Hoxc9 (homeobox C9) - Rat Genome Database

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Gene: Hoxc9 (homeobox C9) Rattus norvegicus
Analyze
Symbol: Hoxc9
Name: homeobox C9
RGD ID: 1595784
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within anterior/posterior pattern specification and embryonic skeletal system morphogenesis. Predicted to be located in aggresome and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human HOXC9 (homeobox C9); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: homeo box C9; homeobox protein Hox-C9; Hoxc8; LOC300264
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,997,292 - 135,999,969 (+)NCBIGRCr8
mRatBN7.27134,118,817 - 134,121,497 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7134,118,817 - 134,121,492 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,874,221 - 135,876,886 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07138,103,596 - 138,106,261 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07138,089,529 - 138,092,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,592,462 - 144,598,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,595,960 - 144,598,632 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07142,383,988 - 142,390,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,745,173 - 141,775,242 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7130,544,848 - 130,547,525 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Chromosomal assignment of seven rat homeobox genes to rat chromosomes 3, 4, 7, and 10. Chung SY, etal., Mamm Genome 1993 Sep;4(9):537-40.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2907739   PMID:7547473   PMID:7702549   PMID:8889548   PMID:11870622   PMID:17626057  


Genomics

Comparative Map Data
Hoxc9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,997,292 - 135,999,969 (+)NCBIGRCr8
mRatBN7.27134,118,817 - 134,121,497 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7134,118,817 - 134,121,492 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,874,221 - 135,876,886 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07138,103,596 - 138,106,261 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07138,089,529 - 138,092,226 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,592,462 - 144,598,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,595,960 - 144,598,632 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07142,383,988 - 142,390,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,745,173 - 141,775,242 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7130,544,848 - 130,547,525 (+)NCBICelera
Cytogenetic Map7q36NCBI
HOXC9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381254,000,161 - 54,003,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,994,895 - 54,003,337 (+)EnsemblGRCh38hg38GRCh38
GRCh371254,393,945 - 54,397,121 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361252,680,144 - 52,683,388 (+)NCBINCBI36Build 36hg18NCBI36
Build 341252,680,143 - 52,683,385NCBI
Celera1254,043,494 - 54,046,738 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1251,431,589 - 51,434,833 (+)NCBIHuRef
CHM1_11254,360,582 - 54,363,824 (+)NCBICHM1_1
T2T-CHM13v2.01253,965,683 - 53,968,859 (+)NCBIT2T-CHM13v2.0
Hoxc9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,885,467 - 102,893,324 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,884,874 - 102,893,531 (+)EnsemblGRCm39 Ensembl
GRCm3815102,977,032 - 102,984,444 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,976,439 - 102,985,099 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715102,807,463 - 102,814,875 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615102,805,066 - 102,812,478 (+)NCBIMGSCv36mm8
Celera15105,137,957 - 105,145,366 (+)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1558.04NCBI
Hoxc9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554581,258,364 - 1,261,510 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554581,258,364 - 1,261,510 (+)NCBIChiLan1.0ChiLan1.0
HOXC9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21040,182,580 - 40,191,726 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11240,179,234 - 40,184,613 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01234,751,922 - 34,755,157 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11235,540,234 - 35,543,486 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1235,540,234 - 35,543,486 (-)Ensemblpanpan1.1panPan2
HOXC9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2744,986,842 - 44,990,561 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0271,262,717 - 1,266,438 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1271,280,424 - 1,284,140 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,261,960 - 1,265,657 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02745,390,457 - 45,394,183 (+)NCBIUU_Cfam_GSD_1.0
Hoxc9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494561,939,375 - 61,942,710 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651211,217,547 - 11,225,455 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651211,222,120 - 11,225,455 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HOXC9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl519,212,905 - 19,215,984 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1519,212,490 - 19,215,859 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2519,637,238 - 19,644,861 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HOXC9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11150,110,729 - 50,113,986 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1150,110,753 - 50,113,975 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037195,928,198 - 195,931,419 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hoxc9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249042,054,386 - 2,058,539 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249042,054,768 - 2,058,556 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hoxc9
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:55
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000021909
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
Hoxc8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27134,129,956 - 134,130,058 (+)MAPPERmRatBN7.2
Rnor_6.07144,607,093 - 144,607,194NCBIRnor6.0
Rnor_5.07142,398,450 - 142,398,551UniSTSRnor5.0
RGSC_v3.47141,756,303 - 141,756,404UniSTSRGSC3.4
Celera7130,555,856 - 130,555,957UniSTS
Cytogenetic Map7q35UniSTS
Cytogenetic Map7q36UniSTS
Hoxc9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27134,121,169 - 134,121,357 (+)MAPPERmRatBN7.2
Rnor_6.07144,598,310 - 144,598,497NCBIRnor6.0
Rnor_5.07142,389,667 - 142,389,854UniSTSRnor5.0
RGSC_v3.47141,747,523 - 141,747,710UniSTSRGSC3.4
Celera7130,547,198 - 130,547,385UniSTS
Cytogenetic Map7q35UniSTS
Cytogenetic Map7q36UniSTS
PMC15172P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27134,121,115 - 134,121,492 (+)MAPPERmRatBN7.2
Rnor_6.07144,598,256 - 144,598,632NCBIRnor6.0
Rnor_5.07142,389,613 - 142,389,989UniSTSRnor5.0
RGSC_v3.47141,747,469 - 141,747,845UniSTSRGSC3.4
Celera7130,547,144 - 130,547,520UniSTS
Cytogenetic Map7q35UniSTS
Cytogenetic Map7q36UniSTS
MARC_41665-41666:1086710236:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27134,128,189 - 134,129,758 (+)MAPPERmRatBN7.2
Rnor_6.07144,605,325 - 144,606,894NCBIRnor6.0
Rnor_5.07142,396,682 - 142,398,251UniSTSRnor5.0
RGSC_v3.47141,754,536 - 141,756,104UniSTSRGSC3.4
Celera7130,554,088 - 130,555,657UniSTS
Cytogenetic Map7q35UniSTS
Cytogenetic Map7q36UniSTS
MARC_46193-46194:1108499233:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27134,136,958 - 134,137,573 (+)MAPPERmRatBN7.2
Rnor_6.07144,614,095 - 144,614,709NCBIRnor6.0
Rnor_5.07142,405,452 - 142,406,066UniSTSRnor5.0
RGSC_v3.47141,763,306 - 141,763,920UniSTSRGSC3.4
Celera7130,562,858 - 130,563,472UniSTS
Cytogenetic Map7q35UniSTS
Cytogenetic Map7q36UniSTS
Hoxc9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27134,118,954 - 134,119,058 (+)MAPPERmRatBN7.2
Rnor_6.07144,592,790 - 144,592,893NCBIRnor6.0
Rnor_6.07144,596,098 - 144,596,201NCBIRnor6.0
Rnor_5.07142,387,455 - 142,387,558UniSTSRnor5.0
Rnor_5.07142,384,147 - 142,384,250UniSTSRnor5.0
Celera7130,544,986 - 130,545,089UniSTS
Cytogenetic Map7q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 6 31 39 29 12 14 12 6 117 43 11 45 60 17

Sequence


Ensembl Acc Id: ENSRNOT00000021909   ⟹   ENSRNOP00000021910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7134,118,817 - 134,121,492 (+)Ensembl
Rnor_6.0 Ensembl7144,595,960 - 144,598,632 (+)Ensembl
RefSeq Acc Id: NM_001100907   ⟹   NP_001094377
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,997,292 - 135,999,969 (+)NCBI
mRatBN7.27134,118,817 - 134,121,497 (+)NCBI
Rnor_6.07144,595,960 - 144,598,637 (+)NCBI
Rnor_5.07142,383,988 - 142,390,164 (+)NCBI
Celera7130,544,848 - 130,547,525 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001094377 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021910.4
RefSeq Acc Id: NP_001094377   ⟸   NM_001100907
- UniProtKB: D4A0V9 (UniProtKB/TrEMBL),   A6KCY8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021910   ⟸   ENSRNOT00000021909
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A0V9-F1-model_v2 AlphaFold D4A0V9 1-260 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695710
Promoter ID:EPDNEW_R6235
Type:single initiation site
Name:Hoxc9_1
Description:homeobox C9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07144,595,932 - 144,595,992EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595784 AgrOrtholog
BioCyc Gene G2FUF-31913 BioCyc
Ensembl Genes ENSRNOG00000016199 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021909.6 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Abd-B_homeobox_TF UniProtKB/TrEMBL
  Homeobox-like UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_Hox9 UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
  Hox9_activation_N UniProtKB/TrEMBL
KEGG Report rno:368178 UniProtKB/TrEMBL
NCBI Gene 368178 ENTREZGENE
PANTHER AGAP004664-PA UniProtKB/TrEMBL
  HOMEOBOX PROTEIN HOX-C9 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
  Hox9_act UniProtKB/TrEMBL
PhenoGen Hoxc9 PhenoGen
PIRSF Homeobox_Hox9 UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016199 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A6KCY8 ENTREZGENE, UniProtKB/TrEMBL
  D4A0V9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-15 Hoxc9  homeobox C9  Hoxc9_predicted  homeo box C9 (predicted)  Data merged from RGD:1305802 1643240 APPROVED
2008-03-04 Hoxc9  homeobox C9  Hoxc8  homeo box C8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   homeo box C8  Hoxc8  homeo box C8 (mapped)  Name updated 737654 APPROVED
2007-04-11 Hoxc8  homeo box C8 (mapped)  Hoxc8_mapped  homeo box C8 (mapped)  Data merged from RGD:2821 737654 APPROVED
2006-11-20 Hoxc8  homeo box C8 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Hoxc8_mapped  homeo box C8 (mapped)  Hoxc8  homeo box C8  Symbol and Name updated 1556543 APPROVED
2005-01-12 Hoxc9_predicted  homeo box C9 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-06-10 Hoxc8  Homeobox gene C8      Symbol and Name status set to approved 70586 APPROVED