Ppard (peroxisome proliferator-activated receptor delta) - Rat Genome Database

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Gene: Ppard (peroxisome proliferator-activated receptor delta) Rattus norvegicus
Symbol: Ppard
Name: peroxisome proliferator-activated receptor delta
RGD ID: 3370
Description: Enables NF-kappaB binding activity and fatty acid binding activity. Involved in several processes, including decidualization; negative regulation of collagen biosynthetic process; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be part of chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta); PARTICIPATES IN acute myeloid leukemia pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; Wnt signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-naringenin; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor beta; Peroxisome proliferator activator receptor delta; peroxisome proliferator activator receptor, delta; Pparb
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2206,298,785 - 6,363,970 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,298,785 - 6,363,968 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,011,517 - 7,076,865 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,373,349 - 6,438,695 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,852,519 - 6,918,193 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,818,289 - 7,883,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,818,289 - 7,885,333 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02010,018,464 - 10,083,772 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,479,108 - 6,544,255 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1206,479,323 - 6,543,249 (+)NCBI
Celera207,855,191 - 7,920,274 (+)NCBICelera
RH 3.4 Map2075.52RGD
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(9E,11E)-octadecadienoic acid  (ISO)
(S)-naringenin  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2-bromohexadecanoic acid  (ISO)
2-Ethylhexanoic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-linolenic acid  (EXP,ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimonite  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
aspartame  (ISO)
atrazine  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (EXP,ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (EXP,ISO)
cilnidipine  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
Clofop  (ISO)
cobalt dichloride  (ISO)
conjugated linoleic acid  (EXP,ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
daunorubicin  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-decyl phthalate  (ISO)
Di-n-hexyl phthalate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diheptyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethyl phthalate  (ISO)
dipentyl phthalate  (ISO)
dipropyl phthalate  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
enalaprilat dihydrate  (EXP)
endosulfan  (EXP)
ethanol  (EXP,ISO)
felodipine  (ISO)
fenofibrate  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
fluvalinate  (ISO)
fructose  (ISO)
furan  (EXP)
gemcitabine  (ISO)
gemfibrozil  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyphosate  (EXP)
graphene oxide  (ISO)
griseofulvin  (ISO)
GW 2433  (ISO)
GW 501516  (EXP,ISO)
GW 7647  (ISO)
HET0016  (EXP)
hexadecanoic acid  (EXP,ISO)
hydroquinone  (ISO)
idarubicin  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
isorhamnetin  (ISO)
ketoconazole  (EXP)
lacidipine  (ISO)
linoleic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
mithramycin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
monohexyl phthalate  (ISO)
Monomethyl phthalate  (ISO)
monooctyl phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
nemorubicin  (ISO)
niclosamide  (ISO)
nimesulide  (ISO)
NMN zwitterion  (ISO)
norathyriol  (ISO)
octanoic acid  (ISO)
octocrylene  (ISO)
okadaic acid  (ISO)
oleic acid  (EXP,ISO)
orlistat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perflubutane  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoropentanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phthalic acid  (ISO)
phytanic acid  (ISO)
pioglitazone  (ISO)
Pirarubicin  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
Ro 41-5253  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
SB 203580  (ISO)
sirolimus  (ISO)
Sodium oleate  (ISO)
Soman  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
telmisartan  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
triphenylstannane  (EXP)
Triptolide  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valproic acid  (ISO)
wortmannin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
apoptotic process  (ISO)
apoptotic signaling pathway  (ISO)
axon ensheathment  (ISO)
cell differentiation  (IBA,ISO)
cell population proliferation  (ISO)
cell-substrate adhesion  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipopolysaccharide  (IDA)
cellular response to nutrient levels  (ISO)
decidualization  (IEP)
embryo implantation  (IEP,ISO)
energy homeostasis  (ISO)
epithelial cell proliferation  (ISO)
fat cell proliferation  (ISO)
fatty acid beta-oxidation  (ISO)
fatty acid metabolic process  (IBA)
fatty acid oxidation  (IDA)
fatty acid transport  (ISO)
heart development  (IEP)
hormone-mediated signaling pathway  (IBA)
intracellular receptor signaling pathway  (IEA)
keratinocyte migration  (ISO)
keratinocyte proliferation  (ISO)
lipid metabolic process  (ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of cell growth  (IDA)
negative regulation of cholesterol storage  (IBA)
negative regulation of collagen biosynthetic process  (IMP)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of inflammatory response  (IBA)
negative regulation of miRNA transcription  (ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of smooth muscle cell migration  (IDA)
negative regulation of smooth muscle cell proliferation  (IDA)
negative regulation of transcription by RNA polymerase II  (IBA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
phospholipid biosynthetic process  (IDA)
placenta development  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epidermis development  (IDA)
positive regulation of fat cell proliferation  (ISO)
positive regulation of fatty acid metabolic process  (IBA)
positive regulation of fatty acid oxidation  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IDA)
positive regulation of myoblast proliferation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of skeletal muscle tissue regeneration  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA)
proteoglycan metabolic process  (IDA)
regulation of cell population proliferation  (ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of fat cell differentiation  (ISO)
regulation of skeletal muscle satellite cell proliferation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to activity  (IEP)
response to glucose  (IEP)
response to organic substance  (IEP)
response to vitamin A  (IEP)
vasodilation  (IDA)
wound healing  (ISO)

Cellular Component
chromatin  (ISO)
nucleus  (ISO)


References - curated
# Reference Title Reference Citation
1. Transcriptional network governing the angiogenic switch in human pancreatic cancer. Abdollahi A, etal., Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12890-5. Epub 2007 Jul 24.
2. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
3. Chronic expression of PPAR-delta by oligodendrocyte lineage cells in the injured rat spinal cord. Almad A and McTigue DM, J Comp Neurol. 2010 Mar 15;518(6):785-99.
4. Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. Andrulionyte L, etal., Diabetes. 2006 Jul;55(7):2148-52.
5. Evidence for the presence of both peroxisome proliferator-activated receptors alpha and beta in the rat spinal cord. Benani A, etal., J Chem Neuroanat 2003 Jan;25(1):29-38.
6. Tetradecylthioacetic acid downregulates cyclooxygenase 2 in the renal cortex of two-kidney, one-clip hypertensive rats. Bivol LM, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1866-73. Epub 2008 Oct 8.
7. Differential expression of peroxisome proliferator-activated receptor delta at implantation sites and in decidual cells of rat uterus. Ding NZ, etal., Reproduction. 2003 Jun;125(6):817-25.
8. Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Escher P, etal., Endocrinology 2001 Oct;142(10):4195-202.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism. Gilde AJ, etal., Circ Res 2003 Mar 21;92(5):518-24.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. Hellemans K, etal., J Lipid Res. 2003 Feb;44(2):280-95. Epub 2002 Nov 16.
13. PPARdelta and its activator PGI2 are reduced in diabetic embryopathy: involvement of PPARdelta activation in lipid metabolic and signalling pathways in rat embryo early organogenesis. Higa R, etal., Mol Hum Reprod. 2007 Feb;13(2):103-10. Epub 2006 Dec 5.
14. PPARdelta activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation. Jiang YJ, etal., J Invest Dermatol. 2010 Feb;130(2):511-9. Epub 2009 Aug 13.
15. Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway. Jimenez R, etal., J Pharmacol Exp Ther. 2010 Feb;332(2):554-61. Epub 2009 Nov 11.
16. Activation of Peroxisome Proliferator-Activated Receptor-beta/delta attenuates myocardial ischemia/reperfusion injury in the rat. Kapoor A, etal., Shock. 2009 Dec 7.
17. Gene expression profiles in gallbladder cancer: the close genetic similarity seen for early and advanced gallbladder cancers may explain the poor prognosis. Kim JH, etal., Tumour Biol. 2008;29(1):41-9. Epub 2008 May 23.
18. The PPARdelta agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition. Kino T, etal., Eur J Clin Invest. 2007 May;37(5):425-33.
19. Carbaprostacyclin, a PPARdelta agonist, ameliorates excess lipid accumulation in diabetic rat placentas. Kurtz M, etal., Life Sci. 2010 May 22;86(21-22):781-90. Epub 2010 Mar 22.
20. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
21. PPAR delta agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle. Lim HJ, etal., Atherosclerosis. 2009 Feb;202(2):446-54. Epub 2008 May 21.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Peroxisome proliferator-activated receptor delta (PPARdelta) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis. Pesant M, etal., Cardiovasc Res. 2006 Feb 1;69(2):440-9. Epub 2005 Dec 6.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. Planavila A, etal., J Biol Chem. 2005 Apr 29;280(17):17464-71. Epub 2005 Feb 22.
27. Agonists of peroxisome proliferators-activated receptors (PPAR) alpha, beta/delta or gamma reduce transforming growth factor (TGF)-beta-induced proteoglycans' production in chondrocytes. Poleni PE, etal., Osteoarthritis Cartilage. 2007 May;15(5):493-505. Epub 2006 Nov 29.
28. PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction. Ravnskjaer K, etal., J Lipid Res. 2010 Jun;51(6):1370-9. Epub 2009 Nov 30.
29. Changes in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF rats. Rector RS, etal., Am J Physiol Endocrinol Metab. 2010 Mar 16.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Peroxisome proliferator-activated receptor beta/delta activation improves angiotensin II-induced cardiac hypertrophy in vitro. Sheng L, etal., Clin Exp Hypertens. 2008 Feb;30(2):109-19.
34. Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity. Shin HD, etal., Diabetes. 2004 Mar;53(3):847-51.
35. Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardiac development of the rat. Steinmetz M, etal., Basic Res Cardiol. 2005 May;100(3):263-9. Epub 2005 Mar 9.
36. Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Tanaka T, etal., Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15924-9. Epub 2003 Dec 15.
37. Effect of nutritional vitamin A deficiency on lipid metabolism in the rat heart: Its relation to PPAR gene expression. Vega VA, etal., Nutrition. 2009 Jul-Aug;25(7-8):828-38. Epub 2009 Apr 1.
38. Improved insulin sensitivity and islet function after PPARdelta activation in diabetic db/db mice. Winzell MS, etal., Eur J Pharmacol. 2009 Oct 7.
39. Rat PPAR delta contains a CGG triplet repeat and is prominently expressed in the thalamic nuclei. Xing G, etal., Biochem Biophys Res Commun 1995 Dec 26;217(3):1015-25.
40. Decrease of peroxisome proliferator-activated receptor delta expression in cardiomyopathy of streptozotocin-induced diabetic rats. Yu BC, etal., Cardiovasc Res. 2008 Oct 1;80(1):78-87. Epub 2008 Jun 23.
41. PPARbeta/delta activation inhibits angiotensin II-induced collagen type I expression in rat cardiac fibroblasts. Zhang H, etal., Arch Biochem Biophys. 2007 Apr 1;460(1):25-32. Epub 2007 Feb 16.
42. Effect of berberine on PPARalpha/delta/gamma expression in type 2 diabetic rat retinae. Zhou JY and Zhou SW, Yao Xue Xue Bao. 2007 Dec;42(12):1243-9.
Additional References at PubMed
PMID:8041794   PMID:8889548   PMID:9113987   PMID:10198642   PMID:10385625   PMID:10866668   PMID:11511099   PMID:11514592   PMID:11551955   PMID:11756685   PMID:12909723   PMID:12955147  
PMID:14758356   PMID:15001550   PMID:15380519   PMID:15713628   PMID:16328010   PMID:16406631   PMID:16581799   PMID:16698033   PMID:16896941   PMID:17463039   PMID:17540700   PMID:17643263  
PMID:17869249   PMID:17908795   PMID:18024478   PMID:18157544   PMID:18239634   PMID:18287212   PMID:18543250   PMID:18701451   PMID:18836674   PMID:19080338   PMID:19224536   PMID:19587222  
PMID:19596004   PMID:20209098   PMID:20445066   PMID:20538899   PMID:20628611   PMID:21825230   PMID:21896929   PMID:22040534   PMID:22271545   PMID:22729460   PMID:22917842   PMID:23052247  
PMID:23555761   PMID:23701913   PMID:23724037   PMID:23779049   PMID:23803968   PMID:24011070   PMID:24128860   PMID:24269940   PMID:24527778   PMID:24624894   PMID:25002582   PMID:25300478  
PMID:25530507   PMID:25732738   PMID:26628385   PMID:26654758   PMID:26862756   PMID:26936652   PMID:27283742   PMID:27413020   PMID:27573670   PMID:28267873   PMID:28621328   PMID:29109080  
PMID:29408825   PMID:31163124   PMID:32102354   PMID:34203800   PMID:34664679   PMID:34736532   PMID:34932851   PMID:35389955  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2206,298,785 - 6,363,970 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,298,785 - 6,363,968 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,011,517 - 7,076,865 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,373,349 - 6,438,695 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,852,519 - 6,918,193 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,818,289 - 7,883,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,818,289 - 7,885,333 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02010,018,464 - 10,083,772 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,479,108 - 6,544,255 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1206,479,323 - 6,543,249 (+)NCBI
Celera207,855,191 - 7,920,274 (+)NCBICelera
RH 3.4 Map2075.52RGD
Cytogenetic Map20p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38635,342,558 - 35,428,178 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl635,342,558 - 35,428,191 (+)EnsemblGRCh38hg38GRCh38
GRCh37635,310,335 - 35,395,955 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36635,418,313 - 35,503,933 (+)NCBINCBI36Build 36hg18NCBI36
Build 34635,418,363 - 35,501,149NCBI
Celera636,864,336 - 36,949,951 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef635,031,309 - 35,116,788 (+)NCBIHuRef
CHM1_1635,312,398 - 35,397,989 (+)NCBICHM1_1
T2T-CHM13v2.0635,165,619 - 35,251,256 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391728,451,715 - 28,520,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,451,674 - 28,520,448 (+)EnsemblGRCm39 Ensembl
GRCm381728,232,754 - 28,301,469 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,232,700 - 28,301,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,369,699 - 28,438,414 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361727,960,392 - 28,029,058 (+)NCBIMGSCv36mm8
Celera1728,786,405 - 28,855,326 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.64NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554373,288,830 - 3,357,048 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554373,285,281 - 3,354,099 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1645,677,650 - 45,761,062 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0634,903,798 - 34,987,208 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1636,003,914 - 36,081,132 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl636,003,988 - 36,081,132 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1124,492,867 - 4,579,340 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl124,492,672 - 4,579,340 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,582,161 - 4,595,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0124,830,969 - 4,918,771 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,830,970 - 4,918,775 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1124,565,298 - 4,578,271 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,643,973 - 4,656,940 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,744,188 - 4,757,152 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494640,073,598 - 40,147,140 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,811,641 - 23,828,176 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647623,799,285 - 23,886,606 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl731,222,585 - 31,295,211 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,222,533 - 31,295,221 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2736,141,634 - 36,215,255 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11736,695,546 - 36,779,554 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1736,695,494 - 36,779,577 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604435,262,151 - 35,340,486 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462475422,021,465 - 22,084,320 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ppard
328 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:210
Count of miRNA genes:129
Interacting mature miRNAs:152
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,327,717 - 6,327,879 (+)MAPPERmRatBN7.2
Rnor_6.0207,847,217 - 7,847,378NCBIRnor6.0
Rnor_5.02010,047,391 - 10,047,552UniSTSRnor5.0
RGSC_v3.4206,508,036 - 6,508,197UniSTSRGSC3.4
Celera207,884,117 - 7,884,278UniSTS
RH 3.4 Map2075.9UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,363,681 - 6,363,864 (+)MAPPERmRatBN7.2
Rnor_6.0207,883,196 - 7,883,378NCBIRnor6.0
Rnor_5.02010,083,486 - 10,083,668UniSTSRnor5.0
RGSC_v3.4206,543,969 - 6,544,151UniSTSRGSC3.4
Celera207,919,988 - 7,920,170UniSTS
RH 3.4 Map2075.93UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,362,528 - 6,362,684 (+)MAPPERmRatBN7.2
Rnor_6.0207,882,043 - 7,882,198NCBIRnor6.0
Rnor_5.02010,082,333 - 10,082,488UniSTSRnor5.0
RGSC_v3.4206,542,816 - 6,542,971UniSTSRGSC3.4
Celera207,918,835 - 7,918,990UniSTS
RH 3.4 Map2075.52UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,360,778 - 6,360,883 (+)MAPPERmRatBN7.2
Rnor_6.0207,880,293 - 7,880,397NCBIRnor6.0
Rnor_5.02010,080,583 - 10,080,687UniSTSRnor5.0
RGSC_v3.4206,541,066 - 6,541,170UniSTSRGSC3.4
Celera207,917,085 - 7,917,189UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,358,306 - 6,359,618 (+)MAPPERmRatBN7.2
Rnor_6.0207,877,821 - 7,879,132NCBIRnor6.0
Rnor_5.02010,078,111 - 10,079,422UniSTSRnor5.0
RGSC_v3.4206,538,594 - 6,539,905UniSTSRGSC3.4
Celera207,914,613 - 7,915,924UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,360,879 - 6,361,416 (+)MAPPERmRatBN7.2
Rnor_6.0207,880,394 - 7,880,930NCBIRnor6.0
Rnor_5.02010,080,684 - 10,081,220UniSTSRnor5.0
RGSC_v3.4206,541,167 - 6,541,703UniSTSRGSC3.4
Celera207,917,186 - 7,917,722UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,359,507 - 6,360,925 (+)MAPPERmRatBN7.2
Rnor_6.0207,879,022 - 7,880,439NCBIRnor6.0
Rnor_5.02010,079,312 - 10,080,729UniSTSRnor5.0
RGSC_v3.4206,539,795 - 6,541,212UniSTSRGSC3.4
Celera207,915,814 - 7,917,231UniSTS
Cytogenetic Map20p12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 18 4 4 1 4 1 11 18 16 2
Low 25 53 37 18 37 8 10 63 17 25 9 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000042539   ⟹   ENSRNOP00000045974
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl206,298,785 - 6,363,968 (+)Ensembl
Rnor_6.0 Ensembl207,818,289 - 7,883,482 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083109   ⟹   ENSRNOP00000069522
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl206,350,524 - 6,363,968 (+)Ensembl
Rnor_6.0 Ensembl207,821,755 - 7,885,333 (+)Ensembl
RefSeq Acc Id: NM_013141   ⟹   NP_037273
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2206,298,785 - 6,363,968 (+)NCBI
Rnor_6.0207,818,289 - 7,883,482 (+)NCBI
Rnor_5.02010,018,464 - 10,083,772 (+)NCBI
RGSC_v3.4206,479,108 - 6,544,255 (+)RGD
Celera207,855,191 - 7,920,274 (+)RGD
RefSeq Acc Id: XM_006256166   ⟹   XP_006256228
Rat AssemblyChrPosition (strand)Source
mRatBN7.2206,301,691 - 6,363,970 (+)NCBI
Rnor_6.0207,821,735 - 7,883,482 (+)NCBI
Rnor_5.02010,018,464 - 10,083,772 (+)NCBI
RefSeq Acc Id: XM_006256167   ⟹   XP_006256229
Rat AssemblyChrPosition (strand)Source
mRatBN7.2206,332,472 - 6,363,970 (+)NCBI
Rnor_6.0207,853,471 - 7,883,482 (+)NCBI
Rnor_5.02010,018,464 - 10,083,772 (+)NCBI
RefSeq Acc Id: XM_006256168   ⟹   XP_006256230
Rat AssemblyChrPosition (strand)Source
mRatBN7.2206,344,311 - 6,363,970 (+)NCBI
Rnor_6.0207,862,656 - 7,883,482 (+)NCBI
Rnor_5.02010,018,464 - 10,083,772 (+)NCBI
RefSeq Acc Id: NP_037273   ⟸   NM_013141
- UniProtKB: Q99ND3 (UniProtKB/TrEMBL),   A6JJP8 (UniProtKB/TrEMBL),   Q62879 (UniProtKB/TrEMBL),   F7FM43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256228   ⟸   XM_006256166
- Peptide Label: isoform X1
- UniProtKB: Q99ND3 (UniProtKB/TrEMBL),   A6JJP8 (UniProtKB/TrEMBL),   Q62879 (UniProtKB/TrEMBL),   F7FM43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256229   ⟸   XM_006256167
- Peptide Label: isoform X1
- UniProtKB: Q99ND3 (UniProtKB/TrEMBL),   A6JJP8 (UniProtKB/TrEMBL),   Q62879 (UniProtKB/TrEMBL),   F7FM43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256230   ⟸   XM_006256168
- Peptide Label: isoform X1
- UniProtKB: Q99ND3 (UniProtKB/TrEMBL),   A6JJP8 (UniProtKB/TrEMBL),   Q62879 (UniProtKB/TrEMBL),   F7FM43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000045974   ⟸   ENSRNOT00000042539
RefSeq Acc Id: ENSRNOP00000069522   ⟸   ENSRNOT00000083109
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99ND3-F1-model_v2 AlphaFold Q99ND3 1-440 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701458
Promoter ID:EPDNEW_R11981
Type:initiation region
Description:peroxisome proliferator-activated receptor delta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0207,818,217 - 7,818,277EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3370 AgrOrtholog
BioCyc Gene G2FUF-4429 BioCyc
Ensembl Genes ENSRNOG00000000503 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042539 ENTREZGENE
  ENSRNOT00000042539.6 UniProtKB/TrEMBL
  ENSRNOT00000083109.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL UniProtKB/TrEMBL
InterPro 1Cnucl_rcpt UniProtKB/TrEMBL
  1Cnucl_rcpt_B UniProtKB/TrEMBL
  NHR_like_domain UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd_core UniProtKB/TrEMBL
  Str_hrmn_rcpt UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
KEGG Report rno:25682 UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PhenoGen Ppard PhenoGen
RatGTEx ENSRNOG00000000503 RatGTEx
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  Str_ncl_receptor UniProtKB/TrEMBL
UniProt Secondary Q99ND3 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Ppard  peroxisome proliferator-activated receptor delta  Ppard  peroxisome proliferator activated receptor delta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ppard  peroxisome proliferator activated receptor delta    Peroxisome proliferator activator receptor, delta  Name updated 629478 APPROVED
2002-06-10 Ppard  Peroxisome proliferator activator receptor, delta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in all tissues except adipose tissue; enriched in the digestive tract, kidney, heart, diaphragm, and esophagus 633659