Gene: Nr1i3 (nuclear receptor subfamily 1, group I, member 3) Rattus norvegicus
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN osteoblast differentiation; negative regulation of transcription, DNA-templated (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH cholestasis; Diabetes Mellitus, Experimental ; Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm; nucleus; cytosol (ortholog); INTERACTS WITH (+)-artemisinin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CAR; constitutive androstane receptor; MGC108525; nuclear receptor constitutive active receptor; nuclear receptor subfamily 1 group I member 3; strain Fischer nuclear receptor (CAR)
Allele / Splice: Nr1i3em1Sage  
Genetic Models: SD-Nr1i2em1Sage Nr1i3em1Sage SD-Nr1i2em1Sage Nr1i3em1Sage Ahrem1Sage SD-Nr1i3em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01389,585,072 - 89,591,278 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01394,211,961 - 94,218,143 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,104,241 - 87,108,563 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11387,292,773 - 87,297,730 (+)NCBI
Celera1383,264,145 - 83,269,088 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nr1i3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621400
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE