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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3369
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:36386
Term: dichloroacetic acid
Definition: An organochlorine compound comprising acetic acid carrying two chloro substituents at the 2-position. It occurs in nature in seaweed, Asparagopsis taxiformis.
Chemical ID: MESH:D003999
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparaincreases activityISOPpara (Mus musculus)6480464CTDDichloroacetic Acid results in increased activity of PPARA proteinPMID:10581215 PMID:9703482
Pparaincreases activityISOPPARA (Homo sapiens)6480464CTDDichloroacetic Acid results in increased activity of PPARA proteinPMID:10581215
Pparamultiple interactionsISOPpara (Mus musculus)6480464CTDPPARA protein promotes the reaction [Dichloroacetic Acid results in increased expression of CYP4A10 protein]PMID:15363585
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