Predicted to enable cytokine activity; frizzled binding activity; and protein domain specific binding activity. Involved in animal organ regeneration; cellular response to peptide hormone stimulus; and hepatocyte differentiation. Predicted to be located in cell surface; cytoplasm; and extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15 and osteoporosis. Orthologous to human WNT1 (Wnt family member 1); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; basal cell carcinoma pathway; INTERACTS WITH allethrin; atrazine; benzo[a]pyrene.
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT1 mRNA, APCDD1 protein promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT1 protein]
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of WNT1 mRNA
TRP53 protein affects the reaction [Benzene results in increased expression of WNT1 mRNA], TRP53 protein promotes the reaction [Benzene results in increased expression of WNT1]
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of WNT1 mRNA
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of WNT1 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT1 mRNA, APCDD1 protein promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of WNT1 protein]
[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of WNT1 mRNA, lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of WNT1 mRNA]
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of WNT1 mRNA
[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of WNT1 mRNA, lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of WNT1 mRNA]
[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of WNT1 mRNA, lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of WNT1 mRNA]
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA
lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of WNT1 mRNA]
Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA], Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA], Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]
[Paraquat co-treated with Maneb] results in decreased expression of WNT1 mRNA, [Paraquat co-treated with Maneb] results in decreased expression of WNT1 protein
[Paraquat co-treated with Maneb] results in decreased expression of WNT1 mRNA, [Paraquat co-treated with Maneb] results in decreased expression of WNT1 protein
LMX1A protein promotes the reaction [Simazine results in increased expression of WNT1 mRNA], LMX1A protein promotes the reaction [Simazine results in increased expression of WNT1 protein]
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA, [sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of WNT1 mRNA
Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms.
predicted to be a member of the Wnt family of secreted glycoproteins which regulate cell proliferation, cell differentiation, and determination of cell fate