GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ppara | affects activity | EXP | | 6480464 | CTD | Nitric Oxide affects the activity of PPARA protein | PMID:16411023 | Ppara | increases expression | EXP | | 6480464 | CTD | Nitric Oxide deficiency results in increased expression of PPARA mRNA; Nitric Oxide deficiency results in increased expression of PPARA protein | PMID:19834340 | Ppara | multiple interactions | EXP | | 6480464 | CTD | [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of Nitric Oxide; [Clofibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of Nitric Oxide; Nitric Oxide deficiency inhibits the reaction [Clofibrate results in increased expression of PPARA protein] | PMID:15018640 PMID:16054168 | Ppara | multiple interactions | ISO | PPARA (Homo sapiens) | 6480464 | CTD | [[resveratrol results in increased activity of PPARA protein] which results in increased expression of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide | PMID:21791144 | | ||||||||||||||||||||||
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