Ndrg1 (N-myc downstream regulated 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ndrg1 (N-myc downstream regulated 1) Rattus norvegicus
Analyze
Symbol: Ndrg1
Name: N-myc downstream regulated 1
RGD ID: 1307303
Description: Predicted to enable cadherin binding activity; small GTPase binding activity; and tubulin binding activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; cellular response to hypoxia; and peripheral nervous system myelin maintenance. Predicted to act upstream of or within mast cell activation. Predicted to be located in several cellular components, including adherens junction; microtubule cytoskeleton; and recycling endosome membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to human NDRG1 (N-myc downstream regulated 1); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299923; N-myc downstream regulated gene 1; N-myc downstream-regulated gene 1 protein; Ndr1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87100,573,526 - 100,614,902 (-)NCBIGRCr8
mRatBN7.2798,684,487 - 98,725,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl798,684,487 - 98,725,880 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7100,449,304 - 100,490,614 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07102,650,974 - 102,692,281 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07102,570,302 - 102,611,611 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07107,734,326 - 107,775,701 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7107,734,323 - 107,775,714 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07107,683,921 - 107,725,300 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47104,302,038 - 104,344,842 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17104,336,268 - 104,379,072 (-)NCBI
Celera795,235,424 - 95,272,338 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetazolamide  (ISO)
aconitine  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
antimycin A  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (ISO)
benzyl isothiocyanate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
ferric oxide  (ISO)
finasteride  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
Heptachlor epoxide  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
menadione  (ISO)
methylarsonic acid  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
octadecanoic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac  (EXP,ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
Tiron  (ISO)
trametinib  (ISO)
triadimefon  (ISO)
tributylstannane  (EXP)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vandetanib  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
adherens junction  (IEA,ISO)
centrosome  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
microtubule  (IEA,ISO)
microtubule cytoskeleton  (ISO)
nucleus  (IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IEA,ISO)
recycling endosome membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Ultanir SK, etal., Neuron. 2012 Mar 22;73(6):1127-42. doi: 10.1016/j.neuron.2012.01.019. Epub 2012 Mar 21.
Additional References at PubMed
PMID:9766676   PMID:12432451   PMID:12477932   PMID:12804568   PMID:15082788   PMID:15247272   PMID:15489334   PMID:17442733   PMID:17634366   PMID:17786215   PMID:18582504   PMID:19056867  
PMID:20810912   PMID:23376485   PMID:23555679   PMID:25468996   PMID:30053369   PMID:37356737  


Genomics

Comparative Map Data
Ndrg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87100,573,526 - 100,614,902 (-)NCBIGRCr8
mRatBN7.2798,684,487 - 98,725,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl798,684,487 - 98,725,880 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7100,449,304 - 100,490,614 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07102,650,974 - 102,692,281 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07102,570,302 - 102,611,611 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07107,734,326 - 107,775,701 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7107,734,323 - 107,775,714 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07107,683,921 - 107,725,300 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47104,302,038 - 104,344,842 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17104,336,268 - 104,379,072 (-)NCBI
Celera795,235,424 - 95,272,338 (-)NCBICelera
Cytogenetic Map7q33NCBI
NDRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388133,237,175 - 133,297,252 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8133,237,175 - 133,302,022 (-)EnsemblGRCh38hg38GRCh38
GRCh378134,249,418 - 134,309,495 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368134,318,596 - 134,378,680 (-)NCBINCBI36Build 36hg18NCBI36
Build 348134,318,595 - 134,378,680NCBI
Celera8130,427,338 - 130,487,468 (-)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8129,569,158 - 129,629,277 (-)NCBIHuRef
CHM1_18134,290,434 - 134,350,564 (-)NCBICHM1_1
T2T-CHM13v2.08134,361,278 - 134,421,339 (-)NCBIT2T-CHM13v2.0
Ndrg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391566,801,167 - 66,841,490 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1566,801,167 - 66,841,489 (-)EnsemblGRCm39 Ensembl
GRCm381566,929,318 - 66,969,641 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1566,929,318 - 66,969,640 (-)EnsemblGRCm38mm10GRCm38
MGSCv371566,760,880 - 66,801,203 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361566,758,991 - 66,799,308 (-)NCBIMGSCv36mm8
Celera1568,461,993 - 68,502,305 (-)NCBICelera
Cytogenetic Map15D2NCBI
cM Map1529.3NCBI
Ndrg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554617,786,850 - 7,836,922 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554617,787,068 - 7,836,380 (-)NCBIChiLan1.0ChiLan1.0
NDRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27150,626,425 - 150,686,809 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18126,140,834 - 126,201,206 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08129,891,918 - 129,952,489 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18132,866,245 - 132,926,514 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8132,866,245 - 132,926,514 (-)Ensemblpanpan1.1panPan2
NDRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11329,689,294 - 29,745,964 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1329,650,444 - 29,746,382 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1329,668,427 - 29,710,107 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01330,048,859 - 30,105,421 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1330,050,503 - 30,092,259 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11329,777,136 - 29,818,739 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01329,876,514 - 29,918,203 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01330,226,181 - 30,267,635 (-)NCBIUU_Cfam_GSD_1.0
Ndrg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053038,625,163 - 8,676,464 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647016,051,015 - 16,102,585 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647016,051,291 - 16,102,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl48,014,446 - 8,069,335 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.148,014,445 - 8,069,335 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.247,894,536 - 7,930,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NDRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18127,668,012 - 127,727,918 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8127,667,981 - 127,719,011 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603912,373,846 - 12,433,462 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndrg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473522,734,228 - 22,782,347 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473522,734,365 - 22,782,247 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ndrg1
332 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:242
Count of miRNA genes:151
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000010811
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
10450828Scl79Serum cholesterol level QTL 793.50.001blood HDL cholesterol amount (VT:0000184)blood low density lipoprotein cholesterol level (CMO:0000053)789867376101773158Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat

Markers in Region
RH130193  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,684,539 - 98,684,725 (+)MAPPERmRatBN7.2
Rnor_6.07107,734,376 - 107,734,561NCBIRnor6.0
Rnor_5.07107,683,974 - 107,684,159UniSTSRnor5.0
RGSC_v3.47104,302,088 - 104,302,273UniSTSRGSC3.4
Celera795,235,474 - 95,235,659UniSTS
RH 3.4 Map7681.9UniSTS
Cytogenetic Map7q33UniSTS
RH130261  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,684,571 - 98,684,776 (+)MAPPERmRatBN7.2
Rnor_6.07107,734,408 - 107,734,612NCBIRnor6.0
Rnor_5.07107,684,006 - 107,684,210UniSTSRnor5.0
RGSC_v3.47104,302,120 - 104,302,324UniSTSRGSC3.4
Celera795,235,506 - 95,235,710UniSTS
RH 3.4 Map7681.6UniSTS
Cytogenetic Map7q33UniSTS
RH131717  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,687,539 - 98,687,742 (+)MAPPERmRatBN7.2
Rnor_6.07107,737,376 - 107,737,578NCBIRnor6.0
Rnor_5.07107,686,974 - 107,687,176UniSTSRnor5.0
RGSC_v3.47104,305,088 - 104,305,290UniSTSRGSC3.4
Celera795,238,474 - 95,238,676UniSTS
RH 3.4 Map7680.8UniSTS
Cytogenetic Map7q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 21 29 16 19 16 2 3 52 35 37 11 2
Low 22 28 25 25 6 8 22 4 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000010811   ⟹   ENSRNOP00000010811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl798,684,487 - 98,725,880 (-)Ensembl
Rnor_6.0 Ensembl7107,734,323 - 107,775,712 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093189   ⟹   ENSRNOP00000076191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl798,684,487 - 98,718,270 (-)Ensembl
Rnor_6.0 Ensembl7107,746,596 - 107,768,072 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093322   ⟹   ENSRNOP00000076179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl798,684,487 - 98,725,880 (-)Ensembl
Rnor_6.0 Ensembl7107,746,640 - 107,774,397 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093459   ⟹   ENSRNOP00000076093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl798,684,487 - 98,725,880 (-)Ensembl
Rnor_6.0 Ensembl7107,744,491 - 107,775,714 (-)Ensembl
RefSeq Acc Id: NM_001011991   ⟹   NP_001011991
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87100,573,526 - 100,614,902 (-)NCBI
mRatBN7.2798,684,490 - 98,725,869 (-)NCBI
Rnor_6.07107,734,326 - 107,775,701 (-)NCBI
Rnor_5.07107,683,921 - 107,725,300 (-)NCBI
RGSC_v3.47104,302,038 - 104,344,842 (-)RGD
Celera795,235,424 - 95,272,338 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078783   ⟹   XP_038934711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87100,573,526 - 100,607,292 (-)NCBI
mRatBN7.2798,684,487 - 98,718,234 (-)NCBI
RefSeq Acc Id: NP_001011991   ⟸   NM_001011991
- UniProtKB: Q6JE36 (UniProtKB/Swiss-Prot),   A0A1W2Q686 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000076179   ⟸   ENSRNOT00000093322
RefSeq Acc Id: ENSRNOP00000076093   ⟸   ENSRNOT00000093459
RefSeq Acc Id: ENSRNOP00000010811   ⟸   ENSRNOT00000010811
RefSeq Acc Id: ENSRNOP00000076191   ⟸   ENSRNOT00000093189
RefSeq Acc Id: XP_038934711   ⟸   XM_039078783
- Peptide Label: isoform X1
- UniProtKB: A0A1W2Q6A2 (UniProtKB/TrEMBL),   A0A1W2Q686 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6JE36-F1-model_v2 AlphaFold Q6JE36 1-394 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695366
Promoter ID:EPDNEW_R5891
Type:multiple initiation site
Name:Ndrg1_1
Description:N-myc downstream regulated 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07107,775,712 - 107,775,772EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307303 AgrOrtholog
BioCyc Gene G2FUF-33118 BioCyc
Ensembl Genes ENSRNOG00000007393 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010811 ENTREZGENE
  ENSRNOT00000010811.8 UniProtKB/Swiss-Prot
  ENSRNOT00000093189.2 UniProtKB/TrEMBL
  ENSRNOT00000093322.2 UniProtKB/TrEMBL
  ENSRNOT00000093459.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110455 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NDRG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:299923 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93814 IMAGE-MGC_LOAD
NCBI Gene 299923 ENTREZGENE
PANTHER PTHR11034 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11034:SF18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ndr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ndrg1 PhenoGen
RatGTEx ENSRNOG00000007393 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2Q609_RAT UniProtKB/TrEMBL
  A0A1W2Q686 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q6A2 ENTREZGENE, UniProtKB/TrEMBL
  NDRG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Ndrg1  N-myc downstream regulated 1  Ndrg1  N-myc downstream regulated gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-29 Ndrg1  N-myc downstream regulated gene 1  Ndrg1  N-myc downstream regulated 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-02-18 Ndrg1  N-myc downstream regulated 1  Ndrg1  N-myc downstream regulated gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ndrg1  N-myc downstream regulated gene 1  Ndrg1_predicted  N-myc downstream regulated gene 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ndrg1_predicted  N-myc downstream regulated gene 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED