Adcy6 (adenylate cyclase 6) - Rat Genome Database

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Gene: Adcy6 (adenylate cyclase 6) Rattus norvegicus
Analyze
Symbol: Adcy6
Name: adenylate cyclase 6
RGD ID: 2035
Description: Enables several functions, including SNARE binding activity; calcium- and calmodulin-responsive adenylate cyclase activity; and protein kinase binding activity. Involved in several processes, including cAMP biosynthetic process; maintenance of protein location in plasma membrane; and negative regulation of neuron projection development. Located in endosome and microvillus membrane. Colocalizes with sarcolemma. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADCY6 (adenylate cyclase 6); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; protein kinase A (PKA) signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AC6; ACVI; ADCYB; adenylate cyclase type 6; adenylate cyclase type VI; adenylyl cyclase 6; ATP pyrophosphate-lyase 6; ca(2+)-inhibitable adenylyl cyclase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27129,742,827 - 129,763,922 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,742,838 - 129,763,754 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,550,191 - 131,571,121 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,775,741 - 133,796,673 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,688,243 - 133,709,175 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,270,678 - 140,291,722 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,270,692 - 140,291,620 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,774,376 - 114,795,062 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,339,933 - 137,360,020 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,418,113 - 137,437,246 (-)NCBI
Celera7126,233,455 - 126,254,162 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (EXP,ISO)
diuron  (EXP)
dobutamine  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
indometacin  (EXP,ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
Licarin A  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (ISO)
morphine  (EXP)
nickel atom  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
paclitaxel  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
starch  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
thiabendazole  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
triclosan  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cilium  (IEA)
endosome  (IDA)
membrane  (IDA)
microvillus membrane  (IDA)
plasma membrane  (IDA,IEA,ISO,ISS)
sarcolemma  (IDA)
stereocilium  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
2. Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation. Creighton J, etal., J Cell Sci. 2008 Jan 1;121(Pt 1):110-9. Epub 2007 Dec 11.
3. Raf kinase activation of adenylyl cyclases: isoform-selective regulation. Ding Q, etal., Mol Pharmacol. 2004 Oct;66(4):921-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands. Han S, etal., J Biol Chem. 2005 Nov 18;280(46):38228-34. Epub 2005 Sep 15.
6. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Head BP, etal., J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.
7. Cellular localization of type 5 and type 6 ACs in collecting duct and regulation of cAMP synthesis. Helies-Toussaint C, etal., Am J Physiol Renal Physiol. 2000 Jul;279(1):F185-94.
8. Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction. Jensen AM, etal., Am J Physiol Renal Physiol. 2009 Jan;296(1):F127-34. Epub 2008 Oct 29.
9. Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries. Jourdan KB, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1359-69.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Indomethacin enhances shuttling of aquaporin-2 despite decreased abundance in rat kidney. Kim SW, etal., J Am Soc Nephrol. 2004 Dec;15(12):2998-3005.
12. Molecular diversity in the adenylylcyclase family. Evidence for eight forms of the enzyme and cloning of type VI. Krupinski J, etal., J Biol Chem 1992 Dec 5;267(34):24858-62.
13. Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver. Merlen C, etal., FEBS Lett. 2006 Oct 16;580(24):5697-704. Epub 2006 Sep 20.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Localization of cyclic nucleotide phosphodiesterase 2 in the brain-derived Triton-insoluble low-density fraction (raft). Noyama K and Maekawa S, Neurosci Res. 2003 Feb;45(2):141-8.
17. Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts. Oshikawa J, etal., Am J Physiol Cell Physiol. 2003 Sep;285(3):C567-74. Epub 2003 May 14.
18. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases. Premont RT, etal., Proc Natl Acad Sci U S A 1992 Oct 15;89(20):9809-13.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Cyclic adenosine monophosphate signaling in the rat vomeronasal organ: role of an adenylyl cyclase type VI. Rossler P, etal., Chem Senses. 2000 Jun;25(3):313-22.
26. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
27. Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes. Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51.
28. Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25. Wu CS, etal., Mol Cell Biol. 2011 Dec;31(24):4874-86. doi: 10.1128/MCB.05593-11. Epub 2011 Oct 10.
Additional References at PubMed
PMID:1379717   PMID:11877398   PMID:15007069   PMID:15192109   PMID:15231818   PMID:15499025   PMID:17081159   PMID:17593019   PMID:17916776   PMID:17934720   PMID:18403039   PMID:18838385  
PMID:19932173   PMID:20164376   PMID:20466003   PMID:20736067   PMID:21127130   PMID:21478251   PMID:21606183   PMID:23132712   PMID:23842570   PMID:25769305   PMID:27923787   PMID:30413613  


Genomics

Comparative Map Data
Adcy6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27129,742,827 - 129,763,922 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,742,838 - 129,763,754 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,550,191 - 131,571,121 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,775,741 - 133,796,673 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,688,243 - 133,709,175 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,270,678 - 140,291,722 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,270,692 - 140,291,620 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,774,376 - 114,795,062 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,339,933 - 137,360,020 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,418,113 - 137,437,246 (-)NCBI
Celera7126,233,455 - 126,254,162 (-)NCBICelera
Cytogenetic Map7q36NCBI
ADCY6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,766,194 - 48,789,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1248,766,194 - 48,789,089 (-)EnsemblGRCh38hg38GRCh38
GRCh371249,159,977 - 49,182,872 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,446,248 - 47,469,087 (-)NCBINCBI36Build 36hg18NCBI36
Build 341247,446,247 - 47,469,087NCBI
Celera1247,955,885 - 47,978,715 (-)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,193,406 - 46,216,105 (-)NCBIHuRef
CHM1_11249,125,807 - 49,148,636 (-)NCBICHM1_1
T2T-CHM13v2.01248,728,221 - 48,752,002 (-)NCBIT2T-CHM13v2.0
Adcy6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,484,982 - 98,508,119 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,487,854 - 98,507,957 (-)EnsemblGRCm39 Ensembl
GRCm381598,589,978 - 98,610,287 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,589,973 - 98,610,076 (-)EnsemblGRCm38mm10GRCm38
MGSCv371598,420,409 - 98,438,064 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,418,012 - 98,435,667 (-)NCBIMGSCv36mm8
Celera15100,737,585 - 100,755,761 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.59NCBI
Adcy6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,637,089 - 7,651,162 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555007,635,946 - 7,655,579 (-)NCBIChiLan1.0ChiLan1.0
ADCY6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11245,388,364 - 45,412,100 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01239,957,394 - 39,981,049 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11240,836,922 - 40,859,131 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,836,922 - 40,859,131 (+)Ensemblpanpan1.1panPan2
ADCY6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,739,514 - 5,752,888 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,733,586 - 5,752,888 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,504,946 - 40,518,306 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,784,673 - 5,805,753 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,788,872 - 5,805,745 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,754,314 - 5,767,654 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,744,379 - 5,757,707 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02740,897,201 - 40,910,552 (-)NCBIUU_Cfam_GSD_1.0
Adcy6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,529,608 - 66,572,952 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,615,012 - 6,629,165 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365126,612,708 - 6,629,202 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,834,426 - 14,850,728 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1514,834,420 - 14,855,309 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,128,970 - 15,146,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11145,006,220 - 45,031,481 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1145,005,637 - 45,025,501 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037201,115,865 - 201,140,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248163,366,744 - 3,387,447 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248163,366,594 - 3,387,431 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adcy6
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:694
Count of miRNA genes:292
Interacting mature miRNAs:394
Transcripts:ENSRNOT00000016623
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
RH127375  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23136,337,031 - 136,337,233 (+)MAPPERmRatBN7.2
mRatBN7.27129,758,363 - 129,758,565 (+)MAPPERmRatBN7.2
Rnor_6.07140,286,211 - 140,286,412NCBIRnor6.0
Rnor_6.03143,219,780 - 143,219,981NCBIRnor6.0
Rnor_5.03149,628,801 - 149,629,002UniSTSRnor5.0
Rnor_5.0X114,789,909 - 114,790,110UniSTSRnor5.0
RGSC_v3.43137,651,012 - 137,651,213UniSTSRGSC3.4
RGSC_v3.47137,355,452 - 137,355,653UniSTSRGSC3.4
Celera7126,248,838 - 126,249,039UniSTS
Celera3135,178,141 - 135,178,342UniSTS
Cytogenetic Map3q41UniSTS
Cytogenetic Map7q36UniSTS
RH129348  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27129,742,881 - 129,743,093 (+)MAPPERmRatBN7.2
Rnor_6.07140,270,736 - 140,270,947NCBIRnor6.0
Rnor_5.0X114,774,434 - 114,774,645UniSTSRnor5.0
RGSC_v3.47137,339,977 - 137,340,188UniSTSRGSC3.4
Celera7126,233,499 - 126,233,710UniSTS
RH 3.4 Map71086.5UniSTS
Cytogenetic Map7q36UniSTS
UniSTS:532125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27129,758,219 - 129,758,426 (+)MAPPERmRatBN7.2
Rnor_6.07140,286,067 - 140,286,273NCBIRnor6.0
Rnor_5.0X114,789,765 - 114,789,971UniSTSRnor5.0
Celera7126,248,694 - 126,248,900UniSTS
Cytogenetic Map3q41UniSTS
Cytogenetic Map7q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 52 36 15 36 1 1 66 35 34 11 1
Low 5 5 4 5 7 10 8 7 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000082699   ⟹   ENSRNOP00000072192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7129,742,838 - 129,757,847 (-)Ensembl
Rnor_6.0 Ensembl7140,270,692 - 140,290,796 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088323   ⟹   ENSRNOP00000072881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7129,742,838 - 129,763,754 (-)Ensembl
Rnor_6.0 Ensembl7140,270,692 - 140,291,620 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109694   ⟹   ENSRNOP00000078118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7129,742,838 - 129,762,975 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112169   ⟹   ENSRNOP00000092305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7129,742,838 - 129,758,402 (-)Ensembl
RefSeq Acc Id: NM_001270785   ⟹   NP_001257714
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27129,742,838 - 129,763,754 (-)NCBI
Rnor_6.07140,270,692 - 140,291,620 (-)NCBI
Rnor_5.0X114,774,376 - 114,795,062 (-)NCBI
Celera7126,233,455 - 126,254,162 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012821   ⟹   NP_036953
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27129,742,838 - 129,762,951 (-)NCBI
Rnor_6.07140,270,692 - 140,290,796 (-)NCBI
Rnor_5.0X114,774,376 - 114,795,062 (-)NCBI
RGSC_v3.47137,339,933 - 137,360,020 (-)RGD
Celera7126,233,455 - 126,253,389 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594669   ⟹   XP_017450158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27129,742,827 - 129,761,371 (-)NCBI
Rnor_6.07140,270,678 - 140,290,328 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594670   ⟹   XP_017450159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27129,742,827 - 129,763,922 (-)NCBI
Rnor_6.07140,270,678 - 140,291,722 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078456   ⟹   XP_038934384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27129,742,827 - 129,763,495 (-)NCBI
RefSeq Acc Id: XM_039078457   ⟹   XP_038934385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27129,742,827 - 129,763,811 (-)NCBI
RefSeq Acc Id: XR_005486546
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27129,747,849 - 129,763,811 (-)NCBI
RefSeq Acc Id: NP_036953   ⟸   NM_012821
- Peptide Label: isoform 2
- UniProtKB: Q03343 (UniProtKB/Swiss-Prot),   A6KC93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257714   ⟸   NM_001270785
- Peptide Label: isoform 1
- UniProtKB: Q03343 (UniProtKB/Swiss-Prot),   A0A0G2K429 (UniProtKB/TrEMBL),   A6KC91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450159   ⟸   XM_017594670
- Peptide Label: isoform X1
- UniProtKB: Q03343 (UniProtKB/Swiss-Prot),   A6KC93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450158   ⟸   XM_017594669
- Peptide Label: isoform X1
- UniProtKB: Q03343 (UniProtKB/Swiss-Prot),   A6KC93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072192   ⟸   ENSRNOT00000082699
RefSeq Acc Id: ENSRNOP00000072881   ⟸   ENSRNOT00000088323
RefSeq Acc Id: XP_038934385   ⟸   XM_039078457
- Peptide Label: isoform X2
- UniProtKB: Q03343 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038934384   ⟸   XM_039078456
- Peptide Label: isoform X1
- UniProtKB: Q03343 (UniProtKB/Swiss-Prot),   A6KC93 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092305   ⟸   ENSRNOT00000112169
RefSeq Acc Id: ENSRNOP00000078118   ⟸   ENSRNOT00000109694
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03343-F1-model_v2 AlphaFold Q03343 1-1166 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695626
Promoter ID:EPDNEW_R6151
Type:single initiation site
Name:Adcy6_1
Description:adenylate cyclase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07140,291,595 - 140,291,655EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2035 AgrOrtholog
BioCyc Gene G2FUF-32126 BioCyc
Ensembl Genes ENSRNOG00000054757 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082699 ENTREZGENE
  ENSRNOT00000082699.2 UniProtKB/TrEMBL
  ENSRNOT00000088323 ENTREZGENE
  ENSRNOT00000088323.2 UniProtKB/TrEMBL
  ENSRNOT00000109694.1 UniProtKB/TrEMBL
  ENSRNOT00000112169.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy_conserved_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25289 UniProtKB/Swiss-Prot
NCBI Gene 25289 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADENYLATE CYCLASE TYPE 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1053 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adcy6 PhenoGen
PIRSF Ade_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054757 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K429 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5YCM9_RAT UniProtKB/TrEMBL
  A0A8I6GK44_RAT UniProtKB/TrEMBL
  A6KC91 ENTREZGENE, UniProtKB/TrEMBL
  A6KC93 ENTREZGENE, UniProtKB/TrEMBL
  ADCY6_RAT UniProtKB/Swiss-Prot
  F1LSD1_RAT UniProtKB/TrEMBL
  Q03343 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Adcy6  adenylate cyclase 6    adenylyl cyclase 6  Name updated 1299863 APPROVED
2002-06-10 Adcy6  adenylyl cyclase 6      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in heart, kidney, and brain 69740
gene_process may a role in intracellular signaling 631706
gene_product member of the adenylylcyclase family 631706