RGD Reference Report - Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. - Rat Genome Database

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Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.

Authors: Sadana, R  Dessauer, CW 
Citation: Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
RGD ID: 2312469
Pubmed: PMID:18948702   (View Abstract at PubMed)
PMCID: PMC2790773   (View Article at PubMed Central)
DOI: DOI:10.1159/000166277   (Journal Full-text)

Cyclic AMP is a universal second messenger, produced by a family of adenylyl cyclase (AC) enzymes. The last three decades have brought a wealth of new information about the regulation of cyclic AMP production by ACs. Nine hormone-sensitive, membrane-bound AC isoforms have been identified in addition to a tenth isoform that lacks membrane spans and more closely resembles the cyanobacterial AC enzymes. New model systems for purifying and characterizing the catalytic domains of AC have led to the crystal structure of these domains and the mapping of numerous interaction sites. However, big hurdles remain in unraveling the roles of individual AC isoforms and their regulation in physiological systems. In this review we explore the latest on AC knockout and overexpression studies to better understand the roles of G protein regulation of ACs in the brain, olfactory bulb, and heart.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADCY1HumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
ADCY2HumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
ADCY3HumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
ADCY4HumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
ADCY5HumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
ADCY6HumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
ADCY7HumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
ADCY8HumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
ADCY9HumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
Adcy1RatG protein mediated signaling pathway via Galphas family  ISOAdcy1 (Mus musculus) RGD 
Adcy1MouseG protein mediated signaling pathway via Galphas family  TAS  RGD 
Adcy2RatG protein mediated signaling pathway via Galphas family  ISOADCY2 (Homo sapiens) RGD 
Adcy3RatG protein mediated signaling pathway via Galphas family  ISOAdcy3 (Mus musculus) RGD 
Adcy3MouseG protein mediated signaling pathway via Galphas family  TAS  RGD 
Adcy4RatG protein mediated signaling pathway via Galphas family  ISOADCY4 (Homo sapiens) RGD 
Adcy5RatG protein mediated signaling pathway via Galphas family  ISOAdcy5 (Mus musculus) RGD 
Adcy5MouseG protein mediated signaling pathway via Galphas family  TAS  RGD 
Adcy6RatG protein mediated signaling pathway via Galphas family  ISOAdcy6 (Mus musculus) RGD 
Adcy6MouseG protein mediated signaling pathway via Galphas family  TAS  RGD 
Adcy7RatG protein mediated signaling pathway via Galphas family  ISOADCY7 (Homo sapiens) RGD 
Adcy8RatG protein mediated signaling pathway via Galphas family  ISOAdcy8 (Mus musculus) RGD 
Adcy8MouseG protein mediated signaling pathway via Galphas family  TAS  RGD 
Adcy9RatG protein mediated signaling pathway via Galphas family  ISOAdcy9 (Mus musculus) RGD 
Adcy9MouseG protein mediated signaling pathway via Galphas family  TAS  RGD 
GNASHumanG protein mediated signaling pathway via Galphas family  TAS  RGD 
GnasRatG protein mediated signaling pathway via Galphas family  ISOGNAS (Homo sapiens) RGD 
GnasMouseG protein mediated signaling pathway via Galphas family  ISOGNAS (Homo sapiens) RGD 
ADCY1Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
ADCY10Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
ADCY2Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
ADCY3Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
ADCY4Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
ADCY5Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
ADCY6Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
ADCY7Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
ADCY8Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
ADCY9Humanprotein kinase A (PKA) signaling pathway   TAS  RGD 
Adcy1Mouseprotein kinase A (PKA) signaling pathway   TAS  RGD 
Adcy1Ratprotein kinase A (PKA) signaling pathway   ISOAdcy1 (Mus musculus) RGD 
Adcy10Ratprotein kinase A (PKA) signaling pathway   ISOAdcy10 (Mus musculus) RGD 
Adcy10Mouseprotein kinase A (PKA) signaling pathway   TAS  RGD 
Adcy2Mouseprotein kinase A (PKA) signaling pathway   ISOADCY2 (Homo sapiens) RGD 
Adcy2Ratprotein kinase A (PKA) signaling pathway   ISOADCY2 (Homo sapiens) RGD 
Adcy3Mouseprotein kinase A (PKA) signaling pathway   TAS  RGD 
Adcy3Ratprotein kinase A (PKA) signaling pathway   ISOAdcy3 (Mus musculus) RGD 
Adcy4Mouseprotein kinase A (PKA) signaling pathway   ISOADCY4 (Homo sapiens) RGD 
Adcy4Ratprotein kinase A (PKA) signaling pathway   ISOADCY4 (Homo sapiens) RGD 
Adcy5Mouseprotein kinase A (PKA) signaling pathway   TAS  RGD 
Adcy5Ratprotein kinase A (PKA) signaling pathway   ISOAdcy5 (Mus musculus) RGD 
Adcy6Mouseprotein kinase A (PKA) signaling pathway   TAS  RGD 
Adcy6Ratprotein kinase A (PKA) signaling pathway   ISOAdcy6 (Mus musculus) RGD 
Adcy7Mouseprotein kinase A (PKA) signaling pathway   ISOADCY7 (Homo sapiens) RGD 
Adcy7Ratprotein kinase A (PKA) signaling pathway   ISOADCY7 (Homo sapiens) RGD 
Adcy8Mouseprotein kinase A (PKA) signaling pathway   TAS  RGD 
Adcy8Ratprotein kinase A (PKA) signaling pathway   ISOAdcy8 (Mus musculus) RGD 
Adcy9Mouseprotein kinase A (PKA) signaling pathway   TAS  RGD 
Adcy9Ratprotein kinase A (PKA) signaling pathway   ISOAdcy9 (Mus musculus) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Adcy1  (adenylate cyclase 1)
Adcy10  (adenylate cyclase 10)
Adcy2  (adenylate cyclase 2)
Adcy3  (adenylate cyclase 3)
Adcy4  (adenylate cyclase 4)
Adcy5  (adenylate cyclase 5)
Adcy6  (adenylate cyclase 6)
Adcy7  (adenylate cyclase 7)
Adcy8  (adenylate cyclase 8)
Adcy9  (adenylate cyclase 9)
Gnas  (GNAS complex locus)

Genes (Mus musculus)
Adcy1  (adenylate cyclase 1)
Adcy10  (adenylate cyclase 10)
Adcy2  (adenylate cyclase 2)
Adcy3  (adenylate cyclase 3)
Adcy4  (adenylate cyclase 4)
Adcy5  (adenylate cyclase 5)
Adcy6  (adenylate cyclase 6)
Adcy7  (adenylate cyclase 7)
Adcy8  (adenylate cyclase 8)
Adcy9  (adenylate cyclase 9)
Gnas  (GNAS complex locus)

Genes (Homo sapiens)
ADCY1  (adenylate cyclase 1)
ADCY10  (adenylate cyclase 10)
ADCY2  (adenylate cyclase 2)
ADCY3  (adenylate cyclase 3)
ADCY4  (adenylate cyclase 4)
ADCY5  (adenylate cyclase 5)
ADCY6  (adenylate cyclase 6)
ADCY7  (adenylate cyclase 7)
ADCY8  (adenylate cyclase 8)
ADCY9  (adenylate cyclase 9)
GNAS  (GNAS complex locus)


Additional Information