Slc4a8 (solute carrier family 4 member 8) - Rat Genome Database

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Gene: Slc4a8 (solute carrier family 4 member 8) Rattus norvegicus
Analyze
Symbol: Slc4a8
Name: solute carrier family 4 member 8
RGD ID: 735164
Description: Enables identical protein binding activity and sodium,bicarbonate:chloride antiporter activity. Involved in basolateral protein secretion and regulation of intracellular pH. Located in several cellular components, including axon; basolateral plasma membrane; and synaptic vesicle membrane. Biomarker of prediabetes syndrome. Orthologous to human SLC4A8 (solute carrier family 4 member 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: electroneutral Na+-driven Cl-HCO3 exchanger; electroneutral sodium bicarbonate exchanger 1; k-NBC3; LOC315311; Na-driven Cl-HCO3 exchanger NDCBE1-A; Na-driven Cl-HCO3 exchanger NDCBE1-B; Na-driven Cl-HCO3 exchanger NDCBE1-C; solute carrier family 4 (anion exchanger), member 8; solute carrier family 4, sodium bicarbonate cotransporter, member 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27131,861,284 - 131,937,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,864,102 - 131,931,051 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,664,012 - 133,733,918 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07135,889,610 - 135,959,523 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07135,803,492 - 135,871,430 (+)NCBIRnor_WKY
Rnor_6.07142,397,352 - 142,467,398 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,397,371 - 142,464,158 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,201,544 - 140,271,679 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,230,085 - 139,575,631 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17139,306,521 - 139,652,068 (+)NCBI
Celera7128,340,100 - 128,399,333 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Effect of prediabetes on membrane bicarbonate transporters in testis and epididymis. Bernardino RL, etal., J Membr Biol. 2013 Dec;246(12):877-83. doi: 10.1007/s00232-013-9601-4. Epub 2013 Oct 9.
2. The sodium-driven chloride/bicarbonate exchanger in presynaptic terminals. Burette AC, etal., J Comp Neurol. 2012 May 1;520(7):1481-92. doi: 10.1002/cne.22806.
3. Expression and localization of Na-driven Cl-HCO(3)(-) exchanger (SLC4A8) in rodent CNS. Chen LM, etal., Neuroscience. 2008 Apr 22;153(1):162-74. doi: 10.1016/j.neuroscience.2008.02.018. Epub 2008 Feb 21.
4. Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues. Damkier HH, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R2136-46. doi: 10.1152/ajpregu.00356.2007. Epub 2007 Aug 22.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. The sodium-driven chloride/bicarbonate exchanger NDCBE in rat brain is upregulated by chronic metabolic acidosis. Lee HJ, etal., Brain Res. 2011 Mar 4;1377:13-20. doi: 10.1016/j.brainres.2010.12.062. Epub 2010 Dec 30.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Information Derived from GenBank Report RGD, Sept. 2003
12. Regulation of intracellular pH in pyramidal neurones from the rat hippocampus by Na(+)-dependent Cl(-)-HCO3- exchange. Schwiening CJ and Boron WF, J Physiol. 1994 Feb 15;475(1):59-67. doi: 10.1113/jphysiol.1994.sp020049.
13. Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE. Wang W, etal., Nat Commun. 2021 Sep 28;12(1):5690. doi: 10.1038/s41467-021-25998-2.
Additional References at PubMed
PMID:11133997   PMID:16916513   PMID:18577713   PMID:21593314   PMID:23500099   PMID:23677982  


Genomics

Comparative Map Data
Slc4a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27131,861,284 - 131,937,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,864,102 - 131,931,051 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,664,012 - 133,733,918 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07135,889,610 - 135,959,523 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07135,803,492 - 135,871,430 (+)NCBIRnor_WKY
Rnor_6.07142,397,352 - 142,467,398 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,397,371 - 142,464,158 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,201,544 - 140,271,679 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,230,085 - 139,575,631 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17139,306,521 - 139,652,068 (+)NCBI
Celera7128,340,100 - 128,399,333 (+)NCBICelera
Cytogenetic Map7q36NCBI
SLC4A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,391,446 - 51,515,763 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1251,391,317 - 51,515,763 (+)EnsemblGRCh38hg38GRCh38
GRCh371251,785,230 - 51,909,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,104,861 - 50,189,247 (+)NCBINCBI36Build 36hg18NCBI36
Build 341250,105,023 - 50,177,915NCBI
Celera1250,620,062 - 50,705,110 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1248,818,058 - 48,942,408 (+)NCBIHuRef
CHM1_11251,751,635 - 51,876,068 (+)NCBICHM1_1
T2T-CHM13v2.01251,354,255 - 51,479,285 (+)NCBIT2T-CHM13v2.0
Slc4a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,659,628 - 100,721,852 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,659,628 - 100,721,849 (+)EnsemblGRCm39 Ensembl
GRCm3815100,761,747 - 100,823,971 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,761,747 - 100,823,968 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715100,592,178 - 100,654,402 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615100,589,836 - 100,643,959 (+)NCBIMGSCv36mm8
Celera15102,908,446 - 102,971,080 (+)NCBICelera
Cytogenetic Map15F1NCBI
Slc4a8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555471,896,862 - 1,969,975 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555471,896,597 - 1,975,285 (+)NCBIChiLan1.0ChiLan1.0
SLC4A8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11238,126,246 - 38,214,036 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1238,134,574 - 38,214,036 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01237,243,593 - 37,329,083 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC4A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,398,776 - 3,460,562 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,403,804 - 3,460,583 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2742,783,879 - 42,858,653 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,392,807 - 3,467,680 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,397,596 - 3,467,725 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,411,808 - 3,486,454 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,398,150 - 3,473,015 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,181,640 - 43,256,519 (+)NCBIUU_Cfam_GSD_1.0
Slc4a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494564,104,543 - 64,176,618 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365128,988,390 - 9,054,997 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365128,988,212 - 9,060,287 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC4A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl516,842,710 - 16,974,004 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1516,842,667 - 16,921,669 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2517,478,543 - 17,580,590 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC4A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,622,602 - 47,704,975 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1147,622,640 - 47,703,215 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037198,388,160 - 198,471,870 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc4a8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816738,237 - 822,140 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624816714,766 - 821,340 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc4a8
458 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:49
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000040890, ENSRNOT00000065379
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
D7Rat90  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,874,715 - 131,874,923 (+)MAPPERmRatBN7.2
Rnor_6.07142,407,471 - 142,407,676NCBIRnor6.0
Rnor_5.07140,211,652 - 140,211,857UniSTSRnor5.0
Celera7128,348,953 - 128,349,158UniSTS
FHH x ACI Map771.29RGD
FHH x ACI Map771.29UniSTS
Cytogenetic Map7q36UniSTS
D7Got244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,772,507 - 131,772,677 (+)MAPPERmRatBN7.2
Rnor_6.07142,304,682 - 142,304,851NCBIRnor6.0
Rnor_5.07140,109,828 - 140,109,997UniSTSRnor5.0
RGSC_v3.47139,438,650 - 139,438,819UniSTSRGSC3.4
Celera7128,248,772 - 128,248,941UniSTS
Cytogenetic Map7q36UniSTS
BF394701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,930,877 - 131,931,033 (+)MAPPERmRatBN7.2
Rnor_6.07142,463,985 - 142,464,140NCBIRnor6.0
Rnor_5.07140,266,800 - 140,266,955UniSTSRnor5.0
RGSC_v3.47139,575,458 - 139,575,613UniSTSRGSC3.4
Celera7128,399,160 - 128,399,315UniSTS
RH 3.4 Map71064.8UniSTS
Cytogenetic Map7q36UniSTS
BF405593  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,617,278 - 131,617,481 (+)MAPPERmRatBN7.2
Rnor_6.07142,139,338 - 142,139,540NCBIRnor6.0
Rnor_5.07139,946,809 - 139,947,011UniSTSRnor5.0
RGSC_v3.47139,254,519 - 139,254,721UniSTSRGSC3.4
Celera7128,094,509 - 128,094,711UniSTS
RH 3.4 Map71076.9UniSTS
Cytogenetic Map7q36UniSTS
RH134575  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,627,768 - 131,627,948 (+)MAPPERmRatBN7.2
Rnor_6.07142,149,828 - 142,150,007NCBIRnor6.0
Rnor_5.07139,957,299 - 139,957,478UniSTSRnor5.0
RGSC_v3.47139,265,009 - 139,265,188UniSTSRGSC3.4
Celera7128,105,001 - 128,105,180UniSTS
RH 3.4 Map71052.6UniSTS
Cytogenetic Map7q36UniSTS
RH134787  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,713,410 - 131,713,598 (+)MAPPERmRatBN7.2
Rnor_6.07142,237,446 - 142,237,633NCBIRnor6.0
Rnor_5.07140,042,101 - 140,042,288UniSTSRnor5.0
RGSC_v3.47139,360,537 - 139,360,724UniSTSRGSC3.4
Celera7128,188,645 - 128,188,832UniSTS
RH 3.4 Map71064.8UniSTS
Cytogenetic Map7q36UniSTS
RH137997  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,807,028 - 131,807,152 (+)MAPPERmRatBN7.2
Rnor_6.07142,339,756 - 142,339,879NCBIRnor6.0
Rnor_5.07140,144,580 - 140,144,703UniSTSRnor5.0
RGSC_v3.47139,473,488 - 139,473,611UniSTSRGSC3.4
Celera7128,283,066 - 128,283,189UniSTS
RH 3.4 Map71064.8UniSTS
Cytogenetic Map7q36UniSTS
RH142093  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,816,108 - 131,816,328 (+)MAPPERmRatBN7.2
Rnor_6.07142,348,836 - 142,349,055NCBIRnor6.0
Rnor_5.07140,153,660 - 140,153,879UniSTSRnor5.0
RGSC_v3.47139,482,568 - 139,482,787UniSTSRGSC3.4
Celera7128,292,146 - 128,292,365UniSTS
RH 3.4 Map71065.7UniSTS
Cytogenetic Map7q36UniSTS
AI179648  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,616,799 - 131,616,986 (+)MAPPERmRatBN7.2
Rnor_6.07142,138,859 - 142,139,045NCBIRnor6.0
Rnor_5.07139,946,330 - 139,946,516UniSTSRnor5.0
RGSC_v3.47139,254,040 - 139,254,226UniSTSRGSC3.4
Celera7128,094,030 - 128,094,216UniSTS
RH 3.4 Map71076.3UniSTS
Cytogenetic Map7q36UniSTS
BQ201011  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,801,329 - 131,801,491 (+)MAPPERmRatBN7.2
Rnor_6.07142,334,057 - 142,334,218NCBIRnor6.0
Rnor_5.07140,138,881 - 140,139,042UniSTSRnor5.0
RGSC_v3.47139,467,790 - 139,467,951UniSTSRGSC3.4
Celera7128,277,367 - 128,277,528UniSTS
RH 3.4 Map71073.7UniSTS
Cytogenetic Map7q36UniSTS
BE097103  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,677,734 - 131,677,913 (+)MAPPERmRatBN7.2
Rnor_6.07142,201,630 - 142,201,808NCBIRnor6.0
Rnor_5.07140,006,285 - 140,006,463UniSTSRnor5.0
RGSC_v3.47139,323,377 - 139,323,555UniSTSRGSC3.4
Celera7128,153,171 - 128,153,349UniSTS
RH 3.4 Map71065.1UniSTS
Cytogenetic Map7q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64 3
Low 2 20 21 5 17 5 10 35 37 11
Below cutoff 1 23 22 22 2 22 8 11 1 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000040890   ⟹   ENSRNOP00000043825
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,864,102 - 131,931,051 (+)Ensembl
Rnor_6.0 Ensembl7142,397,371 - 142,464,043 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000065379   ⟹   ENSRNOP00000059220
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,881,090 - 131,929,840 (+)Ensembl
Rnor_6.0 Ensembl7142,397,413 - 142,464,158 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094837   ⟹   ENSRNOP00000097887
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,864,102 - 131,881,558 (+)Ensembl
RefSeq Acc Id: NM_001270794   ⟹   NP_001257723
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27131,864,102 - 131,931,051 (+)NCBI
Rnor_6.07142,397,413 - 142,464,158 (+)NCBI
Rnor_5.07140,201,544 - 140,271,679 (+)NCBI
Celera7128,340,100 - 128,399,333 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270795   ⟹   NP_001257724
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27131,864,102 - 131,931,051 (+)NCBI
Rnor_6.07142,397,413 - 142,464,158 (+)NCBI
Rnor_5.07140,201,544 - 140,271,679 (+)NCBI
Celera7128,340,100 - 128,399,333 (+)NCBI
Sequence:
RefSeq Acc Id: NM_199497   ⟹   NP_955791
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27131,864,102 - 131,931,051 (+)NCBI
Rnor_6.07142,397,413 - 142,464,158 (+)NCBI
Rnor_5.07140,201,544 - 140,271,679 (+)NCBI
RGSC_v3.47139,230,085 - 139,575,631 (+)RGD
Celera7128,340,100 - 128,399,333 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594897   ⟹   XP_017450386
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27131,864,015 - 131,937,963 (+)NCBI
Rnor_6.07142,397,352 - 142,467,398 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594898   ⟹   XP_017450387
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27131,895,368 - 131,937,963 (+)NCBI
Rnor_6.07142,428,491 - 142,467,398 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039079342   ⟹   XP_038935270
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27131,864,012 - 131,937,963 (+)NCBI
RefSeq Acc Id: XM_039079343   ⟹   XP_038935271
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27131,861,284 - 131,937,963 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_955791   ⟸   NM_199497
- Peptide Label: isoform 1
- UniProtKB: Q6RVG3 (UniProtKB/Swiss-Prot),   Q6RVG2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257723   ⟸   NM_001270794
- Peptide Label: isoform 2
- UniProtKB: Q6RVG2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257724   ⟸   NM_001270795
- Peptide Label: isoform 3
- UniProtKB: Q6RVG2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017450386   ⟸   XM_017594897
- Peptide Label: isoform X1
- UniProtKB: F1LUB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450387   ⟸   XM_017594898
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000059220   ⟸   ENSRNOT00000065379
RefSeq Acc Id: ENSRNOP00000043825   ⟸   ENSRNOT00000040890
RefSeq Acc Id: XP_038935271   ⟸   XM_039079343
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038935270   ⟸   XM_039079342
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000097887   ⟸   ENSRNOT00000094837
Protein Domains
Band_3_cyto   HCO3_cotransp

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6RVG2-F1-model_v2 AlphaFold Q6RVG2 1-1067 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735164 AgrOrtholog
BioCyc Gene G2FUF-32007 BioCyc
Ensembl Genes ENSRNOG00000028879 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000043825 ENTREZGENE
  ENSRNOP00000043825.5 UniProtKB/TrEMBL
  ENSRNOP00000059220 ENTREZGENE
  ENSRNOP00000059220.4 UniProtKB/TrEMBL
  ENSRNOP00000097887.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040890 ENTREZGENE
  ENSRNOT00000040890.7 UniProtKB/TrEMBL
  ENSRNOT00000065379 ENTREZGENE
  ENSRNOT00000065379.4 UniProtKB/TrEMBL
  ENSRNOT00000094837.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.930.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Band3_cytoplasmic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_transpt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_transpt_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/HCO3_transpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTrfase/Anion_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:315311 UniProtKB/Swiss-Prot
NCBI Gene 315311 ENTREZGENE
PANTHER PTHR11453 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Band_3_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_cotransp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc4a8 PhenoGen
PRINTS HCO3TRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAHCO3TRSPRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55804 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs TIGR00834 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GM95_RAT UniProtKB/TrEMBL
  A0A8L2QRW9_RAT UniProtKB/TrEMBL
  F1LUB7 ENTREZGENE, UniProtKB/TrEMBL
  Q6RVG2 ENTREZGENE
  Q6RVG3 ENTREZGENE
  S4A8_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6RVG1 UniProtKB/Swiss-Prot
  Q6RVG3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc4a8  solute carrier family 4 member 8  Slc4a8  solute carrier family 4, sodium bicarbonate cotransporter, member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-02-23 Slc4a8  solute carrier family 4, sodium bicarbonate cotransporter, member 8  Slc4a8  solute carrier family 4 (anion exchanger), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Slc4a8  solute carrier family 4 (anion exchanger), member 8  LOC315311  Na-driven Cl-HCO3 exchanger NDCBE1-A  Symbol and Name updated 1299863 APPROVED