RGD Reference Report - Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. - Rat Genome Database
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Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.

Authors: Boone, M  Deen, PM 
Citation: Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
RGD ID: 2312656
Pubmed: (View Article at PubMed) PMID:18431594
DOI: Full-text: DOI:10.1007/s00424-008-0498-1

To prevent dehydration, terrestrial animals and humans have developed a sensitive and versatile system to maintain their water homeostasis. In states of hypernatremia or hypovolemia, the antidiuretic hormone vasopressin (AVP) is released from the pituitary and binds its type-2 receptor in renal principal cells. This triggers an intracellular cAMP signaling cascade, which phosphorylates aquaporin-2 (AQP2) and targets the channel to the apical plasma membrane. Driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels. When water homeostasis is restored, AVP levels decline, and AQP2 is internalized from the plasma membrane, leaving the plasma membrane watertight again. The action of AVP is counterbalanced by several hormones like prostaglandin E2, bradykinin, dopamine, endothelin-1, acetylcholine, epidermal growth factor, and purines. Moreover, AQP2 is strongly involved in the pathophysiology of disorders characterized by renal concentrating defects, as well as conditions associated with severe water retention. This review focuses on our recent increase in understanding of the molecular mechanisms underlying AVP-regulated renal water transport in both health and disease.

Annotation

Molecular Pathway Annotations    
Objects Annotated

Genes (Rattus norvegicus)
Adcy6  (adenylate cyclase 6)
Akap7  (A-kinase anchoring protein 7)
Aqp2  (aquaporin 2)
Avp  (arginine vasopressin)
Avpr2  (arginine vasopressin receptor 2)
Gnas  (GNAS complex locus)
Myo5b  (myosin Vb)
Pde4d  (phosphodiesterase 4D)
Rab11a  (RAB11a, member RAS oncogene family)
Rab11fip2  (RAB11 family interacting protein 2)
Sipa1  (signal-induced proliferation-associated 1)
Snap23  (synaptosome associated protein 23)
Vamp2  (vesicle-associated membrane protein 2)

Genes (Mus musculus)
Adcy6  (adenylate cyclase 6)
Akap7  (A kinase (PRKA) anchor protein 7)
Aqp2  (aquaporin 2)
Avp  (arginine vasopressin)
Avpr2  (arginine vasopressin receptor 2)
Gnas  (GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus)
Myo5b  (myosin VB)
Pde4d  (phosphodiesterase 4D, cAMP specific)
Rab11a  (RAB11A, member RAS oncogene family)
Rab11fip2  (RAB11 family interacting protein 2 (class I))
Sipa1  (signal-induced proliferation associated gene 1)
Snap23  (synaptosomal-associated protein 23)
Vamp2  (vesicle-associated membrane protein 2)

Genes (Homo sapiens)
ADCY6  (adenylate cyclase 6)
AKAP7  (A-kinase anchoring protein 7)
AQP2  (aquaporin 2)
AVP  (arginine vasopressin)
AVPR2  (arginine vasopressin receptor 2)
GNAS  (GNAS complex locus)
MYO5B  (myosin VB)
PDE4D  (phosphodiesterase 4D)
RAB11A  (RAB11A, member RAS oncogene family)
RAB11FIP2  (RAB11 family interacting protein 2)
SIPA1  (signal-induced proliferation-associated 1)
SNAP23  (synaptosome associated protein 23)
VAMP2  (vesicle associated membrane protein 2)


Additional Information