Livw4 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Livw4 (Liver weight QTL 4) Rattus norvegicus

Symbol: Livw4
Name: Liver weight QTL 4
RGD ID: 10450856
Trait: liver mass   (VT:0003402)    
Measurement Type: liver weight   (CMO:0000092)    
LOD Score: 3.8
P Value: Not Available
Variance: 28.0
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2770,840,118 - 72,474,897RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0778,758,303 - 80,297,776RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0778,786,126 - 80,323,758RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4775,357,125 - 77,004,148RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement
liver weight  (IDA)

Vertebrate Trait
liver mass  (IDA)

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Genomic determinants of triglyceride and cholesterol distribution into lipoprotein fractions in the rat. Hodulova M, etal., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1304943Lrp12LDL receptor related protein 1277094106871012409Rat
1306021Zfpm2zinc finger protein, multitype 277167865872116209Rat
68376Dpysdihydropyrimidinase77082264870929255Rat
1565735Gapdh-ps14Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 1477107256671073546Rat
2318573Zcchc10-ps1zinc finger CCHC-type containing 10, pseudogene 177127388271276787Rat
7655393LOC102556196uncharacterized LOC10255619677236933972427830Rat
9196150LOC103692893uncharacterized LOC10369289377135055471411463Rat
11463877LOC108351485uncharacterized LOC10835148577166616071679410Rat
41120258LOC120093645uncharacterized LOC12009364577220278972209408Rat
41188976LOC120093644uncharacterized LOC12009364477208651072087989Rat
41122073LOC120093642uncharacterized LOC12009364277103645371041241Rat
41126079LOC120093643uncharacterized LOC12009364377175546871761836Rat
41255602LOC120094033U2 spliceosomal RNA77111313671113342Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
42833D7Rat20622977084011870840342Ratregion
41558D7Rat14212577178896371789091Ratregion
60579D7Got5218777247471072474897Ratregion
1631587D7Got23418677190696371907149Ratregion
1634664D7Got22222077117423871174457Ratregion
1634664D7Got22222077117423871174473Ratregion
5073880RH13769216977085137670851545Ratregion
5061092AW53222915877180627171806429Ratregion
5504550PMC303372P148577211540372115888Ratregion
5500230AI84882913977094113870941277Ratregion
Position Markers

Flank 1: (D7Rat206)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2770,840,118 - 70,840,342 (+)MAPPER
Rnor_6.0778,758,303 - 78,758,526NCBI
Rnor_5.0778,786,126 - 78,786,349UniSTS
RGSC_v3.4775,357,125 - 75,357,349RGD
RGSC_v3.4775,357,126 - 75,357,349UniSTS
RGSC_v3.1775,377,855 - 75,378,079RGD
Celera767,893,790 - 67,894,013UniSTS
SHRSP x BN Map745.53RGD
SHRSP x BN Map745.53UniSTS
Flank 2: (D7Got52)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2772,474,710 - 72,474,897 (+)MAPPER
Rnor_6.0780,297,590 - 80,297,776NCBI
Rnor_5.0780,323,572 - 80,323,758UniSTS
RGSC_v3.4777,003,961 - 77,004,147RGD
RGSC_v3.4777,003,962 - 77,004,148UniSTS
RGSC_v3.1777,024,691 - 77,024,877RGD
Celera769,493,553 - 69,493,739UniSTS
RH 3.4 Map7633.3RGD
RH 3.4 Map7633.3UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)77084011872474897Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)77084011872474897Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general 9 genes are present in this region 10402111
qtl_general number of animals used: 8-13 males, 4 month old from 15 PXO recombinant inbred strains 10402111
qtl_general software used: STATISTICA 10 CZ; ANOVA 10402111
qtl_general measurement method: 4 month old male rats were fed high-sucrose diet for 1 week; the rats were sacrificed and liver weight taken 10402111
qtl_general confidence interval: 74,492-76,763 Kbp 10402111