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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3369
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:34698
Term: diethyl phthalate
Definition: The diethyl ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C007379
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparaaffects bindingISOPPARA (Homo sapiens)6480464CTDdiethyl phthalate binds to PPARA proteinPMID:23843199
Pparamultiple interactionsISOPpara (Mus musculus)6480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of PPARA mRNAPMID:28013214
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