models: SD-Nr1i2em1Sage Nr1i3em1Sage SD-Nr1i2em1Sage Nr1i3em1Sage Ahrem1Sage SD-Nr1i3em1Sage
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21383,632,940 - 83,638,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,632,899 - 83,637,906 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,138,802 - 86,143,744 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,537,042 - 87,541,984 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,768,669 - 84,773,611 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,585,072 - 89,591,278 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,586,283 - 89,591,277 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,211,961 - 94,218,143 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,104,241 - 87,108,563 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,292,773 - 87,297,730 (+)NCBI
Celera1383,264,145 - 83,269,088 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP,ISO)
(-)-anisomycin  (ISO)
(E)-azobenzene  (ISO)
(E,E)-germacrone  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dihydrostilbene  (ISO)
1,3-Diphenylpropane  (ISO)
1,4-dichlorobenzene  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-Amino-2,4-dibromoanthraquinone  (ISO)
1-benzofuran  (ISO)
1-benzylpiperazine  (EXP)
1-Hydroxypyrene  (ISO)
1-naphthol  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-tert-Butoxy-2-propanol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3',5-trichlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (ISO)
2,3,4,4'-tetrachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,4,5-tetrachlorobiphenyl  (ISO)
2,3,5,6-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4'-dichlorobiphenyl  (ISO)
2,4,4',6-tetrachlorobiphenyl  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-dichlorobiphenyl  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-chlorobiphenyl  (ISO)
2-Hydroxy-2',3',4',5,5'-pentachlorobiphenyl  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
2-tert-Butylphenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3,6-diaminoacridine  (ISO)
3-chlorobiphenyl  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-Pentadecylphenol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-ethylphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-tert-butylphenol  (ISO)
4-tert-Butylphenyl Salicylate  (ISO)
4-tert-Octylphenol  (ISO)
5,6,7,8-tetrahydro-2-naphthol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5alpha-androst-16-en-3alpha-ol  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (EXP,ISO)
6-propyl-2-thiouracil  (EXP,ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinal  (ISO)
9-cis-retinoic acid  (ISO)
acenaphthene  (ISO)
acetamide  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acifluorfen  (ISO)
aclonifen  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
alachlor  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allethrin  (ISO)
allyl isothiocyanate  (ISO)
alpha-naphthoflavone  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
androst-4-ene-3,17-dione  (ISO)
androstane  (ISO)
androstane-3,17-diol  (ISO)
anthracene  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
artemether  (ISO)
artemotil  (ISO)
aspartame  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
azobenzene  (ISO)
baicalein  (ISO)
benfuracarb  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzophenone  (ISO)
Benzyl parahydroxybenzoate  (ISO)
berberine  (ISO)
bergomottin  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (EXP)
bilirubin IXalpha  (ISO)
bioresmethrin  (EXP)
biphenyl  (ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol A dimethacrylate  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Bromophos-ethyl  (ISO)
bromothymol blue  (ISO)
bromuconazole  (EXP)
bupirimate  (ISO)
buprofezin  (ISO)
bupropion  (ISO)
Butamifos  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
calcipotriol  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbaryl  (EXP)
carbon nanotube  (ISO)
carbosulfan  (ISO)
cefuroxime  (ISO)
cerivastatin  (EXP,ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
Chlomethoxyfen  (ISO)
chlormidazole  (ISO)
chlornitrofen  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chlorpyrifos-methyl  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
ciprofibrate  (EXP,ISO)
clemizole  (ISO)
clofibrate  (EXP,ISO)
clopidogrel  (ISO)
clotrimazole  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cobicistat  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
crotamiton  (ISO)
cyclobutanes  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
cyproterone acetate  (ISO)
D-glucose  (ISO)
DDD  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (ISO)
Diallyl sulfide  (EXP,ISO)
diazinon  (ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (ISO)
diclofenac  (ISO)
dicofol  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (ISO)
dienestrol  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethametryn  (ISO)
Dimethyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
Diphenamid  (ISO)
diphenhydramine  (ISO)
diphenyl ether  (ISO)
dipropyl phthalate  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
doxylamine  (ISO)
drometrizole  (ISO)
edifenphos  (ISO)
efavirenz  (EXP,ISO)
ellagic acid  (ISO)
endosulfan  (ISO)
endrin  (ISO)
enilconazole  (ISO)
enzacamene  (ISO)
EPN  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
estrone  (EXP,ISO)
ethanol  (EXP,ISO)
ethion  (ISO)
etofenprox  (EXP,ISO)
etoposide  (ISO)
everolimus  (ISO)
fenofibrate  (EXP,ISO)
fenoxycarb  (ISO)
fenvalerate  (EXP,ISO)
fipronil  (ISO)
flavanone  (ISO)
flavone  (ISO)
flavonoids  (EXP)
fluazifop-butyl  (ISO)
fluconazole  (ISO)
fludioxonil  (ISO)
fluoranthene  (ISO)
fluorene  (ISO)
fluvastatin  (EXP,ISO)
folpet  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furathiocarb  (ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gemfibrozil  (ISO)
glafenine  (EXP)
glucose  (ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycogen  (ISO)
glyphosate  (EXP)
guggulsterone  (ISO)
GW 4064  (ISO)
GW 7647  (EXP,ISO)
heptachlor  (ISO)
Heptachlor epoxide  (ISO)
herbicide  (ISO)
hexachlorobenzene  (ISO)
hexestrol  (ISO)
imidacloprid  (ISO)
imidazoles  (EXP,ISO)
imperatorin  (ISO)
indole-3-methanol  (ISO)
iprobenfos  (ISO)
irinotecan  (ISO)
Isobutylparaben  (EXP,ISO)
isofenphos  (ISO)
isoniazide  (ISO)
isopimpinellin  (ISO)
isoxazoles  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
kojic acid  (EXP)
L-ethionine  (EXP)
lactacystin  (ISO)
Lasiocarpine  (ISO)
leflunomide  (EXP,ISO)
leptophos  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
loperamide  (ISO)
lycopene  (ISO)
malathion  (ISO)
MC-4379  (ISO)
Meclizine  (EXP,ISO)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methotrexate  (EXP)
methoxychlor  (EXP,ISO)
Methyl 2-benzoylbenzoate  (ISO)
metoprolol  (ISO)
metyrapone  (ISO)
miconazole  (EXP,ISO)
midazolam  (ISO)
mifepristone  (ISO)
Mitotane  (ISO)
molinate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monocrotophos  (ISO)
monoethyl phthalate  (ISO)
Monomethyl phenylphosphonate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP,ISO)
N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine  (ISO)
N-(1-naphthyl)ethylenediamine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene-1,5-diamine  (ISO)
nefazodone  (EXP,ISO)
neticonazole  (ISO)
nevirapine  (ISO)
niclosamide  (ISO)
nitrapyrin  (ISO)
nitrofen  (ISO)
nonan-1-ol  (ISO)
Nonylphenol  (ISO)
O-methyleugenol  (ISO)
Octachlorostyrene  (ISO)
octamethylcyclotetrasiloxane  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oltipraz  (ISO)
omeprazole  (EXP,ISO)
orlistat  (ISO)
ortho-Aminoazotoluene  (ISO)
Oxadiazon  (ISO)
oxazepam  (ISO)
oxolane  (ISO)
oxybenzone  (ISO)
oxycodone  (EXP)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
Padimate O  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (EXP,ISO)
pencycuron  (ISO)
pendimethalin  (ISO)
pentachloronitrobenzene  (ISO)
pentobarbital  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP,ISO)
phenacetin  (ISO)
phenanthrene  (ISO)
phenobarbital  (EXP,ISO)
phenolphthalein  (ISO)
phenols  (ISO)
phenothrin  (EXP,ISO)
Phenoxybenzamine  (ISO)
phenthoate  (ISO)
phenylhydrazine  (ISO)
phenytoin  (EXP,ISO)
phosalone  (ISO)
piperonyl butoxide  (ISO)
Piperophos  (ISO)
pirinixic acid  (EXP,ISO)
PK-11195  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
profenofos  (ISO)
progesterone  (ISO)
propiconazole  (EXP,ISO)
propylparaben  (ISO)
propyzamide  (ISO)
prothiofos  (ISO)
protoporphyrin  (ISO)
pterostilbene  (ISO)
pyrene  (EXP,ISO)
pyriproxyfen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
reserpine  (ISO)
resmethrin  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rifampicin  (EXP,ISO)
romidepsin  (ISO)
rotenone  (EXP)
senecionine  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium cholate  (ISO)
sodium dichromate  (ISO)
stilbene oxide  (ISO)
stilbenoid  (ISO)
Sudan III  (ISO)
sulconazole  (ISO)
sulfluramid  (ISO)
sulfoxaflor  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tartrazine  (ISO)
taurocholic acid  (ISO)
tebuconazole  (EXP,ISO)
tectorigenin  (ISO)
teriflunomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
Tetrahydrogestrinone  (ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
Thiobencarb  (ISO)
thiophanate-methyl  (ISO)
Thymophthalein  (ISO)
thyroxine  (ISO)
tiracizine  (ISO)
titanium dioxide  (ISO)
tolclofos-methyl  (ISO)
toluene  (EXP)
toxaphene  (ISO)
TRAM-34  (ISO)
triadimefon  (ISO)
triazoles  (EXP,ISO)
tribufos  (ISO)
Tributyltin oxide  (ISO)
triclocarban  (ISO)
triclosan  (EXP,ISO)
trifloxystrobin  (ISO)
trifluralin  (ISO)
trifluridine  (ISO)
triphenyl phosphate  (ISO)
triphenylmethane  (ISO)
Tris(2,3-dibromopropyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
uranium atom  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vatalanib  (ISO)
vinclozolin  (EXP,ISO)
voriconazole  (ISO)
zearalenone  (ISO)
ziram  (ISO)
Zoxazolamine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO,ISS)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO,ISS)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats. Forbes KP, etal., Drug Metab Dispos. 2017 Oct;45(10):1068-1076. doi: 10.1124/dmd.117.075788. Epub 2017 Jul 17.
2. Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis. Gabbia D, etal., World J Gastroenterol. 2017 Nov 14;23(42):7519-7530. doi: 10.3748/wjg.v23.i42.7519.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Effects of insulin on CYP3A activity and nicardipine disposition in streptozotocin-induced diabetic rats. Hasegawa Y, etal., J Pharm Pharmacol. 2010 Jul;62(7):883-9. doi: 10.1211/jpp.62.05.0009.
5. Dependence on the microtubule network and 90-kDa heat shock protein of phenobarbital-induced nuclear translocation of the rat constitutive androstane receptor. Kanno Y, etal., Mol Pharmacol. 2010 Feb;77(2):311-6. doi: 10.1124/mol.109.060434. Epub 2009 Nov 17.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Association of a single nucleotide polymorphism in the constitutive androstane receptor gene with bone mineral density. Urano T, etal., Geriatr Gerontol Int. 2009 Sep;9(3):235-41. doi: 10.1111/j.1447-0594.2009.00527.x.
13. Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYB2B1 gene by phenobarbital in rat livers. Yoshinari K, etal., Mol Pharmacol 2001 Feb;59(2):278-84.
Additional References at PubMed
PMID:11114890   PMID:11891224   PMID:12477932   PMID:12885400   PMID:15953603   PMID:16055207   PMID:16153763   PMID:16272689   PMID:17904126   PMID:18023279   PMID:19162173   PMID:19435144  
PMID:20478346   PMID:22066269   PMID:23331901   PMID:24090815   PMID:24368200   PMID:24603056   PMID:25489928   PMID:25989892   PMID:26053941   PMID:27665777   PMID:34264181  


Genomics

Comparative Map Data
Nr1i3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21383,632,940 - 83,638,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,632,899 - 83,637,906 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,138,802 - 86,143,744 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,537,042 - 87,541,984 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,768,669 - 84,773,611 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,585,072 - 89,591,278 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,586,283 - 89,591,277 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,211,961 - 94,218,143 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,104,241 - 87,108,563 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,292,773 - 87,297,730 (+)NCBI
Celera1383,264,145 - 83,269,088 (+)NCBICelera
Cytogenetic Map13q24NCBI
NR1I3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,229,669 - 161,238,203 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,229,666 - 161,238,244 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,199,459 - 161,207,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,466,080 - 159,474,624 (-)NCBINCBI36Build 36hg18NCBI36
Build 341158,012,527 - 158,021,028NCBI
Celera1134,266,598 - 134,275,155 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,556,384 - 132,564,950 (-)NCBIHuRef
CHM1_11162,595,690 - 162,604,231 (-)NCBICHM1_1
T2T-CHM13v2.01160,367,115 - 160,375,669 (-)NCBIT2T-CHM13v2.0
Nr1i3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,041,503 - 171,046,414 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,041,539 - 171,048,270 (+)EnsemblGRCm39 Ensembl
GRCm381171,213,934 - 171,218,845 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,213,970 - 171,220,701 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,144,101 - 173,148,975 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,050,645 - 173,055,519 (+)NCBIMGSCv36mm8
Celera1173,662,106 - 173,666,983 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.21NCBI
Nr1i3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546812,985,105 - 13,002,850 (-)NCBIChiLan1.0ChiLan1.0
NR1I3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1188,298,310 - 88,312,643 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,642,126 - 136,651,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,553,938 - 140,562,799 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,553,951 - 140,562,799 (-)Ensemblpanpan1.1panPan2
NR1I3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,252,874 - 21,257,951 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,253,089 - 21,258,827 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,327,778 - 21,332,809 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,370,731 - 21,375,765 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,370,927 - 21,376,640 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,267,845 - 21,272,874 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,673,095 - 21,678,115 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,082,201 - 22,087,226 (+)NCBIUU_Cfam_GSD_1.0
Nr1i3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,319,081 - 7,325,712 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903527,871 - 533,790 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936903527,838 - 533,930 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR1I3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,226,690 - 89,236,431 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,226,314 - 89,231,781 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,082,997 - 97,088,463 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR1I3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,724,843 - 2,752,999 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,744,908 - 2,756,658 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,793,181 - 1,801,362 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr1i3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624794141,316 - 158,059 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nr1i3
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:116
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000049873
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
RH141655  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,636,714 - 83,636,901 (+)MAPPERmRatBN7.2
Rnor_6.01389,590,099 - 89,590,285NCBIRnor6.0
Rnor_5.01394,216,964 - 94,217,150UniSTSRnor5.0
RGSC_v3.41387,107,668 - 87,107,854UniSTSRGSC3.4
Celera1383,267,909 - 83,268,095UniSTS
RH 3.4 Map13551.9UniSTS
Cytogenetic Map13q24UniSTS


Genetic Models
This gene Nr1i3 is modified in the following models/strains:
SD-Nr1i2em1Sage Nr1i3em1Sage     SD-Nr1i2em1Sage Nr1i3em1Sage Ahrem1Sage     SD-Nr1i3em1Sage    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 3 23 23 23 10 2
Low 2 8 32 16 19 16 8 11 1 11 9 9 8
Below cutoff 2 2 2 16 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB104736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB105071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB105072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB204900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC099236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF133094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF133095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF233431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000049873   ⟹   ENSRNOP00000048836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,632,899 - 83,637,893 (+)Ensembl
Rnor_6.0 Ensembl1389,586,336 - 89,591,277 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079355   ⟹   ENSRNOP00000072813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,632,899 - 83,637,893 (+)Ensembl
Rnor_6.0 Ensembl1389,586,283 - 89,591,277 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104224   ⟹   ENSRNOP00000096651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,632,899 - 83,637,500 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115898   ⟹   ENSRNOP00000086637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,632,899 - 83,637,906 (+)Ensembl
RefSeq Acc Id: NM_001270838   ⟹   NP_001257767
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,952 - 83,637,894 (+)NCBI
Rnor_6.01389,586,336 - 89,591,278 (+)NCBI
Rnor_5.01394,211,961 - 94,218,143 (+)NCBI
Celera1383,264,145 - 83,269,088 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270839   ⟹   NP_001257768
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,952 - 83,637,894 (+)NCBI
Rnor_6.01389,586,336 - 89,591,278 (+)NCBI
Rnor_5.01394,211,961 - 94,218,143 (+)NCBI
Celera1383,264,145 - 83,269,088 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270840   ⟹   NP_001257769
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,952 - 83,637,894 (+)NCBI
Rnor_6.01389,586,336 - 89,591,278 (+)NCBI
Rnor_5.01394,211,961 - 94,218,143 (+)NCBI
Celera1383,264,145 - 83,269,088 (+)NCBI
Sequence:
RefSeq Acc Id: NM_022941   ⟹   NP_075230
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,952 - 83,637,894 (+)NCBI
Rnor_6.01389,586,336 - 89,591,278 (+)NCBI
Rnor_5.01394,211,961 - 94,218,143 (+)NCBI
RGSC_v3.41387,104,241 - 87,108,563 (+)RGD
Celera1383,264,145 - 83,269,088 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091080   ⟹   XP_038947008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,940 - 83,638,193 (+)NCBI
RefSeq Acc Id: XM_039091081   ⟹   XP_038947009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,940 - 83,638,193 (+)NCBI
RefSeq Acc Id: XM_039091082   ⟹   XP_038947010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,940 - 83,637,617 (+)NCBI
RefSeq Acc Id: XM_039091084   ⟹   XP_038947012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,940 - 83,636,371 (+)NCBI
RefSeq Acc Id: XM_039091085   ⟹   XP_038947013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,940 - 83,636,345 (+)NCBI
RefSeq Acc Id: XR_005492284
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,940 - 83,637,617 (+)NCBI
RefSeq Acc Id: XR_005492285
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,940 - 83,636,625 (+)NCBI
RefSeq Acc Id: XR_005492286
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,940 - 83,636,620 (+)NCBI
RefSeq Acc Id: XR_005492287
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,632,940 - 83,636,543 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001257767 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257768 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257769 (Get FASTA)   NCBI Sequence Viewer  
  NP_075230 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947008 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947009 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947010 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947012 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947013 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF22566 (Get FASTA)   NCBI Sequence Viewer  
  AAF22567 (Get FASTA)   NCBI Sequence Viewer  
  AAF37700 (Get FASTA)   NCBI Sequence Viewer  
  AAH89763 (Get FASTA)   NCBI Sequence Viewer  
  BAC82431 (Get FASTA)   NCBI Sequence Viewer  
  BAC84955 (Get FASTA)   NCBI Sequence Viewer  
  BAC84956 (Get FASTA)   NCBI Sequence Viewer  
  BAE19955 (Get FASTA)   NCBI Sequence Viewer  
  BAE19956 (Get FASTA)   NCBI Sequence Viewer  
  BAE19957 (Get FASTA)   NCBI Sequence Viewer  
  BAE19958 (Get FASTA)   NCBI Sequence Viewer  
  EDL94605 (Get FASTA)   NCBI Sequence Viewer  
  EDL94606 (Get FASTA)   NCBI Sequence Viewer  
  EDL94607 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048836
  ENSRNOP00000072813
  ENSRNOP00000072813.1
  ENSRNOP00000086637
  ENSRNOP00000086637.1
  ENSRNOP00000096651
  ENSRNOP00000096651.1
GenBank Protein Q9QUS1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_075230   ⟸   NM_022941
- Peptide Label: isoform 1
- UniProtKB: Q9QUS1 (UniProtKB/Swiss-Prot),   A6JFU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257767   ⟸   NM_001270838
- Peptide Label: isoform 3
- UniProtKB: Q402C1 (UniProtKB/TrEMBL),   A0A8I6AVD8 (UniProtKB/TrEMBL),   A6JFV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257768   ⟸   NM_001270839
- Peptide Label: isoform 4
- UniProtKB: Q402C0 (UniProtKB/TrEMBL),   A0A8I6AVD8 (UniProtKB/TrEMBL),   A6JFV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257769   ⟸   NM_001270840
- Peptide Label: isoform 2
- UniProtKB: Q5FVU7 (UniProtKB/TrEMBL),   A0A8I6AVD8 (UniProtKB/TrEMBL),   A6JFV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072813   ⟸   ENSRNOT00000079355
RefSeq Acc Id: ENSRNOP00000048836   ⟸   ENSRNOT00000049873
RefSeq Acc Id: XP_038947008   ⟸   XM_039091080
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A462 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947009   ⟸   XM_039091081
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038947010   ⟸   XM_039091082
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A462 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947012   ⟸   XM_039091084
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038947013   ⟸   XM_039091085
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000096651   ⟸   ENSRNOT00000104224
RefSeq Acc Id: ENSRNOP00000086637   ⟸   ENSRNOT00000115898
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QUS1-F1-model_v2 AlphaFold Q9QUS1 1-358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699009
Promoter ID:EPDNEW_R9521
Type:initiation region
Name:Nr1i3_1
Description:nuclear receptor subfamily 1, group I, member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,586,312 - 89,586,372EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621400 AgrOrtholog
BioCyc Gene G2FUF-17385 BioCyc
Ensembl Genes ENSRNOG00000003260 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049873 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000079355 ENTREZGENE
  ENSRNOT00000079355.2 UniProtKB/TrEMBL
  ENSRNOT00000104224 ENTREZGENE
  ENSRNOT00000104224.1 UniProtKB/TrEMBL
  ENSRNOT00000115898 ENTREZGENE
  ENSRNOT00000115898.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7324318 IMAGE-MGC_LOAD
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThyrH_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65035 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108525 IMAGE-MGC_LOAD
NCBI Gene 65035 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NR1I3 RGD
PhenoGen Nr1i3 PhenoGen
PRINTS STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROIDHORMR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003260 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A462 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AVD8 ENTREZGENE, UniProtKB/TrEMBL
  A6JFU9 ENTREZGENE, UniProtKB/TrEMBL
  A6JFV0 ENTREZGENE, UniProtKB/TrEMBL
  A6JFV1_RAT UniProtKB/TrEMBL
  NR1I3_RAT UniProtKB/Swiss-Prot
  Q402B9_RAT UniProtKB/TrEMBL
  Q402C0 ENTREZGENE, UniProtKB/TrEMBL
  Q402C1 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVU7 ENTREZGENE, UniProtKB/TrEMBL
  Q76FN2_RAT UniProtKB/TrEMBL
  Q9QUS1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Nr1i3  nuclear receptor subfamily 1, group I, member 3    strain Fischer nuclear receptor (CAR)  Name updated 1299863 APPROVED
2002-08-07 Nr1i3  strain Fischer nuclear receptor (CAR)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation accumulated in the liver nucleus of male rats in response to phenobarbital treatment 633380