Wnt1 (Wnt family member 1) - Rat Genome Database

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Gene: Wnt1 (Wnt family member 1) Rattus norvegicus
Analyze
Symbol: Wnt1
Name: Wnt family member 1
RGD ID: 1597195
Description: Predicted to enable cytokine activity; frizzled binding activity; and protein domain specific binding activity. Involved in animal organ regeneration; cellular response to peptide hormone stimulus; and hepatocyte differentiation. Predicted to be located in cell surface; cytoplasm; and extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15. Orthologous to human WNT1 (Wnt family member 1); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; INTERACTS WITH 4-nitroquinoline N-oxide; 6-propyl-2-thiouracil; allethrin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Int1; proto-oncogene Wnt-1; wingless-related MMTV integration site 1; Wingless-type MMTV integration site 1 homolog; Wingless-type MMTV integration site 1, homolog; wingless-type MMTV integration site family, member 1; wingless-type MMTV integration site family, member 1 (mapped); Wnt1_mapped
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,817,558 - 131,821,605 (+)NCBIGRCr8
mRatBN7.27129,938,604 - 129,942,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,938,604 - 129,942,651 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,745,620 - 131,749,666 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,971,174 - 133,975,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,883,687 - 133,887,733 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,464,999 - 140,469,046 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,464,999 - 140,469,046 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,975,118 - 114,979,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,557,836 - 137,561,883 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7126,427,473 - 126,431,520 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitroquinoline N-oxide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aldehydo-D-glucose  (ISO)
allethrin  (EXP)
amitrole  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (ISO)
delta-tocotrienol  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dichromium trioxide  (ISO)
diethanolamine  (ISO)
dimethylarsinic acid  (ISO)
ethosuximide  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
glucose  (ISO)
glycerol 2-phosphate  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
linalool  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
losartan  (ISO)
maneb  (EXP)
methimazole  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (EXP)
niclosamide  (ISO)
ochratoxin A  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
phenytoin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
simazine  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tebuconazole  (ISO)
titanium dioxide  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IMP)
astrocyte-dopaminergic neuron signaling  (IEA,ISO)
bone development  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cell fate commitment  (IBA)
cell population proliferation  (ISO)
cell proliferation in midbrain  (ISO)
cell-cell signaling  (ISO)
cellular response to peptide hormone stimulus  (IEP)
central nervous system morphogenesis  (ISO)
cerebellum development  (ISO)
cerebellum formation  (ISO)
diencephalon development  (ISO)
dopaminergic neuron differentiation  (ISO)
embryonic axis specification  (ISO)
embryonic brain development  (ISO)
fat cell differentiation  (ISO)
forebrain anterior/posterior pattern specification  (ISO)
hematopoietic stem cell proliferation  (ISO)
hepatocyte differentiation  (IMP)
inner ear morphogenesis  (ISO)
metencephalon development  (ISO)
midbrain development  (ISO)
midbrain dopaminergic neuron differentiation  (ISO)
midbrain-hindbrain boundary development  (ISO)
midbrain-hindbrain boundary maturation during brain development  (ISO)
myoblast fusion  (ISO)
myotube differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of ubiquitin-dependent protein catabolic process  (ISO)
neurogenesis  (ISO)
neuron differentiation  (IBA)
neuron fate commitment  (ISO)
neuron fate determination  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of dermatome development  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of hematopoietic stem cell proliferation  (ISO)
positive regulation of insulin-like growth factor receptor signaling pathway  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
response to wounding  (ISO)
signal transduction in response to DNA damage  (ISO)
Spemann organizer formation  (ISO)
spinal cord association neuron differentiation  (ISO)
T cell differentiation in thymus  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Castelo-Branco G, etal., Proc Natl Acad Sci U S A 2003 Oct 28;100(22):12747-52. Epub 2003 Oct 13.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Wnt/ß-catenin signaling enhances osteoblastogenic differentiation from human periodontal ligament fibroblasts. Heo JS, etal., Mol Cells. 2010 Nov;30(5):449-54. doi: 10.1007/s10059-010-0139-3. Epub 2010 Sep 10.
4. Wnt signalling required for expansion of neural crest and CNS progenitors. Ikeya M, etal., Nature. 1997 Oct 30;389(6654):966-70.
5. Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms. Kim WB, etal., J Endocrinol. 2007 Apr;193(1):93-106.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
12. Cooperative induction of mammary tumorigenesis by TGFalpha and Wnts. Schroeder JA, etal., Oncogene. 2000 Jun 29;19(28):3193-9.
13. Transformation by Wnt family proteins correlates with regulation of beta-catenin. Shimizu H, etal., Cell Growth Differ. 1997 Dec;8(12):1349-58.
14. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
15. The role of the Wnt family of secreted proteins in rat oval "stem" cell-based liver regeneration: Wnt1 drives differentiation. Williams JM, etal., Am J Pathol. 2010 Jun;176(6):2732-42. Epub 2010 Apr 22.
16. Differential transformation of mammary epithelial cells by Wnt genes. Wong GT, etal., Mol Cell Biol. 1994 Sep;14(9):6278-86.
17. Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs inflammation and injury by mediating miR-20a-5p/HDAC4 axis. Yang Y, etal., Inflamm Res. 2022 Sep;71(9):1109-1121. doi: 10.1007/s00011-022-01604-z. Epub 2022 Jul 19.
Additional References at PubMed
PMID:1300513   PMID:2202907   PMID:2205396   PMID:2534596   PMID:8555108   PMID:8710372   PMID:8848044   PMID:9160667   PMID:9192640   PMID:9356179   PMID:9473323   PMID:9505170  
PMID:9601103   PMID:9652750   PMID:9769173   PMID:10557084   PMID:10644691   PMID:10654605   PMID:10937998   PMID:11265645   PMID:11336703   PMID:11357136   PMID:11793365   PMID:11877374  
PMID:12121999   PMID:12154096   PMID:12937339   PMID:14641328   PMID:15035989   PMID:15064719   PMID:15121182   PMID:15143170   PMID:15265686   PMID:15282335   PMID:15454084   PMID:15574752  
PMID:15728361   PMID:15961523   PMID:16054034   PMID:16194878   PMID:16207730   PMID:16339193   PMID:16501043   PMID:16543246   PMID:16601693   PMID:17072303   PMID:17239604   PMID:17982423  
PMID:17988238   PMID:18004065   PMID:18094027   PMID:18347988   PMID:19348510   PMID:19594026   PMID:19734317   PMID:19756656   PMID:19778454   PMID:19847889   PMID:19931241   PMID:19951692  
PMID:20383322   PMID:20499363   PMID:21443457   PMID:21752258   PMID:21935365   PMID:22406377   PMID:23152495   PMID:23324743   PMID:23499309   PMID:23585476   PMID:24961246   PMID:26054493  
PMID:28177765   PMID:28733458   PMID:29152652   PMID:31356809   PMID:31886199   PMID:37658228  


Genomics

Comparative Map Data
Wnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,817,558 - 131,821,605 (+)NCBIGRCr8
mRatBN7.27129,938,604 - 129,942,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,938,604 - 129,942,651 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,745,620 - 131,749,666 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,971,174 - 133,975,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,883,687 - 133,887,733 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,464,999 - 140,469,046 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,464,999 - 140,469,046 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,975,118 - 114,979,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,557,836 - 137,561,883 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7126,427,473 - 126,431,520 (+)NCBICelera
Cytogenetic Map7q36NCBI
WNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,978,322 - 48,982,620 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1248,978,322 - 48,982,620 (+)EnsemblGRCh38hg38GRCh38
GRCh371249,372,105 - 49,376,403 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,658,503 - 47,662,746 (+)NCBINCBI36Build 36hg18NCBI36
Build 341247,658,502 - 47,662,746NCBI
Celera1248,167,028 - 48,171,188 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,403,758 - 46,407,918 (+)NCBIHuRef
CHM1_11249,338,028 - 49,342,188 (+)NCBICHM1_1
T2T-CHM13v2.01248,940,505 - 48,944,803 (+)NCBIT2T-CHM13v2.0
Wnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,687,738 - 98,691,711 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,687,738 - 98,691,718 (+)EnsemblGRCm39 Ensembl
GRCm381598,789,857 - 98,793,830 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,789,857 - 98,793,837 (+)EnsemblGRCm38mm10GRCm38
MGSCv371598,620,288 - 98,624,261 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,617,891 - 98,621,864 (+)NCBIMGSCv36mm8
Celera15100,939,306 - 100,943,279 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.65NCBI
Wnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,797,060 - 7,811,167 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555007,797,063 - 7,811,142 (+)NCBIChiLan1.0ChiLan1.0
WNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21045,202,480 - 45,206,764 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11245,199,231 - 45,203,539 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01239,767,839 - 39,772,460 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11240,648,413 - 40,652,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,648,413 - 40,652,583 (-)Ensemblpanpan1.1panPan2
WNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,588,151 - 5,592,254 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,574,940 - 5,592,060 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,665,906 - 40,669,560 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,639,156 - 5,642,810 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,639,162 - 5,643,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,603,082 - 5,606,734 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,593,278 - 5,596,931 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,058,211 - 41,061,867 (+)NCBIUU_Cfam_GSD_1.0
Wnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,379,465 - 66,383,960 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,780,882 - 6,785,358 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365126,781,001 - 6,785,358 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,010,786 - 15,014,998 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,010,607 - 15,015,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,420,829 - 15,425,219 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,217,402 - 45,222,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,219,027 - 45,222,017 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037200,920,985 - 200,926,676 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248163,209,699 - 3,212,606 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248163,209,605 - 3,212,969 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wnt1
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:507
Count of miRNA genes:237
Interacting mature miRNAs:297
Transcripts:ENSRNOT00000019641, ENSRNOT00000067581
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
D7Kyo2   No map positions available.
Wnt1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27129,940,800 - 129,941,417 (+)MAPPERmRatBN7.2
Rnor_6.07140,467,196 - 140,467,812NCBIRnor6.0
Rnor_5.0X114,977,315 - 114,977,931UniSTSRnor5.0
RGSC_v3.47137,560,033 - 137,560,649UniSTSRGSC3.4
Celera7126,429,670 - 126,430,286UniSTS
Cytogenetic Map7q35UniSTS


Expression

RNA-SEQ Expression

circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 54 4 3 2 2 9 8 52 1 20 3

Sequence


Ensembl Acc Id: ENSRNOT00000090156   ⟹   ENSRNOP00000071688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7129,938,604 - 129,942,651 (+)Ensembl
Rnor_6.0 Ensembl7140,464,999 - 140,469,046 (+)Ensembl
RefSeq Acc Id: NM_001105714   ⟹   NP_001099184
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,817,558 - 131,821,605 (+)NCBI
mRatBN7.27129,938,604 - 129,942,651 (+)NCBI
Rnor_6.07140,464,999 - 140,469,046 (+)NCBI
Rnor_5.0X114,975,118 - 114,979,165 (+)NCBI
RGSC_v3.47137,557,836 - 137,561,883 (+)RGD
Celera7126,427,473 - 126,431,520 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099184 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87034 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071688.1
RefSeq Acc Id: NP_001099184   ⟸   NM_001105714
- Peptide Label: precursor
- UniProtKB: D4A9J2 (UniProtKB/TrEMBL),   A6KCA8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071688   ⟸   ENSRNOT00000090156

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9J2-F1-model_v2 AlphaFold D4A9J2 1-370 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597195 AgrOrtholog
BioCyc Gene G2FUF-32113 BioCyc
Ensembl Genes ENSRNOG00000061818 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090156.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt1 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_grthfactor_CS UniProtKB/TrEMBL
  Wnt_SF UniProtKB/TrEMBL
KEGG Report rno:24881 UniProtKB/TrEMBL
NCBI Gene 24881 ENTREZGENE
PANTHER PROTO-ONCOGENE WNT-1 UniProtKB/TrEMBL
  Wnt UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PhenoGen Wnt1 PhenoGen
PRINTS WNT1PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061818 RatGTEx
SMART WNT1 UniProtKB/TrEMBL
UniProt A6KCA8 ENTREZGENE, UniProtKB/TrEMBL
  D4A9J2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Wnt1  Wnt family member 1  Wnt1  wingless-type MMTV integration site family, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Wnt1  wingless-type MMTV integration site family, member 1  Wnt1  wingless-related MMTV integration site 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Wnt1  wingless-related MMTV integration site 1  Wnt1  wingless-type MMTV integration site family, member 1 (mapped)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13 Wnt1  wingless-type MMTV integration site family, member 1 (mapped)  Wnt1_mapped  wingless-type MMTV integration site family, member 1 (mapped)  Data merged from RGD:3971 737654 APPROVED
2006-11-20 Wnt1  wingless-type MMTV integration site family, member 1 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Wnt1_mapped  wingless-type MMTV integration site family, member 1 (mapped)  Wnt1  wingless-type MMTV integration site family, member 1  Symbol and Name updated 1556543 APPROVED
2003-04-09 Wnt1  wingless-type MMTV integration site family, member 1    Wingless-type MMTV integration site 1, homolog  Name updated 629478 APPROVED
2002-06-10 Wnt1  Wingless-type MMTV integration site 1, homolog      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product predicted to be a member of the Wnt family of secreted glycoproteins which regulate cell proliferation, cell differentiation, and determination of cell fate 1300513