RGD Reference Report - Alternative wnt signaling is initiated by distinct receptors. - Rat Genome Database

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Alternative wnt signaling is initiated by distinct receptors.

Authors: Van Amerongen, R  Mikels, A  Nusse, R 
Citation: van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
RGD ID: 2313743
Pubmed: PMID:18765832   (View Abstract at PubMed)
DOI: DOI:10.1126/scisignal.135re9   (Journal Full-text)

An unanswered question in the field of signal transduction research is how different signaling pathways are activated with strict specificity in a temporally and spatially controlled manner. Because extracellular ligands and membrane receptors constitute the first signaling modalities for most pathways, selectivity in ligand-receptor binding likely dictates the outcome of downstream signaling events. Unfortunately, possible complexities underlying ligand-receptor interactions are often overlooked. Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
WNT1HumanWnt signaling, canonical pathway   TAS  RGD 
WNT10AHumanWnt signaling, canonical pathway   TAS  RGD 
WNT10BHumanWnt signaling, canonical pathway   TAS  RGD 
WNT11HumanWnt signaling, canonical pathway   TAS  RGD 
WNT16HumanWnt signaling, canonical pathway   TAS  RGD 
WNT2HumanWnt signaling, canonical pathway   TAS  RGD 
WNT2BHumanWnt signaling, canonical pathway   TAS  RGD 
WNT3HumanWnt signaling, canonical pathway   TAS  RGD 
WNT3AHumanWnt signaling, canonical pathway   TAS  RGD 
WNT4HumanWnt signaling, canonical pathway   TAS  RGD 
WNT5AHumanWnt signaling, canonical pathway   TAS  RGD 
WNT5BHumanWnt signaling, canonical pathway   TAS  RGD 
WNT6HumanWnt signaling, canonical pathway   TAS  RGD 
WNT7AHumanWnt signaling, canonical pathway   TAS  RGD 
WNT7BHumanWnt signaling, canonical pathway   TAS  RGD 
WNT8AHumanWnt signaling, canonical pathway   TAS  RGD 
WNT8BHumanWnt signaling, canonical pathway   TAS  RGD 
WNT9AHumanWnt signaling, canonical pathway   TAS  RGD 
WNT9BHumanWnt signaling, canonical pathway   TAS  RGD 
Wnt1MouseWnt signaling, canonical pathway   ISORGD:1344355 RGD 
Wnt1RatWnt signaling, canonical pathway   ISORGD:1344355 RGD 
Wnt10aRatWnt signaling, canonical pathway   ISORGD:1315958 RGD 
Wnt10aMouseWnt signaling, canonical pathway   ISORGD:1315958 RGD 
Wnt10bRatWnt signaling, canonical pathway   ISORGD:1312744 RGD 
Wnt10bMouseWnt signaling, canonical pathway   ISORGD:1312744 RGD 
Wnt11RatWnt signaling, canonical pathway   ISORGD:1344477 RGD 
Wnt11MouseWnt signaling, canonical pathway   ISORGD:1344477 RGD 
Wnt16MouseWnt signaling, canonical pathway   ISORGD:1345805 RGD 
Wnt16RatWnt signaling, canonical pathway   ISORGD:1345805 RGD 
Wnt2RatWnt signaling, canonical pathway   ISORGD:736431 RGD 
Wnt2MouseWnt signaling, canonical pathway   ISORGD:736431 RGD 
Wnt2bRatWnt signaling, canonical pathway   ISORGD:733303 RGD 
Wnt2bMouseWnt signaling, canonical pathway   ISORGD:733303 RGD 
Wnt3RatWnt signaling, canonical pathway   ISORGD:1344120 RGD 
Wnt3MouseWnt signaling, canonical pathway   ISORGD:1344120 RGD 
Wnt3aRatWnt signaling, canonical pathway   ISORGD:1317606 RGD 
Wnt3aMouseWnt signaling, canonical pathway   ISORGD:1317606 RGD 
Wnt4RatWnt signaling, canonical pathway   ISORGD:733867 RGD 
Wnt4MouseWnt signaling, canonical pathway   ISORGD:733867 RGD 
Wnt5aRatWnt signaling, canonical pathway   ISORGD:1353257 RGD 
Wnt5aMouseWnt signaling, canonical pathway   ISORGD:1353257 RGD 
Wnt5bRatWnt signaling, canonical pathway   ISORGD:1346792 RGD 
Wnt5bMouseWnt signaling, canonical pathway   ISORGD:1346792 RGD 
Wnt6RatWnt signaling, canonical pathway   ISORGD:1312067 RGD 
Wnt6MouseWnt signaling, canonical pathway   ISORGD:1312067 RGD 
Wnt7aRatWnt signaling, canonical pathway   ISORGD:69159 RGD 
Wnt7aMouseWnt signaling, canonical pathway   ISORGD:69159 RGD 
Wnt7bRatWnt signaling, canonical pathway   ISORGD:13229006 RGD 
Wnt7bMouseWnt signaling, canonical pathway   ISORGD:13229006 RGD 
Wnt8aRatWnt signaling, canonical pathway   ISORGD:1314861 RGD 
Wnt8aMouseWnt signaling, canonical pathway   ISORGD:1314861 RGD 
Wnt8bRatWnt signaling, canonical pathway   ISORGD:1316953 RGD 
Wnt8bMouseWnt signaling, canonical pathway   ISORGD:1316953 RGD 
Wnt9aRatWnt signaling, canonical pathway   ISORGD:1312797 RGD 
Wnt9aMouseWnt signaling, canonical pathway   ISORGD:1312797 RGD 
Wnt9bRatWnt signaling, canonical pathway   ISORGD:1319983 RGD 
Wnt9bMouseWnt signaling, canonical pathway   ISORGD:1319983 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Wnt1  (Wnt family member 1)
Wnt10a  (Wnt family member 10A)
Wnt10b  (Wnt family member 10B)
Wnt11  (Wnt family member 11)
Wnt16  (Wnt family member 16)
Wnt2  (Wnt family member 2)
Wnt2b  (Wnt family member 2B)
Wnt3  (Wnt family member 3)
Wnt3a  (Wnt family member 3A)
Wnt4  (Wnt family member 4)
Wnt5a  (Wnt family member 5A)
Wnt5b  (Wnt family member 5B)
Wnt6  (Wnt family member 6)
Wnt7a  (Wnt family member 7A)
Wnt7b  (Wnt family member 7B)
Wnt8a  (Wnt family member 8A)
Wnt8b  (Wnt family member 8B)
Wnt9a  (Wnt family member 9A)
Wnt9b  (Wnt family member 9B)

Genes (Mus musculus)
Wnt1  (wingless-type MMTV integration site family, member 1)
Wnt10a  (wingless-type MMTV integration site family, member 10A)
Wnt10b  (wingless-type MMTV integration site family, member 10B)
Wnt11  (wingless-type MMTV integration site family, member 11)
Wnt16  (wingless-type MMTV integration site family, member 16)
Wnt2  (wingless-type MMTV integration site family, member 2)
Wnt2b  (wingless-type MMTV integration site family, member 2B)
Wnt3  (wingless-type MMTV integration site family, member 3)
Wnt3a  (wingless-type MMTV integration site family, member 3A)
Wnt4  (wingless-type MMTV integration site family, member 4)
Wnt5a  (wingless-type MMTV integration site family, member 5A)
Wnt5b  (wingless-type MMTV integration site family, member 5B)
Wnt6  (wingless-type MMTV integration site family, member 6)
Wnt7a  (wingless-type MMTV integration site family, member 7A)
Wnt7b  (wingless-type MMTV integration site family, member 7B)
Wnt8a  (wingless-type MMTV integration site family, member 8A)
Wnt8b  (wingless-type MMTV integration site family, member 8B)
Wnt9a  (wingless-type MMTV integration site family, member 9A)
Wnt9b  (wingless-type MMTV integration site family, member 9B)

Genes (Homo sapiens)
WNT1  (Wnt family member 1)
WNT10A  (Wnt family member 10A)
WNT10B  (Wnt family member 10B)
WNT11  (Wnt family member 11)
WNT16  (Wnt family member 16)
WNT2  (Wnt family member 2)
WNT2B  (Wnt family member 2B)
WNT3  (Wnt family member 3)
WNT3A  (Wnt family member 3A)
WNT4  (Wnt family member 4)
WNT5A  (Wnt family member 5A)
WNT5B  (Wnt family member 5B)
WNT6  (Wnt family member 6)
WNT7A  (Wnt family member 7A)
WNT7B  (Wnt family member 7B)
WNT8A  (Wnt family member 8A)
WNT8B  (Wnt family member 8B)
WNT9A  (Wnt family member 9A)
WNT9B  (Wnt family member 9B)


Additional Information