Gene: Wnt1 (Wnt family member 1) Rattus norvegicus
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Symbol:
Wnt1
Name:
Wnt family member 1
Description:
Predicted to have protein domain specific binding activity; signaling receptor binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in animal organ regeneration; cellular response to peptide hormone stimulus; and hepatocyte differentiation. Predicted to localize to cell surface; cytoplasm; and extracellular space. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15 and osteoporosis. Orthologous to human WNT1 (Wnt family member 1); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; INTERACTS WITH atrazine; benzo[a]pyrene; bisphenol A.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Int1; proto-oncogene Wnt-1; wingless-related MMTV integration site 1; Wingless-type MMTV integration site 1 homolog; Wingless-type MMTV integration site 1, homolog; wingless-type MMTV integration site family, member 1; wingless-type MMTV integration site family, member 1 (mapped); Wnt1_mapped
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
WNT1 (Wnt family member 1) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):
Wnt1 (wingless-type MMTV integration site family, member 1) HGNC
NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Wnt1 (Wnt family member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
WNT1 (Wnt family member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
WNT1 (Wnt family member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Wnt1 (Wnt family member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
WNT1 (Wnt family member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
WNT1 (Wnt family member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Wnt1 (Wnt family member 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Wnt1 (wingless-type MMTV integration site family, member 1)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Homo sapiens (human):
WNT1 (Wnt family member 1)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Danio rerio (zebrafish):
wnt1 (wingless-type MMTV integration site family, member 1)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
wg
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 7 140,464,999 - 140,469,046 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 140,464,999 - 140,469,046 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 X 114,975,118 - 114,979,165 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 137,557,836 - 137,561,883 (+) NCBI RGSC3.4 rn4 RGSC3.4 Celera 7 126,427,473 - 126,431,520 (+) NCBI Celera Cytogenetic Map 7 q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
keratoconus ISO RGD:1344355 8554872 ClinVar Annotator: match by term: Keratoconus ClinVar PMID:23434763 osteogenesis imperfecta ISO RGD:1344355 8554872 ClinVar Annotator: match by term: Osteogenesis imperfecta ClinVar PMID:25741868 osteogenesis imperfecta type 15 ISO RGD:1344355 8554872 ClinVar Annotator: match by term: Osteogenesis imperfecta, type xv ClinVar osteogenesis imperfecta type 15 ISO RGD:1344355 8554872 ClinVar Annotator: match by term: Osteogenesis imperfecta, type xv ClinVar PMID:25741868 osteogenesis imperfecta type 15 ISO RGD:1344355 8554872 ClinVar Annotator: match by OMIM:615220 ClinVar PMID:23499310 osteogenesis imperfecta type 15 ISO RGD:1344355 8554872 ClinVar Annotator: match by OMIM:615220 ClinVar PMID:23499309 osteogenesis imperfecta type 15 ISO RGD:1344355 8554872 ClinVar Annotator: match by OMIM:615220 ClinVar PMID:23434763 osteogenesis imperfecta type 3 ISO RGD:1344355 8554872 ClinVar Annotator: match by term: Osteogenesis imperfecta type III ClinVar PMID:25741868 osteoporosis ISO RGD:1344355 8554872 ClinVar Annotator: match by term: Bone mineral density quantitative trait locus 16 ClinVar PMID:23656646 osteoporosis ISO RGD:1344355 8554872 ClinVar Annotator: match by term: Bone mineral density quantitative trait locus 16 ClinVar PMID:23499309
Imported Annotations - CTD
osteoporosis ISO RGD:1344355 11554173 CTD Direct Evidence: marker/mechanism CTD Imported Annotations - MGI
breast cancer ISS RGD:11491 13592920 OMIM:114480 MouseDO Imported Annotations - OMIM
osteogenesis imperfecta type 15 ISO RGD:1344355 7240710 OMIM osteoporosis susceptibility ISO RGD:1344355 7240710 OMIM
3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:11491 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT1 mRNA, APCDD1 protein promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT1 protein] CTD PMID:28242765 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine increases expression ISO RGD:11491 6480464 2-amino-3-methylimidazo(4, 5-f)quinoline results in increased expression of WNT1 protein CTD PMID:22094457 4,4'-sulfonyldiphenol affects expression ISO RGD:11491 6480464 bis(4-hydroxyphenyl)sulfone affects the expression of WNT1 mRNA CTD PMID:30951980 5-aza-2'-deoxycytidine increases expression ISO RGD:11491 6480464 Decitabine results in increased expression of WNT1 mRNA CTD PMID:27915011 aldehydo-D-glucose increases expression ISO RGD:1344355 6480464 Glucose results in increased expression of WNT1 mRNA CTD PMID:29163160 arsenite(3-) increases methylation ISO RGD:1344355 6480464 arsenite results in increased methylation of WNT1 promoter CTD PMID:23974009 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of WNT1 gene CTD PMID:28931070 benzene multiple interactions ISO RGD:11491 6480464 TRP53 protein affects the reaction [Benzene results in increased expression of WNT1 mRNA], TRP53 protein promotes the reaction [Benzene results in increased expression of WNT1] CTD PMID:12928149 , PMID:15935813 benzene increases expression ISO RGD:11491 6480464 Benzene results in increased expression of WNT1, Benzene results in increased expression of WNT1 mRNA CTD PMID:12928149 , PMID:15935813 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of WNT1 protein CTD PMID:21467743 bis(2-chloroethyl) sulfide decreases expression ISO RGD:11491 6480464 Mustard Gas results in decreased expression of WNT1 mRNA CTD PMID:15674843 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1344355 6480464 Diethylhexyl Phthalate results in decreased expression of WNT1 mRNA CTD PMID:31163220 bisphenol A multiple interactions EXP 6480464 Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT1 mRNA] CTD PMID:25963729 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of WNT1 mRNA CTD PMID:30816183 bisphenol A affects methylation ISO RGD:11491 6480464 bisphenol A affects the methylation of WNT1 promoter CTD PMID:27334623 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of WNT1 mRNA CTD PMID:25381574 , PMID:25963729 bisphenol F increases expression ISO RGD:11491 6480464 bisphenol F results in increased expression of WNT1 mRNA CTD PMID:30951980 cadmium dichloride multiple interactions ISO RGD:1344355 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA CTD PMID:12634122 carbon nanotube decreases expression ISO RGD:11491 6480464 Nanotubes, Carbon analog results in decreased expression of WNT1 mRNA, Nanotubes, Carbon results in decreased expression of WNT1 mRNA CTD PMID:25554681 chlorpyrifos affects expression EXP 6480464 Chlorpyrifos affects the expression of WNT1 mRNA CTD PMID:18502319 copper(II) sulfate increases expression ISO RGD:1344355 6480464 Copper Sulfate results in increased expression of WNT1 mRNA CTD PMID:19549813 curcumin increases expression EXP 6480464 Curcumin results in increased expression of WNT1 mRNA CTD PMID:25963729 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT1 mRNA] CTD PMID:25963729 D-glucose increases expression ISO RGD:1344355 6480464 Glucose results in increased expression of WNT1 mRNA CTD PMID:29163160 delta-tocotrienol decreases expression ISO RGD:1344355 6480464 tocotrienol, delta results in decreased expression of WNT1 protein CTD PMID:21453743 dexamethasone multiple interactions ISO RGD:11491 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT1 mRNA, APCDD1 protein promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT1 protein] CTD PMID:28242765 dibenz[a,h]anthracene decreases expression ISO RGD:11491 6480464 1 more ... CTD PMID:26377693 dichromium trioxide multiple interactions ISO RGD:1344355 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA CTD PMID:12634122 dimethylarsinic acid multiple interactions ISO RGD:1344355 6480464 [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of WNT1 mRNA CTD PMID:23192986 ethosuximide multiple interactions EXP 6480464 Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT1 mRNA] CTD PMID:26420483 ethosuximide increases expression EXP 6480464 Ethosuximide results in increased expression of WNT1 mRNA CTD PMID:26420483 folic acid multiple interactions ISO RGD:11491 6480464 [Folic Acid co-treated with sodium arsenite] results in increased methylation of WNT1 mRNA CTD PMID:22959928 glucose increases expression ISO RGD:1344355 6480464 Glucose results in increased expression of WNT1 mRNA CTD PMID:29163160 hydralazine multiple interactions ISO RGD:1344355 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of WNT1 mRNA CTD PMID:17183730 hydrogen peroxide multiple interactions ISO RGD:1344355 6480464 [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of WNT1 mRNA CTD PMID:24489904 lead diacetate multiple interactions ISO RGD:1344355 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA CTD PMID:12634122 linalool increases expression ISO RGD:1344355 6480464 linalool results in increased expression of WNT1 mRNA CTD PMID:19922762 lithium chloride multiple interactions ISO RGD:1344355 6480464 Lithium Chloride inhibits the reaction [quinocetone results in decreased expression of WNT1 protein] CTD PMID:28343033 losartan multiple interactions ISO RGD:11491 6480464 Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA], Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein] CTD PMID:28578904 losartan multiple interactions ISO RGD:1344355 6480464 Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA], Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein] CTD PMID:28578904 maneb multiple interactions EXP 6480464 [Paraquat co-treated with Maneb] results in decreased expression of WNT1 mRNA, [Paraquat co-treated with Maneb] results in decreased expression of WNT1 protein CTD PMID:29152652 methylarsonic acid multiple interactions ISO RGD:1344355 6480464 [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of WNT1 mRNA CTD PMID:23192986 methylmercury chloride affects expression ISO RGD:11491 6480464 methylmercuric chloride affects the expression of WNT1 mRNA CTD PMID:21613230 methylmercury chloride decreases expression ISO RGD:11491 6480464 methylmercuric chloride results in decreased expression of WNT1 mRNA CTD PMID:21385734 N-acetyl-L-cysteine multiple interactions ISO RGD:1344355 6480464 Acetylcysteine inhibits the reaction [quinocetone results in decreased expression of WNT1 protein] CTD PMID:28343033 nickel atom decreases expression EXP 6480464 Nickel results in decreased expression of WNT1 mRNA CTD PMID:19130878 paracetamol affects expression ISO RGD:11491 6480464 Acetaminophen affects the expression of WNT1 mRNA CTD PMID:17562736 paraquat multiple interactions EXP 6480464 [Paraquat co-treated with Maneb] results in decreased expression of WNT1 mRNA, [Paraquat co-treated with Maneb] results in decreased expression of WNT1 protein CTD PMID:29152652 paraquat multiple interactions ISO RGD:1344355 6480464 WNT1 protein inhibits the reaction [Paraquat results in decreased expression of AXIN1 mRNA] more ... CTD PMID:30171970 phenytoin decreases expression ISO RGD:11491 6480464 Phenytoin results in decreased expression of WNT1 mRNA CTD PMID:7841657 reactive oxygen species multiple interactions ISO RGD:1344355 6480464 [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of WNT1 mRNA CTD PMID:24489904 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of WNT1 mRNA CTD PMID:23848300 simazine increases expression ISO RGD:11491 6480464 Simazine results in increased expression of WNT1 mRNA CTD PMID:27513680 sodium arsenite multiple interactions ISO RGD:1344355 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA, [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of WNT1 mRNA CTD PMID:12634122 , PMID:23192986 sodium arsenite multiple interactions ISO RGD:11491 6480464 [Folic Acid co-treated with sodium arsenite] results in increased methylation of WNT1 mRNA CTD PMID:22959928 tebuconazole decreases expression ISO RGD:1344355 6480464 tebuconazole results in decreased expression of WNT1 mRNA CTD PMID:30458266 valproic acid multiple interactions ISO RGD:1344355 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of WNT1 mRNA CTD PMID:17183730 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of WNT1 mRNA, Valproic Acid results in increased expression of WNT1 protein CTD PMID:20734317 valproic acid decreases methylation EXP 6480464 Valproic Acid results in decreased methylation of WNT1 promoter CTD PMID:20734317 valproic acid affects expression ISO RGD:1344355 6480464 Valproic Acid affects the expression of WNT1 mRNA CTD PMID:24849673
Biological Process animal organ regeneration IMP 2326223 RGD astrocyte-dopaminergic neuron signaling ISO RGD:11491 1624291 (MGI:MGI:5770063, PMID:21752258) RGD MGI:MGI:5770063 , PMID:21752258 bone development ISO RGD:1344355 1624291 (PMID:23499309) RGD PMID:23499309 branching involved in ureteric bud morphogenesis ISO RGD:11491 1624291 MGI:MGI:1197020 (MGI:MGI:3588895 , PMID:16054034) RGD MGI:MGI:3588895 , PMID:16054034 canonical Wnt signaling pathway ISO RGD:1344355 1624291 (PMID:10644691), (PMID:12154096), (PMID:19756656), (PMID:19778454), (PMID:28733458) RGD PMID:10644691 more ... canonical Wnt signaling pathway IBA FB:FBgn0004360 more ... 13792537 PMID:21873635 GO_Central canonical Wnt signaling pathway ISO RGD:11491 1624291 MGI:MGI:1329040 (MGI:MGI:1261652 more ... RGD MGI:MGI:1261652 more ... canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation ISO RGD:11491 1624291 (MGI:MGI:5705221, PMID:19951692) RGD MGI:MGI:5705221 , PMID:19951692 cell fate commitment IBA MGI:MGI:98953 more ... 13792537 PMID:21873635 GO_Central cell proliferation in midbrain ISO RGD:11491 1624291 (MGI:MGI:2679774 more ... RGD MGI:MGI:2679774 more ... cell-cell signaling ISO RGD:11491 1624291 (MGI:MGI:4456962, PMID:10557084) RGD MGI:MGI:4456962 , PMID:10557084 cellular response to peptide hormone stimulus IEP 2326224 RGD central nervous system morphogenesis ISO RGD:11491 1624291 (MGI:MGI:1931348, PMID:2202907) RGD MGI:MGI:1931348 , PMID:2202907 cerebellum development ISO RGD:11491 1624291 (MGI:MGI:82938, PMID:8848044) RGD MGI:MGI:82938 , PMID:8848044 cerebellum formation ISO RGD:11491 1624291 (MGI:MGI:1931348, PMID:2202907) RGD MGI:MGI:1931348 , PMID:2202907 diencephalon development ISO RGD:11491 1624291 MGI:MGI:102764 (MGI:MGI:3772426 , PMID:18094027) RGD MGI:MGI:3772426 , PMID:18094027 dopaminergic neuron differentiation ISO RGD:11491 1624291 (MGI:MGI:5469218, PMID:23324743) RGD MGI:MGI:5469218 , PMID:23324743 embryonic axis specification ISO RGD:11491 1624291 (MGI:MGI:4822553, PMID:2534596) RGD MGI:MGI:4822553 , PMID:2534596 embryonic brain development ISO RGD:11491 1624291 (MGI:MGI:3045659, PMID:15121182) RGD MGI:MGI:3045659 , PMID:15121182 forebrain anterior/posterior pattern specification ISO RGD:11491 1624291 MGI:MGI:102764 (MGI:MGI:3772426 , PMID:18094027) RGD MGI:MGI:3772426 , PMID:18094027 hematopoietic stem cell proliferation ISO RGD:11491 1624291 (MGI:MGI:87698, PMID:9160667) RGD MGI:MGI:87698 , PMID:9160667 hepatocyte differentiation IMP 2326223 RGD inner ear morphogenesis ISO RGD:11491 1624291 MGI:MGI:98956 (MGI:MGI:3582112 , PMID:15961523) RGD MGI:MGI:3582112 , PMID:15961523 metencephalon development ISO RGD:11491 1624291 MGI:MGI:1857490 (MGI:MGI:59176 , PMID:2205396) RGD MGI:MGI:59176 , PMID:2205396 midbrain development ISO RGD:11491 1624291 MGI:MGI:1857490 (MGI:MGI:1931348 more ... RGD MGI:MGI:1931348 more ... midbrain dopaminergic neuron differentiation ISO RGD:11491 1624291 (MGI:MGI:5469218, PMID:23324743) RGD MGI:MGI:5469218 , PMID:23324743 midbrain-hindbrain boundary development ISO RGD:11491 1624291 MGI:MGI:1857490 (MGI:MGI:59176 , PMID:2205396) RGD MGI:MGI:59176 , PMID:2205396 midbrain-hindbrain boundary maturation during brain development ISO RGD:11491 1624291 MGI:MGI:1856382 (MGI:MGI:76584 , PMID:8555108) RGD MGI:MGI:76584 , PMID:8555108 myoblast fusion ISO RGD:11491 1624291 MGI:MGI:96573 (MGI:MGI:3522557 , PMID:15282335) RGD MGI:MGI:3522557 , PMID:15282335 myotube differentiation ISO RGD:11491 1624291 MGI:MGI:96573 (MGI:MGI:3522557 , PMID:15282335) RGD MGI:MGI:3522557 , PMID:15282335 negative regulation of apoptotic process ISO RGD:1344355 1624291 (PMID:12154096) RGD PMID:12154096 negative regulation of BMP signaling pathway ISO RGD:1344355 1624291 (PMID:16194878) RGD PMID:16194878 negative regulation of cell aging ISO RGD:1344355 1624291 (PMID:16501043) RGD PMID:16501043 negative regulation of cell differentiation ISO RGD:11491 1624291 (MGI:MGI:5486577, PMID:9473323) RGD MGI:MGI:5486577 , PMID:9473323 negative regulation of cell-cell adhesion ISO RGD:1344355 1624291 (PMID:17072303) RGD PMID:17072303 negative regulation of cell-substrate adhesion ISO RGD:1344355 1624291 (PMID:16501043) RGD PMID:16501043 negative regulation of fat cell differentiation ISO RGD:11491 1624291 (MGI:MGI:3574150 more ... RGD MGI:MGI:3574150 more ... negative regulation of oxidative stress-induced neuron death ISO RGD:11491 1624291 (MGI:MGI:5770063, PMID:21752258) RGD MGI:MGI:5770063 , PMID:21752258 negative regulation of transforming growth factor beta receptor signaling pathway ISO RGD:11491 1624291 (MGI:MGI:3628833, PMID:16601693) RGD MGI:MGI:3628833 , PMID:16601693 negative regulation of ubiquitin-dependent protein catabolic process ISO RGD:11491 1624291 (MGI:MGI:3628833, PMID:16601693) RGD MGI:MGI:3628833 , PMID:16601693 neurogenesis ISO RGD:11491 1624291 (MGI:MGI:2679774, PMID:14557550) RGD MGI:MGI:2679774 , PMID:14557550 neuron differentiation IBA MGI:MGI:98953 more ... 13792537 PMID:21873635 GO_Central neuron fate commitment ISO RGD:11491 1624291 MGI:MGI:2153126 (MGI:MGI:3611719 , PMID:16339193) RGD MGI:MGI:3611719 , PMID:16339193 neuron fate determination ISO RGD:11491 1624291 MGI:MGI:3046939 (MGI:MGI:3611719 , PMID:16339193) RGD MGI:MGI:3611719 , PMID:16339193 positive regulation of cell population proliferation ISO RGD:11491 1624291 (MGI:MGI:87698, PMID:9160667) RGD MGI:MGI:87698 , PMID:9160667 positive regulation of cell population proliferation ISO RGD:1344355 1624291 (PMID:16501043), (PMID:19778454) RGD PMID:16501043 , PMID:19778454 positive regulation of dermatome development ISO RGD:1344355 1624291 (PMID:10654605) RGD PMID:10654605 positive regulation of DNA-binding transcription factor activity ISO RGD:11491 1624291 (MGI:MGI:3621833, PMID:15035989) RGD MGI:MGI:3621833 , PMID:15035989 positive regulation of fibroblast proliferation ISO RGD:1344355 1624291 (PMID:19734317) RGD PMID:19734317 positive regulation of insulin-like growth factor receptor signaling pathway ISO RGD:1344355 1624291 (PMID:12154096) RGD PMID:12154096 positive regulation of lamellipodium assembly ISO RGD:1344355 1624291 (PMID:19756656) RGD PMID:19756656 positive regulation of Notch signaling pathway ISO RGD:1344355 1624291 (PMID:16501043) RGD PMID:16501043 positive regulation of protein phosphorylation ISO RGD:11491 1624291 (MGI:MGI:3045675, PMID:15143170) RGD MGI:MGI:3045675 , PMID:15143170 positive regulation of transcription by RNA polymerase II ISO RGD:11491 1624291 MGI:MGI:1919385 more ... RGD MGI:MGI:1306711 more ... positive regulation of transcription, DNA-templated ISO RGD:1344355 1624291 (PMID:10644691), (PMID:19847889) RGD PMID:10644691 , PMID:19847889 positive regulation of transcription, DNA-templated ISO RGD:11491 1624291 (MGI:MGI:1099602 more ... RGD MGI:MGI:1099602 more ... response to wounding ISO RGD:1344355 1624291 (PMID:17982423) RGD PMID:17982423 signal transduction in response to DNA damage ISO RGD:1344355 1624291 (PMID:16501043) RGD PMID:16501043 Spemann organizer formation ISO RGD:11491 1624291 (MGI:MGI:893982, PMID:9192640) RGD MGI:MGI:893982 , PMID:9192640 spinal cord association neuron differentiation ISO RGD:11491 1624291 MGI:MGI:98956 (MGI:MGI:2176385 , PMID:11877374) RGD MGI:MGI:2176385 , PMID:11877374 T cell differentiation in thymus ISO RGD:11491 1624291 (MGI:MGI:1929591, PMID:11265645) RGD MGI:MGI:1929591 , PMID:11265645 ubiquitin-dependent SMAD protein catabolic process ISO RGD:11491 1624291 (MGI:MGI:3628833, PMID:16601693) RGD MGI:MGI:3628833 , PMID:16601693 Wnt signaling pathway ISO RGD:11491 1624291 (MGI:MGI:5700314, PMID:11357136) RGD MGI:MGI:5700314 , PMID:11357136 Cellular Component cell surface ISO RGD:11491 1624291 (MGI:MGI:81949, PMID:8710372) RGD MGI:MGI:81949 , PMID:8710372 cellular_component ND 1598407 06/2010: no relevant rat data RGD cytoplasm ISO RGD:1344355 1624291 (PMID:11793365), (PMID:19756656) RGD PMID:11793365 , PMID:19756656 extracellular region ISO RGD:11491 1624291 (MGI:MGI:4818258, PMID:11336703) RGD MGI:MGI:4818258 , PMID:11336703 extracellular space IBA FB:FBgn0284084 more ... 13792537 PMID:21873635 GO_Central Molecular Function cytokine activity ISO RGD:11491 1624291 (MGI:MGI:4456962, PMID:10557084) RGD MGI:MGI:4456962 , PMID:10557084 cytokine activity IBA MGI:MGI:98953 more ... 13792537 PMID:21873635 GO_Central frizzled binding IBA FB:FBgn0004360 more ... 13792537 PMID:21873635 GO_Central molecular_function ND 1598407 06/2010: no relevant rat data RGD protein binding ISO RGD:11491 1624291 PR:O88572 more ... RGD MGI:MGI:1860653 more ... protein domain specific binding ISO RGD:11491 1624291 UniProtKB:Q01887 (MGI:MGI:3510085 , PMID:15454084) RGD MGI:MGI:3510085 , PMID:15454084 receptor ligand activity ISO RGD:11491 1624291 (MGI:MGI:4456962, PMID:10557084) RGD MGI:MGI:4456962 , PMID:10557084 receptor ligand activity ISO RGD:1344355 1624291 (PMID:28733458) RGD PMID:28733458
Gene-Chemical Interaction Annotations
