WNT1 (Wnt family member 1) - Rat Genome Database

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Gene: WNT1 (Wnt family member 1) Sus scrofa
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Symbol: WNT1
Name: Wnt family member 1
RGD ID: 13867597
Description: ENCODES a protein that exhibits cytokine activity (inferred); protein domain specific binding (inferred); receptor ligand activity (inferred); INVOLVED IN animal organ regeneration (ortholog); branching involved in ureteric bud morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); genetic disease (ortholog); keratoconus (ortholog); FOUND IN cell surface (inferred); cytoplasm (inferred); extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proto-oncogene Wnt-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,010,786 - 15,014,998 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,010,607 - 15,015,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,420,829 - 15,425,219 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
astrocyte-dopaminergic neuron signaling  (IEA)
bone development  (IEA)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IBA,IEA,ISO)
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  (IEA)
cell fate commitment  (IBA)
cell population proliferation  (IEA,ISO)
cell proliferation in midbrain  (IEA)
cell-cell signaling  (IEA)
cellular response to peptide hormone stimulus  (ISO)
central nervous system morphogenesis  (IEA)
cerebellum development  (IEA)
cerebellum formation  (IEA)
diencephalon development  (IEA,ISO)
dopaminergic neuron differentiation  (IEA)
embryonic axis specification  (IEA)
embryonic brain development  (IEA)
fat cell differentiation  (IEA,ISO)
forebrain anterior/posterior pattern specification  (IEA,ISO)
hematopoietic stem cell proliferation  (IEA,ISO)
hepatocyte differentiation  (ISO)
inner ear morphogenesis  (IEA,ISO)
metencephalon development  (IEA,ISO)
midbrain development  (IEA,ISO)
midbrain dopaminergic neuron differentiation  (IEA)
midbrain-hindbrain boundary development  (IEA,ISO)
midbrain-hindbrain boundary maturation during brain development  (IEA,ISO)
myoblast fusion  (IEA,ISO)
myotube differentiation  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of BMP signaling pathway  (IEA)
negative regulation of cell differentiation  (IEA)
negative regulation of cell-cell adhesion  (IEA)
negative regulation of cell-substrate adhesion  (IEA)
negative regulation of cellular senescence  (IEA)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of oxidative stress-induced neuron death  (IEA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
negative regulation of ubiquitin-dependent protein catabolic process  (IEA,ISO)
neurogenesis  (IEA)
neuron differentiation  (IBA)
neuron fate commitment  (IEA,ISO)
neuron fate determination  (IEA,ISO)
obsolete negative regulation of cell aging  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of dermatome development  (IEA)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of hematopoietic stem cell proliferation  (IEA,ISO)
positive regulation of insulin-like growth factor receptor signaling pathway  (IEA)
positive regulation of lamellipodium assembly  (IEA)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
response to wounding  (IEA)
signal transduction in response to DNA damage  (IEA)
Spemann organizer formation  (IEA)
spinal cord association neuron differentiation  (IEA,ISO)
T cell differentiation in thymus  (IEA,ISO)
ubiquitin-dependent SMAD protein catabolic process  (IEA,ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
WNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,010,786 - 15,014,998 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,010,607 - 15,015,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,420,829 - 15,425,219 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,978,322 - 48,982,620 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1248,978,322 - 48,982,620 (+)EnsemblGRCh38hg38GRCh38
GRCh371249,372,105 - 49,376,403 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,658,503 - 47,662,746 (+)NCBINCBI36hg18NCBI36
Build 341247,658,502 - 47,662,746NCBI
Celera1248,167,028 - 48,171,188 (+)NCBI
Cytogenetic Map12q13.12NCBI
HuRef1246,403,758 - 46,407,918 (+)NCBIHuRef
CHM1_11249,338,028 - 49,342,188 (+)NCBICHM1_1
T2T-CHM13v2.01248,940,505 - 48,944,803 (+)NCBI
Wnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,687,738 - 98,691,711 (+)NCBIGRCm39mm39
GRCm39 Ensembl1598,687,738 - 98,691,718 (+)Ensembl
GRCm381598,789,857 - 98,793,830 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,789,857 - 98,793,837 (+)EnsemblGRCm38mm10GRCm38
MGSCv371598,620,288 - 98,624,261 (+)NCBIGRCm37mm9NCBIm37
MGSCv361598,617,891 - 98,621,864 (+)NCBImm8
Celera15100,939,306 - 100,943,279 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.65NCBI
Wnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27129,938,604 - 129,942,651 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl7129,938,604 - 129,942,651 (+)Ensembl
Rnor_6.07140,464,999 - 140,469,046 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,464,999 - 140,469,046 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,975,118 - 114,979,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,557,836 - 137,561,883 (+)NCBIRGSC3.4rn4RGSC3.4
Celera7126,427,473 - 126,431,520 (+)NCBICelera
Cytogenetic Map7q36NCBI
Wnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,797,060 - 7,811,167 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555007,797,063 - 7,811,142 (+)NCBIChiLan1.0ChiLan1.0
WNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11240,648,413 - 40,652,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,648,413 - 40,652,583 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01239,767,839 - 39,772,460 (-)NCBIMhudiblu_PPA_v0panPan3
WNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,588,151 - 5,592,254 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,574,940 - 5,592,060 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,665,906 - 40,669,560 (+)NCBI
ROS_Cfam_1.0275,639,156 - 5,642,810 (-)NCBI
ROS_Cfam_1.0 Ensembl275,639,162 - 5,643,065 (-)Ensembl
UMICH_Zoey_3.1275,603,082 - 5,606,734 (-)NCBI
UNSW_CanFamBas_1.0275,593,278 - 5,596,931 (-)NCBI
UU_Cfam_GSD_1.02741,058,211 - 41,061,867 (+)NCBI
Wnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,379,465 - 66,383,960 (-)NCBI
SpeTri2.0NW_0049365126,781,001 - 6,785,358 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,217,402 - 45,222,996 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,219,027 - 45,222,017 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037200,920,985 - 200,926,676 (-)NCBIVero_WHO_p1.0
Wnt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248163,209,699 - 3,212,606 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248163,209,605 - 3,212,969 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000000192   ⟹   ENSSSCP00000000190
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl515,010,786 - 15,014,998 (+)Ensembl
RefSeq Acc Id: XM_003126100   ⟹   XP_003126148
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1515,010,607 - 15,015,007 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003126148 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003126148   ⟸   XM_003126100
- Sequence:
RefSeq Acc Id: ENSSSCP00000000190   ⟸   ENSSSCT00000000192


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000183 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015064833 UniProtKB/TrEMBL
  ENSSSCG00025018744 UniProtKB/TrEMBL
  ENSSSCG00030051326 UniProtKB/TrEMBL
  ENSSSCG00035045964 UniProtKB/TrEMBL
  ENSSSCG00040035903 UniProtKB/TrEMBL
  ENSSSCG00045010432 UniProtKB/TrEMBL
  ENSSSCG00050076887 UniProtKB/TrEMBL
  ENSSSCG00055027904 UniProtKB/TrEMBL
  ENSSSCG00060026568 UniProtKB/TrEMBL
  ENSSSCG00065052816 UniProtKB/TrEMBL
  ENSSSCG00070030500 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000000190 ENTREZGENE
  ENSSSCP00000000190.4 UniProtKB/TrEMBL
  ENSSSCP00015035400.1 UniProtKB/TrEMBL
  ENSSSCP00025010751.1 UniProtKB/TrEMBL
  ENSSSCP00030032612.1 UniProtKB/TrEMBL
  ENSSSCP00035024601.1 UniProtKB/TrEMBL
  ENSSSCP00040020140.1 UniProtKB/TrEMBL
  ENSSSCP00045012167.1 UniProtKB/TrEMBL
  ENSSSCP00050046573.1 UniProtKB/TrEMBL
  ENSSSCP00055044145.1 UniProtKB/TrEMBL
  ENSSSCP00060015293.1 UniProtKB/TrEMBL
  ENSSSCP00065031494.1 UniProtKB/TrEMBL
  ENSSSCP00070052345.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000000192 ENTREZGENE
  ENSSSCT00000000192.4 UniProtKB/TrEMBL
  ENSSSCT00015086927.1 UniProtKB/TrEMBL
  ENSSSCT00025025454.1 UniProtKB/TrEMBL
  ENSSSCT00030071540.1 UniProtKB/TrEMBL
  ENSSSCT00035061109.1 UniProtKB/TrEMBL
  ENSSSCT00040048247.1 UniProtKB/TrEMBL
  ENSSSCT00045017675.1 UniProtKB/TrEMBL
  ENSSSCT00050105721.1 UniProtKB/TrEMBL
  ENSSSCT00055055313.1 UniProtKB/TrEMBL
  ENSSSCT00060035962.1 UniProtKB/TrEMBL
  ENSSSCT00065072319.1 UniProtKB/TrEMBL
  ENSSSCT00070061400.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt1 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_CS UniProtKB/TrEMBL
KEGG Report ssc:100525462 UniProtKB/TrEMBL
NCBI Gene WNT1 ENTREZGENE
PANTHER PTHR12027 UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PRINTS WNT1PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A4X1WCQ6_PIG UniProtKB/TrEMBL
  F1SJ15_PIG UniProtKB/TrEMBL