WNT1 (Wnt family member 1) - Rat Genome Database

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Gene: WNT1 (Wnt family member 1) Canis lupus familiaris
Analyze
Symbol: WNT1
Name: Wnt family member 1
RGD ID: 12203558
Description: ENCODES a protein that exhibits cytokine activity (inferred); protein domain specific binding (inferred); receptor ligand activity (inferred); INVOLVED IN animal organ regeneration (ortholog); branching involved in ureteric bud morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); atherosclerosis (ortholog); breast cancer (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proto-oncogene Wnt-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,588,151 - 5,592,254 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,574,940 - 5,592,060 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,665,906 - 40,669,560 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,639,156 - 5,642,810 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,639,162 - 5,643,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,603,082 - 5,606,734 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,593,278 - 5,596,931 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,058,211 - 41,061,867 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
astrocyte-dopaminergic neuron signaling  (IEA)
bone development  (IEA)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell proliferation in midbrain  (IEA)
cell-cell signaling  (IEA)
cellular response to peptide hormone stimulus  (ISO)
central nervous system morphogenesis  (IEA)
cerebellum development  (IEA)
cerebellum formation  (IEA)
diencephalon development  (IEA,ISO)
dopaminergic neuron differentiation  (IEA)
embryonic axis specification  (IEA)
embryonic brain development  (IEA)
fat cell differentiation  (IEA,ISO)
forebrain anterior/posterior pattern specification  (IEA,ISO)
hematopoietic stem cell proliferation  (IEA,ISO)
hepatocyte differentiation  (ISO)
inner ear morphogenesis  (IEA,ISO)
metencephalon development  (IEA,ISO)
midbrain development  (IEA,ISO)
midbrain dopaminergic neuron differentiation  (IEA)
midbrain-hindbrain boundary development  (IEA,ISO)
midbrain-hindbrain boundary maturation during brain development  (IEA,ISO)
myoblast fusion  (IEA,ISO)
myotube differentiation  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of BMP signaling pathway  (IEA)
negative regulation of cell differentiation  (IEA)
negative regulation of cell-cell adhesion  (IEA)
negative regulation of cell-substrate adhesion  (IEA)
negative regulation of cellular senescence  (IEA)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
negative regulation of ubiquitin-dependent protein catabolic process  (IEA,ISO)
neurogenesis  (IEA)
neuron fate commitment  (IEA,ISO)
neuron fate determination  (IEA,ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of dermatome development  (IEA)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of hematopoietic stem cell proliferation  (IEA,ISO)
positive regulation of insulin-like growth factor receptor signaling pathway  (IEA)
positive regulation of lamellipodium assembly  (IEA)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
response to wounding  (IEA)
signal transduction in response to DNA damage  (IEA)
Spemann organizer formation  (IEA)
spinal cord association neuron differentiation  (IEA,ISO)
T cell differentiation in thymus  (IEA,ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,588,151 - 5,592,254 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,574,940 - 5,592,060 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,665,906 - 40,669,560 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,639,156 - 5,642,810 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,639,162 - 5,643,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,603,082 - 5,606,734 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,593,278 - 5,596,931 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,058,211 - 41,061,867 (+)NCBIUU_Cfam_GSD_1.0
WNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,978,322 - 48,982,620 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1248,978,322 - 48,982,620 (+)EnsemblGRCh38hg38GRCh38
GRCh371249,372,105 - 49,376,403 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,658,503 - 47,662,746 (+)NCBINCBI36Build 36hg18NCBI36
Build 341247,658,502 - 47,662,746NCBI
Celera1248,167,028 - 48,171,188 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,403,758 - 46,407,918 (+)NCBIHuRef
CHM1_11249,338,028 - 49,342,188 (+)NCBICHM1_1
T2T-CHM13v2.01248,940,505 - 48,944,803 (+)NCBIT2T-CHM13v2.0
Wnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,687,738 - 98,691,711 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,687,738 - 98,691,718 (+)EnsemblGRCm39 Ensembl
GRCm381598,789,857 - 98,793,830 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,789,857 - 98,793,837 (+)EnsemblGRCm38mm10GRCm38
MGSCv371598,620,288 - 98,624,261 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,617,891 - 98,621,864 (+)NCBIMGSCv36mm8
Celera15100,939,306 - 100,943,279 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.65NCBI
Wnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,817,558 - 131,821,605 (+)NCBIGRCr8
mRatBN7.27129,938,604 - 129,942,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,938,604 - 129,942,651 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,745,620 - 131,749,666 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,971,174 - 133,975,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,883,687 - 133,887,733 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,464,999 - 140,469,046 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,464,999 - 140,469,046 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,975,118 - 114,979,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,557,836 - 137,561,883 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7126,427,473 - 126,431,520 (+)NCBICelera
Cytogenetic Map7q36NCBI
Wnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,797,060 - 7,811,167 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555007,797,063 - 7,811,142 (+)NCBIChiLan1.0ChiLan1.0
WNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21045,202,480 - 45,206,764 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11245,199,231 - 45,203,539 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01239,767,839 - 39,772,460 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11240,648,413 - 40,652,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,648,413 - 40,652,583 (-)Ensemblpanpan1.1panPan2
Wnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,379,465 - 66,383,960 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,780,882 - 6,785,358 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365126,781,001 - 6,785,358 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,010,786 - 15,014,998 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,010,607 - 15,015,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,420,829 - 15,425,219 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,217,402 - 45,222,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,219,027 - 45,222,017 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037200,920,985 - 200,926,676 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248163,209,699 - 3,212,606 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248163,209,605 - 3,212,969 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WNT1
28 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5
Low 1 4
Below cutoff 1 1 13 4 5 3 5 4 8 6

Sequence


Ensembl Acc Id: ENSCAFT00000013918   ⟹   ENSCAFP00000012878
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl275,589,117 - 5,592,060 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000045709   ⟹   ENSCAFP00000041958
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl275,588,376 - 5,591,740 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000072146   ⟹   ENSCAFP00000052863
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl275,574,940 - 5,592,060 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845039833   ⟹   ENSCAFP00845031197
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl275,639,162 - 5,643,065 (-)Ensembl
RefSeq Acc Id: XM_038437859   ⟹   XP_038293787
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0275,639,156 - 5,642,810 (-)NCBI
RefSeq Acc Id: XM_038514279   ⟹   XP_038370207
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1275,603,082 - 5,606,734 (-)NCBI
RefSeq Acc Id: XM_038576164   ⟹   XP_038432092
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02741,058,211 - 41,061,867 (+)NCBI
RefSeq Acc Id: XM_038640328   ⟹   XP_038496256
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0275,593,278 - 5,596,931 (-)NCBI
RefSeq Acc Id: XM_543686   ⟹   XP_543686
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1275,588,151 - 5,592,254 (-)NCBI
Dog10K_Boxer_Tasha2740,665,906 - 40,669,560 (+)NCBI
Sequence:
RefSeq Acc Id: XP_543686   ⟸   XM_543686
- UniProtKB: A0A8C0P633 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000041958   ⟸   ENSCAFT00000045709
Ensembl Acc Id: ENSCAFP00000012878   ⟸   ENSCAFT00000013918
Ensembl Acc Id: ENSCAFP00000052863   ⟸   ENSCAFT00000072146
RefSeq Acc Id: XP_038370207   ⟸   XM_038514279
RefSeq Acc Id: XP_038496256   ⟸   XM_038640328
RefSeq Acc Id: XP_038293787   ⟸   XM_038437859
- UniProtKB: A0A8C0P633 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038432092   ⟸   XM_038576164
- UniProtKB: A0A8C0P633 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845031197   ⟸   ENSCAFT00845039833


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008760 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021462 UniProtKB/TrEMBL
  ENSCAFG00040024722 UniProtKB/TrEMBL
  ENSCAFG00845022557 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000045709.4 UniProtKB/TrEMBL
  ENSCAFT00030039468.1 UniProtKB/TrEMBL
  ENSCAFT00040046069.1 UniProtKB/TrEMBL
  ENSCAFT00845039833 ENTREZGENE
  ENSCAFT00845039833.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt1 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
KEGG Report cfa:486560 UniProtKB/TrEMBL
NCBI Gene WNT1 ENTREZGENE
PANTHER PROTO-ONCOGENE WNT-1 UniProtKB/TrEMBL
  PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT1PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A8C0P633 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PGI7_CANLF UniProtKB/TrEMBL
  A0A8P0SVN5_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:48419 ENTREZGENE