Gene: Sqle (squalene epoxidase) Ictidomys tridecemlineatus

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Symbol:

Sqle

Name:

squalene epoxidase

RGD ID:

12701916

Description:

ENCODES a protein that exhibits squalene monooxygenase activity (ortholog); INVOLVED IN cholesterol metabolic process (ortholog); response to biphenyl (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); cervical cancer (ortholog); cholelithiasis (ortholog); FOUND IN cytoplasmic side of endoplasmic reticulum membrane (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

squalene epoxidase, transcript variant X1; squalene epoxidase, transcript variant X2; squalene monooxygenase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SQLE (squalene epoxidase)	NCBI	Ortholog
Mus musculus (house mouse):	Sqle (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Sqle (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sqle (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SQLE (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SQLE (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SQLE (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SQLE (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sqle (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Sqle (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

mIctTri1.hap1 - mIctTri1.hap1 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	7	15,329,026 - 15,353,685 (-)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405303	15,300,693 - 15,326,293 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	22,725,888 - 22,752,500 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	22,726,793 - 22,752,429 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

cervical cancer (ISO)

cholelithiasis (ISO)

colon adenocarcinoma (ISO)

colorectal cancer (ISO)

Experimental Liver Neoplasms (ISO)

familial hypercholesterolemia (ISO)

Hypercholesterolemia (ISO)

obesity (ISO)

ovarian serous cystadenocarcinoma (ISO)

sarcoma (ISO)

thymoma (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

urinary bladder cancer (ISO)

uterine corpus endometrial carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cholesterol biosynthetic process (IEA)

cholesterol metabolic process (IEA,ISO)

lipid droplet formation (IEA)

regulation of cell population proliferation (IEA)

response to biphenyl (ISO)

sterol biosynthetic process (IEA)

sterol metabolic process (IEA)

zymosterol biosynthetic process (IEA)

Cellular Component

cytoplasmic side of endoplasmic reticulum membrane (IEA)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

Molecular Function

FAD binding (IEA)

flavin adenine dinucleotide binding (IEA)

squalene monooxygenase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alendronate pharmacodynamics pathway (ISO)

cholesterol biosynthetic pathway (ISO)

cholesterol ester storage disease pathway (ISO)

congenital hemidysplasia with ichthyosiform erythroderma and limb defects pathway (ISO)

desmosterolosis pathway (ISO)

hypercholesterolemia pathway (ISO)

ibandronate pharmacodynamics pathway (ISO)

mevalonic aciduria pathway (ISO)

nitrogenous bisphosphonate pharmacodynamics pathway (ISO)

pamidronate pharmacodynamics pathway (ISO)

risedronate pharmacodynamics pathway (ISO)

Smith-Lemli-Opitz Syndrome pathway (ISO)

statin pharmacodynamics pathway (ISO)

Wolman disease pathway (ISO)

X-linked dominant chondrodysplasia punctata 2 pathway (ISO)

zoledronate pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Sqle
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	7	15,329,026 - 15,353,685 (-)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405303	15,300,693 - 15,326,293 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	22,725,888 - 22,752,500 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	22,726,793 - 22,752,429 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SQLE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	124,998,505 - 125,022,283 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	124,998,467 - 125,022,294 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	8	126,010,747 - 126,034,525 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	126,079,901 - 126,103,707 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	8	126,080,612 - 126,103,706	NCBI
Celera	8	122,199,057 - 122,223,195 (+)	NCBI		Celera
Cytogenetic Map	8	q24.13	NCBI
HuRef	8	121,334,165 - 121,358,312 (+)	NCBI		HuRef
CHM1_1	8	126,050,996 - 126,075,149 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	126,131,528 - 126,156,104 (+)	NCBI		T2T-CHM13v2.0

Sqle
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	59,186,941 - 59,203,042 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	59,186,869 - 59,203,043 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	59,315,092 - 59,331,193 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	59,315,077 - 59,331,192 (+)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	15	59,146,647 - 59,162,748 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	59,144,773 - 59,160,874 (+)	NCBI		MGSCv36	mm8
Celera	15	60,845,733 - 60,861,834 (+)	NCBI		Celera
Cytogenetic Map	15	D1	NCBI
cM Map	15	25.16	NCBI

Sqle
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	92,758,175 - 92,773,049 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	92,757,409 - 92,773,050 (+)	Ensembl				GRCr8
mRatBN7.2	7	90,867,973 - 90,883,623 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	90,868,011 - 90,883,618 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	92,758,583 - 92,773,453 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	94,959,761 - 94,974,631 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	94,787,067 - 94,801,940 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	7	94,830,883 - 94,845,756 (+)	NCBI
Lyon_Normotensive	7	95,719,031 - 95,733,904 (+)	NCBI
Lyon_Hypertensive	7	95,856,126 - 95,870,999 (+)	NCBI
F344_StmMcwi	7	94,313,070 - 94,327,943 (+)	NCBI
Rnor_6.0	7	99,609,929 - 99,624,803 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	99,609,191 - 99,624,732 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	7	100,197,094 - 100,211,968 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	96,096,897 - 96,111,772 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	87,631,412 - 87,646,286 (+)	NCBI		Celera
RGSC_v3.1	7	96,130,995 - 96,146,001 (+)	NCBI
Cytogenetic Map	7	q33	NCBI

Sqle
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955461	122,528 - 143,064 (+)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955461	121,886 - 143,389 (+)	NCBI	ChiLan1.0	ChiLan1.0

SQLE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	142,421,180 - 142,445,046 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	117,932,264 - 117,956,167 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	121,684,269 - 121,708,131 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	124,435,668 - 124,459,441 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	124,435,668 - 124,459,441 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

SQLE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	22,994,010 - 23,018,134 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	22,993,862 - 23,017,978 (+)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	22,958,181 - 22,982,327 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	23,335,721 - 23,359,940 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	23,334,422 - 23,359,939 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	23,056,318 - 23,080,692 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	23,165,695 - 23,189,887 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	23,408,709 - 23,432,884 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

SQLE
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	14,669,791 - 14,700,126 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	4	14,669,789 - 14,700,152 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	15,248,863 - 15,279,281 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SQLE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	8	128,801,969 - 128,828,336 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666039	20,569,199 - 20,595,508 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	8	119,586,639 - 119,610,980 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	119,586,659 - 119,611,142 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Sqle
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624735	30,225,307 - 30,246,202 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624735	30,226,465 - 30,246,294 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl	10	66,878,267 - 66,898,895 (+)	Ensembl

Sqle
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	233,829,246 - 233,844,950 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005316162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021724270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JBPVTT010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000008446 ⟹ ENSSTOP00000007571

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936470	22,725,888 - 22,752,500 (-)	Ensembl

Ensembl Acc Id:

ENSSTOT00000032239 ⟹ ENSSTOP00000027544

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936470	22,727,103 - 22,751,560 (-)	Ensembl

RefSeq Acc Id:

XM_005316162 ⟹ XP_005316219

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
mIctTri1.hap1	7	15,329,026 - 15,353,685 (-)	NCBI
HiC_Itri_2	NW_024405303	15,300,693 - 15,326,293 (-)	NCBI
SpeTri2.0	NW_004936470	22,726,793 - 22,752,429 (-)	NCBI

Sequence:

show sequence

AGCCTACCCAGGCTGCCCAGGCTGCCCAGGCTGCCCAGGCTTCCCAGGCGTGCTGAGGGCGTTC
GGCGGTTACTCTGGTTACTACGGAAGCGCGGCGCTGGGGAGGGCGGCCGCCGCCCGCGTGGGAT
GCTGGAGAGGAGGCCGTCGGGAACCGCCGCCGCCCTCTGAGCGAGGCTCCCTGTAGACCGCTGT
TCACCCGAGAGGCAGCCGAGTCGCGGGTTGGCAGGCTCGGGACTGGGGAATCAGAGCCTGCCGA
GGAGCGTCGGGGCCGCGCTGCCCGAATCCGAGGCCATCTCTTGTTGGGAAGGCCGACCGGGGGG
CCGAGGGTGGTTGGGCAGTGTCGCCGTCCAGGGAATCCGGAGCCTCCGGCGCTCGCCAGCAGCC
CCCGCGCCTCTCGCTGCCGCGGGCGAGCGCTCTCCGCGGAGGCGAGCTTCCCCCGCCCCCAGCT
CCCTCCCGCTGGGCACCTGCTGCTGGTGAGGGGAGAGAAACGTTTTTCCAGTAGGACGAACCAG
ACGTCAGAATACACAGCATCGCCTGCAGCCGCCCCCCGAGACCCCGTCAGGAAAAGGAAAGTAT
GGTTTGCCCGAAGGAGGAGAGCGTGTCCCACCGGGAGCTGCTGGAGCAGGCCAATTTTTAATAC
TGCCCCCCAAGTACCGTACGACTTATCCTTAAGATTGTTTTGTACTATGTACGATTTTAAATTT
TGATCTCTGACTTGCAATCCTGGGATCGCGGTTCCTGAGTTTGGCCGGTGCCCCCTGTTCCTTT
TGGTACTAGGATTTGTCGGGAGCCTCTAATTACCAAACTCCCACCGCGGGGAGAAAAGAATTTC
AACCTTGGTCGGTACTACCAAAGAAGCCCTTGGCATCATGTGGACTTTTCTCGGAATTGCCACT
TTCACCTATTTTTATAAGAAATGCGGGGACTTCATCACTTTGGCCAACAAGGAGCTCTTCTTGT
GCGTGCTGGTGTTCCTGTCGCTGGGCCTGGTGCTCTCCTACCGTTTTCGCCACCGAAATGGGGG
CGTCCTGGGGCGCCAGCAGAGTGGCTCTCAGTTCGCCCTCTTCTCAGATATTCTCTCAGCTTTG
CCACTTATTGGCTTCTTCTGGGCCAAGCCACCCCCTGGATCAGAAAAGAAGGAGCAGCTAGAGT
CCAGGAGGCACAGAAAAGGAAACAATATTTCAGAAACAACTTCAGTAGGAGCAGCTACCTCTGT
GTCAACATCTTCTCTAAATGATCCAGAAGTTATCATCGTGGGATCTGGTATACTTGGCTCTGCT
CTGGCAGCAGTGCTTTCCAGAGATGGAAGAAAGGTGACTGTAATTGAAAGAGATTTAAAAGAAC
CTGACAGAATAGTTGGAGAGTTTCTGCAGCCAGGTGGTTGTCATGTTCTGAGAGACCTGGGTCT
TGGAGATACAGTAGAAGGTCTTGATGCCCAATCTATAAATGGCTACATAATTCATGATCGGGAA
AGCAAATCAGAGGTTCAGATTCCTTACCCTCTGTCAGAAGAAAATCAAGTGCAGAGTGGAAGAG
CTTTCCATCATGGAAGATTCATCATGGGTCTCCGGAAAGCAGCCATGGCAGAGCCCAATGCCAA
GTTTATTGAAGGCACAGTGCTGCAGTTGTTAGAGGAAGATGATGCTGTGACAGGAGTTCAGTAC
AAGGACAAAGAGACTGGAGACATCAAGGAACTCCATGCTCCATTGACTGTCGTTGCAGATGGGC
TTTTCTCCAAGTTTAGGAAAAATCTTGTCTCCACTAAAGTTTCTGTTTCATCTCATTTTGTTGG
CTTCCTTATGAAGAATGCACCACAGTTTAAAGCCAATCATGCTGAACTTCTTTTAGTTAACCCA
AGTCCAGTTCTCATCTACCAGATTTCATCCAGTGAAACTAGAGTACTTGTTGACATTCGTGGAG
AAATGCCAAGGAATTTAAGAGACTACCTGACTGAACAAATTTACCCACAAGTTCCTGATCACCT
GAAAGAACCATTCCTAGAAGGCATTCAGAATTCTCGTTTGCGAGCCATGCCAGCAAGCTTTCTT
CCTCCTTCACCAGTAAACAAACGAGGTGTTCTTCTTTTGGGAGATGCATATAATTTGAGGCACC
CTCTTACTGGTGGTGGCATGACTGTTGCCTTTAAAGATATAAAACTGTGGAGAAAACTGCTGAA
GGGCATTCCTGACCTGTATGATGATACAGCCATTTTCCAGGCCAAAAAATCATTCTATTGGTCA
AGAAGAAAGTCTCATTCCTTTGTTGTGAATGTCCTTGCCCAAGCGCTTTATGAATTATTTTCTT
CCACAGATGATTACCTGCATCAACTAAGAAAAGCCTGTTTTCTTTATTTCAAACTTGGTGGAGA
ATGTGTGGCTGGTCCGGTTGGGCTGCTTTCTGTGTTGTCTCCTAACCCTCTGGTTTTAATTGGA
CACTTCTTTGCTGTTGCAGTCTATGCCTCATATTTTTGCTTTAAATCGGAACCGTGGATCACAA
AACCCCGAGCCCTTTTCAGTACTGGTGCTGTCTTGTACAAAGCGTGTTCTGTGATATTTCCTCT
AATTTACTCAGAAATGAAGTATATGGTTCATTAAGCTCAGAGGGGATCATGTGTAACTCAAGTC
CCATGAGAAATTCTGGAAACAGCTGTGTGCCCACCACTTCTGAAGTGGCCACTCTTGAACCAAG
ACTGGGATTACTTTCTTTGTGATGTTTTTGTATATAAGCATGTAAATATATGCCTTAATTTTCA
ATTTAAAATGAAGGGTAAAATAAGTTAGATATTTAAAAGATATGGTTGTTACCATAAATTAGCA
CTAACATGGAAAAACTTCAGTTTTTCTTTTGATTTCAGTATTGGGGATGAGTCTTGGGACATGC
AAATAAAATGAAGAGTGAACCCTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005316219	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000007571.3
	ENSSTOP00000027544.1
	ENSSTOP00015008423
GenBank Protein	KAG3273627	(Get FASTA)	NCBI Sequence Viewer
	KAG3273628	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005316219 ⟸ XM_005316162

- UniProtKB:

I3MBM9 (UniProtKB/TrEMBL), A0A287D1X9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWTFLGIATFTYFYKKCGDFITLANKELFLCVLVFLSLGLVLSYRFRHRNGGVLGRQQSGSQFA
LFSDILSALPLIGFFWAKPPPGSEKKEQLESRRHRKGNNISETTSVGAATSVSTSSLNDPEVII
VGSGILGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGCHVLRDLGLGDTVEGLDAQSI
NGYIIHDRESKSEVQIPYPLSEENQVQSGRAFHHGRFIMGLRKAAMAEPNAKFIEGTVLQLLEE
DDAVTGVQYKDKETGDIKELHAPLTVVADGLFSKFRKNLVSTKVSVSSHFVGFLMKNAPQFKAN
HAELLLVNPSPVLIYQISSSETRVLVDIRGEMPRNLRDYLTEQIYPQVPDHLKEPFLEGIQNSR
LRAMPASFLPPSPVNKRGVLLLGDAYNLRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDTAIF
QAKKSFYWSRRKSHSFVVNVLAQALYELFSSTDDYLHQLRKACFLYFKLGGECVAGPVGLLSVL
SPNPLVLIGHFFAVAVYASYFCFKSEPWITKPRALFSTGAVLYKACSVIFPLIYSEMKYMVH

hide sequence

Ensembl Acc Id:

ENSSTOP00000027544 ⟸ ENSSTOT00000032239

Ensembl Acc Id:

ENSSTOP00000007571 ⟸ ENSSTOT00000008446

Protein Domains

FAD-binding Squalene epoxidase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000008446	Ensembl, UniProtKB/TrEMBL
	ENSSTOG00015006922	ENTREZGENE
Ensembl Transcript	ENSSTOT00000008446.3	UniProtKB/TrEMBL
	ENSSTOT00000032239.1	UniProtKB/TrEMBL
Gene3D-CATH	3.50.50.60	UniProtKB/TrEMBL
InterPro	FAD-bd	UniProtKB/TrEMBL
	FAD/NAD-bd_sf	UniProtKB/TrEMBL
	Squalene_epoxidase	UniProtKB/TrEMBL
	Squalene_monox	UniProtKB/TrEMBL
KEGG Report	iti:101958808	UniProtKB/TrEMBL
NCBI Gene	Sqle	ENTREZGENE
PANTHER	PTHR10835	UniProtKB/TrEMBL
	SQUALENE MONOOXYGENASE	UniProtKB/TrEMBL
Pfam	FAD_binding_3	UniProtKB/TrEMBL
	NAD_binding_8	UniProtKB/TrEMBL
	PF08491	UniProtKB/TrEMBL
PRINTS	RNGMNOXGNASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51905	UniProtKB/TrEMBL
UniProt	A0A287D1X9	ENTREZGENE, UniProtKB/TrEMBL
	I3MBM9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB