RGD Reference Report - Alternative wnt signaling is initiated by distinct receptors. - Rat Genome Database

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Alternative wnt signaling is initiated by distinct receptors.

Authors: Van Amerongen, R  Mikels, A  Nusse, R 
Citation: van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
RGD ID: 2313743
Pubmed: PMID:18765832   (View Abstract at PubMed)
DOI: DOI:10.1126/scisignal.135re9   (Journal Full-text)

An unanswered question in the field of signal transduction research is how different signaling pathways are activated with strict specificity in a temporally and spatially controlled manner. Because extracellular ligands and membrane receptors constitute the first signaling modalities for most pathways, selectivity in ligand-receptor binding likely dictates the outcome of downstream signaling events. Unfortunately, possible complexities underlying ligand-receptor interactions are often overlooked. Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Wnt signaling, canonical pathway   TAS 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT1 (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT10A (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT10B (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT11 (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT16 (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT2 (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT2B (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT3 (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT3A (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT4 (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT5A (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT5B (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT6 (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT7A (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOLOC111096312 (Canis lupus familiaris)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT8A (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT8B (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT9A (Homo sapiens)2313743; 2313743 RGD 
Wnt signaling, canonical pathway   ISOWNT9B (Homo sapiens)2313743; 2313743 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Wnt1  (Wnt family member 1)
Wnt10a  (Wnt family member 10A)
Wnt10b  (Wnt family member 10B)
Wnt11  (Wnt family member 11)
Wnt16  (Wnt family member 16)
Wnt2  (Wnt family member 2)
Wnt2b  (Wnt family member 2B)
Wnt3  (Wnt family member 3)
Wnt3a  (Wnt family member 3A)
Wnt4  (Wnt family member 4)
Wnt5a  (Wnt family member 5A)
Wnt5b  (Wnt family member 5B)
Wnt6  (Wnt family member 6)
Wnt7a  (Wnt family member 7A)
Wnt7b  (Wnt family member 7B)
Wnt8a  (Wnt family member 8A)
Wnt8b  (Wnt family member 8B)
Wnt9a  (Wnt family member 9A)
Wnt9b  (Wnt family member 9B)

Genes (Mus musculus)
Wnt1  (wingless-type MMTV integration site family, member 1)
Wnt10a  (wingless-type MMTV integration site family, member 10A)
Wnt10b  (wingless-type MMTV integration site family, member 10B)
Wnt11  (wingless-type MMTV integration site family, member 11)
Wnt16  (wingless-type MMTV integration site family, member 16)
Wnt2  (wingless-type MMTV integration site family, member 2)
Wnt2b  (wingless-type MMTV integration site family, member 2B)
Wnt3  (wingless-type MMTV integration site family, member 3)
Wnt3a  (wingless-type MMTV integration site family, member 3A)
Wnt4  (wingless-type MMTV integration site family, member 4)
Wnt5a  (wingless-type MMTV integration site family, member 5A)
Wnt5b  (wingless-type MMTV integration site family, member 5B)
Wnt6  (wingless-type MMTV integration site family, member 6)
Wnt7a  (wingless-type MMTV integration site family, member 7A)
Wnt7b  (wingless-type MMTV integration site family, member 7B)
Wnt8a  (wingless-type MMTV integration site family, member 8A)
Wnt8b  (wingless-type MMTV integration site family, member 8B)
Wnt9a  (wingless-type MMTV integration site family, member 9A)
Wnt9b  (wingless-type MMTV integration site family, member 9B)

Genes (Homo sapiens)
WNT1  (Wnt family member 1)
WNT10A  (Wnt family member 10A)
WNT10B  (Wnt family member 10B)
WNT11  (Wnt family member 11)
WNT16  (Wnt family member 16)
WNT2  (Wnt family member 2)
WNT2B  (Wnt family member 2B)
WNT3  (Wnt family member 3)
WNT3A  (Wnt family member 3A)
WNT4  (Wnt family member 4)
WNT5A  (Wnt family member 5A)
WNT5B  (Wnt family member 5B)
WNT6  (Wnt family member 6)
WNT7A  (Wnt family member 7A)
WNT7B  (Wnt family member 7B)
WNT8A  (Wnt family member 8A)
WNT8B  (Wnt family member 8B)
WNT9A  (Wnt family member 9A)
WNT9B  (Wnt family member 9B)


Additional Information