Alternative wnt signaling is initiated by distinct receptors.
Authors:
Van Amerongen, R Mikels, A Nusse, R
Citation:
van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
RGD ID:
2313743
Pubmed:
PMID:18765832 (View Abstract at PubMed)
DOI:
DOI:10.1126/scisignal.135re9 (Journal Full-text)
An unanswered question in the field of signal transduction research is how different signaling pathways are activated with strict specificity in a temporally and spatially controlled manner. Because extracellular ligands and membrane receptors constitute the first signaling modalities for most pathways, selectivity in ligand-receptor binding likely dictates the outcome of downstream signaling events. Unfortunately, possible complexities underlying ligand-receptor interactions are often overlooked. Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example.
RGD Manual Annotations
Only show annotations with direct experimental evidence (0 objects hidden)
Wnt signaling, canonical pathway TAS 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT1 (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT10A (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT10B (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT11 (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT16 (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT2 (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT2B (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT3 (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT3A (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT4 (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT5A (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT5B (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT6 (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT7A (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO LOC111096312 (Canis lupus familiaris) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT8A (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT8B (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT9A (Homo sapiens) 2313743 ; 2313743 RGD Wnt signaling, canonical pathway ISO WNT9B (Homo sapiens) 2313743 ; 2313743 RGD
Molecular Pathway Annotations
Objects Annotated
Genes (Rattus norvegicus)
Wnt1 (Wnt family member 1) Wnt10a (Wnt family member 10A) Wnt10b (Wnt family member 10B) Wnt11 (Wnt family member 11) Wnt16 (Wnt family member 16) Wnt2 (Wnt family member 2) Wnt2b (Wnt family member 2B)
Wnt3 (Wnt family member 3) Wnt3a (Wnt family member 3A) Wnt4 (Wnt family member 4) Wnt5a (Wnt family member 5A) Wnt5b (Wnt family member 5B) Wnt6 (Wnt family member 6) Wnt7a (Wnt family member 7A)
Wnt7b (Wnt family member 7B) Wnt8a (Wnt family member 8A) Wnt8b (Wnt family member 8B) Wnt9a (Wnt family member 9A) Wnt9b (Wnt family member 9B)
Genes (Mus musculus)
Wnt1 (wingless-type MMTV integration site family, member 1) Wnt10a (wingless-type MMTV integration site family, member 10A) Wnt10b (wingless-type MMTV integration site family, member 10B) Wnt11 (wingless-type MMTV integration site family, member 11) Wnt16 (wingless-type MMTV integration site family, member 16) Wnt2 (wingless-type MMTV integration site family, member 2) Wnt2b (wingless-type MMTV integration site family, member 2B)
Wnt3 (wingless-type MMTV integration site family, member 3) Wnt3a (wingless-type MMTV integration site family, member 3A) Wnt4 (wingless-type MMTV integration site family, member 4) Wnt5a (wingless-type MMTV integration site family, member 5A) Wnt5b (wingless-type MMTV integration site family, member 5B) Wnt6 (wingless-type MMTV integration site family, member 6) Wnt7a (wingless-type MMTV integration site family, member 7A)
Wnt7b (wingless-type MMTV integration site family, member 7B) Wnt8a (wingless-type MMTV integration site family, member 8A) Wnt8b (wingless-type MMTV integration site family, member 8B) Wnt9a (wingless-type MMTV integration site family, member 9A) Wnt9b (wingless-type MMTV integration site family, member 9B)
Genes (Homo sapiens)
WNT1 (Wnt family member 1) WNT10A (Wnt family member 10A) WNT10B (Wnt family member 10B) WNT11 (Wnt family member 11) WNT16 (Wnt family member 16) WNT2 (Wnt family member 2) WNT2B (Wnt family member 2B)
WNT3 (Wnt family member 3) WNT3A (Wnt family member 3A) WNT4 (Wnt family member 4) WNT5A (Wnt family member 5A) WNT5B (Wnt family member 5B) WNT6 (Wnt family member 6) WNT7A (Wnt family member 7A)
WNT7B (Wnt family member 7B) WNT8A (Wnt family member 8A) WNT8B (Wnt family member 8B) WNT9A (Wnt family member 9A) WNT9B (Wnt family member 9B)
Additional Information