Serhl2 (serine hydrolase-like 2) - Rat Genome Database

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Gene: Serhl2 (serine hydrolase-like 2) Rattus norvegicus
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Symbol: Serhl2
Name: serine hydrolase-like 2
RGD ID: 1563386
Description: Predicted to enable hydrolase activity. Predicted to be located in cytoplasmic vesicle. Orthologous to several human genes including SERHL2 (serine hydrolase like 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC500911; RGD1563386; serine hydrolase-like protein 2; similar to serine hydolase like protein, isoforms Serhl-2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87116,126,085 - 116,146,345 (+)NCBIGRCr8
mRatBN7.27114,246,035 - 114,266,298 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,246,056 - 114,272,781 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7116,001,164 - 116,021,447 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,225,274 - 118,245,525 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,194,720 - 118,214,972 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,963,381 - 123,990,103 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,963,381 - 123,990,103 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,946,390 - 123,972,802 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47121,126,466 - 121,153,421 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7110,560,255 - 110,586,960 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11352564   PMID:18614015  


Genomics

Comparative Map Data
Serhl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87116,126,085 - 116,146,345 (+)NCBIGRCr8
mRatBN7.27114,246,035 - 114,266,298 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,246,056 - 114,272,781 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7116,001,164 - 116,021,447 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,225,274 - 118,245,525 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,194,720 - 118,214,972 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,963,381 - 123,990,103 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,963,381 - 123,990,103 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,946,390 - 123,972,802 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47121,126,466 - 121,153,421 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7110,560,255 - 110,586,960 (+)NCBICelera
Cytogenetic Map7q34NCBI
SERHL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382242,553,956 - 42,574,382 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2242,553,617 - 42,574,382 (+)EnsemblGRCh38hg38GRCh38
GRCh372242,949,962 - 42,970,388 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,279,869 - 41,300,332 (+)NCBINCBI36Build 36hg18NCBI36
Celera2226,860,413 - 26,880,873 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2225,910,619 - 25,931,056 (+)NCBIHuRef
CHM1_12242,909,057 - 42,929,534 (+)NCBICHM1_1
T2T-CHM13v2.02243,034,822 - 43,055,247 (+)NCBIT2T-CHM13v2.0
Serhl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391582,984,394 - 83,000,876 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1582,973,707 - 83,000,875 (+)EnsemblGRCm39 Ensembl
GRCm381583,100,192 - 83,116,676 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,089,506 - 83,116,674 (+)EnsemblGRCm38mm10GRCm38
MGSCv371582,930,635 - 82,947,101 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361582,927,981 - 82,950,511 (+)NCBIMGSCv36mm8
Celera1585,232,976 - 85,250,013 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1539.32NCBI
SERHL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22352,353,671 - 52,409,462 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12255,045,926 - 55,101,936 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02223,413,724 - 23,469,689 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12241,602,540 - 41,622,944 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2241,602,540 - 41,622,944 (+)Ensemblpanpan1.1panPan2
SERHL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11022,891,092 - 22,928,524 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1022,891,095 - 22,928,110 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1022,826,394 - 22,863,487 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01023,635,950 - 23,673,048 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1023,635,955 - 23,673,084 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11023,353,511 - 23,390,593 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01023,672,980 - 23,710,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01023,848,611 - 23,885,706 (-)NCBIUU_Cfam_GSD_1.0
Serhl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049456,480,310 - 6,498,093 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936718482,102 - 499,855 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERHL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl56,216,326 - 6,230,367 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.156,216,323 - 6,239,811 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103223420
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11925,028,646 - 25,132,117 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366617487,839 - 149,351 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:161
Interacting mature miRNAs:194
Transcripts:ENSRNOT00000036586
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH130857  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27114,265,546 - 114,265,766 (+)MAPPERmRatBN7.2
Rnor_6.07123,982,869 - 123,983,088NCBIRnor6.0
Rnor_5.07123,965,568 - 123,965,787UniSTSRnor5.0
RGSC_v3.47121,146,187 - 121,146,406UniSTSRGSC3.4
Celera7110,579,726 - 110,579,945UniSTS
RH 3.4 Map7905.5UniSTS
Cytogenetic Map7q34UniSTS
BE114170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27114,250,054 - 114,250,248 (+)MAPPERmRatBN7.2
Rnor_6.07123,967,378 - 123,967,571NCBIRnor6.0
Rnor_5.07123,950,387 - 123,950,580UniSTSRnor5.0
RGSC_v3.47121,130,463 - 121,130,656UniSTSRGSC3.4
Celera7110,564,242 - 110,564,435UniSTS
RH 3.4 Map7903.2UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000036586   ⟹   ENSRNOP00000028962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7114,246,056 - 114,272,781 (+)Ensembl
Rnor_6.0 Ensembl7123,963,381 - 123,990,103 (+)Ensembl
RefSeq Acc Id: NM_001130579   ⟹   NP_001124051
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87116,126,085 - 116,146,345 (+)NCBI
mRatBN7.27114,246,035 - 114,266,298 (+)NCBI
Rnor_6.07123,963,381 - 123,990,103 (+)NCBI
Rnor_5.07123,946,390 - 123,972,802 (+)NCBI
RGSC_v3.47121,126,466 - 121,153,421 (+)RGD
Celera7110,560,255 - 110,586,960 (+)RGD
Sequence:
RefSeq Acc Id: XM_008765775   ⟹   XP_008763997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87116,126,197 - 116,146,345 (+)NCBI
mRatBN7.27114,246,176 - 114,266,298 (+)NCBI
Rnor_6.07123,963,518 - 123,983,620 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039079766   ⟹   XP_038935694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87116,126,215 - 116,146,020 (+)NCBI
mRatBN7.27114,246,165 - 114,266,002 (+)NCBI
RefSeq Acc Id: XR_010053031
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87116,126,215 - 116,145,215 (+)NCBI
RefSeq Acc Id: XR_010053032
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87116,126,097 - 116,145,233 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001124051 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763997 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935694 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM15641 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028962.3
RefSeq Acc Id: NP_001124051   ⟸   NM_001130579
- UniProtKB: D4A071 (UniProtKB/TrEMBL),   A6HT81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763997   ⟸   XM_008765775
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000028962   ⟸   ENSRNOT00000036586
RefSeq Acc Id: XP_038935694   ⟸   XM_039079766
- Peptide Label: isoform X2
Protein Domains
AB hydrolase-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A071-F1-model_v2 AlphaFold D4A071 1-310 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695541
Promoter ID:EPDNEW_R6066
Type:single initiation site
Name:Serhl2_1
Description:serine hydrolase-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07123,963,451 - 123,963,511EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563386 AgrOrtholog
BioCyc Gene G2FUF-32613 BioCyc
Ensembl Genes ENSRNOG00000022932 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036586.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/TrEMBL
  AB_hydrolase_sf UniProtKB/TrEMBL
KEGG Report rno:500911 UniProtKB/TrEMBL
NCBI Gene 500911 ENTREZGENE
PANTHER MONOACYLGLYCEROL LIPASE UniProtKB/TrEMBL
  SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239 UniProtKB/TrEMBL
Pfam Abhydrolase_1 UniProtKB/TrEMBL
PhenoGen Serhl2 PhenoGen
PRINTS ABHYDROLASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022932 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A6HT81 ENTREZGENE, UniProtKB/TrEMBL
  D4A071 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Serhl2  serine hydrolase-like 2  RGD1563386_predicted  similar to serine hydolase like protein, isoforms Serhl-2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563386_predicted  similar to serine hydolase like protein, isoforms Serhl-2 (predicted)  LOC500911  similar to serine hydolase like protein, isoforms Serhl-2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500911  similar to serine hydolase like protein, isoforms Serhl-2      Symbol and Name status set to provisional 70820 PROVISIONAL