SQLE (squalene epoxidase) - Rat Genome Database

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Pathways
Gene: SQLE (squalene epoxidase) Chlorocebus sabaeus
Analyze
Symbol: SQLE
Name: squalene epoxidase
RGD ID: 18480422
Description: ENCODES a protein that exhibits squalene monooxygenase activity (ortholog); INVOLVED IN cholesterol metabolic process (ortholog); response to biphenyl (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); cervical cancer (ortholog); cholelithiasis (ortholog); FOUND IN cytoplasmic side of endoplasmic reticulum membrane (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: squalene monooxygenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap18128,801,969 - 128,828,336 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366603920,569,199 - 20,595,508 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.18119,586,639 - 119,610,980 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8119,586,659 - 119,611,142 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SQLE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap18128,801,969 - 128,828,336 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366603920,569,199 - 20,595,508 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.18119,586,639 - 119,610,980 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8119,586,659 - 119,611,142 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
SQLE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388124,998,505 - 125,022,283 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8124,998,467 - 125,022,294 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh378126,010,747 - 126,034,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368126,079,901 - 126,103,707 (+)NCBIBuild 36Build 36hg18NCBI36
Build 348126,080,612 - 126,103,706NCBI
Celera8122,199,057 - 122,223,195 (+)NCBICelera
Cytogenetic Map8q24.13NCBI
HuRef8121,334,165 - 121,358,312 (+)NCBIHuRef
CHM1_18126,050,996 - 126,075,149 (+)NCBICHM1_1
T2T-CHM13v2.08126,131,528 - 126,156,104 (+)NCBIT2T-CHM13v2.0
Sqle
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391559,186,941 - 59,203,042 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1559,186,869 - 59,203,043 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381559,315,092 - 59,331,193 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1559,315,077 - 59,331,192 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371559,146,647 - 59,162,748 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361559,144,773 - 59,160,874 (+)NCBIMGSCv36mm8
Celera1560,845,733 - 60,861,834 (+)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1525.16NCBI
Sqle
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8792,758,175 - 92,773,049 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl792,757,409 - 92,773,050 (+)EnsemblGRCr8
mRatBN7.2790,867,973 - 90,883,623 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl790,868,011 - 90,883,618 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx792,758,583 - 92,773,453 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0794,959,761 - 94,974,631 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0794,787,067 - 94,801,940 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd794,830,883 - 94,845,756 (+)NCBI
Lyon_Normotensive795,719,031 - 95,733,904 (+)NCBI
Lyon_Hypertensive795,856,126 - 95,870,999 (+)NCBI
F344_StmMcwi794,313,070 - 94,327,943 (+)NCBI
Rnor_6.0799,609,929 - 99,624,803 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl799,609,191 - 99,624,732 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.07100,197,094 - 100,211,968 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4796,096,897 - 96,111,772 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera787,631,412 - 87,646,286 (+)NCBICelera
RGSC_v3.1796,130,995 - 96,146,001 (+)NCBI
Cytogenetic Map7q33NCBI
Sqle
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955461122,528 - 143,064 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_004955461121,886 - 143,389 (+)NCBIChiLan1.0ChiLan1.0
SQLE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27142,421,180 - 142,445,046 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18117,932,264 - 117,956,167 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08121,684,269 - 121,708,131 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18124,435,668 - 124,459,441 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8124,435,668 - 124,459,441 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
SQLE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11322,994,010 - 23,018,134 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1322,993,862 - 23,017,978 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1322,958,181 - 22,982,327 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01323,335,721 - 23,359,940 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1323,334,422 - 23,359,939 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11323,056,318 - 23,080,692 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01323,165,695 - 23,189,887 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01323,408,709 - 23,432,884 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sqle
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1715,329,026 - 15,353,685 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_02440530315,300,693 - 15,326,293 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647022,725,888 - 22,752,500 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647022,726,793 - 22,752,429 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SQLE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl414,669,791 - 14,700,126 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1414,669,789 - 14,700,152 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2415,248,863 - 15,279,281 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sqle
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473530,225,307 - 30,246,202 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462473530,226,465 - 30,246,294 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl1066,878,267 - 66,898,895 (+)Ensembl
Sqle
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11233,829,246 - 233,844,950 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in SQLE
479 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008001509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JBLKOC010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000008246   ⟹   ENSCSAP00000006398
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl8119,586,659 - 119,611,142 (+)Ensembl
RefSeq Acc Id: XM_008001509   ⟹   XP_007999700
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap18128,801,969 - 128,828,336 (+)NCBI
Vero_WHO_p1.0NW_02366603920,569,199 - 20,595,508 (-)NCBI
ChlSab1.18119,586,639 - 119,610,980 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007999700 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006398
  ENSCSAP00000006398.1
RefSeq Acc Id: XP_007999700   ⟸   XM_008001509
- UniProtKB: A0A0D9RCQ9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000006398   ⟸   ENSCSAT00000008246


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010159 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008246.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  Squalene_epoxidase UniProtKB/TrEMBL
  Squalene_monox UniProtKB/TrEMBL
KEGG Report csab:103237411 UniProtKB/TrEMBL
NCBI Gene SQLE ENTREZGENE
PANTHER PTHR10835 UniProtKB/TrEMBL
  SQUALENE MONOOXYGENASE UniProtKB/TrEMBL
Pfam NAD_binding_8 UniProtKB/TrEMBL
  PF08491 UniProtKB/TrEMBL
PRINTS RNGMNOXGNASE UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
UniProt A0A0D9RCQ9 ENTREZGENE, UniProtKB/TrEMBL