Sqle (squalene epoxidase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Sqle (squalene epoxidase) Rattus norvegicus
Analyze
Symbol: Sqle
Name: squalene epoxidase
RGD ID: 3755
Description: Enables squalene monooxygenase activity. Involved in cellular aromatic compound metabolic process; cholesterol metabolic process; and response to organic substance. Located in intracellular membrane-bounded organelle. Orthologous to human SQLE (squalene epoxidase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-(3-(trifluoromethyl)phenyl)piperazine; 1-benzylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: SE; squalene monooxygenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2790,867,973 - 90,883,623 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl790,868,011 - 90,883,618 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx792,758,583 - 92,773,453 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0794,959,761 - 94,974,631 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0794,787,067 - 94,801,940 (+)NCBIRnor_WKY
Rnor_6.0799,609,929 - 99,624,803 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl799,609,191 - 99,624,732 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07100,197,094 - 100,211,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4796,096,897 - 96,111,772 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1796,130,995 - 96,146,001 (+)NCBI
Celera787,631,412 - 87,646,286 (+)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
Archazolid B  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
difenoconazole  (EXP)
dimethylarsinic acid  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fingolimod hydrochloride  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP)
flusilazole  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hexaconazole  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
lead(II) chloride  (ISO)
leflunomide  (ISO)
linalool  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nickel dichloride  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
phytosterols  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanil  (ISO)
propiconazole  (EXP,ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
resveratrol  (ISO)
ritodrine  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sevoflurane  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topiramate  (EXP)
triadimefon  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
FAD binding  (IEA,ISO,ISS)
protein binding  (ISO)
squalene monooxygenase activity  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. Abe I, etal., J Nat Prod. 2001 Aug;64(8):1010-4.
2. Cholesterol synthesis inhibition distal to squalene upregulates biliary phospholipid secretion and counteracts cholelithiasis in the genetically prone C57L/J mouse. Clarke GA, etal., Gut. 2004 Jan;53(1):136-42.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model. Kim S, etal., Gene. 2004 Sep 29;340(1):99-109.
7. Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice. Marmugi A, etal., Toxicology. 2014 Nov 5;325:133-43. doi: 10.1016/j.tox.2014.08.006. Epub 2014 Aug 26.
8. Inhibition of cholesterol biosynthesis by squalene epoxidase inhibitor avoids apoptotic cell death in L6 myoblasts. Matzno S, etal., J Lipid Res. 1997 Aug;38(8):1639-48.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase. Nagai M, etal., Biochem Biophys Res Commun 2002 Jul 5;295(1):74-80.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Purification and partial characterization of squalene epoxidase from rat liver microsomes. Ono T, etal., Biochim Biophys Acta. 1982 Dec 6;709(1):84-90.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Molecular cloning and expression of rat squalene epoxidase. Sakakibara J, etal., J Biol Chem 1995 Jan 6;270(1):17-20.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
Additional References at PubMed
PMID:12454003   PMID:12477932   PMID:17112472   PMID:29765154   PMID:30626872  


Genomics

Comparative Map Data
Sqle
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2790,867,973 - 90,883,623 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl790,868,011 - 90,883,618 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx792,758,583 - 92,773,453 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0794,959,761 - 94,974,631 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0794,787,067 - 94,801,940 (+)NCBIRnor_WKY
Rnor_6.0799,609,929 - 99,624,803 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl799,609,191 - 99,624,732 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07100,197,094 - 100,211,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4796,096,897 - 96,111,772 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1796,130,995 - 96,146,001 (+)NCBI
Celera787,631,412 - 87,646,286 (+)NCBICelera
Cytogenetic Map7q33NCBI
SQLE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388124,998,505 - 125,022,283 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl8124,998,497 - 125,022,283 (+)EnsemblGRCh38hg38GRCh38
GRCh378126,010,747 - 126,034,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368126,079,901 - 126,103,707 (+)NCBINCBI36Build 36hg18NCBI36
Build 348126,080,612 - 126,103,706NCBI
Celera8122,199,057 - 122,223,195 (+)NCBICelera
Cytogenetic Map8q24.13NCBI
HuRef8121,334,165 - 121,358,312 (+)NCBIHuRef
CHM1_18126,050,996 - 126,075,149 (+)NCBICHM1_1
T2T-CHM13v2.08126,131,978 - 126,156,104 (+)NCBIT2T-CHM13v2.0
Sqle
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391559,186,941 - 59,203,042 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1559,186,926 - 59,203,041 (+)EnsemblGRCm39 Ensembl
GRCm381559,315,092 - 59,331,193 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1559,315,077 - 59,331,192 (+)EnsemblGRCm38mm10GRCm38
MGSCv371559,146,647 - 59,162,748 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361559,144,773 - 59,160,874 (+)NCBIMGSCv36mm8
Celera1560,845,733 - 60,861,834 (+)NCBICelera
Cytogenetic Map15D1NCBI
Sqle
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955461122,528 - 143,064 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955461121,886 - 143,389 (+)NCBIChiLan1.0ChiLan1.0
SQLE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18124,435,668 - 124,459,441 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8124,435,668 - 124,459,441 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08121,684,269 - 121,708,131 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SQLE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11322,994,010 - 23,018,134 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1322,993,862 - 23,017,978 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1322,958,181 - 22,982,327 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01323,335,721 - 23,359,940 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1323,334,422 - 23,359,939 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11323,056,318 - 23,080,692 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01323,165,695 - 23,189,887 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01323,408,709 - 23,432,884 (+)NCBIUU_Cfam_GSD_1.0
Sqle
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530315,300,693 - 15,326,293 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647022,725,888 - 22,752,500 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647022,726,793 - 22,752,429 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SQLE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl414,669,791 - 14,700,126 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1414,669,789 - 14,700,152 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2415,248,863 - 15,279,281 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SQLE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18119,586,639 - 119,610,980 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8119,586,659 - 119,611,142 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603920,569,199 - 20,595,508 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sqle
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473530,226,465 - 30,246,294 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473530,225,307 - 30,246,202 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sqle
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:114
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000012883
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78022129993595843Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78022129994811326Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
10450828Scl79Serum cholesterol level QTL 793.50.001blood HDL cholesterol amount (VT:0000184)blood low density lipoprotein cholesterol level (CMO:0000053)789867376101773158Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat

Markers in Region
RH130198  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2790,883,363 - 90,883,574 (+)MAPPERmRatBN7.2
Rnor_6.0799,624,551 - 99,624,761NCBIRnor6.0
Rnor_5.07100,211,716 - 100,211,926UniSTSRnor5.0
RGSC_v3.4796,111,520 - 96,111,730UniSTSRGSC3.4
Celera787,646,034 - 87,646,244UniSTS
RH 3.4 Map7651.28UniSTS
Cytogenetic Map7q33UniSTS
RH133886  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2790,868,435 - 90,868,624 (+)MAPPERmRatBN7.2
Rnor_6.0799,609,623 - 99,609,811NCBIRnor6.0
Rnor_5.07100,196,788 - 100,196,976UniSTSRnor5.0
RGSC_v3.4796,096,591 - 96,096,779UniSTSRGSC3.4
Celera787,631,106 - 87,631,294UniSTS
Cytogenetic Map7q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 46 39 12 39 74 33 41 11
Low 17 11 2 7 2 8 11 2 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012883   ⟹   ENSRNOP00000012883
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl790,868,011 - 90,883,618 (+)Ensembl
Rnor_6.0 Ensembl799,609,191 - 99,624,732 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101449   ⟹   ENSRNOP00000094097
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl790,868,011 - 90,883,618 (+)Ensembl
RefSeq Acc Id: NM_017136   ⟹   NP_058832
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2790,868,742 - 90,883,616 (+)NCBI
Rnor_6.0799,609,929 - 99,624,803 (+)NCBI
Rnor_5.07100,197,094 - 100,211,968 (+)NCBI
RGSC_v3.4796,096,897 - 96,111,772 (+)RGD
Celera787,631,412 - 87,646,286 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078562   ⟹   XP_038934490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2790,867,973 - 90,883,623 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058832   ⟸   NM_017136
- UniProtKB: Q4V8L3 (UniProtKB/Swiss-Prot),   P52020 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012883   ⟸   ENSRNOT00000012883
RefSeq Acc Id: XP_038934490   ⟸   XM_039078562
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000094097   ⟸   ENSRNOT00000101449
Protein Domains
FAD_binding_3   SE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52020-F1-model_v2 AlphaFold P52020 1-573 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695356
Promoter ID:EPDNEW_R5881
Type:initiation region
Name:Sqle_1
Description:squalene epoxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0799,609,189 - 99,609,249EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3755 AgrOrtholog
BioCyc Gene G2FUF-33291 BioCyc
BioCyc Pathway PWY-5670 [epoxysqualene biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000009550 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012883 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000094097.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012883 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000101449.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7460860 IMAGE-MGC_LOAD
InterPro FAD-bd UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Squalene_epoxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Squalene_monox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29230 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114336 IMAGE-MGC_LOAD
NCBI Gene 29230 ENTREZGENE
PANTHER PTHR10835 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FAD_binding_3 UniProtKB/TrEMBL
  PF08491 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sqle PhenoGen
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204824
UniProt A0A8I6AKW2_RAT UniProtKB/TrEMBL
  ERG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V8L3 ENTREZGENE
UniProt Secondary Q4V8L3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Sqle  squalene epoxidase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains protein contains one transmembrane domain and one consensus FAD binding domain 70024
gene_protein putative protein contains 573 aa residues and has mass of 63.9 kDa 70024