SQLE (squalene epoxidase) - Rat Genome Database

Name: SQLE
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: SQLE (squalene epoxidase) Pan paniscus

Analyze

Symbol:

SQLE

Name:

squalene epoxidase

RGD ID:

11811331

Description:

ENCODES a protein that exhibits squalene monooxygenase activity (ortholog); INVOLVED IN cholesterol metabolic process (ortholog); response to biphenyl (ortholog); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH cholelithiasis (ortholog); Experimental Liver Neoplasms (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); intracellular membrane-bounded organelle (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

squalene monooxygenase

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SQLE (squalene epoxidase)	NCBI	Ortholog
Mus musculus (house mouse):	Sqle (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Sqle (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sqle (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SQLE (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sqle (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SQLE (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SQLE (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sqle (squalene epoxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	142,421,180 - 142,445,046 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	117,932,264 - 117,956,167 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	121,684,269 - 121,708,131 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	124,435,668 - 124,459,441 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	124,435,668 - 124,459,441 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cholelithiasis (ISO)

Experimental Liver Neoplasms (ISO)

genetic disease (ISO)

Hypercholesterolemia (ISO)

obesity (ISO)

trichorhinophalangeal syndrome type I (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cholesterol metabolic process (IEA,ISO)

ergosterol biosynthetic process (IEA)

lipid droplet formation (IEA)

regulation of cell population proliferation (IEA)

response to biphenyl (ISO)

sterol biosynthetic process (IEA)

sterol metabolic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

intracellular membrane-bounded organelle (IEA)

membrane (IEA)

Molecular Function

FAD binding (IEA)

flavin adenine dinucleotide binding (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

squalene monooxygenase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alendronate pharmacodynamics pathway (ISO)

cholesterol biosynthetic pathway (ISO)

cholesterol ester storage disease pathway (ISO)

congenital hemidysplasia with ichthyosiform erythroderma and limb defects pathway (ISO)

desmosterolosis pathway (ISO)

hypercholesterolemia pathway (ISO)

ibandronate pharmacodynamics pathway (ISO)

mevalonic aciduria pathway (ISO)

nitrogenous bisphosphonate pharmacodynamics pathway (ISO)

pamidronate pharmacodynamics pathway (ISO)

risedronate pharmacodynamics pathway (ISO)

Smith-Lemli-Opitz Syndrome pathway (ISO)

statin pharmacodynamics pathway (ISO)

Wolman disease pathway (ISO)

X-linked dominant chondrodysplasia punctata 2 pathway (ISO)

zoledronate pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SQLE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	142,421,180 - 142,445,046 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	117,932,264 - 117,956,167 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	121,684,269 - 121,708,131 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	124,435,668 - 124,459,441 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	124,435,668 - 124,459,441 (+)	Ensembl	panpan1.1		panPan2

SQLE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	124,998,505 - 125,022,283 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	124,998,497 - 125,022,283 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	126,010,747 - 126,034,525 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	126,079,901 - 126,103,707 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	126,080,612 - 126,103,706	NCBI
Celera	8	122,199,057 - 122,223,195 (+)	NCBI		Celera
Cytogenetic Map	8	q24.13	NCBI
HuRef	8	121,334,165 - 121,358,312 (+)	NCBI		HuRef
CHM1_1	8	126,050,996 - 126,075,149 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	126,131,528 - 126,156,104 (+)	NCBI		T2T-CHM13v2.0

Sqle
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	59,186,941 - 59,203,042 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	59,186,926 - 59,203,041 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	59,315,092 - 59,331,193 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	59,315,077 - 59,331,192 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	59,146,647 - 59,162,748 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	59,144,773 - 59,160,874 (+)	NCBI		MGSCv36	mm8
Celera	15	60,845,733 - 60,861,834 (+)	NCBI		Celera
Cytogenetic Map	15	D1	NCBI
cM Map	15	25.16	NCBI

Sqle
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	92,758,175 - 92,773,049 (+)	NCBI		GRCr8
mRatBN7.2	7	90,867,973 - 90,883,623 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	90,868,011 - 90,883,618 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	92,758,583 - 92,773,453 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	94,959,761 - 94,974,631 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	94,787,067 - 94,801,940 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	99,609,929 - 99,624,803 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	99,609,191 - 99,624,732 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	100,197,094 - 100,211,968 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	96,096,897 - 96,111,772 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	96,130,995 - 96,146,001 (+)	NCBI
Celera	7	87,631,412 - 87,646,286 (+)	NCBI		Celera
Cytogenetic Map	7	q33	NCBI

Sqle
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955461	122,528 - 143,064 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955461	121,886 - 143,389 (+)	NCBI	ChiLan1.0	ChiLan1.0

SQLE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	22,994,010 - 23,018,134 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	22,993,862 - 23,017,978 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	22,958,181 - 22,982,327 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	23,335,721 - 23,359,940 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	23,334,422 - 23,359,939 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	23,056,318 - 23,080,692 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	23,165,695 - 23,189,887 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	23,408,709 - 23,432,884 (+)	NCBI		UU_Cfam_GSD_1.0

Sqle
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	15,300,693 - 15,326,293 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	22,725,888 - 22,752,500 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	22,726,793 - 22,752,429 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SQLE
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	14,669,791 - 14,700,126 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	14,669,789 - 14,700,152 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	15,248,863 - 15,279,281 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SQLE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	119,586,639 - 119,610,980 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	119,586,659 - 119,611,142 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	20,569,199 - 20,595,508 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sqle
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	30,226,465 - 30,246,294 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624735	30,225,307 - 30,246,202 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003820461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008973922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034966577	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000066096 ⟹ ENSPPAP00000043161

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	8	124,435,668 - 124,459,441 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000066098 ⟹ ENSPPAP00000043163

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	8	124,439,267 - 124,459,103 (+)	Ensembl

RefSeq Acc Id:

XM_003820461 ⟹ XP_003820509

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	142,421,785 - 142,445,046 (+)	NCBI
NHGRI_mPanPan1	8	117,933,228 - 117,956,167 (+)	NCBI
Mhudiblu_PPA_v0	8	121,684,292 - 121,708,131 (+)	NCBI
PanPan1.1	8	124,435,668 - 124,459,441 (+)	NCBI

Sequence:

show sequence

GCGCTGGCGAGAGCCGCCGCCCGCGAGGGATGCTGGTGAGGAAGCCGTCGGGAGCCGCCGCCGC
CATCTGAGGGAGGTACCCTGGAAACCACCTTTTATCGGTGGGGAGGTGCAGTCGCGGTGGGCGG
GTCTGGGGGCCAACGAAGCGGGAGGCCTCTAAATCGCGAGGTTGGGGCTGCATTGCCCTGGAGC
CGCACTCTTGAGTCCGAGGCCATCTTTTGTTGGAGAAGGCGTCGGCGCTGGCGTTTTCCCGAGG
TTGGGCTGTACAGTGTCTCCGTCCGCGGAAAAAGAAGCCTCTGAACCCGCGCCGGCCCGCAGCC
CCCGTGCCTTCCGGCCGCTGCTCGCCGTCGCCAGAGGCGAGGCCACGTTTCCCCCAGTGCCGAG
GTGTTTCTGTGACCCTCCCTCCACTCCCATTCCCTTCTGAAAGGGCACCTGCTCTTGGTGAGAA
AAGAAATTATAGCACGAAGAGCCAGTATCAGAAGAGTATCCATCACCCGCAGCAACCGCTCAGG
GAACACCATCAAAAAGAAAAAAAGGGAATATCTGGATTGCCTGGGCGAGGAGGAGCGAGTCTGC
TCGGGAGCTGTTCCAGCAGGCGATTTTTAAATACTGCTTTCTACGTCCTATATAACTTGGCTTC
ACATACTTTTACACTAACTTTATATGATTTTTAAAAACTGGTCTGATCGGACTTCTCGTCCTGG
GACACTGTTTACTGGAGTCTGGCCGGCTCCCCGTGCTCCTCTTGGTACCTCATTTTGGGGAGAA
CCTTAAACCCACCCGAGCAGATAATCTCCGCCTTGACCGGTGCCACCAAAGAAGCCTTGGAACC
ATGTGGACTTTTCTGGGCATTGCCACTTTCACCTATTTTTATAAGAAGTTCGGGGACTTCATCA
CTTTGGCCAACAGGGAGGTCCTGTTGTGCATGCTGGTGTTCCTCTCGCTGGGCCTGGTGCTGTC
CTACCGCTGTCGCCACCGAAACGGGGGTCTCCTCGGGCGCCAGCAGAGCGGCTCCCAGTTCGCC
CTCTTCTCGGATATTCTCTCAGGCCTGCCTTTCATTGGCTTCTTCTGGGCCAAGTCCCCCCCTG
AATCAGAAAATAAGGAGCAGCTCGAGGCCAGGAGGCGCAGAAAAGGAACCAATATTTCAGAAAC
AAGCTTAATAGGAGCAGCTGCCTGTACATCAACATCTCAGAATGACCCGGAAGTTATCATCGTG
GGAGCTGGCGTGCTTGGCTCTGCTTTGGCAGCCGTGCTTTCCAGAGATGGAAGAAAGGTGACAG
TCATTGAGAGAGACTTAAAAGAGCCTGACAGAATAGTTGGAGAATTCCTGCAGCCGGGTGGTTA
TCATGTTCTCAAAGACCTTGGTCTTGGAGATACAGTGGAAGGTCTTGATGCCCAGGTTGTAAAT
GGTTACATGATTCATGATCAGGAAAGCAAATCAGAGGTTCAGATTCCTTACCCCCTGTCAGAAA
ACAATCAAGTGCAGAGTGGAAGAGCTTTCCATCACGGAAGATTCATCATGAGTCTCCGGAAAGC
AGCTATGGCAGAGCCCAATGCAAAGTTTATTGAAGGTGTTGTGTTACAGTTATTAGAGGAAGAT
GATGTTGTGATGGGAGTTCAGTACAAGGATAAAGAGACTGGAGATATCAAGGAACTCCATGCTC
CACTGACTGTTGTTGCAGATGGGCTTTTCTCCAAGTTCAGGAAAAGCCTGGTCTCCAATAAAGT
TTCTGTATCATCTCATTTTGTTGGCTTTCTTATGAAGAATGCACCACAGTTTAAAGCAAATCAT
GCTGAACTTATTTTAGCTAACCCGAGTCCAGTTCTCATCTACCAGATTTCATCCAGTGAAACTC
GAGTACTTGTTGACGTTAGAGGAGAAATGCCAAGGAATTTAAGAGAATACATGGTTGAAAAAAT
TTACCCACAAATACCTGATCACCTGAAAGAACCATTCTTAGAAGCCACTGACAATTCTCATCTG
AGGTCCATGCCAGCAAGCTTCCTTCCTCCTTCATCAGTGAAGAAACGAGGTGTTCTTCTTTTGG
GAGACGCATATAATATGAGGCATCCACTTACTGGTGGAGGAATGACTGTTGCTTTTAAAGATAT
AAAACTATGGAGAAAACTGCTAAAGGGTATCCCTGACCTTTATGATGATGCAGCTATTTTCGAG
GCCAAAAAATCATTTTACTGGGCAAGAAAAACATCTCATTCCTTTGTCGTGAATATCCTTGCTC
AGGCTCTTTATGAATTATTTTCTGCCACAGATGATTCCCTGCATCAACTAAGAAAAGCCTGTTT
TCTTTATTTCAAACTTGGTGGCGAATGTGTTGCGGGTCCTGTTGGGCTGCTTTCTGTATTGTCT
CCTAACCCTCTAGTTTTAATTGGACACTTCTTTGCTGTTGCAATCTATGCCGTGTATTTTTGCT
TTAAGTCAGAACCTTGGATTACAAAACCTCGAGCCCTTCTCAGTAGTGGTGCTGTATTGTACAA
AGCGTGTTCTGTAATATTTCCTCTAATTTACTCAGAAATGAAGTATATGGTTCATTAAGCTTAA
AGGGGAACCATTTGTGAATGAATATTTGGAACTTCCCAAGTCCTAAGAGACTTTTGGAAGAGGA
CACGTGTAGCATAGGACCATAGCACTTACAAAGCGGAAACTCTTGGACCAAGATTTGGATTAAT
TTGTTTTTGAAGTTTTTTGTATATAAATATGTAAATGCTTTAATTTGCAATTTAAAATGAAGGG
GTTAAATGAGTTAGACATTTAAAAGAAATGATTGTTACCATAAATTAGTGCTAATGCTGAGGAG
AACTACAGTTTTTCTTTTGAATTTAGTATTTGAGATGAGTTGTTGGGACATGCAAATAAAATGG
AGAATGAACTTT

hide sequence

RefSeq Acc Id:

XM_008973922 ⟹ XP_008972170

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	142,421,220 - 142,445,046 (+)	NCBI
NHGRI_mPanPan1	8	117,932,343 - 117,956,167 (+)	NCBI
Mhudiblu_PPA_v0	8	121,684,307 - 121,708,131 (+)	NCBI
PanPan1.1	8	124,435,668 - 124,459,435 (+)	NCBI

Sequence:

show sequence

GCGCTGGCGAGAGCCGCCGCCCGCGAGGGATGCTGGTGAGGAAGCCGTCGGGAGCCGCCGCCGC
CATCTGAGGGAGCATTGGTTGAGCCTCAGATGGAGGTTGGATATTTGATTATGAAAGATGGAAC
GAAATGTTAGAATTTCATTTTGAAGGAGAAGAACAACCACTTTCCATGATGAAAAAGTTTTTAA
AAAGTTCTTGGGTAAGGATTGGATTTGTGCCTGAGGAAGAAAGAAACGTGCTGCGGCGCAGAAA
AGGAACCAATATTTCAGAAACAAGCTTAATAGGAGCAGCTGCCTGTACATCAACATCTCAGAAT
GACCCGGAAGTTATCATCGTGGGAGCTGGCGTGCTTGGCTCTGCTTTGGCAGCCGTGCTTTCCA
GAGATGGAAGAAAGGTGACAGTCATTGAGAGAGACTTAAAAGAGCCTGACAGAATAGTTGGAGA
ATTCCTGCAGCCGGGTGGTTATCATGTTCTCAAAGACCTTGGTCTTGGAGATACAGTGGAAGGT
CTTGATGCCCAGGTTGTAAATGGTTACATGATTCATGATCAGGAAAGCAAATCAGAGGTTCAGA
TTCCTTACCCCCTGTCAGAAAACAATCAAGTGCAGAGTGGAAGAGCTTTCCATCACGGAAGATT
CATCATGAGTCTCCGGAAAGCAGCTATGGCAGAGCCCAATGCAAAGTTTATTGAAGGTGTTGTG
TTACAGTTATTAGAGGAAGATGATGTTGTGATGGGAGTTCAGTACAAGGATAAAGAGACTGGAG
ATATCAAGGAACTCCATGCTCCACTGACTGTTGTTGCAGATGGGCTTTTCTCCAAGTTCAGGAA
AAGCCTGGTCTCCAATAAAGTTTCTGTATCATCTCATTTTGTTGGCTTTCTTATGAAGAATGCA
CCACAGTTTAAAGCAAATCATGCTGAACTTATTTTAGCTAACCCGAGTCCAGTTCTCATCTACC
AGATTTCATCCAGTGAAACTCGAGTACTTGTTGACGTTAGAGGAGAAATGCCAAGGAATTTAAG
AGAATACATGGTTGAAAAAATTTACCCACAAATACCTGATCACCTGAAAGAACCATTCTTAGAA
GCCACTGACAATTCTCATCTGAGGTCCATGCCAGCAAGCTTCCTTCCTCCTTCATCAGTGAAGA
AACGAGGTGTTCTTCTTTTGGGAGACGCATATAATATGAGGCATCCACTTACTGGTGGAGGAAT
GACTGTTGCTTTTAAAGATATAAAACTATGGAGAAAACTGCTAAAGGGTATCCCTGACCTTTAT
GATGATGCAGCTATTTTCGAGGCCAAAAAATCATTTTACTGGGCAAGAAAAACATCTCATTCCT
TTGTCGTGAATATCCTTGCTCAGGCTCTTTATGAATTATTTTCTGCCACAGATGATTCCCTGCA
TCAACTAAGAAAAGCCTGTTTTCTTTATTTCAAACTTGGTGGCGAATGTGTTGCGGGTCCTGTT
GGGCTGCTTTCTGTATTGTCTCCTAACCCTCTAGTTTTAATTGGACACTTCTTTGCTGTTGCAA
TCTATGCCGTGTATTTTTGCTTTAAGTCAGAACCTTGGATTACAAAACCTCGAGCCCTTCTCAG
TAGTGGTGCTGTATTGTACAAAGCGTGTTCTGTAATATTTCCTCTAATTTACTCAGAAATGAAG
TATATGGTTCATTAAGCTTAAAGGGGAACCATTTGTGAATGAATATTTGGAACTTCCCAAGTCC
TAAGAGACTTTTGGAAGAGGACACGTGTAGCATAGGACCATAGCACTTACAAAGCGGAAACTCT
TGGACCAAGATTTGGATTAATTTGTTTTTGAAGTTTTTTGTATATAAATATGTAAATGCTTTAA
TTTGCAATTTAAAATGAAGGGGTTAAATGAGTTAGACATTTAAAAGAAATGATTGTTACCATAA
ATTAGTGCTAATGCTGAGGAGAACTACAGTTTTTCTTTTGAATTTAGTATTTGAGATGAGTTGT
TGGGACATGCAAATAAAATGGAGAATG

hide sequence

RefSeq Acc Id:

XM_034966577 ⟹ XP_034822468

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	142,421,180 - 142,445,046 (+)	NCBI
NHGRI_mPanPan1	8	117,932,264 - 117,956,167 (+)	NCBI
Mhudiblu_PPA_v0	8	121,684,269 - 121,708,131 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003820509	(Get FASTA)	NCBI Sequence Viewer
	XP_008972170	(Get FASTA)	NCBI Sequence Viewer
	XP_034822468	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000043161
	ENSPPAP00000043161.1
	ENSPPAP00000043163
	ENSPPAP00000043163.1

RefSeq Acc Id:	XP_003820509 ⟸ XM_003820461
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9CMG7 (UniProtKB/TrEMBL), A0A2R9CP89 (UniProtKB/TrEMBL)
- Sequence:	show sequence MWTFLGIATFTYFYKKFGDFITLANREVLLCMLVFLSLGLVLSYRCRHRNGGLLGRQQSGSQFA LFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGAAACTSTSQNDPEVIIV GAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVN GYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEED DVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANH AELILANPSPVLIYQISSSETRVLVDVRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHL RSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFE AKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLS PNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH hide sequence

RefSeq Acc Id:	XP_008972170 ⟸ XM_008973922
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9CP89 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLEFHFEGEEQPLSMMKKFLKSSWVRIGFVPEEERNVLRRRKGTNISETSLIGAAACTSTSQND PEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGL DAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVL QLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAP QFKANHAELILANPSPVLIYQISSSETRVLVDVRGEMPRNLREYMVEKIYPQIPDHLKEPFLEA TDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYD DAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVG LLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKY MVH hide sequence

RefSeq Acc Id:	XP_034822468 ⟸ XM_034966577
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSPPAP00000043163 ⟸ ENSPPAT00000066098

RefSeq Acc Id:

ENSPPAP00000043161 ⟸ ENSPPAT00000066096

Protein Domains

Squalene epoxidase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000044116	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000066096.1	UniProtKB/TrEMBL
	ENSPPAT00000066098.1	UniProtKB/TrEMBL
Gene3D-CATH	3.50.50.60	UniProtKB/TrEMBL
InterPro	FAD/NAD-bd_sf	UniProtKB/TrEMBL
	Squalene_epoxidase	UniProtKB/TrEMBL
	Squalene_monox	UniProtKB/TrEMBL
KEGG Report	pps:100976805	UniProtKB/TrEMBL
NCBI Gene	SQLE	ENTREZGENE
PANTHER	PTHR10835	UniProtKB/TrEMBL
	SQUALENE MONOOXYGENASE	UniProtKB/TrEMBL
Pfam	NAD_binding_8	UniProtKB/TrEMBL
	PF08491	UniProtKB/TrEMBL
PRINTS	RNGMNOXGNASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51905	UniProtKB/TrEMBL
UniProt	A0A2R9CMG7	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9CP89	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB