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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1597195
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wnt1
Name: Wnt family member 1
Acc ID: CHEBI:27496
Term: simazine
Definition: A diamino-1,3,5-triazine that is N,N'-diethyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.
Chemical ID: MESH:D012839
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wnt1decreases expressionISOWnt1 (Mus musculus)6480464CTDSimazine results in decreased expression of WNT1 mRNA; Simazine results in decreased expression of WNT1 proteinPMID:34936186
Wnt1increases expressionISOWnt1 (Mus musculus)6480464CTDSimazine results in increased expression of WNT1 mRNA; Simazine results in increased expression of WNT1 proteinPMID:27513680 PMID:32822773
Wnt1multiple interactionsISOWnt1 (Mus musculus)6480464CTDLMX1A protein promotes the reaction [Simazine results in increased expression of WNT1 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of WNT1 protein]PMID:32822773
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